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  1. Article ; Online: The COVID-19 pandemic: growth patterns, power law scaling, and saturation.

    Singer, H M

    Physical biology

    2020  Volume 17, Issue 5, Page(s) 55001

    Abstract: More and more countries are showing a significant slowdown in the number of new COVID-19 infections due to effective governmentally instituted lockdown and social distancing measures. We have analyzed the growth behavior of the top 25 most affected ... ...

    Abstract More and more countries are showing a significant slowdown in the number of new COVID-19 infections due to effective governmentally instituted lockdown and social distancing measures. We have analyzed the growth behavior of the top 25 most affected countries by means of a local slope analysis and found three distinct patterns that individual countries follow depending on the strictness of the lockdown protocols: rise and fall, power law, or logistic. For countries showing power law growth we have determined the scaling exponents. For countries that showed a strong slowdown in the rate of infections we have extrapolated the expected saturation of the total number of infections and the expected final date. Three different extrapolation methods (logistic, parabolic, and cutoff power law) were used. All methods agree on the order of magnitude of saturation and end dates. Global infection rates are analyzed with the same methods. The relevance and accuracy of these extrapolations is discussed.
    MeSH term(s) Algorithms ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/transmission ; Databases, Factual ; Geography ; Human Activities ; Humans ; Logistic Models ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/transmission ; Public Health ; SARS-CoV-2 ; Time Factors
    Keywords covid19
    Language English
    Publishing date 2020-07-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2133216-2
    ISSN 1478-3975 ; 1478-3967
    ISSN (online) 1478-3975
    ISSN 1478-3967
    DOI 10.1088/1478-3975/ab9bf5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: The drug-survival of low-dose thioguanine in patients with inflammatory bowel disease: a retrospective observational study.

    Gensmyr-Singer, Helena / Werner, Mårten / Karling, Pontus

    Therapeutic advances in gastroenterology

    2024  Volume 17, Page(s) 17562848241228064

    Abstract: Background: Thiopurines are commonly used to treat inflammatory bowel disease but withdrawal due to side effects are common. Thioguanine has been suggested to be better tolerated than conventional thiopurines.: Objectives: We studied drug-survival of ...

    Abstract Background: Thiopurines are commonly used to treat inflammatory bowel disease but withdrawal due to side effects are common. Thioguanine has been suggested to be better tolerated than conventional thiopurines.
    Objectives: We studied drug-survival of low dose of thioguanine in real-life clinical practice in comparison to conventional thiopurines.
    Design: Retrospective observational study.
    Methods: All patients born 1956 and later, and who at least once started thiopurine treatment between 2006 and 2022 were included. A medical chart review was performed that noted drug-survival for every thiopurine treatment attempt. The Mantel-Cox rank test was used to test differences in drug-survival for different thiopurines. Blood chemistry analysis and faecal calprotectin levels were registered for the first 5 years of treatment.
    Results: In the study population, there was 379 initiated thiopurine treatments (210 for Crohn's disease and 169 for ulcerative colitis) in 307 patients with inflammatory bowel disease (IBD). Low-dose thioguanine (median dose 11 mg; 25-75th percentile 7-19 mg) had been initiated in 31 patients. Overall, when including all thiopurine attempts, thioguanine had the longest drug-survival [Mantel-Cox rank test: thioguanine
    Conclusion: Treatment with a low dose of thioguanine is well-tolerated in patients with IBD and had a significantly higher drug-survival than conventional thiopurines.
    Language English
    Publishing date 2024-02-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2440710-0
    ISSN 1756-2848 ; 1756-283X
    ISSN (online) 1756-2848
    ISSN 1756-283X
    DOI 10.1177/17562848241228064
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: Medical anthropology and the world system

    Baer, Hans A. / Singer, Merrill / Susser, Ida

    2013  

    Author's details Hans A. Baer, Merrill Singer, and Ida Susser
    Keywords Anthropology ; Social Medicine ; Medizin ; Anthropologie
    Subject Menschenkunde ; Humanmedizin ; Heilkunst ; Medicine
    Language English
    Size XII, 521 S. : Ill.
    Edition 3. ed.
    Publisher Praeger
    Publishing place Santa Barbara, Calif. u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT017490995
    ISBN 978-1-4408-2915-4 ; 978-1-4408-0255-3 ; 9781440802560 ; 1-4408-2915-2 ; 1-4408-0255-6 ; 1440802564
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2013 A 2291 available for loan (reading room) Lesesaal EG

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  4. Article ; Online: The COVID-19 pandemic

    Singer, H M

    Physical Biology

    growth patterns, power law scaling, and saturation

    2020  Volume 17, Issue 5, Page(s) 55001

    Keywords Biophysics ; Cell Biology ; Molecular Biology ; Structural Biology ; covid19
    Publisher IOP Publishing
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 2133216-2
    ISSN 1478-3975 ; 1478-3967
    ISSN (online) 1478-3975
    ISSN 1478-3967
    DOI 10.1088/1478-3975/ab9bf5
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Conference proceedings: Establishment and specification analysis of LSEC-like endothelial cells for the detection of endogenous FVIII

    Chawla, P / Rath, M / Oldenburg, J / Singer, H

    Hämostaseologie

    2023  Volume 43, Issue S 01

    Event/congress GTH Congress 2023 - 67th Annual Meeting of the Society of Thrombosis and Haemostasis Research - The patient as a benchmark, Frankfurt, Germany, 2023-02-21
    Language English
    Publishing date 2023-02-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 801512-0
    ISSN 2567-5761 ; 0720-9355
    ISSN (online) 2567-5761
    ISSN 0720-9355
    DOI 10.1055/s-0042-1760541
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1631: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Short-term predictions of country-specific Covid-19 infection rates based on power law scaling exponents

    Singer, H. M.

    Abstract: The number of corona virus (COVID-19) infections grows worldwide. In order to create short term predictions to prepare for the extent of the global pandemic we analyze infection data from the top 25 affected countries. It is shown that all country- ... ...

    Abstract The number of corona virus (COVID-19) infections grows worldwide. In order to create short term predictions to prepare for the extent of the global pandemic we analyze infection data from the top 25 affected countries. It is shown that all country-specific infection rates follow a power law growth behavior and the scaling exponents per country are calculated. We find two different growth patterns: either steady power law growth from the very beginning with moderate scaling exponents of 3-5 or explosive power law growth with dramatic scaling exponents of 8-11. In the case of the USA we even find an exponent of 16.59. By means of data analysis we confirm that instituting strict measures of lock-downs combined with a strong adherence by the population are effective means to bring the growth rates down. While many countries have instituted measures there are only three countries (Denmark, Norway, and South Korea) so far where such lock-downs led to a significant reduction of the growth rate. In the case of Denmark we calculate the reduction of the scaling exponents to move from 6.82 to 1.47.
    Keywords covid19
    Publisher ArXiv
    Document type Article
    Database COVID19

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  7. Article: The COVID-19 pandemic: growth patterns, power law scaling, and saturation

    Singer, H. M.

    Abstract: More and more countries show a significant slowdown in the number of new COVID-19 infections due to effective governmentally instituted lockdown and social distancing measures. We have analyzed the growth behavior of the top 25 most affected countries by ...

    Abstract More and more countries show a significant slowdown in the number of new COVID-19 infections due to effective governmentally instituted lockdown and social distancing measures. We have analyzed the growth behavior of the top 25 most affected countries by means of a local slope analysis and found three distinct patterns that individual countries follow depending on the strictness of the lockdown protocols: exponential rise and fall, power law, or logistic. For countries showing power law growth we have determined the scaling exponents. For countries that showed a strong slowdown in the rate of infections we have extrapolated the expected saturation of the number of infections and the expected final date. Two different extrapolation methods (logistic and parabolic) were used. Both methods agree on the order of magnitude of saturation and end dates. Global infections rates are analyzed with the same methods. The relevance and accuracy of these extrapolations is discussed.
    Keywords covid19
    Publisher ArXiv
    Document type Article
    Database COVID19

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  8. Book ; Online: Short-term predictions of country-specific Covid-19 infection rates based on power law scaling exponents

    Singer, H. M.

    2020  

    Abstract: The number of corona virus (COVID-19) infections grows worldwide. In order to create short term predictions to prepare for the extent of the global pandemic we analyze infection data from the top 25 affected countries. It is shown that all country- ... ...

    Abstract The number of corona virus (COVID-19) infections grows worldwide. In order to create short term predictions to prepare for the extent of the global pandemic we analyze infection data from the top 25 affected countries. It is shown that all country-specific infection rates follow a power law growth behavior and the scaling exponents per country are calculated. We find two different growth patterns: either steady power law growth from the very beginning with moderate scaling exponents of 3-5 or explosive power law growth with dramatic scaling exponents of 8-11. In the case of the USA we even find an exponent of 16.59. By means of data analysis we confirm that instituting strict measures of lock-downs combined with a strong adherence by the population are effective means to bring the growth rates down. While many countries have instituted measures there are only three countries (Denmark, Norway, and South Korea) so far where such lock-downs led to a significant reduction of the growth rate. In the case of Denmark we calculate the reduction of the scaling exponents to move from 6.82 to 1.47.

    Comment: 6 pages, 8 figures
    Keywords Physics - Physics and Society ; Quantitative Biology - Populations and Evolution ; covid19
    Subject code 612
    Publishing date 2020-03-26
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  9. Book ; Online: The COVID-19 pandemic

    Singer, H. M.

    growth patterns, power law scaling, and saturation

    2020  

    Abstract: More and more countries show a significant slowdown in the number of new COVID-19 infections due to effective governmentally instituted lockdown and social distancing measures. We have analyzed the growth behavior of the top 25 most affected countries by ...

    Abstract More and more countries show a significant slowdown in the number of new COVID-19 infections due to effective governmentally instituted lockdown and social distancing measures. We have analyzed the growth behavior of the top 25 most affected countries by means of a local slope analysis and found three distinct patterns that individual countries follow depending on the strictness of the lockdown protocols: exponential rise and fall, power law, or logistic. For countries showing power law growth we have determined the scaling exponents. For countries that showed a strong slowdown in the rate of infections we have extrapolated the expected saturation of the number of infections and the expected final date. Two different extrapolation methods (logistic and parabolic) were used. Both methods agree on the order of magnitude of saturation and end dates. Global infections rates are analyzed with the same methods. The relevance and accuracy of these extrapolations is discussed.

    Comment: 10 pages, 13 figures, 3 tables
    Keywords Quantitative Biology - Populations and Evolution ; Physics - Physics and Society ; covid19
    Publishing date 2020-04-08
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  10. Article ; Online: From market to environment - consumption-normalised pharmaceutical emissions in the Rhine catchment.

    Varga, Laura / Fenner, Kathrin / Singer, Heinz / Honti, Mark

    Water research

    2023  Volume 239, Page(s) 120017

    Abstract: Direct and indirect threats by organic micropollutants can only be reliably assessed and prevented if the exposure to these chemicals is known, which in turn requires a confident estimate of their emitted amounts into the environment. APIs (Active ... ...

    Abstract Direct and indirect threats by organic micropollutants can only be reliably assessed and prevented if the exposure to these chemicals is known, which in turn requires a confident estimate of their emitted amounts into the environment. APIs (Active Pharmaceutical Ingredients) enter surface waters mostly through the sewer system and wastewater treatment plants (WWTPs). However, their effluent fluxes are highly variable and influenced by several different factors that challenge robust emission estimates. Here, we defined a dimensionless, theoretically consumption-independent 'escape factor' (k
    MeSH term(s) Water Pollutants, Chemical/analysis ; Rivers ; Water Purification ; Uncertainty ; Pharmaceutical Preparations ; Environmental Monitoring ; Waste Disposal, Fluid
    Chemical Substances Water Pollutants, Chemical ; Pharmaceutical Preparations
    Language English
    Publishing date 2023-04-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 202613-2
    ISSN 1879-2448 ; 0043-1354
    ISSN (online) 1879-2448
    ISSN 0043-1354
    DOI 10.1016/j.watres.2023.120017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 78/260: Show issues
    Z 3381: Show issues

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