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  1. Article: The COVID-19 pandemic: implications for the cytology laboratory.

    Pambuccian, Stefan E

    Journal of the American Society of Cytopathology

    2020  Volume 9, Issue 3, Page(s) 202–211

    Abstract: The coronavirus disease 2019 (COVID-19) is a pandemic caused by the SARS-CoV-2 virus. The infection has predominantly respiratory transmission and is transmitted through large droplets or aerosols, and less commonly by contact with infected surfaces or ... ...

    Abstract The coronavirus disease 2019 (COVID-19) is a pandemic caused by the SARS-CoV-2 virus. The infection has predominantly respiratory transmission and is transmitted through large droplets or aerosols, and less commonly by contact with infected surfaces or fomites. The alarming spread of the infection and the severe clinical disease that it may cause have led to the widespread institution of social distancing measures. Because of repeated exposure to potentially infectious patients and specimens, health care and laboratory personnel are particularly susceptible to contract COVID-19. This review paper provides an assessment of the current state of knowledge about the disease and its pathology, and the potential presence of the virus in cytology specimens. It also discusses the measures that cytology laboratories can take to function during the pandemic, and minimize the risk to their personnel, trainees, and pathologists. In addition, it explores potential means to continue to educate trainees during the COVID-19 pandemic.
    MeSH term(s) Betacoronavirus/pathogenicity ; COVID-19 ; Cell Biology/trends ; Clinical Laboratory Services/standards ; Clinical Laboratory Services/trends ; Containment of Biohazards/standards ; Coronavirus Infections/pathology ; Coronavirus Infections/prevention & control ; Coronavirus Infections/transmission ; Coronavirus Infections/virology ; Humans ; Pandemics/prevention & control ; Pneumonia, Viral/pathology ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/transmission ; Pneumonia, Viral/virology ; SARS-CoV-2 ; Safety ; Specimen Handling/standards ; Specimen Handling/trends
    Keywords covid19
    Language English
    Publishing date 2020-03-26
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2213-2945
    ISSN 2213-2945
    DOI 10.1016/j.jasc.2020.03.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book: Lymph node cytopathology

    Pambuccian, Stefan E. / Bardales, Ricardo H.

    (Essentials in cytopathology [10] ; [10])

    2011  

    Author's details Stefan E. Pambuccian ; Ricardo H. Bardales
    Series title Essentials in cytopathology [10] ; [10]
    Essentials in cytopathology series
    Essentials in cytopathology [10]
    Collection Essentials in cytopathology series
    Essentials in cytopathology [10]
    Language English
    Size X, 287 S. : Ill., graph. Darst., 260 mm x 193 mm
    Publisher Springer
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    Note Zählung aus DNB ermittelt
    HBZ-ID HT016568562
    ISBN 978-1-4419-6963-7 ; 9781441969644 ; 1-4419-6963-2 ; 1441969640
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2010 A 5445 order for loan Magazin

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  3. Article: Testing for lipid-laden macrophages in bronchoalveolar lavage fluid to diagnose vaping-associated pulmonary injury. Are we there yet?

    Pambuccian, Stefan E

    Journal of the American Society of Cytopathology

    2019  Volume 9, Issue 1, Page(s) 1–8

    Abstract: Vaping-associated pulmonary injury (VAPI) is a severe respiratory disorder associated with the inhalation of nicotine, tetrahydrocannabinol, cannabidiol, or other active substances through a personal vaporizer ("vaping"). Within 2 months after its ... ...

    Abstract Vaping-associated pulmonary injury (VAPI) is a severe respiratory disorder associated with the inhalation of nicotine, tetrahydrocannabinol, cannabidiol, or other active substances through a personal vaporizer ("vaping"). Within 2 months after its description, the disease has reached epidemic proportion, affecting over 2000 people and resulting in a number of fatalities. The substance(s) responsible for the lung injury are still unknown, and the pathophysiology of the disease is still incompletely understood. The manifestations of the disease are protean, and the insidiously starting respiratory, gastrointestinal, and constitutional symptoms may initially resemble a viral flu-like illness. The disease may increase in severity, requiring hospitalization, and in more severe cases, mechanical ventilation. The diagnosis of VAPI currently relies on the identification of pulmonary infiltrates on imaging studies in patients who have used vaping products, after excluding infections and other plausible alternative diagnoses. Because VAPI is currently a diagnosis of exclusion, some authors have suggested the use of lipid-laden macrophages (LLM) as a diagnostic test to confirm the disease. We review the current state of the knowledge about the pathologic basis of VAPI, and the literature on the analytic performance of the LLM test to better understand the potential utility of this test in the diagnosis of VAPI. Our review finds little evidence to suggest the use of LLM in the diagnosis of VAPI, since its underlying pathology is acute lung injury, which is unrelated to LLM, and the frequency of their detection varies greatly in different reported series.
    MeSH term(s) Acute Lung Injury/diagnosis ; Acute Lung Injury/epidemiology ; Acute Lung Injury/etiology ; Acute Lung Injury/immunology ; Adolescent ; Adult ; Aged ; Bronchoalveolar Lavage Fluid/immunology ; Electronic Nicotine Delivery Systems ; Female ; Humans ; Lipid Droplets/metabolism ; Macrophages, Alveolar/metabolism ; Male ; Middle Aged ; United States/epidemiology ; Vaping/adverse effects ; Young Adult
    Language English
    Publishing date 2019-11-06
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2213-2945
    ISSN 2213-2945
    DOI 10.1016/j.jasc.2019.10.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The COVID-19 pandemic

    Pambuccian, Stefan E.

    Journal of the American Society of Cytopathology

    implications for the cytology laboratory

    2020  Volume 9, Issue 3, Page(s) 202–211

    Keywords Pathology and Forensic Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ISSN 2213-2945
    DOI 10.1016/j.jasc.2020.03.001
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: The COVID-19 pandemic: implications for the cytology laboratory

    Pambuccian, Stefan E

    J Am Soc Cytopathol

    Abstract: The coronavirus disease 2019 (COVID-19) is a pandemic caused by the SARS-CoV-2 virus. The infection has predominantly respiratory transmission and is transmitted through large droplets or aerosols, and less commonly by contact with infected surfaces or ... ...

    Abstract The coronavirus disease 2019 (COVID-19) is a pandemic caused by the SARS-CoV-2 virus. The infection has predominantly respiratory transmission and is transmitted through large droplets or aerosols, and less commonly by contact with infected surfaces or fomites. The alarming spread of the infection and the severe clinical disease that it may cause have led to the widespread institution of social distancing measures. Because of repeated exposure to potentially infectious patients and specimens, health care and laboratory personnel are particularly susceptible to contract COVID-19. This review paper provides an assessment of the current state of knowledge about the disease and its pathology, and the potential presence of the virus in cytology specimens. It also discusses the measures that cytology laboratories can take to function during the pandemic, and minimize the risk to their personnel, trainees, and pathologists. In addition, it explores potential means to continue to educate trainees during the COVID-19 pandemic.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #15970
    Database COVID19

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  6. Article ; Online: "Bird's eye" cells in a pericardial effusion: Metastatic renal medullary carcinoma.

    Mon, Khin Su / Kilic, Irem / Barkan, Güliz A / Pambuccian, Stefan E

    Diagnostic cytopathology

    2021  Volume 49, Issue 6, Page(s) 773–778

    MeSH term(s) Adult ; Carcinoma, Medullary/pathology ; Carcinoma, Renal Cell/pathology ; Humans ; Kidney Neoplasms/pathology ; Male ; Pericardial Effusion/pathology
    Language English
    Publishing date 2021-04-28
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 632710-2
    ISSN 1097-0339 ; 8755-1039
    ISSN (online) 1097-0339
    ISSN 8755-1039
    DOI 10.1002/dc.24736
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2117: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: "Bull's eye" cells in a pleural effusion: Metastatic pulmonary adenocarcinoma.

    Trabzonlu, Levent / Atieh, Mohammed / Pambuccian, Stefan E

    Diagnostic cytopathology

    2020  Volume 49, Issue 5, Page(s) 661–663

    MeSH term(s) Adenocarcinoma of Lung/complications ; Adenocarcinoma of Lung/pathology ; Aged ; Carcinoma, Signet Ring Cell/diagnosis ; Humans ; Lung/pathology ; Lung Neoplasms/complications ; Lung Neoplasms/pathology ; Male ; Neoplasm Metastasis ; Pleural Effusion/pathology
    Language English
    Publishing date 2020-11-25
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 632710-2
    ISSN 1097-0339 ; 8755-1039
    ISSN (online) 1097-0339
    ISSN 8755-1039
    DOI 10.1002/dc.24667
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2117: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Foreword: JASC urine cytology special edition.

    Wojcik, Eva M / Pambuccian, Stefan E / Rosenthal, Dorothy L

    Journal of the American Society of Cytopathology

    2020  Volume 10, Issue 1, Page(s) 1–2

    MeSH term(s) Carcinoma/genetics ; Carcinoma/pathology ; Carcinoma/urine ; Early Detection of Cancer ; Humans ; Microscopy ; Molecular Diagnostic Techniques ; Neoplasm Grading ; Predictive Value of Tests ; Urinalysis ; Urine/cytology ; Urologic Neoplasms/genetics ; Urologic Neoplasms/pathology ; Urologic Neoplasms/urine ; Urothelium/pathology
    Language English
    Publishing date 2020-10-15
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ISSN 2213-2945
    ISSN 2213-2945
    DOI 10.1016/j.jasc.2020.10.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: What is atypia? Use, misuse and overuse of the term atypia in diagnostic cytopathology.

    Pambuccian, Stefan E

    Journal of the American Society of Cytopathology

    2014  Volume 4, Issue 1, Page(s) 44–52

    Abstract: The term "atypical" was introduced by the founder of modern cytodiagnosis, Dr. George N. Papanicolaou, to convey a very low suspicion of (pre)malignancy. Despite controversies concerning its ambiguous and imprecise definition and its uncertain optimal ... ...

    Abstract The term "atypical" was introduced by the founder of modern cytodiagnosis, Dr. George N. Papanicolaou, to convey a very low suspicion of (pre)malignancy. Despite controversies concerning its ambiguous and imprecise definition and its uncertain optimal use, the term "atypia" has continued to be used in cytopathology, and has recently been increasingly used in standardized nongynecologic cytopathology diagnostic reporting terminologies. Its increasing use suggests that "atypia" continues to be a useful category to fill the gap between what we can recognize as entirely normal (including reactive changes) and what we can recognize as clearly abnormal (premalignant or malignant). However, this diagnosis should be used parsimoniously, since the potential overuse of "atypia" diagnoses can lead to the erosion of clinicians' confidence in cytopathology, their misunderstanding of the cytopathology report, and to an increase the clinicians' diagnostic uncertainty, with negative consequences on patients' satisfaction and wellbeing, and on health care costs. A clinically meaningful, standardized cytodiagnostic category of "atypia" requires a narrow definition, quantitative criteria, agreed-upon reference images, a clear clinical meaning (likelihood of underlying malignancy or premalignancy) and, ideally, well-defined management options. The successful implementation of such a standardized "atypia" diagnostic category requires continuous education of cytology professionals and quality assurance efforts to monitor its use. The interobserver variability and potential excessive use of the diagnosis of "atypia" may be reduced by considering and addressing the major factors involved in its variable use, namely the quality of the sample, the definition of "atypia", the education/training of the cytologist/pathologist, and cytologist/pathologist-related "supracytologic" factors.
    Language English
    Publishing date 2014-11-04
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2213-2945
    ISSN 2213-2945
    DOI 10.1016/j.jasc.2014.10.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Extranodal extension, an international survey on its evaluation and reporting in breast cancer patients.

    Tang, Ping / Moravek, Michael / Oprea-Ilies, Gabriela / Mon, Khin Su / Pambuccian, Stefan E

    Pathology, research and practice

    2022  Volume 237, Page(s) 154070

    Abstract: ... of a lymph node. (4) 71% felt that the H&E stain is adequate to evaluate ENE, deeper levels and IHC analysis ...

    Abstract Lymph node metastasis is the most important prognostic factor for breast cancer patients. In addition to the number of nodes involved and the largest metastatic focus, extranodal extension (ENE) is also used to subclassify breast cancer patients into different risk groups. More recently, pathologists are required to report the size/extent of ENE per the new CAP guideline, as it seems to be associated with more axillary nodal burden and/or a worse prognosis. Although the definition of ENE is largely understood and agreed upon among pathologists around the world, evaluation and reporting for the size of ENE are not. To understand current practice, we conducted an international survey among pathologists who are interested in breast pathology. A total of 70 pathologists responded. The results showed that (1) 98% of the participants reported the presence or absence of ENE and 61% also reported the size of ENE in millimeter (mm). (2) There was no uniform method of measuring the size of ENE; 47% measured the largest dimension regardless of orientation, while 30% measured the largest perpendicular distance from the capsule. (3) The most common factors affecting the accuracy in diagnosis of ENE are the presence of lymphovascular invasion (LVI), lack of capsule integrity, and the presence of fatty hilar or fatty replacement of a lymph node. (4) 71% felt that the H&E stain is adequate to evaluate ENE, deeper levels and IHC analysis for vascular and cytokeratin markers can be helpful if needed. (5) 75% agreed that there is an urgent need to standardize the measurement and reporting for ENE. Our survey highlights the variation in ENE evaluation and the need for its standardization in breast cancer patients with axillary node metastasis.
    MeSH term(s) Humans ; Female ; Breast Neoplasms/diagnosis ; Breast Neoplasms/pathology ; Extranodal Extension ; Lymphatic Metastasis/diagnosis ; Lymphatic Metastasis/pathology ; Lymph Nodes/pathology ; Prognosis ; Keratins ; Retrospective Studies
    Chemical Substances Keratins (68238-35-7)
    Language English
    Publishing date 2022-08-10
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 391889-0
    ISSN 1618-0631 ; 0344-0338
    ISSN (online) 1618-0631
    ISSN 0344-0338
    DOI 10.1016/j.prp.2022.154070
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ud III Zs.20: Show issues Location:
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