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Article ; Online: Convalescent Plasma for Covid-19. Reply.

Sullivan, David J / Gebo, Kelly A / Hanley, Daniel F

2022 Volume 387, Issue 10, Page(s) 955–956

MeSH term(s)	Ambulatory Care ; COVID-19/therapy ; Humans ; Immunization, Passive ; Outpatients ; Plasma
Language	English
Publishing date	2022-09-07
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMc2208338
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Article ; Online: Tumor and Peritoneum-Associated Macrophage Gene Signature as a Novel Molecular Biomarker in Gastric Cancer.

Sullivan, Kevin M / Li, Haiqing / Yang, Annie / Zhang, Zhifang / Munoz, Ruben R / Mahuron, Kelly M / Yuan, Yate-Ching / Paz, Isaac Benjamin / Von Hoff, Daniel / Han, Haiyong / Fong, Yuman / Woo, Yanghee

International journal of molecular sciences

2024 Volume 25, Issue 7

Abstract: A spectrum of immune states resulting from tumor resident macrophages and T-lymphocytes in the solid tumor microenvironment correlates with patient outcomes. We hypothesized that in gastric cancer (GC), macrophages in a polarized immunosuppressive ... ...

Abstract	A spectrum of immune states resulting from tumor resident macrophages and T-lymphocytes in the solid tumor microenvironment correlates with patient outcomes. We hypothesized that in gastric cancer (GC), macrophages in a polarized immunosuppressive transcriptional state would be prognostic of poor survival. We derived transcriptomic signatures for M2 (M2
MeSH term(s)	Humans ; Stomach Neoplasms/genetics ; Peritoneum ; Macrophages, Peritoneal ; Biomarkers ; Macrophages ; Tumor Microenvironment/genetics ; Fibrinogen
Chemical Substances	Biomarkers ; FGL2 protein, human ; Fibrinogen (9001-32-5)
Language	English
Publishing date	2024-04-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25074117
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: External validation of GO-FAR 2 calculator for outcomes after in-hospital cardiac arrest with comparison to GO-FAR and trial of expanded applications.

Maravelas, Rheanne / Aydemir, Baturay / Vos, Duncan / Brauner, Daniel / Zamihovsky, Rachel / O'Sullivan, Kelly / Bell, Anita F

Resuscitation plus

2023 Volume 16, Page(s) 100462

Abstract: Aim: Externally validate the GO-FAR 2 tool for predicting survival with good neurologic function after in-hospital cardiac arrest with comparison to the original GO-FAR tool. Additionally, we collected qualitative descriptors and performed exploratory ... ...

Abstract	Aim: Externally validate the GO-FAR 2 tool for predicting survival with good neurologic function after in-hospital cardiac arrest with comparison to the original GO-FAR tool. Additionally, we collected qualitative descriptors and performed exploratory analyses with various levels of neurologic function and discharge destination. Methods: Retrospective chart review of all patients who underwent in-hospital resuscitation after cardiac arrest during the calendar years 2016-2019 in our institution ( Results: The GO-FAR 2 score accurately predicted outcomes in our study population with a c-statistic of 0.625. The original GO-FAR score also had accurate calibration with a stronger c-statistic of 0.726. The GO-FAR score had decreased predictive value for lesser levels of neurologic function (c-statistic 0.56 for alive at discharge) and discharge destination (0.69). Descriptors of functional status by CPC score were collected. Conclusion: Our findings support the validity of the GO-FAR and GO-FAR 2 tools as published, but the c-statistics suggest modest predictive discrimination. We include functional descriptors of CPC outcomes to aid clinicians in using these tools. We propose that information about expected outcomes could be valuable in shared decision-making conversations.
Language	English
Publishing date	2023-09-06
Publishing country	Netherlands
Document type	Journal Article
ISSN	2666-5204
ISSN (online)	2666-5204
DOI	10.1016/j.resplu.2023.100462
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Kagami Ogata syndrome: a small deletion refines critical region for imprinting.

Kilich, Gonench / Hassey, Kelly / Behrens, Edward M / Falk, Marni / Vanderver, Adeline / Rader, Daniel J / Cahill, Patrick J / Raper, Anna / Zhang, Zhe / Westerfer, Dawn / Jadhav, Tanaya / Conlin, Laura / Izumi, Kosuke / Rajagopalan, Ramakrishnan / Sullivan, Kathleen E

NPJ genomic medicine

2024 Volume 9, Issue 1, Page(s) 5

Abstract: Kagami-Ogata syndrome is a rare imprinting disorder and its phenotypic overlap with multiple different etiologies hampers diagnosis. Genetic etiologies include paternal uniparental isodisomy (upd(14)pat), maternal allele deletions of differentially ... ...

Abstract	Kagami-Ogata syndrome is a rare imprinting disorder and its phenotypic overlap with multiple different etiologies hampers diagnosis. Genetic etiologies include paternal uniparental isodisomy (upd(14)pat), maternal allele deletions of differentially methylated regions (DMR) in 14q32.2 or pure primary epimutations. We report a patient with Kagami-Ogata syndrome and an atypical diagnostic odyssey with several negative standard-of-care genetic tests followed by epigenetic testing using methylation microarray and a targeted analysis of whole-genome sequencing to reveal a 203 bp deletion involving the MEG3 transcript and MEG3:TSS-DMR. Long-read sequencing enabled the simultaneous detection of the deletion, phasing, and biallelic hypermethylation of the MEG3:TSS-DMR region in a single assay. This case highlights the challenges in the sequential genetic testing paradigm, the utility of long-read sequencing as a single comprehensive diagnostic assay, and the smallest reported deletion causing Kagami-Ogata syndrome allowing important insights into the mechanism of imprinting effects at this locus.
Language	English
Publishing date	2024-01-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2813848-X
ISSN	2056-7944 ; 2056-7944
ISSN (online)	2056-7944
ISSN	2056-7944
DOI	10.1038/s41525-023-00389-2
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Article ; Online: Show me the roads and give me a road map: Development of a patient conversation tool to improve lung cancer treatment decision-making.

Golden, Sara E / Disher, Natalie / Dieckmann, Nathan F / Eden, Karen B / Matlock, Daniel / Vranas, Kelly C / Slatore, Christopher G / Sullivan, Donald R

PEC innovation

2022 Volume 1, Page(s) 100094

Abstract: Objective: Evidence-based decision support resources do not exist for persons with lung cancer. We sought to develop and refine a treatment decision support, or conversation tool, to improve shared decision-making (SDM).: Methods: We conducted a ... ...

Abstract	Objective: Evidence-based decision support resources do not exist for persons with lung cancer. We sought to develop and refine a treatment decision support, or conversation tool, to improve shared decision-making (SDM). Methods: We conducted a multi-site study among patients with stage I-IV non-small cell lung cancer (NSCLC) who completed or had ongoing lung cancer treatment using semi-structured, cognitive qualitative interviews to assess participant understanding of content. We used an integrated approach of deductive and inductive thematic analysis. Results: Twenty-seven patients with NSCLC participated. Participants with prior cancer experiences or those with family members with prior cancer experiences reported better preparedness for cancer treatment decision-making. All participants agreed the conversation tool would be helpful to clarify their thinking about values, comparisons, and goals of treatment, and to help patients communicate more effectively with their clinicians. Conclusion: Participants reported that the tool may empower them with confidence and agency to actively participate in cancer treatment SDM. The conversation tool was acceptable, comprehensible, and usable. Next steps will test effectiveness on patient-centered and decisional outcomes. Innovation: A personalized conversation tool using consequence tables and core SDM components is novel in that it can encourage a tailored, conversational dynamic and includes patient-centered values along with traditional decisional outcomes.
Language	English
Publishing date	2022-10-21
Publishing country	Netherlands
Document type	Journal Article
ISSN	2772-6282
ISSN (online)	2772-6282
DOI	10.1016/j.pecinn.2022.100094
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Kagami Ogata syndrome

Gonench Kilich / Kelly Hassey / Edward M. Behrens / Marni Falk / Adeline Vanderver / Daniel J. Rader / Patrick J. Cahill / Anna Raper / Zhe Zhang / Dawn Westerfer / Tanaya Jadhav / Laura Conlin / Kosuke Izumi / Ramakrishnan Rajagopalan / Kathleen E. Sullivan / UDN Consortium

npj Genomic Medicine, Vol 9, Iss 1, Pp 1-

a small deletion refines critical region for imprinting

2024 Volume 6

Abstract: Abstract Kagami–Ogata syndrome is a rare imprinting disorder and its phenotypic overlap with multiple different etiologies hampers diagnosis. Genetic etiologies include paternal uniparental isodisomy (upd(14)pat), maternal allele deletions of ... ...

Abstract	Abstract Kagami–Ogata syndrome is a rare imprinting disorder and its phenotypic overlap with multiple different etiologies hampers diagnosis. Genetic etiologies include paternal uniparental isodisomy (upd(14)pat), maternal allele deletions of differentially methylated regions (DMR) in 14q32.2 or pure primary epimutations. We report a patient with Kagami–Ogata syndrome and an atypical diagnostic odyssey with several negative standard-of-care genetic tests followed by epigenetic testing using methylation microarray and a targeted analysis of whole-genome sequencing to reveal a 203 bp deletion involving the MEG3 transcript and MEG3:TSS-DMR. Long-read sequencing enabled the simultaneous detection of the deletion, phasing, and biallelic hypermethylation of the MEG3:TSS-DMR region in a single assay. This case highlights the challenges in the sequential genetic testing paradigm, the utility of long-read sequencing as a single comprehensive diagnostic assay, and the smallest reported deletion causing Kagami–Ogata syndrome allowing important insights into the mechanism of imprinting effects at this locus.
Keywords	Medicine ; R ; Genetics ; QH426-470
Subject code	570
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Associations of religious and existential variables with psychosocial factors and biomarkers of cardiovascular risk in bereavement.

Palitsky, Roman / Chen, Zhuo Job / Rentscher, Kelly E / Friedman, Sydney E / Wilson, Da' Mere T / Ruiz, John M / Sullivan, Daniel / Grant, George H / O'Connor, Mary-Frances

Aging cell

2023 Volume 23, Issue 1, Page(s) e14014

Abstract: Bereavement increases in prevalence as people age and is associated with multiple psychological and health risks, including cardiovascular risk. Religious and existential variables may play an important role in the health impacts of bereavement. ... ...

Abstract	Bereavement increases in prevalence as people age and is associated with multiple psychological and health risks, including cardiovascular risk. Religious and existential variables may play an important role in the health impacts of bereavement. Theorized pathways linking religious and existential variables with health have suggested these associations are due to intermediary psychosocial variables, but have not been tested in bereavement. This research empirically tested these pathways in a bereaved population. In N = 73 adults within 1 year of bereavement (mean age = 64.36), this study examined associations between (1) religious and existential characteristics (religious and spiritual struggles, intrinsic religiosity, and existential quest) and intermediary psychosocial variables (depression, loneliness, and difficulties in emotion regulation), and between (2) intermediary psychosocial variables and bereavement-relevant health outcomes (self-reported health, change in health since last year, grief severity, and cardiovascular biomarkers). Cardiovascular biomarkers (heart rate, heart rate variability, and blood pressure) were collected before, during, and after a laboratory grief recall emotion elicitation. Anticipated associations between self-reported religious and existential characteristics and intermediary variables, and between intermediary variables and self-reported bereavement-relevant outcomes, were consistently observed. However, associations between intermediary variables and cardiovascular biomarkers were largely unobserved. This study examined the role of religious and existential variables in whole-person health after bereavement and is among the first to include biomarkers of cardiovascular risk. Results suggest that although religious and existential variables are associated with important bereavement-related outcomes, these associations may be "skin-deep," and extensions to cardiovascular functioning should be re-examined.
MeSH term(s)	Adult ; Humans ; Middle Aged ; Cardiovascular Diseases ; Spirituality ; Adaptation, Psychological ; Risk Factors ; Grief ; Bereavement ; Heart Disease Risk Factors
Language	English
Publishing date	2023-10-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2113083-8
ISSN	1474-9726 ; 1474-9718
ISSN (online)	1474-9726
ISSN	1474-9718
DOI	10.1111/acel.14014
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Article ; Online: Intact mitochondrial function in the setting of telomere-induced senescence.

Sullivan, Daniel I / Bello, Fiona M / Silva, Agustin Gil / Redding, Kevin M / Giordano, Luca / Hinchie, Angela M / Loughridge, Kelly E / Mora, Ana L / Königshoff, Melanie / Kaufman, Brett A / Jurczak, Michael J / Alder, Jonathan K

Aging cell

2023 Volume 22, Issue 10, Page(s) e13941

Abstract: Mitochondria play essential roles in metabolic support and signaling within all cells. Congenital and acquired defects in mitochondria are responsible for several pathologies, including premature entrance to cellar senescence. Conversely, we examined the ...

Abstract	Mitochondria play essential roles in metabolic support and signaling within all cells. Congenital and acquired defects in mitochondria are responsible for several pathologies, including premature entrance to cellar senescence. Conversely, we examined the consequences of dysfunctional telomere-driven cellular senescence on mitochondrial biogenesis and function. We drove senescence in vitro and in vivo by deleting the telomere-binding protein TRF2 in fibroblasts and hepatocytes, respectively. Deletion of TRF2 led to a robust DNA damage response, global changes in transcription, and induction of cellular senescence. In vitro, senescent cells had significant increases in mitochondrial respiratory capacity driven by increased cellular and mitochondrial volume. Hepatocytes with dysfunctional telomeres maintained their mitochondrial respiratory capacity in vivo, whether measured in intact cells or purified mitochondria. Induction of senescence led to the upregulation of overlapping and distinct genes in fibroblasts and hepatocytes, but transcripts related to mitochondria were preserved. Our results support that mitochondrial function and activity are preserved in telomere dysfunction-induced senescence, which may facilitate continued cellular functions.
MeSH term(s)	Telomere/genetics ; Telomere-Binding Proteins/metabolism ; Mitochondria/genetics ; Mitochondria/metabolism ; Cellular Senescence/genetics ; Fibroblasts/metabolism
Chemical Substances	Telomere-Binding Proteins
Language	English
Publishing date	2023-09-08
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2113083-8
ISSN	1474-9726 ; 1474-9718
ISSN (online)	1474-9726
ISSN	1474-9718
DOI	10.1111/acel.13941
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Article: Tumor cell-based liquid biopsy using high-throughput microfluidic enrichment of entire leukapheresis product.

Mishra, Avanish / Huang, Shih-Bo / Dubash, Taronish / Burr, Risa / Edd, Jon F / Wittner, Ben S / Cunneely, Quinn E / Putaturo, Victor R / Deshpande, Akansha / Antmen, Ezgi / Gopinathan, Kaustav A / Otani, Keisuke / Miyazawa, Yoshiyuki / Kwak, Ji Eun / Guay, Sara Y / Kelly, Justin / Walsh, John / Nieman, Linda / Galler, Isabella /

Chan, PuiYee / Lawrence, Michael S / Sullivan, Ryan J / Bardia, Aditya / Micalizzi, Douglas S / Sequist, Lecia V / Lee, Richard J / Franses, Joseph W / Ting, David T / Brunker, Patricia A R / Maheswaran, Shyamala / Miyamoto, David T / Haber, Daniel A / Toner, Mehmet

bioRxiv : the preprint server for biology

2024

Abstract: Circulating Tumor Cells (CTCs), interrogated by sampling blood from patients with cancer, contain multiple analytes, including intact RNA, high molecular weight DNA, proteins, and metabolic markers. However, the clinical utility of tumor cell-based ... ...

Abstract	Circulating Tumor Cells (CTCs), interrogated by sampling blood from patients with cancer, contain multiple analytes, including intact RNA, high molecular weight DNA, proteins, and metabolic markers. However, the clinical utility of tumor cell-based liquid biopsy has been limited since CTCs are very rare, and current technologies cannot process the blood volumes required to isolate a sufficient number of tumor cells for in-depth assays. We previously described a high-throughput microfluidic prototype utilizing high-flow channels and amplification of cell sorting forces through magnetic lenses. Here, we apply this technology to analyze patient-derived leukapheresis products, interrogating a mean blood volume of 5.83 liters from patients with metastatic cancer, with a median of 2,799 CTCs purified per patient. Isolation of many CTCs from individual patients enables characterization of their morphological and molecular heterogeneity, including cell and nuclear size and RNA expression. It also allows robust detection of gene copy number variation, a definitive cancer marker with potential diagnostic applications. High-volume microfluidic enrichment of CTCs constitutes a new dimension in liquid biopsies.
Language	English
Publishing date	2024-03-14
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.03.13.583573
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Article ; Online: Show me the roads and give me a road map

Sara E. Golden / Natalie Disher / Nathan F. Dieckmann / Karen B. Eden / Daniel Matlock / Kelly C. Vranas / Christopher G. Slatore / Donald R. Sullivan

PEC Innovation, Vol 1, Iss , Pp 100094- (2022)

Development of a patient conversation tool to improve lung cancer treatment decision-making

2022

Abstract	Objective: Evidence-based decision support resources do not exist for persons with lung cancer. We sought to develop and refine a treatment decision support, or conversation tool, to improve shared decision-making (SDM). Methods: We conducted a multi-site study among patients with stage I-IV non-small cell lung cancer (NSCLC) who completed or had ongoing lung cancer treatment using semi-structured, cognitive qualitative interviews to assess participant understanding of content. We used an integrated approach of deductive and inductive thematic analysis. Results: Twenty-seven patients with NSCLC participated. Participants with prior cancer experiences or those with family members with prior cancer experiences reported better preparedness for cancer treatment decision-making. All participants agreed the conversation tool would be helpful to clarify their thinking about values, comparisons, and goals of treatment, and to help patients communicate more effectively with their clinicians. Conclusion: Participants reported that the tool may empower them with confidence and agency to actively participate in cancer treatment SDM. The conversation tool was acceptable, comprehensible, and usable. Next steps will test effectiveness on patient-centered and decisional outcomes. Innovation: A personalized conversation tool using consequence tables and core SDM components is novel in that it can encourage a tailored, conversational dynamic and includes patient-centered values along with traditional decisional outcomes.
Keywords	Lung neoplasm ; Decision support techniques ; Qualitative research ; Public aspects of medicine ; RA1-1270
Subject code	150
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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