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Article ; Online: Intradermal vitamin C: A new paradigm in the treatment of exogenous ochronosis.

Rajesh Gulwani, Priyanka / Parekh, Abhishek R / Shah, Hiral A

Indian journal of dermatology, venereology and leprology

2024 , Page(s) 1–3

Language	English
Publishing date	2024-03-14
Publishing country	United States
Document type	Letter
ZDB-ID	416068-x
ISSN	0973-3922 ; 0019-5162 ; 0378-6323
ISSN (online)	0973-3922
ISSN	0019-5162 ; 0378-6323
DOI	10.25259/IJDVL_890_2023
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: An Updated Trial Sequential Meta-analysis of Vitamin D Receptor Gene Polymorphism (Fok1, Bsm1, Taq1 and Apa1) and Risk to Tuberculosis.

Shah, Srishti / Priyanka / Sharma, Sadhna

Indian journal of clinical biochemistry : IJCB

2022 Volume 39, Issue 1, Page(s) 60–72

Abstract: Vitamin D receptor (VDR) is one of the most widely studied genes for the Tuberculosis (TB) susceptibility. Several studies have been conducted to establish some association between them but most of the time they are contradictory and underpowered. So, a ... ...

Abstract	Vitamin D receptor (VDR) is one of the most widely studied genes for the Tuberculosis (TB) susceptibility. Several studies have been conducted to establish some association between them but most of the time they are contradictory and underpowered. So, a trial sequential meta-analysis between VDR gene polymorphisms and TB susceptibility can provide a better understanding of the relationship. A meta-analysis was carried out using a total of 17 case-control studies which includes Fok1 (14 Studies), Bsm1 (8 Studies), Apa1 (8 Studies) and Taq1 (12 Studies) polymorphisms in the VDR gene searched from Pubmed and Google Scholar. Pooled Odds Ratio (OR) and 95% Confidence Interval (CI) were calculated using StatsDirect Version 3, using random effects model. Trial sequential analysis (TSA) was also performed to assess if the statistical significance of the meta-analysis was within monitoring boundaries. It was found that the individuals with BB genotype of Bsm1 polymorphism with OR = 0.713 (95%CI = 0.521, 0.974; p value < 0.05) and FF genotype of Fok1 polymorphism with pooled OR = 0.716 (95%CI = 0.523, 0.979; p value < 0.05) had decreased incidence of TB. Also, the aa genotype of Apa1 gene polymorphism increases susceptibility to TB with pooled OR = 1.997 (95%CI = 1.121, 3.558; p value < 0.05). All these analyses reached the required information size through TSA analysis. No statistically significant result was found for Taq1 polymorphisms and TB susceptibility. VDR polymorphisms in Fok1 and Bsm1 played protective roles against development of TB infection, while Apa1 appeared to have a significant association to TB susceptibility. Supplementary information: The online version contains supplementary material available at 10.1007/s12291-022-01091-3.
Language	English
Publishing date	2022-10-31
Publishing country	India
Document type	Journal Article
ZDB-ID	1033583-3
ISSN	0974-0422 ; 0970-1915
ISSN (online)	0974-0422
ISSN	0970-1915
DOI	10.1007/s12291-022-01091-3
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Article ; Online: Neonatal Disseminated Tuberculosis With Genitourinary Involvement.

Dey, Meenakshi / Sahajwani, Priyanka / Shah, Ira

The Pediatric infectious disease journal

2023 Volume 42, Issue 12, Page(s) e493–e494

MeSH term(s)	Humans ; Infant, Newborn ; Tuberculosis, Miliary/complications ; Urogenital Diseases/etiology
Language	English
Publishing date	2023-08-14
Publishing country	United States
Document type	Case Reports ; Letter
ZDB-ID	392481-6
ISSN	1532-0987 ; 0891-3668
ISSN (online)	1532-0987
ISSN	0891-3668
DOI	10.1097/INF.0000000000004071
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Article ; Online: Transmucosal Delivery of Peptides and Proteins Through Nanofibers: Current Status and Emerging Developments.

Gavali, Priyanka / Desai, Jagruti / Shah, Pranav / Sawarkar, Sujata

AAPS PharmSciTech

2024 Volume 25, Issue 4, Page(s) 74

Abstract: Advancements in recombinant DNA technology have made proteins and peptides available for diagnostic and therapeutic applications, but their effectiveness when taken orally leads to poor patient compliance, requiring clinical administration. Among the ... ...

Abstract	Advancements in recombinant DNA technology have made proteins and peptides available for diagnostic and therapeutic applications, but their effectiveness when taken orally leads to poor patient compliance, requiring clinical administration. Among the alternative routes, transmucosal delivery has the advantage of being noninvasive and bypassing hepato-gastrointestinal clearance. Various mucosal routes-buccal, nasal, pulmonary, rectal, and vaginal-have been explored for delivering these macromolecules. Nanofibers, due to their unique properties like high surface-area-to-volume ratio, mechanical strength, and improved encapsulation efficiency, serve as promising carriers for proteins and peptides. These nanofibers can be tailored for quick dissolution, controlled release, enhanced encapsulation, targeted delivery, and improved bioavailability, offering superior pharmaceutical and pharmacokinetic performance compared to conventional methods. This leads to reduced dosages, fewer side effects, and enhanced patient compliance. Hence, nanofibers hold tremendous potential for protein/peptide delivery, especially through mucosal routes. This review focuses on the therapeutic application of proteins and peptides, challenges faced in their conventional delivery, techniques for fabricating different types of nanofibers and, various nanofiber-based dosage forms, and factors influencing nanofiber generation. Insights pertaining to the precise selection of materials used for fabricating nanofibers and regulatory aspects have been covered. Case studies wherein the use of specific protein/peptide-loaded nanofibers and delivered via oral/vaginal/nasal mucosa for diagnostic/therapeutic use and related preclinical and clinical studies conducted have been included in this review.
MeSH term(s)	Female ; Humans ; Drug Delivery Systems/methods ; Nanofibers/chemistry ; Proteins ; Peptides ; Pharmaceutical Preparations
Chemical Substances	Proteins ; Peptides ; Pharmaceutical Preparations
Language	English
Publishing date	2024-04-04
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2052070-0
ISSN	1530-9932 ; 1530-9932
ISSN (online)	1530-9932
ISSN	1530-9932
DOI	10.1208/s12249-024-02794-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Editorial: Oscillatory brain activity as a marker of brain function and dysfunction in aging and in neurodegenerative disorders.

Kielar, Aneta / Shah-Basak, Priyanka / Meyer, Lars / Fujioka, Takako

Frontiers in aging neuroscience

2023 Volume 15, Page(s) 1153150

Language	English
Publishing date	2023-02-15
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2558898-9
ISSN	1663-4365
ISSN	1663-4365
DOI	10.3389/fnagi.2023.1153150
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Article ; Online: Developing ophthalmology in Cambodia.

Mandal, Priyanka / Shah, Camrun / Shah, Sunil

Eye (London, England)

2023 Volume 38, Issue 6, Page(s) 1084–1090

Abstract: ... pterygium. The Khmer Sight Foundation (KSF) is a charity reincarnated by Professor Sunil Shah and Sean Ngu ...

Abstract	Over 180,000 Cambodian people are blind and a further 10,000 suffer avoidable blindness each year. Ninety percent of this blindness is avoidable, 79% is curable and 11% is preventable. Three-quarters of this blindness is due to cataracts and the remainder is due to uncorrected vision, glaucoma, corneal scarring and pterygium. The Khmer Sight Foundation (KSF) is a charity reincarnated by Professor Sunil Shah and Sean Ngu. Its mission is to deliver a sustainable eye care model for the country. KSF takes a three pronged approach to this. It is working to develop sustainable eye-care within the country through building physical infrastructure. The second approach is to impact the current cataract backlog of over 300,000 patients with the aid of international support. Thirdly, KSF is paving the way for the next generation through the development of an optometry education programme and training of Cambodian ophthalmologists. Here we present the workings of KSF, clinical cases we have encountered and elaborate upon the future goals of this charity.
MeSH term(s)	Humans ; Ophthalmology ; Cambodia ; Cataract ; Blindness/prevention & control ; Southeast Asian People
Language	English
Publishing date	2023-12-22
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	91001-6
ISSN	1476-5454 ; 0950-222X
ISSN (online)	1476-5454
ISSN	0950-222X
DOI	10.1038/s41433-023-02846-9
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Zs.MO 603: Show issues

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Article: Silvery Gray Hair Syndrome With Hemophagocytic Lymphohistiocytosis: A Case Report.

Chalipat, Shiji / Kulkarni, Vishwanath / Malwade, Sudhir / Shah, Priyanka / Bijaspur, Prasad

Cureus

2024 Volume 16, Issue 3, Page(s) e55649

Abstract: Griscelli syndrome (GS) is a rare autosomal recessive disorder, which has been classified into three subtypes based on clinical and genetic differences. GS subtype 2 is commonly associated with hemophagocytic lymphohistiocytosis (HLH) and recurrent ... ...

Abstract	Griscelli syndrome (GS) is a rare autosomal recessive disorder, which has been classified into three subtypes based on clinical and genetic differences. GS subtype 2 is commonly associated with hemophagocytic lymphohistiocytosis (HLH) and recurrent infections due to immunodeficiency. In this study, we describe a four-month-old boy with genetically proven GS2, with neurological and immunological manifestations. He presented with fever, refusal of feeds, drowsiness, and multiple episodes of seizures. Examination revealed hypopigmented skin, silvery gray hair, and organomegaly. The child developed features of HLH, fulfilling clinical and laboratory criteria. Neuroimaging findings were in concordance with HLH of the central nervous system. Microscopic examination of the hair showed clumps of melanin pigment along the hair shaft. All findings were in favor of GS type 2, complicated with HLH, which was later confirmed with a homozygous deletion of the RAB27A gene on exome sequencing. Unfortunately, the baby succumbed to death due to severe sepsis and multiorgan dysfunction. The silvery gray hair, with typical hair microscopic findings, and association with HLH are strong indicators for this potentially fatal condition and aid in prompt diagnosis and initiation of treatment. Hematopoietic stem cell transplantation is the only lifesaving treatment option.
Language	English
Publishing date	2024-03-06
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.55649
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Uncovering the green frontier: harnessing deep eutectic solvents for sustainable bioanalysis.

Shah, Priyanka A / Shrivastav, Pranav S / Sharma, Vinay S / Chavda, Vishwajit

Bioanalysis

2023 Volume 15, Issue 14, Page(s) 815–821

MeSH term(s)	Deep Eutectic Solvents ; Solvents ; Liquid Phase Microextraction ; Limit of Detection
Chemical Substances	Deep Eutectic Solvents ; Solvents
Language	English
Publishing date	2023-08-08
Publishing country	England
Document type	Journal Article
ISSN	1757-6199
ISSN (online)	1757-6199
DOI	10.4155/bio-2023-0088
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Plummer-Vinson Syndrome and Role of Endoscopic Balloon Dilatation in a 4-Year-Old Child.

Sahajwani, Priyanka / Rustagi, Megha / Tetarbe, Shivangi / Shah, Ira

JPGN reports

2023 Volume 4, Issue 4, Page(s) e375

Abstract: Plummer-Vinson syndrome (PVS), also called Patterson-Kelly-Brown syndrome, is a rare cause of dysphagia in children. This syndrome is associated with single or multiple webs in the upper esophagus with frequent iron deficiency. PVS usually occurs in ... ...

Abstract	Plummer-Vinson syndrome (PVS), also called Patterson-Kelly-Brown syndrome, is a rare cause of dysphagia in children. This syndrome is associated with single or multiple webs in the upper esophagus with frequent iron deficiency. PVS usually occurs in adults, particularly in Caucasian middle-aged women, in the fourth to seventh decade of life, and is rare in childhood. There are various theories about what causes PVS. One theory suggests that iron deficiency plays a crucial role in its development. Iron repletion often improves dysphagia, although some patients require esophageal dilatation or bougienage. Herein, we describe the case of a 4-year-old male child, having complaints of difficulty in swallowing solid food, diagnosed with PVS.
Language	English
Publishing date	2023-10-26
Publishing country	United States
Document type	Case Reports
ISSN	2691-171X
ISSN (online)	2691-171X
DOI	10.1097/PG9.0000000000000375
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: An evidence-based review on host modulatory agents in treatment of peri-implant disease

Mudra Andharia / Jasuma Rai / Monali Shah / Priyanka Sonavane

Advances in Human Biology, Vol 13, Iss 1, Pp 10-

2023 Volume 16

Abstract: Antimicrobials have traditionally been the only chemotherapeutic option for treating periodontitis and peri-implant disorders. With a growing understanding of the host–pathogen interactions in periodontal pathogenesis, novel therapeutic options for ... ...

Abstract	Antimicrobials have traditionally been the only chemotherapeutic option for treating periodontitis and peri-implant disorders. With a growing understanding of the host–pathogen interactions in periodontal pathogenesis, novel therapeutic options for periodontitis and peri-implant disorders are developed by focusing on the host response with host-modulating drugs. When employed as host-modifying agents, a variety of sub-antimicrobial dose doxycycline (SDD), bisphosphonates and non-steroidal anti-inflammatory drugs were found to be successful in both experimental animal research and human trials. The current state and future prospects of host modulatory agents used to treat peri-implant disease are discussed in this evidence-based review.
Keywords	bisphosphonates ; melatonin ; peri-implantitis ; probiotics ; sub-antimicrobial dose doxycycline ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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