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  1. Article ; Online: Hepatopathology of flaviviruses.

    Bailey, Adam L / Diamond, Michael S

    Journal of hepatology

    2022  Volume 77, Issue 6, Page(s) 1711–1713

    Language English
    Publishing date 2022-08-16
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2022.05.024
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  2. Book: West nile encephalitis virus infection

    Diamond, Michael S.

    viral pathogenesis and the host immune response

    (Emerging infectious diseases of the 21st century)

    2009  

    Author's details Michael S. Diamond (ed.)
    Series title Emerging infectious diseases of the 21st century
    Keywords West Nile Virus / pathogenicity ; West Nile Virus / immunology ; West Nile Fever / immunology ; West Nile Fever / physiopathology
    Language English
    Size XIX, 485 S. : Ill., graph. Darst., Kt., 235 mm x 155 mm
    Publisher Springer Science+Business Media
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT015828671
    ISBN 978-0-387-79839-4 ; 0-387-79839-0 ; 9780387798400 ; 0387798404
    Database Catalogue ZB MED Medicine, Health

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    2009 A 1083 order for loan Magazin

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  3. Article ; Online: A molecular understanding of alphavirus entry and antibody protection.

    Kim, Arthur S / Diamond, Michael S

    Nature reviews. Microbiology

    2022  Volume 21, Issue 6, Page(s) 396–407

    Abstract: Alphaviruses are arthropod-transmitted RNA viruses that cause epidemics of human infection and disease on a global scale. These viruses are classified as either arthritogenic or encephalitic based on their genetic relatedness and the clinical syndromes ... ...

    Abstract Alphaviruses are arthropod-transmitted RNA viruses that cause epidemics of human infection and disease on a global scale. These viruses are classified as either arthritogenic or encephalitic based on their genetic relatedness and the clinical syndromes they cause. Although there are currently no approved therapeutics or vaccines against alphaviruses, passive transfer of monoclonal antibodies confers protection in animal models. This Review highlights recent advances in our understanding of the host factors required for alphavirus entry, the mechanisms of action by which protective antibodies inhibit different steps in the alphavirus infection cycle and candidate alphavirus vaccines currently under clinical evaluation that focus on humoral immunity. A comprehensive understanding of alphavirus entry and antibody-mediated protection may inform the development of new classes of countermeasures for these emerging viruses.
    MeSH term(s) Animals ; Humans ; Alphavirus/genetics ; Alphavirus Infections/prevention & control ; Antibodies, Monoclonal
    Chemical Substances Antibodies, Monoclonal
    Language English
    Publishing date 2022-12-06
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2139054-X
    ISSN 1740-1534 ; 1740-1526
    ISSN (online) 1740-1534
    ISSN 1740-1526
    DOI 10.1038/s41579-022-00825-7
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  4. Article ; Online: No IL-18BP? Avoid HAV.

    Diamond, Michael S

    The Journal of experimental medicine

    2019  Volume 216, Issue 8, Page(s) 1728–1729

    Abstract: Fulminant viral hepatitis occurs in a very small number of infected individuals. Until now, the basis for this phenotype has remained unknown. In this issue ... ...

    Abstract Fulminant viral hepatitis occurs in a very small number of infected individuals. Until now, the basis for this phenotype has remained unknown. In this issue of
    MeSH term(s) Child ; Hepatitis ; Hepatocytes ; Humans
    Language English
    Publishing date 2019-06-26
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 218343-2
    ISSN 1540-9538 ; 0022-1007
    ISSN (online) 1540-9538
    ISSN 0022-1007
    DOI 10.1084/jem.20190841
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  5. Article ; Online: Innate immunity: the first line of defense against SARS-CoV-2.

    Diamond, Michael S / Kanneganti, Thirumala-Devi

    Nature immunology

    2022  Volume 23, Issue 2, Page(s) 165–176

    Abstract: The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus (SARS-CoV)-2, continues to cause substantial morbidity and mortality. While most infections are mild, some patients experience severe and ... ...

    Abstract The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus (SARS-CoV)-2, continues to cause substantial morbidity and mortality. While most infections are mild, some patients experience severe and potentially fatal systemic inflammation, tissue damage, cytokine storm and acute respiratory distress syndrome. The innate immune system acts as the first line of defense, sensing the virus through pattern recognition receptors and activating inflammatory pathways that promote viral clearance. Here, we discuss innate immune processes involved in SARS-CoV-2 recognition and the resultant inflammation. Improved understanding of how the innate immune system detects and responds to SARS-CoV-2 will help identify targeted therapeutic modalities that mitigate severe disease and improve patient outcomes.
    MeSH term(s) Animals ; COVID-19/immunology ; COVID-19/metabolism ; COVID-19/virology ; Cytokines/immunology ; Cytokines/metabolism ; Humans ; Immune Evasion ; Immunity, Innate ; Inflammasomes/immunology ; Inflammasomes/metabolism ; NLR Proteins/immunology ; NLR Proteins/metabolism ; Receptors, Pattern Recognition/immunology ; Receptors, Pattern Recognition/metabolism ; SARS-CoV-2/immunology ; SARS-CoV-2/pathogenicity ; Signal Transduction ; Toll-Like Receptors/immunology ; Toll-Like Receptors/metabolism ; Virus Internalization
    Chemical Substances Cytokines ; Inflammasomes ; NLR Proteins ; Receptors, Pattern Recognition ; Toll-Like Receptors
    Language English
    Publishing date 2022-02-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-021-01091-0
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  6. Article ; Online: The many ways in which alphaviruses bind to cells.

    Raju, Saravanan / Adams, Lucas J / Diamond, Michael S

    Trends in immunology

    2023  Volume 45, Issue 2, Page(s) 85–93

    Abstract: Only a subset of viruses can productively infect many different host species. Some arthropod-transmitted viruses, such as alphaviruses, can infect invertebrate and vertebrate species including insects, reptiles, birds, and mammals. This broad tropism may ...

    Abstract Only a subset of viruses can productively infect many different host species. Some arthropod-transmitted viruses, such as alphaviruses, can infect invertebrate and vertebrate species including insects, reptiles, birds, and mammals. This broad tropism may be explained by their ability to engage receptors that are conserved across vertebrate and invertebrate classes. Through several genome-wide loss-of-function screens, new alphavirus receptors have been identified, some of which bind to multiple related viruses in different antigenic complexes. Structural analysis has revealed that distinct sites on the alphavirus glycoprotein can mediate receptor binding, which opposes the idea that a single receptor-binding site mediates viral entry. Here, we discuss how different paradigms of receptor engagement on cells might explain the promiscuity of alphaviruses for multiple hosts.
    MeSH term(s) Humans ; Animals ; Alphavirus/metabolism ; Virus Replication ; Mammals
    Language English
    Publishing date 2023-12-22
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2036831-8
    ISSN 1471-4981 ; 1471-4906
    ISSN (online) 1471-4981
    ISSN 1471-4906
    DOI 10.1016/j.it.2023.11.006
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  7. Article ; Online: Host cell-intrinsic innate immune recognition of SARS-CoV-2.

    Madden, Emily A / Diamond, Michael S

    Current opinion in virology

    2021  Volume 52, Page(s) 30–38

    Abstract: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) emerged at the end of 2019 and caused the pandemic of coronavirus disease 2019 (COVID-19). Basic and clinical investigations indicate that severe forms of COVID-19 are due in part to ... ...

    Abstract Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) emerged at the end of 2019 and caused the pandemic of coronavirus disease 2019 (COVID-19). Basic and clinical investigations indicate that severe forms of COVID-19 are due in part to dysregulated immune responses to virus infection. The innate immune system is the first line of host defense against most virus infections, with pathogen recognition receptors detecting SARS-CoV-2 RNA and protein components and initiating pro-inflammatory and antiviral responses. Notwithstanding this response, SARS-CoV-2 proteins evade, inhibit, and skew innate immune signaling early in infection. In this review, we highlight the components of cell-based recognition of SARS-CoV-2 infection and the mechanisms employed by the virus to modulate these innate immune host defense pathways.
    MeSH term(s) COVID-19 ; Humans ; Immunity, Innate ; Pandemics ; RNA, Viral ; SARS-CoV-2
    Chemical Substances RNA, Viral
    Language English
    Publishing date 2021-11-11
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2611378-8
    ISSN 1879-6265 ; 1879-6257
    ISSN (online) 1879-6265
    ISSN 1879-6257
    DOI 10.1016/j.coviro.2021.11.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Distinct Cellular Tropism and Immune Responses to Alphavirus Infection.

    Kafai, Natasha M / Diamond, Michael S / Fox, Julie M

    Annual review of immunology

    2022  Volume 40, Page(s) 615–649

    Abstract: Alphaviruses are emerging and reemerging viruses that cause disease syndromes ranging from incapacitating arthritis to potentially fatal encephalitis. While infection by arthritogenic and encephalitic alphaviruses results in distinct clinical ... ...

    Abstract Alphaviruses are emerging and reemerging viruses that cause disease syndromes ranging from incapacitating arthritis to potentially fatal encephalitis. While infection by arthritogenic and encephalitic alphaviruses results in distinct clinical manifestations, both virus groups induce robust innate and adaptive immune responses. However, differences in cellular tropism, type I interferon induction, immune cell recruitment, and B and T cell responses result in differential disease progression and outcome. In this review, we discuss aspects of immune responses that contribute to protective or pathogenic outcomes after alphavirus infection.
    MeSH term(s) Alphavirus ; Alphavirus Infections/pathology ; Animals ; Humans ; Immunity ; Interferon Type I ; Tropism
    Chemical Substances Interferon Type I
    Language English
    Publishing date 2022-02-08
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 604953-9
    ISSN 1545-3278 ; 0732-0582
    ISSN (online) 1545-3278
    ISSN 0732-0582
    DOI 10.1146/annurev-immunol-101220-014952
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  9. Article ; Online: Epitope Mapping of Japanese Encephalitis Virus Neutralizing Antibodies by Native Mass Spectrometry and Hydrogen/Deuterium Exchange.

    Adhikari, Jagat / Heffernan, James / Edeling, Melissa / Fernandez, Estefania / Jethva, Prashant N / Diamond, Michael S / Fremont, Daved H / Gross, Michael L

    Biomolecules

    2024  Volume 14, Issue 3

    Abstract: Japanese encephalitis virus (JEV) remains a global public health concern due to its epidemiological distribution and the existence of multiple strains. Neutralizing antibodies against this infection have shown efficacy in in vivo studies. Thus, ... ...

    Abstract Japanese encephalitis virus (JEV) remains a global public health concern due to its epidemiological distribution and the existence of multiple strains. Neutralizing antibodies against this infection have shown efficacy in in vivo studies. Thus, elucidation of the epitopes of neutralizing antibodies can aid in the design and development of effective vaccines against different strains of JEV. Here, we describe a combination of native mass spectrometry (native-MS) and hydrogen/deuterium exchange mass spectrometry (HDX-MS) to complete screening of eight mouse monoclonal antibodies (MAbs) against JEV E-DIII to identify epitope regions. Native-MS was used as a first pass to identify the antibodies that formed a complex with the target antigen, and it revealed that seven of the eight monoclonal antibodies underwent binding. Native mass spectra of a MAb (JEV-27) known to be non-binding showed broad native-MS peaks and poor signal, suggesting the protein is a mixture or that there are impurities in the sample. We followed native-MS with HDX-MS to locate the binding sites for several of the complex-forming antibodies. This combination of two mass spectrometry-based approaches should be generally applicable and particularly suitable for screening of antigen-antibody and other protein-protein interactions when other traditional approaches give unclear results or are difficult, unavailable, or need to be validated.
    MeSH term(s) Animals ; Mice ; Epitope Mapping/methods ; Hydrogen ; Encephalitis Virus, Japanese/metabolism ; Deuterium/chemistry ; Antibodies, Viral ; Epitopes/chemistry ; Antibodies, Neutralizing ; Mass Spectrometry/methods ; Antibodies, Monoclonal
    Chemical Substances Hydrogen (7YNJ3PO35Z) ; Deuterium (AR09D82C7G) ; Antibodies, Viral ; Epitopes ; Antibodies, Neutralizing ; Antibodies, Monoclonal
    Language English
    Publishing date 2024-03-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom14030374
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  10. Article ; Online: A Crisp(r) New Perspective on SARS-CoV-2 Biology.

    Bailey, Adam L / Diamond, Michael S

    Cell

    2020  Volume 184, Issue 1, Page(s) 15–17

    Abstract: Complementary genome-wide CRISPR-Cas9 screens performed by multiple groups reveal new insights into SARS-CoV-2 biology including aspects of viral entry, translation, replication, egress, and the genes regulating these processes. Comparisons with other ... ...

    Abstract Complementary genome-wide CRISPR-Cas9 screens performed by multiple groups reveal new insights into SARS-CoV-2 biology including aspects of viral entry, translation, replication, egress, and the genes regulating these processes. Comparisons with other coronaviruses enhances our understanding of the cellular life cycle of this medically important family of emerging viruses.
    Language English
    Publishing date 2020-12-17
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2020.12.003
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