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  1. Article ; Online: Validation of the PyloPlus Urea Breath Test System in pediatric patients.

    Price, Travis K / Realegeno, Susan / Azad, Kamran / Shier, Kileen L

    Microbiology spectrum

    2023  Volume 12, Issue 1, Page(s) e0318223

    Abstract: Importance: For the diagnosis and post-treatment monitoring ... ...

    Abstract Importance: For the diagnosis and post-treatment monitoring of
    MeSH term(s) Humans ; Child ; Urea ; Helicobacter pylori ; Sensitivity and Specificity ; Helicobacter Infections/diagnosis ; Breath Tests/methods
    Chemical Substances Urea (8W8T17847W)
    Language English
    Publishing date 2023-12-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.03182-23
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  2. Article: Intracellular Lactate Dynamics Reveal the Metabolic Diversity of

    Price, Matthew S / Moore, Travis I / Venkatachalam, Kartik

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Lactate, an intermediary between glycolysis and mitochondrial oxidative phosphorylation, reflects the metabolic state of neurons. Here, we utilized a genetically-encoded lactate FRET biosensor to uncover subpopulations of distinct metabolic states ... ...

    Abstract Lactate, an intermediary between glycolysis and mitochondrial oxidative phosphorylation, reflects the metabolic state of neurons. Here, we utilized a genetically-encoded lactate FRET biosensor to uncover subpopulations of distinct metabolic states among
    Language English
    Publishing date 2024-02-28
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.02.26.582095
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  3. Article ; Online: Fungal Whole-Genome Sequencing for Species Identification: From Test Development to Clinical Utilization.

    Salem-Bango, Zackary / Price, Travis K / Chan, June L / Chandrasekaran, Sukantha / Garner, Omai B / Yang, Shangxin

    Journal of fungi (Basel, Switzerland)

    2023  Volume 9, Issue 2

    Abstract: Using next-generation sequencing (NGS), we developed and validated a whole-genome sequencing (WGS)-based clinical test for fungal species identification on clinical isolates. The identification is mainly based on the fungal ribosomal internal transcribed ...

    Abstract Using next-generation sequencing (NGS), we developed and validated a whole-genome sequencing (WGS)-based clinical test for fungal species identification on clinical isolates. The identification is mainly based on the fungal ribosomal internal transcribed spacer (ITS) region as the primary marker, and additional marker and genomic analysis applied for species within the Mucorales family (using the 28S rRNA gene) and
    Language English
    Publishing date 2023-01-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof9020183
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  4. Article ; Online: Complete Genome Sequences of Streptococcus mitis Strains Isolated from the Oral Cavity and Urogenital Tract of a Woman and Her Male Sexual Partner.

    Mores, Carine R / Price, Travis K / Brassil, Bridget / Putonti, Catherine / Wolfe, Alan J

    Microbiology resource announcements

    2020  Volume 9, Issue 1

    Abstract: Streptococcus ... ...

    Abstract Streptococcus mitis
    Language English
    Publishing date 2020-01-02
    Publishing country United States
    Document type Journal Article
    ISSN 2576-098X
    ISSN (online) 2576-098X
    DOI 10.1128/MRA.01379-19
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  5. Article ; Online: Investigation of SARS-CoV-2 Epsilon Variant and Hospitalization Status by Genomic Surveillance in a Single Large Health System During the 2020-2021 Winter Surge in Southern California.

    Yang, Shangxin / Hemarajata, Peera / Hilt, Evann E / Price, Travis K / Garner, Omai B / Green, Nicole M

    American journal of clinical pathology

    2021  Volume 157, Issue 5, Page(s) 649–652

    Abstract: Objectives: This study aimed to assess whether the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Epsilon variant (B.1.429/427) is more virulent, leading to more hospitalization and more severe disease requiring intensive care unit (ICU) ... ...

    Abstract Objectives: This study aimed to assess whether the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Epsilon variant (B.1.429/427) is more virulent, leading to more hospitalization and more severe disease requiring intensive care unit (ICU) admission.
    Methods: SARS-CoV-2 genomic surveillance was performed on respiratory samples from 231 unique patients, collected at a single large health system in Southern California between November 2020 and March 2021 during the winter surge.
    Results: The frequencies of the Epsilon variant among outpatients, hospitalized patients, and ICU patients were indifferent.
    Conclusions: Our study suggests that the Epsilon variant is not associated with increased hospitalization and ICU admission.
    MeSH term(s) COVID-19/epidemiology ; California/epidemiology ; Genomics ; Hospitalization ; Humans ; Intensive Care Units ; SARS-CoV-2/genetics
    Language English
    Publishing date 2021-12-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2944-0
    ISSN 1943-7722 ; 0002-9173
    ISSN (online) 1943-7722
    ISSN 0002-9173
    DOI 10.1093/ajcp/aqab203
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    Ud II Zs.91: Show issues Location:
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  6. Article ; Online: Urinary microbiota of women with recurrent urinary tract infection: collection and culture methods.

    Hochstedler, Baylie R / Burnett, Lindsey / Price, Travis K / Jung, Carrie / Wolfe, Alan J / Brubaker, Linda

    International urogynecology journal

    2021  Volume 33, Issue 3, Page(s) 563–570

    Abstract: Introduction and hypothesis: Many clinicians utilize standard culture of voided urine to guide treatment for women with recurrent urinary tract infections (RUTI). However, despite antibiotic treatment, symptoms may persist and events frequently recur. ... ...

    Abstract Introduction and hypothesis: Many clinicians utilize standard culture of voided urine to guide treatment for women with recurrent urinary tract infections (RUTI). However, despite antibiotic treatment, symptoms may persist and events frequently recur. The cyclic nature and ineffective treatment of RUTI suggest that underlying uropathogens pass undetected because of the preferential growth of Escherichia coli. Expanded quantitative urine culture (EQUC) detects more clinically relevant microbes. The objective of this study was to assess how urine collection and culture methods influence microbial detection in RUTI patients.
    Methods: This cross-sectional study enrolled symptomatic adult women with an established RUTI diagnosis. Participants contributed both midstream voided and catheterized urine specimens for culture via both standard urine culture (SUC) and EQUC. Presence and abundance of microbiota were compared between culture and collection methods.
    Results: Forty-three symptomatic women participants (mean age 67 years) contributed specimens. Compared to SUC, EQUC detected more unique bacterial species and consistently detected more uropathogens from catheterized and voided urine specimens. For both collection methods, the most commonly detected uropathogens by EQUC were E. coli (catheterized: n = 8, voided: n = 12) and E. faecalis (catheterized: n = 7, voided: n = 17). Compared to catheterized urine samples assessed by EQUC, SUC often missed uropathogens, and culture of voided urines by either method yielded high false-positive rates.
    Conclusions: In women with symptomatic RUTI, SUC and assessment of voided urines have clinically relevant limitations in uropathogen detection. These results suggest that, in this population, catheterized specimens analyzed via EQUC provide clinically relevant information for appropriate diagnosis.
    MeSH term(s) Adult ; Aged ; Cross-Sectional Studies ; Escherichia coli ; Female ; Humans ; Microbiota ; Urinalysis ; Urinary Tract Infections/diagnosis ; Urinary Tract Infections/microbiology
    Language English
    Publishing date 2021-04-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 1050631-7
    ISSN 1433-3023 ; 0937-3462
    ISSN (online) 1433-3023
    ISSN 0937-3462
    DOI 10.1007/s00192-021-04780-4
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  7. Article ; Online: Genome Investigation of Urinary

    Putonti, Catherine / Thomas-White, Krystal / Crum, Elias / Hilt, Evann E / Price, Travis K / Wolfe, Alan J

    mSphere

    2021  Volume 6, Issue 3

    Abstract: ... ...

    Abstract Gardnerella
    MeSH term(s) Female ; Gardnerella/classification ; Gardnerella/genetics ; Gardnerella/pathogenicity ; Genome, Bacterial ; Genotype ; Gram-Positive Bacterial Infections/microbiology ; Gram-Positive Bacterial Infections/urine ; Humans ; Microbiota/genetics ; Microbiota/physiology ; Phylogeny ; RNA, Ribosomal, 16S/genetics ; Urinary Tract Infections/microbiology ; Vagina/microbiology ; Vaginosis, Bacterial/microbiology ; Vaginosis, Bacterial/urine ; Whole Genome Sequencing
    Chemical Substances RNA, Ribosomal, 16S
    Language English
    Publishing date 2021-05-12
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ISSN 2379-5042
    ISSN (online) 2379-5042
    DOI 10.1128/mSphere.00154-21
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  8. Article ; Online: Association Between Social Determinants of Health, Distance from Treatment Center, and Treatment Type with Outcomes in Human Papillomavirus Associated Oropharyngeal cancer.

    Aden, Aisha A / Olawuni, Felicia O / Abdel-Halim, Chadi N / Zhu, Agnes Q / Haller, Travis J / O'Byrne, Thomas J / Moore, Eric J / Price, Daniel L / Tasche, Kendall L / Ma, Daniel J / Lester, Scott C / Gamez, Mauricio / Neben-Wittich, Michelle A / Price, Katharine / Fuentes-Bayne, Harry E / Routman, David / Van Abel, Kathryn M

    Oral oncology

    2024  Volume 149, Page(s) 106675

    Abstract: Objectives: Social determinants of health (SDOH) can influence access to cancer care, clinical trials, and oncologic outcomes. We investigated the association between SDOH, distance from treatment center, and treatment type with outcomes in human ... ...

    Abstract Objectives: Social determinants of health (SDOH) can influence access to cancer care, clinical trials, and oncologic outcomes. We investigated the association between SDOH, distance from treatment center, and treatment type with outcomes in human papillomavirus associated oropharyngeal squamous cell carcinoma [HPV(+)OPSCC] patients treated at a tertiary care center.
    Study design: Retrospective review.
    Methods: HPV(+)OPSCC patients treated surgically from 2006 to 2021 were selected from our departmental Oropharyngeal Cancer RedCap database. Demographic data, treatment, and oncologic outcomes were extracted. Distance was calculated in miles between the centroid of each patient zip code and our hospital zip code (zipdistance).
    Results: 874 patients (89 % male; mean age: 58 years) were identified. Most patients (96 %) reported Non-Hispanic White as their primary race. 204 patients (23 %) had a high-school degree or less, 217 patients (25 %) reported some college education or a 2-year degree, 153 patients (18 %) completed a four-year college degree, and 155 patients (18 %) had post-graduate degrees. Relative to those with a high-school degree, patients with higher levels of education were more likely to live further away from our institution (p < 0.0001). Patients who received adjuvant radiation therapy elsewhere lived, on average, 104 miles further away than patients receiving radiation at our institution (Estimate 104.3, 95 % CI 14.2-194.4, p-value = 0.02). In univariable Cox PH models, oncologic outcomes did not significantly differ by zipdistance.
    Conclusions: Education level-and access to resources-varied proportionally to a patient's distance from our center. Patients travelling further distances for surgical management of OPSCC were more likely to pursue adjuvant radiation therapy at an outside institution. Distance traveled was not associated with oncologic outcomes. Breaking down barriers to currently excluded populations may improve access to clinical trials and improve oncologic outcomes for diverse patient populations.
    MeSH term(s) Humans ; Male ; Middle Aged ; Female ; Human Papillomavirus Viruses ; Carcinoma, Squamous Cell/pathology ; Papillomavirus Infections/complications ; Papillomavirus Infections/pathology ; Social Determinants of Health ; Oropharyngeal Neoplasms/pathology ; Retrospective Studies ; Head and Neck Neoplasms/complications
    Language English
    Publishing date 2024-01-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 1120465-5
    ISSN 1879-0593 ; 0964-1955 ; 1368-8375
    ISSN (online) 1879-0593
    ISSN 0964-1955 ; 1368-8375
    DOI 10.1016/j.oraloncology.2023.106675
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    Zs.A 4869: Show issues Location:
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    Zs.A 456: Show issues Location:
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  9. Article ; Online: Performance Characteristics of Severe Acute Respiratory Syndrome Coronavirus 2 RT-PCR Tests in a Single Health System: Analysis of >10,000 Results from Three Different Assays.

    Price, Travis K / Bowland, Brian C / Chandrasekaran, Sukantha / Garner, Omai B / Yang, Shangxin

    The Journal of molecular diagnostics : JMD

    2020  Volume 23, Issue 2, Page(s) 159–163

    Abstract: The current pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in the approval of numerous molecular diagnostic assays with various performance and technical capacities. There are limited data comparing performance ... ...

    Abstract The current pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in the approval of numerous molecular diagnostic assays with various performance and technical capacities. There are limited data comparing performance among assays. We conducted a retrospective analysis of >10,000 test results among three widely used RT-PCR assays for coronavirus disease 2019 (CDC, Simplexa Direct, and TaqPath) to assess performance characteristics. We also retested remnant weakly positive specimens to assess analytical sensitivity. All assays had strong linear correlation and little bias among C
    MeSH term(s) Biological Assay ; COVID-19/diagnosis ; COVID-19/virology ; COVID-19 Testing ; Humans ; Predictive Value of Tests ; Reverse Transcriptase Polymerase Chain Reaction/methods ; SARS-CoV-2/genetics ; SARS-CoV-2/isolation & purification
    Language English
    Publishing date 2020-12-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2000060-1
    ISSN 1943-7811 ; 1525-1578
    ISSN (online) 1943-7811
    ISSN 1525-1578
    DOI 10.1016/j.jmoldx.2020.11.008
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    Zs.A 5146: Show issues Location:
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  10. Article ; Online: Phenyl-Lactic Acid Is an Active Ingredient in Bactericidal Supernatants of Lactobacillus crispatus.

    Abdul-Rahim, Omar / Wu, Qihao / Price, Travis K / Pistone, Giuseppe / Diebel, Katherine / Bugni, Tim S / Wolfe, Alan J

    Journal of bacteriology

    2021  Volume 203, Issue 19, Page(s) e0036021

    Abstract: Lactobacillus crispatus is a well-established probiotic with antimicrobial activity against pathogens across several niches of the human body generally attributed to the production of bacteriostatic molecules, including hydrogen peroxide and lactic acid. ...

    Abstract Lactobacillus crispatus is a well-established probiotic with antimicrobial activity against pathogens across several niches of the human body generally attributed to the production of bacteriostatic molecules, including hydrogen peroxide and lactic acid. Here, we show that the cell-free supernatants of clinical isolates of L. crispatus harbor robust bactericidal activity. We further identify phenyl-lactic acid as a bactericidal compound with properties and a susceptibility range nearly identical to that of the cell-free supernatant. As such, we hypothesize that phenyl-lactic acid is a key active ingredient in L. crispatus supernatant.
    MeSH term(s) Anti-Infective Agents/chemistry ; Anti-Infective Agents/metabolism ; Anti-Infective Agents/pharmacology ; Bacteria/drug effects ; Candida/drug effects ; Lactates/chemistry ; Lactates/metabolism ; Lactates/pharmacology ; Lactobacillus crispatus/metabolism
    Chemical Substances Anti-Infective Agents ; Lactates ; 3-phenyllactic acid (156-05-8)
    Language English
    Publishing date 2021-09-08
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2968-3
    ISSN 1098-5530 ; 0021-9193
    ISSN (online) 1098-5530
    ISSN 0021-9193
    DOI 10.1128/JB.00360-21
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