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Article ; Online: Anti-urolithiatic activity of Salvia hispanica L. seeds in ethylene glycol induced urolithiasis rat’s model

UZMA SALEEM / NAZIR AHMAD / MUHAMMAD AJMAL SHAH / FAREEHA ANWAR / BASHIR AHMAD

Anais da Academia Brasileira de Ciências, Vol 92, Iss

2020 Volume 4

Abstract: ... objective was to explore scientifically the anti-urolithiatic effect of Salvia hispanica seed’s methanol ... inhibition of crystal’s nucleation, growth and aggregation. In vivo study revealed anti-urolithiatic activity ... deposition of minerals in the urinary tract. It affects 12% of the population worldwide. Salvia hispanica ...

Abstract	Abstract Urolithiasis is a disorder of kidneys in which stones formation occur due to the excessive deposition of minerals in the urinary tract. It affects 12% of the population worldwide. Salvia hispanica seeds are rich source of quercetin which has preventive role in renal stone formation. The study objective was to explore scientifically the anti-urolithiatic effect of Salvia hispanica seed’s methanol extract using in vitro and in vivo urolithiasis models. For in-vitro study nucleation, growth and aggregation assays were performed. In vivo study was performed on rats and they were divided into six groups (n=6). Group-I was given vehicle only. Group-II was disease control, treated with 0.75% EG in drinking water which triggered urolithiasis. Groups-III received cystone (750 mg/kg, orally). Groups IV–VI were treated with extract at 100, 300 and 700 mg/kg doses orally once daily. Groups III-VI additionally received 0.75% EG in drinking water. In vitro study revealed concentration dependent increase in percentage inhibition of crystal’s nucleation, growth and aggregation. In vivo study revealed anti-urolithiatic activity by lowering oxalate, calcium, phosphate, sodium and potassium levels in the urine and the serum uric acid, blood urea nitrogen, total proteins and total albumin. Salvia hispanica seeds are good alterative of allopathic anti-urolithiatic drugs to treat urolithiasis.
Keywords	Urolithiasis ; Salvia hispanica ; calcium oxalate ; calcium phosphate ; ethylene glycol ; Science ; Q
Subject code	500
Language	English
Publishing date	2020-11-01T00:00:00Z
Publisher	Academia Brasileira de Ciências
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: A Randomized Control Trial Comparing the Efficacy of Platelet-Rich Plasma and 5% Topical Minoxidil for the Treatment of Androgenetic Alopecia.

Asim, Mehmood / Shah, Rohan / Sharif, Shawana / Ouellette, Samantha / Shah, Amar / Rao, Babar

Journal of drugs in dermatology : JDD

2023 Volume 22, Issue 9, Page(s) 905–909

Abstract: ... minoxidil. Citation: Shah R, Asim M, Ouellette S, et al. A randomized control trial comparing ...

Abstract	Androgenetic alopecia (AGA) is the most common cause of hair loss in men and has limited treatment options. Minoxidil is a common therapeutic option for AGA patients because of its availability. Platelet-rich plasma (PRP) therapy is a newer option in AGA management with promising results that may be suitable for some patients. Despite a great prevalence of AGA outside the United States and Europe, there remains limited studies on the efficacy of PRP for AGA treatment. Our study's objective was to compare the efficacy of PRP and minoxidil therapy for the treatment of AGA in a Pakistani population. 72 patients were included in this randomized control trial and were either treated with PRP or topical minoxidil. After 12 weeks of treatment, the hair pull test was performed and extracted hair was counted. We report a 91.7% negative hair pull rate in the PRP treatment group which was significantly greater than the 69.4% negative hair pull rate in the minoxidil-treated group. Our study suggests that PRP therapy demonstrates a higher efficacy compared to minoxidil for treating AGA, especially in our patient demographic. These results have the opportunity to improve patient compliance and overall satisfaction while offering an improved option in patients unsatisfied with topical minoxidil. Citation: Shah R, Asim M, Ouellette S, et al. A randomized control trial comparing the efficacy of platelet-rich plasma and 5% topical minoxidil for the treatment of androgenetic alopecia. J Drugs Dermatol. 2023;22(9):905-909. doi:10.36849/JDD.7031.
MeSH term(s)	Humans ; Male ; Alopecia/drug therapy ; Hair ; Minoxidil/therapeutic use ; Platelet-Rich Plasma
Chemical Substances	Minoxidil (5965120SH1)
Language	English
Publishing date	2023-09-08
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2145090-0
ISSN	1545-9616
ISSN	1545-9616
DOI	10.36849/JDD.7031
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Article ; Online: Smoking impacts outcomes in transcervical Zenker's diverticulectomy.

Kumar, Keshav D / Choudhry, Hannaan S / Shah, Vraj P / Desai, Amar D / Sibala, Dhiraj R / Patel, Aman M / Patel, Prayag / Eloy, Jean Anderson

American journal of otolaryngology

2024 Volume 45, Issue 4, Page(s) 104288

Abstract: Purpose: There is sparse literature discussing the impact of smoking on postoperative outcomes following surgical treatment of Zenker's diverticulum. In this study, we seek to characterize differences in the management and outcomes of open Zenker's ... ...

Abstract	Purpose: There is sparse literature discussing the impact of smoking on postoperative outcomes following surgical treatment of Zenker's diverticulum. In this study, we seek to characterize differences in the management and outcomes of open Zenker's diverticulectomy based on patient smoking status. Methods and materials: This paper is a retrospective cohort review. The 2005-2018 American College of Surgeons National Surgical Quality Improvement (ACS-NSQIP) database was queried for patients undergoing open Zenker's diverticulectomy. Chi-square and multivariable logistic regression were performed to determine statistical associations between postoperative outcomes and smoking status. Results: Of the 715 identified patients, 70 (9.8 %) were smokers and 645 (91.2 %) were non-smokers. Smokers were younger than non-smokers (mean 63.9 vs. 71.7 years, p < 0.001) and more likely to have a prolonged operative time (20.0 % vs. 11.6 %, p = 0.044). On multivariable regression analysis controlling for demographics and comorbidities, smokers had greater odds than non-smokers for developing overall postoperative complications (OR: 2.776, p = 0.013), surgical infections (OR: 3.194, p = 0.039), medical complications (OR: 3.563, p = 0.011), and medical infections (OR: 1.247, p = 0.016). Smokers also had greater odds for requiring ventilation/intubation (OR: 8.508, p = 0.025) and having a prolonged postoperative stay (OR: 2.425, p = 0.030). Conclusion: In a cohort of patients undergoing transcervical Zenker's diverticulectomy, smokers are at increased risk for overall complications, medical complications, medical infections, surgical infections, prolonged postoperative stay, and ventilation/intubation.
Language	English
Publishing date	2024-04-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	604541-8
ISSN	1532-818X ; 0196-0709
ISSN (online)	1532-818X
ISSN	0196-0709
DOI	10.1016/j.amjoto.2024.104288
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Article: A Case of Acute Encephalitis in COVID-19 Patient: A Rare Complication.

Sarmast, Shah T / Mohamed, Alaa S / Amar, Zain / Sarwar, Sobia / Ahmed, Zahoor

Cureus

2021 Volume 13, Issue 6, Page(s) e15636

Abstract: Coronavirus disease 19 (COVID-19) is a respiratory disease, has a variable presentation, and neurological involvement in COVID-19 is not widely reported. We report a rare case of acute encephalitis in a COVID-19 patient presented with fever, dry cough, ... ...

Abstract	Coronavirus disease 19 (COVID-19) is a respiratory disease, has a variable presentation, and neurological involvement in COVID-19 is not widely reported. We report a rare case of acute encephalitis in a COVID-19 patient presented with fever, dry cough, and dyspnea. She had a fever, tachypnea, and tachycardia. On auscultation, she had scattered wheezing in both lung fiends. Chest X-ray revealed small infiltrates in the lower lobe of both lungs. A nasopharyngeal swab for the COVID-19 polymerase chain reaction was positive. Later on, she developed sudden onset confusion accompanied by restlessness and visual hallucinations. Neurological examination revealed an altered level of consciousness, slight trembling of the limbs, psychomotor restlessness, and poor speech with no signs of meningeal irritation. Magnetic resonance imaging of the brain revealed diffuse hyperintense signals. A possible diagnosis of acute encephalitis was made due to concurrent COVID-19 infection and lack of other findings suggesting a diagnosis other than COVID-19. She was treated with azithromycin, tocilizumab, and methylprednisolone. Her condition started improving gradually.
Language	English
Publishing date	2021-06-14
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.15636
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Article ; Online: Cardiovascular outcomes in patients with COPD-OSA overlap syndrome: A systematic review and meta-analysis.

Shah, Amar J / Quek, Eleanor / Alqahtani, Jaber S / Hurst, John R / Mandal, Swapna

Sleep medicine reviews

2022 Volume 63, Page(s) 101627

Abstract: Chronic obstructive pulmonary disease (COPD) and obstructive sleep apnoea (OSA) are prevalent respiratory conditions that are independently associated with increased cardiovascular disease (CVD). It is not clear from current evidence whether COPD-OSA ... ...

Abstract	Chronic obstructive pulmonary disease (COPD) and obstructive sleep apnoea (OSA) are prevalent respiratory conditions that are independently associated with increased cardiovascular disease (CVD). It is not clear from current evidence whether COPD-OSA overlap syndrome confers an additive risk. This systematic review and meta-analysis investigated whether CVD was more prevalent in patients with overlap syndrome compared to either condition alone. We searched four electronic databases, screened 1826 records against the inclusion criteria. After screening, 18 retrospective, observational studies involving 4613 overlap patients, 16,046 OSA patients and 1679 COPD patients met the inclusion criteria. A random-effects meta-analysis of five studies (I
MeSH term(s)	Cardiovascular Diseases/complications ; Cardiovascular Diseases/epidemiology ; Humans ; Pulmonary Disease, Chronic Obstructive/complications ; Pulmonary Disease, Chronic Obstructive/epidemiology ; Retrospective Studies ; Sleep Apnea Syndromes/complications ; Sleep Apnea, Obstructive/complications ; Sleep Apnea, Obstructive/epidemiology
Language	English
Publishing date	2022-03-22
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Review ; Systematic Review
ZDB-ID	1414211-9
ISSN	1532-2955 ; 1087-0792
ISSN (online)	1532-2955
ISSN	1087-0792
DOI	10.1016/j.smrv.2022.101627
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Zs.A 5901: Show issues

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Article ; Online: Acute disseminated encephalomyelitis associated with a novel paraneoplastic process in hepatic epithelial hemangioendothelioma: A case report.

Shah, Amar S / Yahanda, Alexander T / Loftspring, Matthew C / Osbun, Joshua W

Clinical neurology and neurosurgery

2020 Volume 194, Page(s) 105903

MeSH term(s)	Biopsy ; Brain/diagnostic imaging ; Encephalomyelitis, Acute Disseminated/diagnostic imaging ; Encephalomyelitis, Acute Disseminated/etiology ; Female ; Hemangioendothelioma, Epithelioid/complications ; Hemangioendothelioma, Epithelioid/diagnostic imaging ; Humans ; Liver Neoplasms/complications ; Liver Neoplasms/diagnostic imaging ; Magnetic Resonance Imaging ; Paraneoplastic Polyneuropathy/complications ; Paraneoplastic Polyneuropathy/diagnostic imaging ; Treatment Outcome ; Young Adult
Language	English
Publishing date	2020-05-12
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	193107-6
ISSN	1872-6968 ; 0303-8467
ISSN (online)	1872-6968
ISSN	0303-8467
DOI	10.1016/j.clineuro.2020.105903
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Article ; Online: An Unusual Presentation: High-Grade Serous Carcinoma of the Fallopian Tube Manifesting With Altered Mental Status Secondary to a Single Brain Metastasis-A Case Report and Review of the Literature.

Shah, Amar S / Menias, Christine O / Schmitt, Alessandra / Chen, Longwen / Magtibay, Paul M / Nguyen, Ba / Martinez, Felipe

Journal of minimally invasive gynecology

2023 Volume 31, Issue 2, Page(s) 155–160

Abstract: Epithelial ovarian and fallopian cancers are aggressive lesions that rarely metastasize to the central nervous system. Brain metastases usually occur in the setting of known primary disease or widespread metastatic disease. However, in extremely rare ... ...

Abstract	Epithelial ovarian and fallopian cancers are aggressive lesions that rarely metastasize to the central nervous system. Brain metastases usually occur in the setting of known primary disease or widespread metastatic disease. However, in extremely rare cases, an isolated intracranial neoplasm may be the first presentation of fallopian cancer. To the best of our knowledge, only one such case has been reported previously. We present an illustrative case with multimodality imaging and histopathologic correlation of a fallopian tube carcinoma first presenting with altered mental status secondary to an isolated brain metastasis. A 64-year-old female with no pertinent medical history presented with altered mentation. Initial workup identified a 1.6 cm avidly enhancing, solitary brain lesion at the gray-white junction with associated vasogenic edema concerning for either central nervous system lymphoma or metastatic disease. Additional imaging identified a 7.5 × 3 cm left adnexal lesion, initially thought to be a hydrosalpinx with hemorrhage, but magnetic resonance imaging suggested gynecologic malignancy. No lesions elsewhere in the body were identified. Given the lack of locoregional or systemic disease, the intracranial and pelvic lesions were assumed to represent synchronous but distinct processes. The intracranial lesion was biopsied. Preliminary results were suggestive of lymphoma, but further analysis was consistent with high-grade serous carcinoma of müllerian origin. Positron emission tomography/computed tomography was performed to evaluate for other neoplastic lesions, only highlighting the intracranial and pelvic lesions. At this point, a diagnosis of metastatic fallopian cancer was made. The patient was taken for robot-assisted laparoscopy with surgical debulking of the pelvic neoplasm, pathology demonstrating high-grade serous carcinoma of the fallopian tube, matching that of the intracranial lesion. Even though rare, metastatic fallopian cancer should be considered in patients with isolated brain lesions and adnexal lesions, even in the absence of locoregional or systemic disease.
MeSH term(s)	Humans ; Female ; Middle Aged ; Fallopian Tubes/surgery ; Ovarian Neoplasms/surgery ; Ovarian Neoplasms/pathology ; Fallopian Tube Neoplasms/surgery ; Fallopian Tube Neoplasms/pathology ; Brain Neoplasms/surgery ; Brain Neoplasms/pathology ; Carcinoma ; Brain ; Lymphoma/pathology
Language	English
Publishing date	2023-11-19
Publishing country	United States
Document type	Review ; Case Reports ; Journal Article
ZDB-ID	2186934-0
ISSN	1553-4669 ; 1553-4650
ISSN (online)	1553-4669
ISSN	1553-4650
DOI	10.1016/j.jmig.2023.11.012
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Article ; Online: Single-incision laparoscopic sleeve gastrectomy: Is it worth it?

Shah, Amar S / Campos, Guilherme M

Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery

2016 Volume 12, Issue 4, Page(s) 935–936

MeSH term(s)	Gastrectomy ; Humans ; Laparoscopy ; Obesity, Morbid/surgery ; Surgical Wound ; Weight Loss
Language	English
Publishing date	2016
Publishing country	United States
Document type	Editorial
ZDB-ID	2274243-8
ISSN	1878-7533 ; 1550-7289
ISSN (online)	1878-7533
ISSN	1550-7289
DOI	10.1016/j.soard.2016.01.012
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Article ; Online: Prognostic significance of head and neck spindle cell carcinoma.

Patel, Aman M / Choudhry, Hannaan S / Desai, Amar D / Shah, Vraj P / Patel, Prayag / Eloy, Jean Anderson / Roden, Dylan F / Fang, Christina H

Head & neck

2022 Volume 45, Issue 3, Page(s) 685–696

MeSH term(s)	Humans ; Prognosis ; Squamous Cell Carcinoma of Head and Neck/therapy ; Carcinoma, Squamous Cell/pathology ; Head and Neck Neoplasms/therapy
Language	English
Publishing date	2022-12-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	645165-2
ISSN	1097-0347 ; 0148-6403 ; 1043-3074
ISSN (online)	1097-0347
ISSN	0148-6403 ; 1043-3074
DOI	10.1002/hed.27285
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Article ; Online: A Case of S-Variant Hepatitis B Virus: An Immune System Escape Artist.

Shah, Amar S / Civelli, Valerie F / Bali, Varun / Johnson, Royce H / Heidari, Arash

Journal of investigative medicine high impact case reports

2021 Volume 9, Page(s) 23247096211045450

Abstract: Genomic variants of the hepatitis B virus (HBV) preS/S protein are well-known to occur. Typically ... mutations that may enable HBV escape from the immune detection. PreS/S mutants may present ... HBV variants is not routinely performed by reference guidelines. s-variant HBV management remains ...

Abstract	Genomic variants of the hepatitis B virus (HBV) preS/S protein are well-known to occur. Typically, immunity is gained through recovered HBV infection or by immunization. Very rarely, there are certain mutations that may enable HBV escape from the immune detection. PreS/S mutants may present with unpredictable pathobiologic, clinical, and transmittable implications. Standard laboratory testing for genomic HBV variants is not routinely performed by reference guidelines. s-variant HBV management remains challenging. Herein is a case of s-variant chronic HBV infection in a 55-year-old man. Diagnosis and treatment are described.
MeSH term(s)	Genetic Variation ; Hepatitis B/diagnosis ; Hepatitis B Surface Antigens ; Hepatitis B virus/genetics ; Humans ; Immune System ; Male ; Middle Aged
Chemical Substances	Hepatitis B Surface Antigens
Language	English
Publishing date	2021-09-14
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2710326-2
ISSN	2324-7096 ; 2324-7096
ISSN (online)	2324-7096
ISSN	2324-7096
DOI	10.1177/23247096211045450
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