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  1. Article ; Online: Environmental footprints of food consumption: Protocol for a systematic literature review.

    de Souza, Camila Valdejane Silva / Seabra, Larissa Mont'Alverne Jucá / Hatjiathanassiadou, Maria / Vale, Diogo / de Medeiros, Gidyenne Christine Bandeira Silva / Marchioni, Dirce Maria Lobo / Lima, Severina Carla Vieira Cunha / Lyra, Clélia de Oliveira

    PloS one

    2022  Volume 17, Issue 11, Page(s) e0277227

    Abstract: Environmental footprints are indicators that can be used to estimate the impacts of diet on the environment. Since contemporary dietary practices are related to negative environmental impacts, this paper aims to describe a systematic review protocol to ... ...

    Abstract Environmental footprints are indicators that can be used to estimate the impacts of diet on the environment. Since contemporary dietary practices are related to negative environmental impacts, this paper aims to describe a systematic review protocol to investigate the environmental footprints of food consumption by adults and elderly individuals worldwide. This protocol was developed based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Search strategies and records of evidence searched in previously defined electronic databases will be defined. Original, population-based articles investigating the environmental footprints of food consumption by adults and the elderly will be included. Two independent reviewers will conduct the study selection and data extraction steps. Critical appraisal of the included studies will be based on the Newcastle-Ottawa Scale. For data synthesis, a narrative synthesis and, if possible, also a meta-analysis will be performed. The systematic review produced from this protocol will provide evidence for data synthesis of the environmental impact through environmental footprints of food consumption of the adult and elderly population from different territories and the footprint assessment tools used around the world. Therefore, it is a gap that needs to be filled because knowing these impacts will be important to inform the development of public policies that encourage healthy and sustainable food in the face of climate and epidemiological changes. PROSPERO registration number: CRD42021281488.
    MeSH term(s) Humans ; Adult ; Aged ; Diet ; Systematic Reviews as Topic ; Meta-Analysis as Topic
    Language English
    Publishing date 2022-11-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0277227
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Environmental footprints of food consumption

    Camila Valdejane Silva de Souza / Larissa Mont'Alverne Jucá Seabra / Maria Hatjiathanassiadou / Diogo Vale / Gidyenne Christine Bandeira Silva de Medeiros / Dirce Maria Lobo Marchioni / Severina Carla Vieira Cunha Lima / Clélia de Oliveira Lyra

    PLoS ONE, Vol 17, Iss 11, p e

    Protocol for a systematic literature review.

    2022  Volume 0277227

    Abstract: Environmental footprints are indicators that can be used to estimate the impacts of diet on the environment. Since contemporary dietary practices are related to negative environmental impacts, this paper aims to describe a systematic review protocol to ... ...

    Abstract Environmental footprints are indicators that can be used to estimate the impacts of diet on the environment. Since contemporary dietary practices are related to negative environmental impacts, this paper aims to describe a systematic review protocol to investigate the environmental footprints of food consumption by adults and elderly individuals worldwide. This protocol was developed based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Search strategies and records of evidence searched in previously defined electronic databases will be defined. Original, population-based articles investigating the environmental footprints of food consumption by adults and the elderly will be included. Two independent reviewers will conduct the study selection and data extraction steps. Critical appraisal of the included studies will be based on the Newcastle-Ottawa Scale. For data synthesis, a narrative synthesis and, if possible, also a meta-analysis will be performed. The systematic review produced from this protocol will provide evidence for data synthesis of the environmental impact through environmental footprints of food consumption of the adult and elderly population from different territories and the footprint assessment tools used around the world. Therefore, it is a gap that needs to be filled because knowing these impacts will be important to inform the development of public policies that encourage healthy and sustainable food in the face of climate and epidemiological changes. PROSPERO registration number: CRD42021281488.
    Keywords Medicine ; R ; Science ; Q
    Subject code 333
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Mechanism of the action of bioactive proteins of vegetables in diabetes mellitus type 2: Systematic review protocol.

    Medeiros, Amanda Fernandes de / Costa, Izael de Sousa / Piuvezam, Grasiela / Medeiros, Gidyenne Christine Bandeira Silva de / Maciel, Bruna Leal Lima / Morais, Ana Heloneida de Araújo

    Medicine

    2019  Volume 98, Issue 39, Page(s) e17326

    Abstract: Background: Diabetes mellitus type 2 (DM2) is a chronic disease of significant prevalence causing hyperglycemia and several comorbidities. Evidences highlight the performance of non - protein bioactive compounds found in vegetables in the control of ... ...

    Abstract Background: Diabetes mellitus type 2 (DM2) is a chronic disease of significant prevalence causing hyperglycemia and several comorbidities. Evidences highlight the performance of non - protein bioactive compounds found in vegetables in the control of hyperglycemia. This study describes a protocol of a systematic review, which analyzes the action of proteins and bioactive peptides of plants in DM2.
    Methods: The Preferred Reporting Items guide this protocol for Systematic Reviews and Meta-Analyzes Protocols (PRISMA-P) was used. The databases that will be used for searching will be PubMed, ScienceDirect, Scopus, Web of Science, EMBASE, and Virtual Health Library, Brazil (VHL). Studies that use bioactive proteins and peptides of vegetal origin in DM2 will be included in the systematic review. The studies will be identified using clinical parameters and the effect on insulin resistance. The characteristics of the studies as control groups, test substance, dosage, intervention time, and the main results will be described. Selection of studies, data extraction, and methodological quality assessment will be performed independently by two experienced reviewers.
    Results: This protocol will be the basis for a systematic review identifying the mechanism of action of plant proteins and peptides in type 2 diabetes mellitus.
    Conclusion: Systematic reviews from this protocol will provide support for the construction of researches that analyze the effect of plant bioactive proteins and peptides on the control of hyperglycemia and how these molecules act in the control of DM2.
    Prospero registration number: CRD42019110956.
    MeSH term(s) Humans ; Biological Products/pharmacology ; Diabetes Mellitus, Type 2/therapy ; Plant Proteins, Dietary/pharmacology ; Treatment Outcome ; Systematic Reviews as Topic
    Chemical Substances Biological Products ; Plant Proteins, Dietary
    Language English
    Publishing date 2019-09-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000017326
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Association between sedentary behavior and Brain-Derived Neurotrophic Factor (BDNF) in children and adolescents: A protocol for systematic review and meta-analysis.

    de Oliveira Segundo, Victor Hugo / de Azevedo, Kesley Pablo Morais / de Medeiros, Gidyenne Christine Bandeira Silva / Mata, Ádala Nayana de Sousa / Piuvezam, Grasiela

    PloS one

    2024  Volume 19, Issue 3, Page(s) e0299024

    Abstract: Background: There is evidence in the literature suggesting that high time spent in sedentary behavior (SB) can reduce the Brain-Derived Neurotrophic Factor (BDNF) levels, an important neurotrophin that plays a role in modulating cognition, learning and ... ...

    Abstract Background: There is evidence in the literature suggesting that high time spent in sedentary behavior (SB) can reduce the Brain-Derived Neurotrophic Factor (BDNF) levels, an important neurotrophin that plays a role in modulating cognition, learning and memory. Children and adolescents usually spend many hours a day on SB, either sitting for a long time and/or using screen equipment.
    Objective: The aim of this study is to describe a systematic review and meta-analysis protocol on the associations between SB and BDNF levels in children and adolescents.
    Methods: This protocol is guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols and was published in the International Prospective Register of Systematic Reviews database (PROSPERO: CRD42023392246). The databases that will be searched are EMBASE, Scopus, ScienceDirect, Web of Science, SPORTDiscus, CINAHL, and PubMed. Cross-sectional and cohort studies conducted with children and adolescents (5 to 19 yr) that analyzed the association between SB and BDNF will be included in the systematic review. The characteristics of the studies, methodological aspects, and main results will be described. Then, the risk of bias (assessed by STROBE and Newcastle-Ottawa scales) and the level of evidence (assessed by the GRADE tool) from included studies will be evaluated. Sub-group analysis will also be performed. Two experienced reviewers will perform the studies selection, data extraction, and methodological quality assessment.
    Conclusion: This systematic review and meta-analysis will analyze the association between SB and BDNF in children and adolescents. The results will provide subsidies to better understand this relationship and will strengthen evidence-based practice for both health professionals and future researches.
    MeSH term(s) Adolescent ; Child ; Humans ; Brain-Derived Neurotrophic Factor ; Cross-Sectional Studies ; Meta-Analysis as Topic ; Sedentary Behavior ; Systematic Reviews as Topic
    Chemical Substances Brain-Derived Neurotrophic Factor
    Language English
    Publishing date 2024-03-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0299024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Influence of curcumin supplementation on metabolic and lipid parameters of people living with HIV/AIDS: a randomized controlled trial.

    Silva, Tatiane Andreza Lima / Medeiros, Danielle Coutinho / Medeiros, Gidyenne Christine Bandeira Silva / Medeiros, Rafaela Catherine Silva Cunha / de Souza Araújo, Juliany / Medeiros, Jason Azevedo / Ururahy, Marcela Abbott Galvao / Santos, Ronaldo Vagner Thomatieli / Medeiros, Radames Maciel Vitor / Leite-Lais, Lucia / Dantas, Paulo Moreira Silva

    BMC complementary and alternative medicine

    2019  Volume 19, Issue 1, Page(s) 202

    Abstract: Background: Scientific studies have shown that the potential therapeutic efficacy of curcumin in several diseases is due to its potent antioxidant and anti-inflammatory properties. Consequently, curcumin supplementation seems to be a valuable ... ...

    Abstract Background: Scientific studies have shown that the potential therapeutic efficacy of curcumin in several diseases is due to its potent antioxidant and anti-inflammatory properties. Consequently, curcumin supplementation seems to be a valuable alternative for HIV-infected individuals. The aim of this study is to evaluate the influence of curcumin supplementation on substrate oxidation at rest, body composition, and the lipid profile of physically active people living with HIV/AIDS under antiretroviral therapy.
    Methods: This double-blind, crossover, randomized clinical trial was comprised of 20 subjects divided into experimental (EG) and control (CG) groups, receiving 1000 mg curcumin/day and placebo, respectively, during a 30-day period. Substrate oxidation at rest was assessed by indirect calorimetry, body composition was measured by dual-energy x-ray absorptiometry, and the lipid profile was evaluated by blood tests. Data analysis was performed by independent samples and paired t-tests to compare the differences between groups and times. A p-value < 0.05 was accepted as significant.
    Results: There were no differences between groups regarding substrate oxidation at rest or body composition. However, serum triglyceride levels were increased after curcumin supplementation (182 vs. 219 mg/dL; p = 0.004).
    Conclusion: Curcumin supplementation promoted the elevation of serum triglyceride levels in HIV-infected subjects. Further studies with a larger sample cohort, different curcumin doses, and longer intervention times are needed to validate current observations. In addition, the influence of physical activity, dietary intake, and genetic polymorphisms must be considered in future studies to better understand the impact of curcumin supplementation on the lipid profile of people living with HIV/AIDS under antiretroviral therapy.
    MeSH term(s) Adult ; Body Composition/drug effects ; Curcumin/administration & dosage ; Dietary Supplements/analysis ; Double-Blind Method ; Female ; HIV Infections/drug therapy ; HIV Infections/metabolism ; Humans ; Lipid Metabolism ; Lipids/blood ; Lipids/chemistry ; Male ; Middle Aged ; Young Adult
    Chemical Substances Lipids ; Curcumin (IT942ZTH98)
    Language English
    Publishing date 2019-08-06
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 2050429-9
    ISSN 1472-6882 ; 1472-6882
    ISSN (online) 1472-6882
    ISSN 1472-6882
    DOI 10.1186/s12906-019-2620-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Media and scientific communication about the COVID-19 pandemic and the repercussions on the population's mental health: A protocol for a systematic review and meta-analysis.

    Pimenta, Isac Davidson Santiago Fernandes / de Sousa Mata, Ádala Nayana / Braga, Liliane Pereira / de Medeiros, Gidyenne Christine Bandeira Silva / de Azevedo, Kesley Pablo Morais / Bezerra, Isaac Newton Machado / de Oliveira Segundo, Victor Hugo / de França Nunes, Ana Clara / Santos, Gilberto Martins / Grosseman, Suely / Nicolás, Ismael Martínez / Piuvezam, Grasiela

    Medicine

    2020  Volume 99, Issue 50, Page(s) e23298

    Abstract: Background: Good communication strategies are essential in times of crisis, such as the coronavirus pandemic. The dissemination of inaccurate information and the need for social isolation to control coronavirus disease 2019 (COVID-19) have shown a ... ...

    Abstract Background: Good communication strategies are essential in times of crisis, such as the coronavirus pandemic. The dissemination of inaccurate information and the need for social isolation to control coronavirus disease 2019 (COVID-19) have shown a negative impact on the population, causing damage to mental health, with the appearance or worsening of symptoms of stress, fear, anxiety, and depression. Thus, the systematic review study is intended to gather evidence on the impact of information about COVID-19 on the mental health of the population.
    Methods: This systematic review protocol is conducted using the guidelines of the preferred reporting items for systematic reviews and meta-analyses protocols and the Cochrane Handbook for Systematic Reviews of Interventions. The review aims to include published studies that address the exposure of the general population to information about COVID-19, through observational and experimental studies, which consider the following outcomes: fear, stress, anxiety, and depression. Thus, a comprehensive research strategy will be conducted in the following databases: PubMed / Medline, Scopus, Web of Science, EMBASE, Science Direct, CINAHL, PsycINFO and Cochrane Central Register of Controlled Trials (CENTRAL). Two independent reviewers will perform all procedures, such as study selection, data collection, and methodological evaluation. Disagreements will be forwarded to a third reviewer. RevMan 5.3 software will be used for data analysis.
    Results: This systematic review will provide evidence of the influence of access to and consumption of media and scientific information about COVID-19 on the mental health of the population. It will consider information about the characterization of the study and the population studied, clinical and epidemiological information on mental health, and data on access to and consumption of media and scientific information.
    Discussion: The results should inform about the consequences of communication about the new coronavirus on the emergence or worsening of psychological and psychiatric symptoms, allowing to develop strategies to achieve effective communication of information to promote the mental health of the population.
    Systematic review registration number: PROSPERO CRD42020182918.
    MeSH term(s) Anxiety/epidemiology ; COVID-19/epidemiology ; COVID-19/psychology ; Depression/epidemiology ; Fear/psychology ; Health Communication/methods ; Humans ; Mass Media/statistics & numerical data ; Mental Health/statistics & numerical data ; Pandemics ; Research Design ; SARS-CoV-2 ; Social Isolation ; Stress, Psychological/epidemiology ; Meta-Analysis as Topic ; Systematic Review as Topic
    Language English
    Publishing date 2020-12-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000023298
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The Control and Prevention of COVID-19 Transmission in Children: A Protocol for Systematic Review and Meta-analysis.

    Medeiros, Gidyenne Christine Bandeira Silva de / Nunes, Ana Clara de França / Azevedo, Kesley Pablo Morais de / de Oliveira Segundo, Victor Hugo / Santos, Gilberto Martins / Mata, Ádala Nayana de Sousa / Pimenta, Isac Davidson / Bezerra, Isaac Newton Machado / Braga, Liliane Pereira / Capucho, Helaine Carneiro / Piuvezam, Márcia Regina / Barbosa Filho, Valter Cordeiro / Leitão, José Carlos / Martínez, Daniel Guillén / Piuvezam, Grasiela

    Medicine

    2020  Volume 99, Issue 31, Page(s) e21393

    Abstract: Background: The pandemic following the rapid spread of the new SARS-CoV-2 virus has hit all continents and caused thousands of deaths worldwide. Evidence has been published on epidemiological and clinical characteristics of population groups considered ... ...

    Abstract Background: The pandemic following the rapid spread of the new SARS-CoV-2 virus has hit all continents and caused thousands of deaths worldwide. Evidence has been published on epidemiological and clinical characteristics of population groups considered at risk; however, information for the other population groups, especially for the child population, is needed. In this context, this protocol describes a systematic review that will aim to identify the evidence on control and prevention of COVID-19 transmission among children and adolescents, as well as to describe the epidemiological profile and clinical and immunological characteristics of COVID-19 in this population.
    Methods: This protocol will be developed in accordance with PRISMA-P. The searches will be conducted in PubMed, Web of Science, ScienceDirect, EMBASE, and Scopus, seeking clinical trials. Observational studies and case reports with Children and adolescents (≤19 years) infected with SARS-CoV-2 will be included whether they report information on the control of prevention and COVID-19 transmission. Two independent researchers will perform the selection of articles, removal of duplication, and screening by Rayyan QCRI application. Cochrane's RoB 2.0, ROBINS-I, and CASP tools will be used to assess the risk of bias. Meta-analysis, subgroup analyses, and/or descriptive analyses will be carried out based on the data conditions included.
    Results: A high-quality synthesis of the available evidences on the epidemiological profile, the clinical and immunological characteristics involved in children, and adolescents diagnosed with COVID-19, as well as the participation of this population in the transmission dynamics of SARS-CoV-2 will be provided.
    Conclusion: This systematic review has an important relevance in the current context because it has a great potential to help the development of new control and prevention strategies in the pediatric population.
    Record of systematic review: CRD42020179263.
    MeSH term(s) Adolescent ; Betacoronavirus ; COVID-19 ; Child ; Coronavirus Infections/transmission ; Disease Transmission, Infectious/prevention & control ; Humans ; Meta-Analysis as Topic ; Pandemics ; Pneumonia, Viral/transmission ; Research Design ; SARS-CoV-2 ; Systematic Reviews as Topic
    Keywords covid19
    Language English
    Publishing date 2020-07-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000021393
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The Control and Prevention of COVID-19 Transmission in Children ; A Protocol for Systematic Review and Meta-analysis

    Medeiros, Gidyenne Christine Bandeira Silva de / Nunes, Ana Clara de França / Azevedo, Kesley Pablo Morais de / de Oliveira Segundo, Victor Hugo / Santos, Gilberto Martins / Mata, Ádala Nayana de Sousa / Pimenta, Isac Davidson / Bezerra, Isaac Newton Machado / Braga, Liliane Pereira / Capucho, Helaine Carneiro / Piuvezam, Márcia Regina / Barbosa Filho, Valter Cordeiro / Leitão, José Carlos / Martínez, Daniel Guillén / Piuvezam, Grasiela

    Medicine

    2020  Volume 99, Issue 31, Page(s) e21393

    Keywords General Medicine ; covid19
    Language English
    Publisher Ovid Technologies (Wolters Kluwer Health)
    Publishing country us
    Document type Article ; Online
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/md.0000000000021393
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Influence of curcumin supplementation on metabolic and lipid parameters of people living with HIV/AIDS

    Tatiane Andreza Lima Silva / Danielle Coutinho Medeiros / Gidyenne Christine Bandeira Silva Medeiros / Rafaela Catherine Silva Cunha Medeiros / Juliany de Souza Araújo / Jason Azevedo Medeiros / Marcela Abbott Galvao Ururahy / Ronaldo Vagner Thomatieli Santos / Radames Maciel Vitor Medeiros / Lucia Leite-Lais / Paulo Moreira Silva Dantas

    BMC Complementary and Alternative Medicine, Vol 19, Iss 1, Pp 1-

    a randomized controlled trial

    2019  Volume 8

    Abstract: Abstract Background Scientific studies have shown that the potential therapeutic efficacy of curcumin in several diseases is due to its potent antioxidant and anti-inflammatory properties. Consequently, curcumin supplementation seems to be a valuable ... ...

    Abstract Abstract Background Scientific studies have shown that the potential therapeutic efficacy of curcumin in several diseases is due to its potent antioxidant and anti-inflammatory properties. Consequently, curcumin supplementation seems to be a valuable alternative for HIV-infected individuals. The aim of this study is to evaluate the influence of curcumin supplementation on substrate oxidation at rest, body composition, and the lipid profile of physically active people living with HIV/AIDS under antiretroviral therapy. Methods This double-blind, crossover, randomized clinical trial was comprised of 20 subjects divided into experimental (EG) and control (CG) groups, receiving 1000 mg curcumin/day and placebo, respectively, during a 30-day period. Substrate oxidation at rest was assessed by indirect calorimetry, body composition was measured by dual-energy x-ray absorptiometry, and the lipid profile was evaluated by blood tests. Data analysis was performed by independent samples and paired t-tests to compare the differences between groups and times. A p-value < 0.05 was accepted as significant. Results There were no differences between groups regarding substrate oxidation at rest or body composition. However, serum triglyceride levels were increased after curcumin supplementation (182 vs. 219 mg/dL; p = 0.004). Conclusion Curcumin supplementation promoted the elevation of serum triglyceride levels in HIV-infected subjects. Further studies with a larger sample cohort, different curcumin doses, and longer intervention times are needed to validate current observations. In addition, the influence of physical activity, dietary intake, and genetic polymorphisms must be considered in future studies to better understand the impact of curcumin supplementation on the lipid profile of people living with HIV/AIDS under antiretroviral therapy.
    Keywords Curcumin ; Dyslipidemia ; HIV/Aids ; Other systems of medicine ; RZ201-999
    Language English
    Publishing date 2019-08-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Influence of curcumin supplementation on metabolic and lipid parameters of people living with HIV/AIDS: a randomized controlled trial

    Silva, Tatiane Andreza Lima / Medeiros, Danielle Coutinho / Medeiros, Gidyenne Christine Bandeira Silva / Medeiros, Rafaela Catherine Silva Cunha / de Souza Araújo, Juliany / Medeiros, Jason Azevedo / Ururahy, Marcela Abbott Galvao / Santos, Ronaldo Vagner Thomatieli / Medeiros, Radames Maciel Vitor / Leite-Lais, Lucia / Dantas, Paulo Moreira Silva

    BMC Complement Altern Med. 2019 Dec., v. 19, no. 1 p.202-202

    2019  

    Abstract: BACKGROUND: Scientific studies have shown that the potential therapeutic efficacy of curcumin in several diseases is due to its potent antioxidant and anti-inflammatory properties. Consequently, curcumin supplementation seems to be a valuable alternative ...

    Abstract BACKGROUND: Scientific studies have shown that the potential therapeutic efficacy of curcumin in several diseases is due to its potent antioxidant and anti-inflammatory properties. Consequently, curcumin supplementation seems to be a valuable alternative for HIV-infected individuals. The aim of this study is to evaluate the influence of curcumin supplementation on substrate oxidation at rest, body composition, and the lipid profile of physically active people living with HIV/AIDS under antiretroviral therapy. METHODS: This double-blind, crossover, randomized clinical trial was comprised of 20 subjects divided into experimental (EG) and control (CG) groups, receiving 1000 mg curcumin/day and placebo, respectively, during a 30-day period. Substrate oxidation at rest was assessed by indirect calorimetry, body composition was measured by dual-energy x-ray absorptiometry, and the lipid profile was evaluated by blood tests. Data analysis was performed by independent samples and paired t-tests to compare the differences between groups and times. A p-value < 0.05 was accepted as significant. RESULTS: There were no differences between groups regarding substrate oxidation at rest or body composition. However, serum triglyceride levels were increased after curcumin supplementation (182 vs. 219 mg/dL; p = 0.004). CONCLUSION: Curcumin supplementation promoted the elevation of serum triglyceride levels in HIV-infected subjects. Further studies with a larger sample cohort, different curcumin doses, and longer intervention times are needed to validate current observations. In addition, the influence of physical activity, dietary intake, and genetic polymorphisms must be considered in future studies to better understand the impact of curcumin supplementation on the lipid profile of people living with HIV/AIDS under antiretroviral therapy.
    Keywords HIV infections ; antioxidants ; antiretroviral agents ; blood serum ; body composition ; calorimetry ; complement ; curcumin ; dual-energy X-ray absorptiometry ; food intake ; lipid composition ; oxidation ; people ; physical activity ; placebos ; randomized clinical trials ; t-test ; therapeutics ; triacylglycerols
    Language English
    Dates of publication 2019-12
    Size p. 202.
    Publishing place BioMed Central
    Document type Article ; Online
    Note Resource is Open Access
    ZDB-ID 2050429-9
    ISSN 1472-6882
    ISSN 1472-6882
    DOI 10.1186/s12906-019-2620-7
    Database NAL-Catalogue (AGRICOLA)

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