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  1. Article: Neuentwicklungen haben heute keinen leichten Stand - Interview mit Dr. med. Andreas Arendt

    Krämer, Sabine / Arendt, Andreas

    Der Merkurstab

    2022  Volume 75, Issue 3, Page(s) 196

    Language German
    Document type Article
    ZDB-ID 392536-5
    ISSN 0935-798X
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4326: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Sprungtraining: negative Folgen von Inaktivität vermeiden. Im Gespräch mit Andreas Kramer

    Kramer, Andreas

    Zeitschrift für Physiotherapeuten

    2019  Volume 71, Issue 4, Page(s) 36

    Language German
    Document type Article
    ZDB-ID 2274399-6
    ISSN 1614-0397
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.161: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: The sorting receptor Rer1 controls Purkinje cell function via voltage gated sodium channels

    Krämer, Andreas

    Scientific reports, 7:41248

    2017  

    Abstract: Rer1 is a sorting receptor in the early secretory pathway that controls the assembly and the cell surface transport of selected multimeric membrane protein complexes. Mice with a Purkinje cell (PC) specific deletion of Rer1 showed normal polarization and ...

    Institution Leibniz-Institut für Alternsforschung
    Abstract Rer1 is a sorting receptor in the early secretory pathway that controls the assembly and the cell surface transport of selected multimeric membrane protein complexes. Mice with a Purkinje cell (PC) specific deletion of Rer1 showed normal polarization and differentiation of PCs and normal development of the cerebellum. However, PC-specific loss of Rer1 led to age-dependent motor deficits in beam walk, ladder climbing and gait. Analysis of brain sections revealed a specific degeneration of PCs in the anterior cerebellar lobe in old animals. Electrophysiological recordings demonstrated severe deficits in spontaneous action potential generation. Measurements of resurgent currents indicated decreased surface densities of voltage-gated sodium channels (Nav), but not changes in individual channels. Analysis of mice with a whole brain Rer1-deletion demonstrated a strong down-regulation of Nav1.6 and 1.1 in the absence of Rer1, whereas protein levels of the related Cav2.1 and of Kv3.3 and 7.2 channels were not affected. The data suggest that Rer1 controls the assembly and transport of Nav1.1 and 1.6, the principal sodium channels responsible for recurrent firing, in PCs.
    Keywords Cellular neuroscience ; Endoplasmic reticulum
    Language English
    Document type Article
    Database Repository for Life Sciences

    Full text online

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  4. Book ; Thesis: Charakterisierung einer Pyrrolidin-Derivat-Fixierung an humanem Gewebe

    Kramer, Andreas Markus

    2019  

    Institution Eberhard Karls Universität Tübingen
    Author's details vorgelegt von Kramer, Andreas Markus
    Language German
    Size 121 Seiten, Illustrationen, Diagramme, 21 cm
    Publishing place Tübingen
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Eberhard Karls Universität zu Tübingen, 2019
    HBZ-ID HT020461338
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2020 D 395 order for loan Magazin

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  5. Article: [Besprechung von:] Hoff, Andreas: Betriebliche Arbeitszeitpolitik zwischen Arbeitszeitverkürzung und Arbeitszeitflexibilisierung. München 1983

    Krämer, W / Hoff, Andreas

    Zeitschrift für Wirtschafts- und Sozialwissenschaften : ZWS ; Vierteljahresschrift der Gesellschaft für Wirtschafts- und Sozialwissenschaften - Verein für Socialpolitik Vol. 104, No. 4 , p. 441-443

    Beiträge zur Sozialökonomik der Arbeit. Bd 7

    1984  Volume 104, Issue 4, Page(s) 441–443

    Author's details W. Krämer
    Publisher Duncker & Humblot
    Publishing place Berlin
    Document type Article
    ZDB-ID 120927-9
    Database ECONomics Information System

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  6. Book ; Thesis: Visualisierung von Instrumenten und Implantaten in der Magnetresonanztomographie

    Krämer, Nils Andreas

    [kumulative Habilitationsschrift]

    2014  

    Author's details vorgelegt von Nils A. Krämer
    Language German ; English
    Size 152 Bl. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Aachen, Techn. Hochsch., Habil.-Schr., 2014
    Note Zeitschriftenartikel in engl. Sprache ; Enth. u.a.: 7 Sonderabdr. aus verschiedenen Zeitschriften
    HBZ-ID HT018364779
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2015 E 11 order for loan Magazin

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  7. Book ; Thesis: Score-gesteuerte Dauer der Anschlussheilbehandlung nach alloplastischem Hüft- und Kniegelenkersatz

    Krämer, Andreas

    2009  

    Author's details vorgelegt von Andreas Krämer
    Language German
    Size 55 S. : graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Aachen, Techn. Hochsch., Diss., 2009
    HBZ-ID HT016057532
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2010 D 305 order for loan Magazin

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  8. Article ; Online: Master regulators as order parameters of gene expression states.

    Krämer, Andreas

    Physical review. E

    2021  Volume 103, Issue 1-1, Page(s) 12409

    Abstract: Cell type-specific gene expression patterns are represented as memory states of a Hopfield neural network model. It is shown that order parameters of this model can be interpreted as concentrations of master transcription regulators that form concurrent ... ...

    Abstract Cell type-specific gene expression patterns are represented as memory states of a Hopfield neural network model. It is shown that order parameters of this model can be interpreted as concentrations of master transcription regulators that form concurrent positive feedback loops with a large number of downstream regulated genes. The order parameter free energy then defines an epigenetic landscape in which local minima correspond to stable cell states. The model is applied to gene expression data in the context of hematopoiesis.
    MeSH term(s) Gene Expression Regulation ; Hematopoiesis/genetics ; Models, Genetic ; Neural Networks, Computer
    Language English
    Publishing date 2021-02-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2844562-4
    ISSN 2470-0053 ; 2470-0045
    ISSN (online) 2470-0053
    ISSN 2470-0045
    DOI 10.1103/PhysRevE.103.012409
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Notch1 signaling is mediated by importins alpha 3, 4, and 7

    Krämer, Andreas

    Cellular and molecular life sciences, 67(18): 3187–3196

    2010  

    Abstract: The Notch signaling pathway is an important regulation system for the development and self-renewal of different tissues. A specific feature of this signaling cascade is the function of Notch as a surface receptor and regulator of gene expression. Hence, ... ...

    Institution Leibniz-Institut für Alternsforschung
    Abstract The Notch signaling pathway is an important regulation system for the development and self-renewal of different tissues. A specific feature of this signaling cascade is the function of Notch as a surface receptor and regulator of gene expression. Hence, Notch activation and signal transduction requires the proteolytic release of the Notch intracellular domain (NICD), which activates the transcription of cell-specific genes after its transport into the nucleus. To date, little is known about the mechanisms that mediate NICD nuclear import. We here show that transport of NICD into the nucleus is mediated by the canonical importin α/β1 pathway. GST pull-down experiments revealed that NICD binds via one of its four potential nuclear localization signals to importins α3, α4, and α7, but not to α1 and α5. siRNA-mediated knockdown experiments showed that importins α3, α4 (and to a lesser extent, α7) mediate nuclear import of NICD and thus are directly involved in Notch signaling.
    Keywords Importin alpha ; Myoblast ; Notch signaling ; Nuclear import
    Language English
    Document type Article
    Database Repository for Life Sciences

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  10. Book: Flossing in Therapie und Training

    Ahlhorn, Andreas / Krämer, Dennis

    2016  

    Author's details Andreas Ahlhorn ; Dennis Krämer
    Keywords Beweglichkeitstraining ; Sportverletzung ; Medical Flossing
    Subject Voodoo Flossing ; Ninja Flossing
    Language German
    Size 150 S. : zahlr. Ill.
    Edition Originalausg., 1. Aufl.
    Publisher riva
    Publishing place München
    Publishing country Germany
    Document type Book
    HBZ-ID HT018870243
    ISBN 978-3-86883-912-8 ; 3-86883-912-7 ; 9783959712408 ; 9783959712392 ; 3959712405 ; 3959712391
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2017 A 97 available for loan (reading room) Lesesaal EG

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