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  1. Article: Urinary-Tract-Infection Induced Noncirrhotic Hyperammonemic Encephalopathy Mimicking Nonconvulsive Status Epilepticus.

    Lee, Yujin / Kwack, Dong Won / Kim, Dong Wook

    Journal of clinical neurology (Seoul, Korea)

    2023  Volume 19, Issue 6, Page(s) 627–629

    Language English
    Publishing date 2023-10-25
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2500489-X
    ISSN 2005-5013 ; 1738-6586
    ISSN (online) 2005-5013
    ISSN 1738-6586
    DOI 10.3988/jcn.2023.0135
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Headache Is a Common Aura in Patients with Generalized Seizures.

    Kwack, Dong Won / Kim, Dong Wook

    Journal of epilepsy research

    2023  Volume 13, Issue 2, Page(s) 51–54

    Abstract: Background and purpose: Although aura in epilepsy is usually considered as a phenomenon in patients with focal seizures, headache can occur as an aura or solitary epileptic symptom in patients with generalized seizures.: Methods: We performed a 14- ... ...

    Abstract Background and purpose: Although aura in epilepsy is usually considered as a phenomenon in patients with focal seizures, headache can occur as an aura or solitary epileptic symptom in patients with generalized seizures.
    Methods: We performed a 14-year retrospective study of patients with generalized seizures and analyzed the proportion and characteristics of patients with auras including headache.
    Results: Among the 102 patients diagnosed with generalized seizures, aura was reported in 45 patients and headache was the most common aura in 26 patients. The age of onset of seizures was significantly lower in patients with headache as an aura than in patients without headache (14.8±3.8 vs. 24.7±16.2;
    Conclusions: Our study showed that headache was the most common aura in patients with generalized seizures and patients with a younger age of onset of seizures were more likely to experience headache as an aura in these patients.
    Language English
    Publishing date 2023-12-31
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2771719-7
    ISSN 2233-6257 ; 2233-6249
    ISSN (online) 2233-6257
    ISSN 2233-6249
    DOI 10.14581/jer.23008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Steroid-Responsive Dengue Encephalitis Without Typical Dengue Symptoms.

    Mun, Yeon-Jung / Shin, Dong-Hyeon / Cho, Jae Wook / Kim, Hyun-Woo

    Journal of clinical neurology (Seoul, Korea)

    2024  Volume 20, Issue 2, Page(s) 232–234

    Language English
    Publishing date 2024-03-04
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2500489-X
    ISSN 2005-5013 ; 1738-6586
    ISSN (online) 2005-5013
    ISSN 1738-6586
    DOI 10.3988/jcn.2023.0254
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  4. Article ; Online: Potential efficacy and safety of eslicarbazepine acetate oral loading in patients with epilepsy.

    Kwack, Dong Won / Kim, Dong Wook

    Epilepsia

    2023  Volume 64, Issue 9, Page(s) e190–e193

    Abstract: Eslicarbazepine acetate (ESL) is a new antiseizure medication (ASM) approved as an adjunctive therapy or monotherapy for focal onset seizures. We performed this study to explore the potential efficacy and safety of ESL oral loading in selected patients ... ...

    Abstract Eslicarbazepine acetate (ESL) is a new antiseizure medication (ASM) approved as an adjunctive therapy or monotherapy for focal onset seizures. We performed this study to explore the potential efficacy and safety of ESL oral loading in selected patients with epilepsy. Thirty adult patients with status epilepticus or acute repetitive seizures were enrolled, and ESL was administered at a single loading dosage of 30 mg/kg. Plasma levels of an active metabolite of ESL, monohydroxy derivative (MHD), were measured at 2, 4, 6, 12, and 24 h after ESL oral loading. Two thirds of the patients reached a therapeutic level of MHD 2 h after ESL loading, and most of the patients achieved a therapeutic range within 12 h after loading. Plasma MHD levels did not rise above the supratherapeutic level in any patient throughout the study. The reported adverse effects included one patient with gaze-evoked nystagmus and another patient with a rash. No serious adverse events leading to drug discontinuation occurred. There was no discernible difference in sodium levels before and after ESL oral loading. Our study findings suggest that ESL oral loading could be a useful therapeutic option for patients with epilepsy who need rapid elevations in the therapeutic levels of ASMs.
    MeSH term(s) Adult ; Humans ; Anticonvulsants/adverse effects ; Epilepsy/drug therapy ; Epilepsy/chemically induced ; Seizures/drug therapy ; Dibenzazepines/therapeutic use ; Treatment Outcome
    Chemical Substances eslicarbazepine acetate (BEA68ZVB2K) ; Anticonvulsants ; Dibenzazepines
    Language English
    Publishing date 2023-07-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 216382-2
    ISSN 1528-1167 ; 0013-9580
    ISSN (online) 1528-1167
    ISSN 0013-9580
    DOI 10.1111/epi.17704
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 517: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 475: Show issues

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  5. Article ; Online: Risk factors of hyperammonemia in epilepsy patients with valproic acid therapy.

    Kwack, Dong Won / Kim, Dong Wook

    Clinical neurology and neurosurgery

    2023  Volume 233, Page(s) 107962

    Abstract: Background: Hyperammonemia can occur after acute overdose or chronic use of valproic acid (VPA). Although VPA-related hyperammonemic encephalopathy (VHE) is a rare complication of VPA therapy, early recognition of VHE and identifying its risk factors ... ...

    Abstract Background: Hyperammonemia can occur after acute overdose or chronic use of valproic acid (VPA). Although VPA-related hyperammonemic encephalopathy (VHE) is a rare complication of VPA therapy, early recognition of VHE and identifying its risk factors are important because VHE can lead to loss of consciousness and increased seizure frequency.
    Purpose: The purpose of our study is to evaluate the risk factors of hyperammonemia in epilepsy patients during treatment with VPA therapy.
    Methods: We reviewed the medical records of 1084 adult patients with epilepsy and enrolled 116 patients with VPA therapy who had results of blood levels of ammonia over a 3-year period. Hyperammonemia was defined as a blood ammonia level exceeding 80 µg/dL. Correlations of blood levels of ammonia with dosages and blood levels of VPA were evaluated. We further performed univariate and multivariate linear regression analyses to identify risk factors for hyperammonemia in epilepsy patients treated with VPA therapy.
    Results: Blood levels of ammonia were well correlated with dosages of VPA (p = 0.036), but not with blood levels of VPA (p = 0.463). Hyperammonemia was more common in patients with higher VPA dosage and higher total drug loads of concurrent antiseizure medications (ASMs). Hyperammonemia was also associated with the use of topiramate and phenobarbital. In multivariate analysis, we identified total drug load of ASMs (p = 0.003) and use of topiramate (p = 0.007) as independent predictors of hyperammonemia. Four patients (4/116, 3.4 %) had clinical symptoms of VHE. Three of them had hyperammonemia while the other patient had normal blood level of ammonia with a high blood level of VPA.
    Conclusion: Our study shows that higher total drug loads of concurrent ASMs and use of topiramate were independent risk factors of hyperammonemia in epilepsy patients with VPA therapy. Although the incidence of VHE was not high in our study, clinicians should be aware of this potential adverse effect of VPA therapy, especially in patients with polytherapy of ASMs including topiramate.
    MeSH term(s) Adult ; Humans ; Valproic Acid/adverse effects ; Anticonvulsants/adverse effects ; Topiramate/adverse effects ; Hyperammonemia/chemically induced ; Ammonia/therapeutic use ; Epilepsy/drug therapy ; Risk Factors
    Chemical Substances Valproic Acid (614OI1Z5WI) ; Anticonvulsants ; Topiramate (0H73WJJ391) ; Ammonia (7664-41-7)
    Language English
    Publishing date 2023-09-06
    Publishing country Netherlands
    Document type Review ; Journal Article
    ZDB-ID 193107-6
    ISSN 1872-6968 ; 0303-8467
    ISSN (online) 1872-6968
    ISSN 0303-8467
    DOI 10.1016/j.clineuro.2023.107962
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui I Zs.53: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Comparative analysis of adverse drug reactions associated with new antiseizure medications from the Korea Adverse Event Reporting System database.

    Kim, Hyun Kyung / Jang, Kyung Sik / Kim, Dong Wook

    Epilepsy & behavior : E&B

    2024  Volume 154, Page(s) 109784

    Abstract: Objective: This study aimed to compare and characterize the safety profiles of new antiseizure medications (ASMs) using a nationwide pharmacovigilance database from a long-term perspective in Korea.: Methods: We reviewed adverse event reports from ... ...

    Abstract Objective: This study aimed to compare and characterize the safety profiles of new antiseizure medications (ASMs) using a nationwide pharmacovigilance database from a long-term perspective in Korea.
    Methods: We reviewed adverse event reports from the Korea Adverse Event Reporting System database between January 2013 and December 2022 for descriptive analysis of six new ASMs (lacosamide, levetiracetam, lamotrigine, oxcarbazepine, topiramate, and zonisamide). We investigated the frequency and characteristics of adverse drug reactions (ADRs) based on the MedDRA terminology, system organ classes, and modified WHO classification.
    Results: We identified 5,733 reported cases of ADRs. The commonly reported ADRs associated with total ASMs were rash/urticaria (1,822, 31.8 %), dizziness (409, 7.1 %), somnolence/drowsiness (311, 5.4 %), and hepatotoxic effects (273, 4.8 %). Type B (idiosyncratic) effects (2,932; 51.1 %) were more commonly reported than Type A (related to known drug mechanisms) effects (2,613; 45.6 %). Skin and subcutaneous tissue disorders and type B effects were most commonly reported for lamotrigine and oxcarbazepine, whereas nervous system disorders and type A effects were most commonly reported for lacosamide, topiramate, and zonisamide. The pediatric group (<18 years) exhibited skin and subcutaneous tissue disorders and type B effects relatively more frequently than the adult and older adult groups.
    Conclusion: Hypersensitivity skin reactions and type B effects remained significant ADRs in the new ASMs; however, type A effects were more commonly reported in some ASMs. The pediatric group showed a higher rate of type B effects. Overall, new ASMs should also be used with caution.
    Language English
    Publishing date 2024-04-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2010587-3
    ISSN 1525-5069 ; 1525-5050
    ISSN (online) 1525-5069
    ISSN 1525-5050
    DOI 10.1016/j.yebeh.2024.109784
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5289: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Study on antioxidant activity and cytotoxicity of

    Kim, Dong-Wook / Park, Mi-Hye / Kim, Meera

    Food science and biotechnology

    2023  Volume 32, Issue 10, Page(s) 1423–1433

    Abstract: Aronia leaf tea, which is generally discarded after harvesting the fruit, was prepared using three different methods. Water extract from ... ...

    Abstract Aronia leaf tea, which is generally discarded after harvesting the fruit, was prepared using three different methods. Water extract from dried
    Language English
    Publishing date 2023-03-07
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2000008-X
    ISSN 2092-6456 ; 1226-7708
    ISSN (online) 2092-6456
    ISSN 1226-7708
    DOI 10.1007/s10068-023-01280-7
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    Full text online

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    In stock of ZB MED Bonn / Germany

    Z 7438: Show issues

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  8. Article ; Online: Flexible and Ultra Low Weight Energy Harvesters Based on 2D Phosphorene or Black phosphorus (BP): Current and Futuristic Prospects.

    Kumar, Avneesh / Kim, Joo Hyun / Chang, Dong Wook

    ChemSusChem

    2024  , Page(s) e202301718

    Abstract: Phosphorene, or two-dimensional (2D) black phosphorus, has recently emerged as a competitor of graphene as it offers several advantages, including a tunable band gap, higher on/off current ratio, piezoelectric nature, and biocompatibility. Researchers ... ...

    Abstract Phosphorene, or two-dimensional (2D) black phosphorus, has recently emerged as a competitor of graphene as it offers several advantages, including a tunable band gap, higher on/off current ratio, piezoelectric nature, and biocompatibility. Researchers have succeeded in obtaining several forms of phosphorene, such as nanosheets, nanorods, nanoribbons, and quantum dots, with satisfactory yields. Nanostructures with various controlled properties have been fabricated in multiple devices for energy production. These phosphorene-based devices are lightweight, flexible, and efficient, demonstrating great potential for energy-harvesting applications in sensors and nanogenerators. While ongoing exploration and advancements continue for these lightweight energy harvesters, it is essential to review the current progress in order to develop a future roadmap for the potential use of these phosphorene-based energy harvesters in space programs. They could be employed in applications such as wearable devices for astronauts, where ultralow weight is a vital component of any integrated device. This review also anticipates the growing significance of phosphorene in various emerging applications such as robots, information storage devices, and artificial intelligence.
    Language English
    Publishing date 2024-02-06
    Publishing country Germany
    Document type Journal Article ; Review
    ISSN 1864-564X
    ISSN (online) 1864-564X
    DOI 10.1002/cssc.202301718
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  9. Article: Nanofibrous Material-Reinforced Printable Ink for Enhanced Cell Proliferation and Tissue Regeneration.

    Raja, Iruthayapandi Selestin / Kim, Bongju / Han, Dong-Wook

    Bioengineering (Basel, Switzerland)

    2024  Volume 11, Issue 4

    Abstract: The three-dimensional (3D) printing of biomaterials, cells, and bioactive components, including growth factors, has gained interest among researchers in the field of tissue engineering (TE) with the aim of developing many scaffolds to sustain size, shape ...

    Abstract The three-dimensional (3D) printing of biomaterials, cells, and bioactive components, including growth factors, has gained interest among researchers in the field of tissue engineering (TE) with the aim of developing many scaffolds to sustain size, shape fidelity, and structure and retain viable cells inside a network. The biocompatible hydrogel employed in 3D printing should be soft enough to accommodate cell survival. At the same time, the gel should be mechanically strong to avoid the leakage of cells into the surrounding medium. Considering these basic criteria, researchers have developed nanocomposite-based printable inks with suitable mechanical and electroconductive properties. These nanomaterials, including carbon family nanomaterials, transition metal dichalcogenides, and polymeric nanoparticles, act as nanofillers and dissipate stress across polymeric networks through their electroactive interactions. Nanofiber-reinforced printable ink is one kind of nanocomposite-based ink that comprises dispersed nanofiber components in a hydrogel matrix. In this current review, we compile various TE applications of nanofiber-reinforced printable ink and describe the 3D-printing parameters, classification, and impact of cross-linkage. Furthermore, we discuss the challenges and future perspectives in this field.
    Language English
    Publishing date 2024-04-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2746191-9
    ISSN 2306-5354
    ISSN 2306-5354
    DOI 10.3390/bioengineering11040363
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  10. Article: The Increased Interleukin-6 Levels Can Be an Early Diagnostic Marker for New-Onset Refractory Status Epilepticus.

    Kwack, Dong Won / Kim, Dong Wook

    Journal of epilepsy research

    2022  Volume 12, Issue 2, Page(s) 78–81

    Abstract: New-onset refractory status epilepticus (NORSE) is a condition defined as the occurrence of refractory status epilepticus in patients without active epilepsy and no other acute causes of seizure. Although there is evidence that immune-mediated ... ...

    Abstract New-onset refractory status epilepticus (NORSE) is a condition defined as the occurrence of refractory status epilepticus in patients without active epilepsy and no other acute causes of seizure. Although there is evidence that immune-mediated pathogenesis has a pivotal role in the epileptogenesis of NORSE, the diagnosis of NORSE is usually made on the clinical observation because there is no established biological marker suggesting the diagnosis of NORSE. We recently encountered a NORSE patient who was successfully treated with immunotherapy including tocilizumab, an anti-interleukin-6 (IL-6) receptor monoclonal antibody, and the markedly increased levels of serum and cerebrospinal fluid IL-6 were the only laboratory abnormality during the early treatment of the patient.
    Language English
    Publishing date 2022-12-30
    Publishing country Korea (South)
    Document type Case Reports
    ZDB-ID 2771719-7
    ISSN 2233-6257 ; 2233-6249
    ISSN (online) 2233-6257
    ISSN 2233-6249
    DOI 10.14581/jer.22015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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