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Article: The Current Recommended Drugs and Strategies for the Treatment of Coronavirus Disease (COVID-19).

Sheikhpour, Mojgan

Therapeutics and clinical risk management

2020 Volume 16, Page(s) 933–946

Abstract: Background: The coronavirus 2019 (COVID-19) has been known as a pandemic disease by the World Health Organization (WHO) worldwide. The drugs currently used for treatment of COVID-19 are often selected and tested based on their effectiveness in other ... ...

Abstract	Background: The coronavirus 2019 (COVID-19) has been known as a pandemic disease by the World Health Organization (WHO) worldwide. The drugs currently used for treatment of COVID-19 are often selected and tested based on their effectiveness in other diseases such as influenza and AIDS and their major identified targets are viral protease, host cell produced protease, viral RNA polymerase, and the interaction site of viral protein with host cell receptors. Until now, there are no approved therapeutic drugs for definitive treatment of this dangerous disease. Methods: In this article, all of the documentary information, such as clinical trials, original research and reviews, government's database, and treatment guidelines, were reviewed critically and comprehensively. Moreover, it was attempted to present the most common and effective drugs and strategies, to suggest the possible treatment way of COVID19 by focusing on the body's defense mechanism against pathogens. Results: Antiviral drugs and immune-modulatory agents with the traditional medicines using the natural compound are usual accessible treatments. Accordingly, they have better beneficence due to the large existence studies, long time follow-ups, proximity to the natural system, and the normal physiological routine of the pathogen and host interactions. Besides, the serotonergic and dopaminergic pathways are considered as attractive targets to treat human immune, infectious, and cancerous diseases. Fluoxetine, as a host-targeted small molecule with immunomodulatory action, may be known as effective drug for treatment and prevention of COVID19 disease, in combination with antiviral drugs and natural compounds. Conclusion: Co-administration of fluoxetine in the treatment of COVID19 could be considered due to the possibility of its interaction with ACE2 receptors, immune-modulatory function, and a proper immune response at the right time. Fluoxetine plays a beneficial role in reducing stress due to fear of infecting by COVID19 or worsening the disease and psychological support for the affected patients.
Keywords	covid19
Language	English
Publishing date	2020-10-07
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	2186560-7
ISSN	1178-203X ; 1176-6336
ISSN (online)	1178-203X
ISSN	1176-6336
DOI	10.2147/TCRM.S262936
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Article ; Book ; Online: The Current Recommended Drugs and Strategies for the Treatment of Coronavirus Disease (COVID-19)

Sheikhpour, Mojgan

2020

Abstract: ... IranCorrespondence: Mojgan Sheikhpour Tel +98-9122969712Fax +98 21 64112313Email mshaikhpoor@gmail.comBackground ... Mojgan Sheikhpour1,2 1Department of Mycobacteriology and Pulmonary Research, Pasteur Institute ...

Abstract	Mojgan Sheikhpour1,2 1Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran, Tehran, Iran; 2Microbiology Research Center, Pasteur Institute of Iran, Tehran, IranCorrespondence: Mojgan Sheikhpour Tel +98-9122969712Fax +98 21 64112313Email mshaikhpoor@gmail.comBackground: The coronavirus 2019 (COVID-19) has been known as a pandemic disease by the World Health Organization (WHO) worldwide. The drugs currently used for treatment of COVID-19 are often selected and tested based on their effectiveness in other diseases such as influenza and AIDS and their major identified targets are viral protease, host cell produced protease, viral RNA polymerase, and the interaction site of viral protein with host cell receptors. Until now, there are no approved therapeutic drugs for definitive treatment of this dangerous disease.Methods: In this article, all of the documentary information, such as clinical trials, original research and reviews, government’s database, and treatment guidelines, were reviewed critically and comprehensively. Moreover, it was attempted to present the most common and effective drugs and strategies, to suggest the possible treatment way of COVID19 by focusing on the body’s defense mechanism against pathogens.Results: Antiviral drugs and immune-modulatory agents with the traditional medicines using the natural compound are usual accessible treatments. Accordingly, they have better beneficence due to the large existence studies, long time follow-ups, proximity to the natural system, and the normal physiological routine of the pathogen and host interactions. Besides, the serotonergic and dopaminergic pathways are considered as attractive targets to treat human immune, infectious, and cancerous diseases. Fluoxetine, as a host-targeted small molecule with immunomodulatory action, may be known as effective drug for treatment and prevention of COVID19 disease, in combination with antiviral drugs and natural compounds.Conclusion: Co-administration of fluoxetine in the treatment of COVID19 could be considered due to the possibility of its interaction with ACE2 receptors, immune-modulatory function, and a proper immune response at the right time. Fluoxetine plays a beneficial role in reducing stress due to fear of infecting by COVID19 or worsening the disease and psychological support for the affected patients.Keywords: COVID-19, clinical trials, therapeutic drugs, immunomodulatory, fluoxetine
Keywords	Therapeutics and Clinical Risk Management ; covid19
Subject code	610
Language	English
Publishing date	2020-10-07
Publisher	Dove Press
Publishing country	us
Document type	Article ; Book ; Online
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Article ; Online: The Current Recommended Drugs and Strategies for the Treatment of Coronavirus Disease (COVID-19)

Sheikhpour, Mojgan

Therapeutics and Clinical Risk Management

2020 Volume Volume 16, Page(s) 933–946

Keywords	covid19
Language	English
Publisher	Informa UK Limited
Publishing country	uk
Document type	Article ; Online
ZDB-ID	2186560-7
ISSN	1178-203X ; 1176-6336
ISSN (online)	1178-203X
ISSN	1176-6336
DOI	10.2147/tcrm.s262936
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Bioinformatics study and experimental evaluation of miR-182, and miR-34 expression profiles in Tuberculosis and lung cancer.

Alimardanian, Leila / Soltani, Bahram Mohammad / Irani, Shiva / Sheikhpour, Mojgan

Tuberculosis and respiratory diseases

2024

Abstract: Background: Lung cancer is one of the most dangerous diseases among cancers and tuberculosis is one of the deadliest infectious diseases in the world. Many studies have mentioned the connection between lung cancer and tuberculosis, and also the ... ...

Abstract	Background: Lung cancer is one of the most dangerous diseases among cancers and tuberculosis is one of the deadliest infectious diseases in the world. Many studies have mentioned the connection between lung cancer and tuberculosis, and also the microRNAs that play a significant role in the development of these two diseases. This study aims to use different databases to find effective miRNAs and their role on different genes on lung and tuberculosis diseases. Also determining the role of miR-34a and miR-182 in lung cancer and tuberculosis. Methods: Using the GEO database, the influential microRNA databases were studied in two diseases. Finally, regarding bioinformatics results and literature studies, two miR-34a and miR-182 were selected. The role of these microRNAs and their target genes was carefully evaluated using bioinformatics. The expression of microRNAs in the blood plasma of patients with lung cancer and tuberculosis and healthy people were investigated. Results: According to the GEO database, miR-34a and miR-182 are microRNAs that affect tuberculosis and lung cancer. By checking the miRBase, miRcode, Diana, miRDB, galaxy, KEGG databases, the role of these microRNAs on genes and different molecular pathways and their effect on these microRNAs were mentioned. The results of the present study showed that the expression of miR-34a and miR-182 was lower than that of healthy people. The P value amount for miR-182 was <0.0001 and for miR-34a was 0.3380. Conclusion: Reducing the expression pattern of these microRNAs indicates their role in lung cancer and tuberculosis occurrence. Therefore, these microRNAs can be used as a biomarker for prognosis, diagnosis, and treatment methods.
Language	English
Publishing date	2024-04-15
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2161256-0
ISSN	1738-3536 ; 0378-0066
ISSN	1738-3536 ; 0378-0066
DOI	10.4046/trd.2023.0172
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Article ; Online: Biocompatibility evaluation of polyethersulfone-pyrolytic carbon composite membrane in artificial pancreas.

Peighami, Reza / Mehrnia, Mohamadreza / Yazdian, Fatemeh / Sheikhpour, Mojgan

Biointerphases

2023 Volume 18, Issue 2, Page(s) 21003

Abstract: Polyethersulfone (PES) membranes are widely used in medical devices, especially intravascular devices such as intravascular bioartificial pancreases. In the current work, the pure PES and PES-pyrolytic carbon (PyC) composite membranes were synthesized ... ...

Abstract	Polyethersulfone (PES) membranes are widely used in medical devices, especially intravascular devices such as intravascular bioartificial pancreases. In the current work, the pure PES and PES-pyrolytic carbon (PyC) composite membranes were synthesized and permeability studies were conducted. In addition, the cytocompatibility and hemocompatibility of the pure PES and PES-PyC membranes were investigated. These materials were characterized using peripheral blood mononuclear cell (PBMC) activation, platelet activation, platelet adhesion, ß-cell viability and proliferation, and ß-cell response to hyperglycemia. The results showed that platelet activation decreased from 87.3% to 27.8%. Any alteration in the morphology of sticking platelets was prevented, and the number of attached platelets decreased by modification with PyC. The 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide assay corroborated that PBMC activation was encouraged by the PyC-modified PES membrane surface. It can be concluded that PES-modified membranes show higher hemocompatibility than pure PES membranes. ß-cells cultured on all the three membranes displayed a lower rate of proliferation although the cells on the PES-PyC (0.1 wt. %) membrane indicated a slightly higher viability and proliferation than those on the pure PES and PES-PyC (0.05 wt. %) membranes. It shows that the PES-PyC (0.1 wt. %) membrane possesses superior cytocompatibility over the other membranes.
MeSH term(s)	Biocompatible Materials/pharmacology ; Leukocytes, Mononuclear ; Pancreas, Artificial ; Membranes, Artificial
Chemical Substances	polyether sulfone (25667-42-9) ; Biocompatible Materials ; pyrolytic carbon ; Membranes, Artificial
Language	English
Publishing date	2023-03-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2234510-3
ISSN	1559-4106 ; 1559-4106
ISSN (online)	1559-4106
ISSN	1559-4106
DOI	10.1116/6.0002155
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Article ; Online: A literature review of microRNA and gene signaling pathways involved in the apoptosis pathway of lung cancer.

Abolfathi, Hanie / Arabi, Mohadeseh / Sheikhpour, Mojgan

Respiratory research

2023 Volume 24, Issue 1, Page(s) 55

Abstract: Background: Lung cancer is one of the leading causes of death in the world and the deadliest of all cancers. Apoptosis is a key pathway in regulating the cell growth rate, proliferation, and occurrence of lung cancer. This process is controlled by many ... ...

Abstract	Background: Lung cancer is one of the leading causes of death in the world and the deadliest of all cancers. Apoptosis is a key pathway in regulating the cell growth rate, proliferation, and occurrence of lung cancer. This process is controlled by many molecules, such as microRNAs and their target genes. Therefore, finding new medical approaches such as exploring diagnostic and prognostic biomarkers involved in apoptosis is needed for this disease. In the present study, we aimed to identify key microRNAs and their target genes that could be used in the prognosis and diagnosis of lung cancer. Methods: Signaling pathways, genes, and microRNAs involved in the apoptotic pathway were identified by bioinformatics analysis and recent clinical studies. Bioinformatics analysis was performed on databases including NCBI, TargetScan, UALCAN, UCSC, KEGG, miRPathDB, and Enrichr, and clinical studies were extracted from PubMed, web of science, and SCOPUS databases. Results: NF-κB, PI3K/AKT, and MAPK pathways play critical roles in the regulation of apoptosis. MiR-146b, 146a, 21, 23a, 135a, 30a, 202, and 181 were identified as the involved microRNAs in the apoptosis signaling pathway, and IRAK1, TRAF6, Bcl-2, PTEN, Akt, PIK3, KRAS, and MAPK1 were classified as the target genes of the mentioned microRNAs respectively. The essential roles of these signaling pathways and miRNAs/target genes were approved through both databases and clinical studies. Moreover, surviving, living, BRUCE, and XIAP was the main inhibitor of apoptosis which act by regulating the apoptosis-involved genes and miRNAs. Conclusion: Identifying the abnormal expression and regulation of miRNAs and signaling pathways in apoptosis of lung cancer can represent a novel class of biomarkers that can facilitate the early diagnosis, personalized treatment, and prediction of drug response for lung cancer patients. Therefore, studying the mechanisms of apoptosis including signaling pathways, miRNAs/target genes, and the inhibitors of apoptosis are advantageous for finding the most practical approach and reducing the pathological demonstrations of lung cancer.
MeSH term(s)	Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Early Detection of Cancer ; Lung Neoplasms/metabolism ; Signal Transduction/genetics ; Apoptosis/genetics
Chemical Substances	MicroRNAs ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-)
Language	English
Publishing date	2023-02-17
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2041675-1
ISSN	1465-993X ; 1465-993X
ISSN (online)	1465-993X
ISSN	1465-993X
DOI	10.1186/s12931-023-02366-w
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Article ; Online: Oncolytic viruses in lung cancer treatment: a review article.

Sakhi, Hanie / Arabi, Mohadeseh / Ghaemi, Amir / Movafagh, Abolfazl / Sheikhpour, Mojgan

Immunotherapy

2023 Volume 16, Issue 2, Page(s) 75–97

Abstract: Lung cancer has a high morbidity rate worldwide due to its resistance to therapy. So new treatment options are needed to improve the outcomes of lung cancer treatment. This study aimed to evaluate the effectiveness of oncolytic viruses (OVs) as a new ... ...

Abstract	Lung cancer has a high morbidity rate worldwide due to its resistance to therapy. So new treatment options are needed to improve the outcomes of lung cancer treatment. This study aimed to evaluate the effectiveness of oncolytic viruses (OVs) as a new type of cancer treatment. In this study, 158 articles from PubMed and Scopus from 1994 to 2022 were reviewed on the effectiveness of OVs in the treatment of lung cancer. The oncolytic properties of eight categories of OVs and their interactions with treatment options were investigated. OVs can be applied as a promising immunotherapy option, as they are reproduced selectively in different types of cancer cells, cause tumor cell lysis and trigger efficient immune responses.
MeSH term(s)	Humans ; Oncolytic Viruses ; Oncolytic Virotherapy ; Lung Neoplasms/therapy ; Neoplasms ; Immunotherapy
Language	English
Publishing date	2023-12-19
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2495964-9
ISSN	1750-7448 ; 1750-743X
ISSN (online)	1750-7448
ISSN	1750-743X
DOI	10.2217/imt-2023-0124
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Article: A Comprehensive Study on the Correlation of Treatment, Diagnosis and Epidemiology of Tuberculosis and Lung Cancer.

Sheikhpour, Mojgan / Mirbahari, Seyedeh Nasim / Sadr, Makan / Maleki, Mobina / Arabi, Mohadeseh / Abolfathi, Hanie

Tanaffos

2023 Volume 22, Issue 1, Page(s) 7–18

Abstract: The correlation between tuberculosis (TB) and lung cancer (LC) in diagnosis, epidemiology, and treatment is still unclear. Based on different cohort and retrospective studies, this correlation could be justified by immune weakness because of exposure to ... ...

Abstract	The correlation between tuberculosis (TB) and lung cancer (LC) in diagnosis, epidemiology, and treatment is still unclear. Based on different cohort and retrospective studies, this correlation could be justified by immune weakness because of exposure to TB which may increase the risk of LC. In this study, we tried to exhibit a prominent connection between TB and LC. The diagnosis and treatment of patients with concomitant TB and LC differ from patients with only one of the diseases. In this review, it was well clarified that the most practical diagnostic method for LC is chest tomography, biopsy, and histopathology, and for pulmonary TB sputum microscopic examination, Autofluorescence bronchoscopy (AFB), culture, and PCR. Also, immunological methods can be a good alternative for differential diagnosis. Most epidemiological studies were about concomitant TB and LC in TB-endemic areas, especially in the Middle East. The most suggested methods for definite treatment of LC are chemotherapy, radiotherapy, and surgery while for TB, a long course of anti-TB therapy can be used. Moreover, immunotherapy is considered a good treatment for lung cancer if the interferon-gamma release assay (IGRA) is negative.
Language	English
Publishing date	2023-10-17
Publishing country	Iran
Document type	Journal Article ; Review
ZDB-ID	2233372-1
ISSN	1735-0344
ISSN	1735-0344
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Article ; Online: Antibiotic delivery evaluation against Mycobacterium fortuitum using nanofluids containing carbon nanotubes.

Pargami, Hamid Naderi / Siadat, Seyed Davar / Amiri, Vahid / Sheikhpour, Mojgan

BMC microbiology

2022 Volume 22, Issue 1, Page(s) 96

Abstract: Background: Mycobacterium fortuitum (M. fortuitum) is a bacterium, which can cause infections in many anatomical regions of the body, including the skin, lymph nodes, and joints. This bacterium, which belongs to a group of bacteria known as ... ...

Abstract	Background: Mycobacterium fortuitum (M. fortuitum) is a bacterium, which can cause infections in many anatomical regions of the body, including the skin, lymph nodes, and joints. This bacterium, which belongs to a group of bacteria known as nontuberculous mycobacteria, is regarded as an important nosocomial pathogen worldwide owing to its increasing antibiotic resistance. Recently, the antimicrobial effects of carbon nanotubes have been reported in numerous studies. These nanotubes can be very useful in drug delivery; besides, they exhibit unique properties against multidrug-resistant bacterial infections. This study aimed to investigate the antimicrobial effects of carboxyl-functionalized multi-walled carbon nanotubes (MWCNT-COOH) to reduce antibiotic resistance. Methods: In this study, antibacterial effects of nanofluids containing functionalized MWCNTs at initial concentration of 2 mg/mL and serial dilutions of 54, 28.5, 14.25, 7.12, 3.5 µg/mL, antibiotics alone and combination of nanofluids with antibiotics were investigated. Standard and resistant strains of M. fortuitum were obtained from the microbial bank of the Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran. Results: It was observed that nanofluid containing MWCNT-COOH can exert antimicrobial effects on M. fortuitum and significantly reduce bacterial resistance to antibiotics including kanamycin and streptomycin. In the presence of antibiotics and nanofluids containing MWCNT-COOH at a dose of 28.5 µg/mL, no growth was observed. Conclusion: One of the main antimicrobial mechanisms of MWCNT-COOH is penetration into the bacterial cell wall. In this study, by using the nanofluid containing MWCNT-COOH with increased stability, the antibiotic resistance of M. fortuitum was significantly reduced at lower dilutions compared to the antibiotic alone.
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Anti-Infective Agents/pharmacology ; Bacteria ; Drug Resistance, Microbial ; Mycobacterium fortuitum ; Nanotubes, Carbon/chemistry
Chemical Substances	Anti-Bacterial Agents ; Anti-Infective Agents ; Nanotubes, Carbon
Language	English
Publishing date	2022-04-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2041505-9
ISSN	1471-2180 ; 1471-2180
ISSN (online)	1471-2180
ISSN	1471-2180
DOI	10.1186/s12866-022-02523-z
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Article ; Online: An in Vitro Study of Molecular Effects of a Combination Treatment with Antibiotics and Nanofluid Containing Carbon Nano-tubes on

Mehdizadeh, Maryam / Sheikhpour, Mojgan / Salahshourifar, Iman / Siadat, Seyed Davar / Saffarian, Parvaneh

Iranian journal of public health

2022 Volume 50, Issue 11, Page(s) 2292–2301

Abstract: Background: We aimed to prepare a nanofluid, containing : Methods: This study was carried out from 2019 to 2020, in the Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran. The nanofluid containing antibiotic and : ... ...

Abstract	Background: We aimed to prepare a nanofluid, containing Methods: This study was carried out from 2019 to 2020, in the Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran. The nanofluid containing antibiotic and Results: The effect of 8 μg/ml ciprofloxacin + 400 μg/ml Conclusion: Simultaneous treatment of resistant isolate of
Language	English
Publishing date	2022-02-09
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2240935-X
ISSN	2251-6093 ; 2251-6093
ISSN (online)	2251-6093
ISSN	2251-6093
DOI	10.18502/ijph.v50i11.7585
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