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Article ; Online: The diagnostic role of the systemic inflammation index in patients with immunological diseases: a systematic review and meta-analysis.

Mangoni, Arduino A / Zinellu, Angelo

2024 Volume 24, Issue 1, Page(s) 27

Abstract: The identification of novel, easily measurable biomarkers of inflammation might enhance the diagnosis and management of immunological diseases (IDs). We conducted a systematic review and meta-analysis to investigate an emerging biomarker derived from the ...

Abstract	The identification of novel, easily measurable biomarkers of inflammation might enhance the diagnosis and management of immunological diseases (IDs). We conducted a systematic review and meta-analysis to investigate an emerging biomarker derived from the full blood count, the systemic inflammation index (SII), in patients with IDs and healthy controls. We searched Scopus, PubMed, and Web of Science from inception to 12 December 2023 for relevant articles and evaluated the risk of bias and the certainty of evidence using the Joanna Briggs Checklist and the Grades of Recommendation, Assessment, Development, and Evaluation Working Group system, respectively. In 16 eligible studies, patients with IDs had a significantly higher SII when compared to controls (standard mean difference, SMD = 1.08, 95% CI 0.75 to 1.41, p < 0.001; I
MeSH term(s)	Humans ; Immune System Diseases ; Inflammation/diagnosis ; Lupus Erythematosus, Systemic
Language	English
Publishing date	2024-01-29
Publishing country	Italy
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review
ZDB-ID	2053018-3
ISSN	1591-9528 ; 1591-8890
ISSN (online)	1591-9528
ISSN	1591-8890
DOI	10.1007/s10238-024-01294-3
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Zs.A 5481: Show issues

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Article ; Online: Transsulfuration and folate pathways in rheumatoid arthritis: A systematic review and meta-analysis.

Mangoni, Arduino A / Zinellu, Angelo

European journal of clinical investigation

2024 Volume 54, Issue 4, Page(s) e14158

Abstract: Background: Metabolomic assessment of the transsulfuration and folic acid biochemical pathways could lead to the identification of promising biomarkers of nitric oxide dysregulation and oxidative stress in rheumatoid arthritis (RA).: Methods: We ... ...

Abstract	Background: Metabolomic assessment of the transsulfuration and folic acid biochemical pathways could lead to the identification of promising biomarkers of nitric oxide dysregulation and oxidative stress in rheumatoid arthritis (RA). Methods: We conducted a systematic review and meta-analysis of transsulfuration (methionine, homocysteine, and cysteine) and folic acid (folic acid, vitamin B Results: In 28 eligible studies, compared to controls, RA patients had significantly higher concentrations of homocysteine (standardized mean difference, SMD = 0.74, 95% CI 0.54-0.93, p < 0.001; low certainty of evidence) and methionine (SMD = 1.00, 95% CI 0.57-1.44, p < 0.001; low certainty) and lower concentrations of vitamin B Conclusions: The results of our study suggest that homocysteine, methionine, and vitamin B
MeSH term(s)	Humans ; Folic Acid ; Nitric Oxide ; Vitamin B 12 ; Vitamin B 6 ; Methionine ; Vitamins ; Arthritis, Rheumatoid ; Biomarkers ; Homocysteine
Chemical Substances	Folic Acid (935E97BOY8) ; Nitric Oxide (31C4KY9ESH) ; Vitamin B 12 (P6YC3EG204) ; Vitamin B 6 (8059-24-3) ; Methionine (AE28F7PNPL) ; Vitamins ; Biomarkers ; Homocysteine (0LVT1QZ0BA)
Language	English
Publishing date	2024-01-12
Publishing country	England
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review
ZDB-ID	186196-7
ISSN	1365-2362 ; 0014-2972 ; 0960-135X
ISSN (online)	1365-2362
ISSN	0014-2972 ; 0960-135X
DOI	10.1111/eci.14158
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Zs.A 677: Show issues

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Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: A systematic review and meta-analysis of circulating adhesion molecules in rheumatoid arthritis.

Mangoni, Arduino A / Zinellu, Angelo

Inflammation research : official journal of the European Histamine Research Society ... [et al.

2024 Volume 73, Issue 3, Page(s) 305–327

Abstract: Background: The availability of robust biomarkers of endothelial activation might enhance the identification of subclinical atherosclerosis in rheumatoid arthritis (RA). We investigated this issue by conducting a systematic review and meta-analysis of ... ...

Abstract	Background: The availability of robust biomarkers of endothelial activation might enhance the identification of subclinical atherosclerosis in rheumatoid arthritis (RA). We investigated this issue by conducting a systematic review and meta-analysis of cell adhesion molecules in RA patients. Methods: We searched electronic databases from inception to 31 July 2023 for case-control studies assessing the circulating concentrations of immunoglobulin-like adhesion molecules (vascular cell, VCAM-1, intercellular, ICAM-1, and platelet endothelial cell, PECAM-1, adhesion molecule-1) and selectins (E, L, and P selectin) in RA patients and healthy controls. Risk of bias and certainty of evidence were assessed using the JBI checklist and GRADE, respectively. Results: In 39 studies, compared to controls, RA patients had significantly higher concentrations of ICAM-1 (standard mean difference, SMD = 0.81, 95% CI 0.62-1.00, p < 0.001; I Conclusions: The results of our study support a significant role of cell adhesion molecules in mediating the interplay between RA and atherosclerosis. Further studies are warranted to determine whether the routine use of these biomarkers can facilitate the detection and management of early atherosclerosis in this patient group. PROSPERO Registration Number: CRD42023466662.
MeSH term(s)	Humans ; Intercellular Adhesion Molecule-1 ; Vascular Cell Adhesion Molecule-1 ; Platelet Endothelial Cell Adhesion Molecule-1 ; E-Selectin ; P-Selectin ; Cell Adhesion Molecules ; Arthritis, Rheumatoid ; Biomarkers ; Atherosclerosis
Chemical Substances	Intercellular Adhesion Molecule-1 (126547-89-5) ; Vascular Cell Adhesion Molecule-1 ; Platelet Endothelial Cell Adhesion Molecule-1 ; E-Selectin ; P-Selectin ; Cell Adhesion Molecules ; Biomarkers
Language	English
Publishing date	2024-01-19
Publishing country	Switzerland
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review
ZDB-ID	1221794-3
ISSN	1420-908X ; 1023-3830
ISSN (online)	1420-908X
ISSN	1023-3830
DOI	10.1007/s00011-023-01837-6
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Zs.A 675: Show issues

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Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Arginine, Transsulfuration, and Folic Acid Pathway Metabolomics in Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis.

Zinellu, Angelo / Mangoni, Arduino A

Cells

2023 Volume 12, Issue 17

Abstract: There is an increasing interest in biomarkers of nitric oxide dysregulation and oxidative stress to guide management and identify new therapeutic targets in patients with chronic obstructive pulmonary disease (COPD). We conducted a systematic review and ... ...

Abstract	There is an increasing interest in biomarkers of nitric oxide dysregulation and oxidative stress to guide management and identify new therapeutic targets in patients with chronic obstructive pulmonary disease (COPD). We conducted a systematic review and meta-analysis of the association between circulating metabolites within the arginine (arginine, citrulline, ornithine, asymmetric, ADMA, and symmetric, SDMA dimethylarginine), transsulfuration (methionine, homocysteine, and cysteine) and folic acid (folic acid, vitamin B
MeSH term(s)	Humans ; Cysteine ; Nitric Oxide ; Metabolomics ; Arginine ; Methionine ; Racemethionine ; Folic Acid ; Homocysteine ; Vitamins
Chemical Substances	Cysteine (K848JZ4886) ; Nitric Oxide (31C4KY9ESH) ; Arginine (94ZLA3W45F) ; Methionine (AE28F7PNPL) ; Racemethionine (73JWT2K6T3) ; Folic Acid (935E97BOY8) ; Homocysteine (0LVT1QZ0BA) ; Vitamins
Language	English
Publishing date	2023-08-30
Publishing country	Switzerland
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells12172180
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Article ; Online: A systematic review and meta-analysis of the kynurenine pathway of tryptophan metabolism in rheumatic diseases.

Mangoni, Arduino A / Zinellu, Angelo

Frontiers in immunology

2023 Volume 14, Page(s) 1257159

Abstract: There is an increasing interest in the pathophysiological role of the kynurenine pathway of tryptophan metabolism in the regulation of immune function and inflammation. We sought to address the link between this pathway and the presence rheumatic ... ...

Abstract	There is an increasing interest in the pathophysiological role of the kynurenine pathway of tryptophan metabolism in the regulation of immune function and inflammation. We sought to address the link between this pathway and the presence rheumatic diseases (RD) by conducting a systematic review and meta-analysis of studies reporting the plasma or serum concentrations of tryptophan, kynurenine, and other relevant metabolites in RD patients and healthy controls. We searched electronic databases for relevant articles published between inception and the 30 Systematic review registration: https://www.crd.york.ac.uk/prospero, identifier CRD CRD42023443718.
MeSH term(s)	Humans ; Kynurenine/metabolism ; Tryptophan/metabolism ; Quinolinic Acid ; C-Reactive Protein/metabolism ; Rheumatic Diseases
Chemical Substances	Kynurenine (343-65-7) ; Tryptophan (8DUH1N11BX) ; Quinolinic Acid (F6F0HK1URN) ; C-Reactive Protein (9007-41-4)
Language	English
Publishing date	2023-10-23
Publishing country	Switzerland
Document type	Meta-Analysis ; Systematic Review
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1257159
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Article: A Systematic Review and Meta-Analysis of the Association between Uric Acid and Allantoin and Rheumatoid Arthritis.

Zinellu, Angelo / Mangoni, Arduino A

Antioxidants (Basel, Switzerland)

2023 Volume 12, Issue 8

Abstract: Alterations in the circulating concentrations of uric acid and its degradation product, allantoin, might account for the systemic pro-oxidant state and the increased cardiovascular risk in rheumatoid arthritis (RA). We sought to address this issue by ... ...

Abstract	Alterations in the circulating concentrations of uric acid and its degradation product, allantoin, might account for the systemic pro-oxidant state and the increased cardiovascular risk in rheumatoid arthritis (RA). We sought to address this issue by conducting a systematic review and meta-analysis of the association between the plasma/serum concentrations of uric acid and allantoin and RA. We searched PubMed, Scopus, and Web of Science from inception to 20 June 2023 for studies comparing plasma/serum concentrations of uric acid and allantoin between RA patients and healthy controls. We assessed the risk of bias with the JBI Critical Appraisal Checklist for analytical studies and the certainty of evidence with the Grades of Recommendation, Assessment, Development and Evaluation (GRADE) Working Group system. In the 19 studies selected for analysis, there were non-significant differences in uric acid concentrations between RA patients and controls (standard mean difference, SMD = 0.11, 95% CI -0.07 to 0.30,
Language	English
Publishing date	2023-08-05
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox12081569
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Article: An Updated Systematic Review and Meta-Analysis of the Association between the De Ritis Ratio and Disease Severity and Mortality in Patients with COVID-19.

Mangoni, Arduino A / Zinellu, Angelo

Life (Basel, Switzerland)

2023 Volume 13, Issue 6

Abstract: Patients with Coronavirus disease 2019 (COVID-19) often have elevations in markers of liver injury, particularly serum aspartate transaminase (AST) and alanine transaminase (ALT). Such alterations may affect the AST/ALT ratio (De Ritis ratio) and, ... ...

Abstract	Patients with Coronavirus disease 2019 (COVID-19) often have elevations in markers of liver injury, particularly serum aspartate transaminase (AST) and alanine transaminase (ALT). Such alterations may affect the AST/ALT ratio (De Ritis ratio) and, potentially, clinical outcomes. We conducted an updated systematic review and meta-analysis of the association between the De Ritis ratio and COVID-19 severity and mortality in hospitalized patients. PubMed, Web of Science, and Scopus were searched between 1 December 2019 and 15 February 2023. The Joanna Briggs Institute Critical Appraisal Checklist and the Grading of Recommendations, Assessment, Development, and Evaluation were used to assess the risk of bias and the certainty of the evidence, respectively. Twenty-four studies were identified. The De Ritis ratio on admission was significantly higher in patients with severe disease and non-survivors vs. patients with non-severe disease and survivors (15 studies, weighted mean difference = 0.36, 95% CI 0.24 to 0.49,
Language	English
Publishing date	2023-06-05
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life13061324
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Article ; Online: A systematic review and meta-analysis of neopterin in rheumatic diseases.

Mangoni, Arduino A / Zinellu, Angelo

Frontiers in immunology

2023 Volume 14, Page(s) 1271383

Abstract: Introduction: Novel biomarkers of inflammation and oxidative stress might enhance the early recognition, management, and clinical outcomes of patients with rheumatic diseases (RDs). We assessed the available evidence regarding the pathophysiological ... ...

Abstract	Introduction: Novel biomarkers of inflammation and oxidative stress might enhance the early recognition, management, and clinical outcomes of patients with rheumatic diseases (RDs). We assessed the available evidence regarding the pathophysiological role of neopterin, the oxidation product of 7,8-dihydroneopterin, a pteridine generated in macrophages activated by interferon-γ, by conducting a systematic review and meta-analysis of studies reporting its concentrations in biological fluids in RD patients and healthy controls. Methods: We searched electronic databases for relevant articles published between inception and 31 August 2023. The risk of bias and the certainty of evidence were assessed using the Joanna Briggs Institute Critical Appraisal Checklist and the Grades of Recommendation, Assessment, Development and Evaluation Working Group system, respectively. Results: In 37 studies, when compared to healthy controls, RD patients had significantly higher concentrations of neopterin both in plasma or serum (standard mean difference, SMD=1.31, 95% CI 1.01 to 1.61; p<0.001; moderate certainty of evidence) and in the urine (SMD=1.65, 95% CI 0.86 to 2.43, p<0.001; I Discussion: Pending additional studies that also focus on early forms of disease, our systematic review and meta-analysis supports the proposition that neopterin, a biomarker of inflammation and oxidative stress, can be useful for the identification of RDs. (PROSPERO registration number: CRD42023450209). Systematic review registration: PROSPERO, identifier CRD42023450209.
MeSH term(s)	Humans ; Male ; Female ; Neopterin ; Inflammation ; Oxidation-Reduction ; Oxidative Stress ; Rheumatic Diseases ; Biomarkers
Chemical Substances	Neopterin (670-65-5) ; Biomarkers
Language	English
Publishing date	2023-09-18
Publishing country	Switzerland
Document type	Meta-Analysis ; Systematic Review
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1271383
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Article ; Online: The pathophysiological role of circulating adhesion molecules in schizophrenia: A systematic review and meta-analysis.

Zinellu, Angelo / Mangoni, Arduino A

Schizophrenia research

2023 Volume 264, Page(s) 157–169

Abstract: Background: Increasing evidence suggests an association between schizophrenia and atherosclerosis. We conducted a systematic review and meta-analysis of cell adhesion molecules, critically involved in early atherosclerosis, in schizophrenia.: Methods!# ...

Abstract	Background: Increasing evidence suggests an association between schizophrenia and atherosclerosis. We conducted a systematic review and meta-analysis of cell adhesion molecules, critically involved in early atherosclerosis, in schizophrenia. Methods: We searched electronic databases from inception to 11 November 2023 for case-control studies assessing vascular cell, VCAM-1, intercellular, ICAM-1, platelet endothelial cell, PECAM-1, neural cell, NCAM, and Down syndrome cell, DSCAM, adhesion molecules, selectins (E-, L-, and P-selectin), integrins, and cadherins in patients with schizophrenia and healthy controls. Risk of bias and certainty of evidence were assessed using the JBI checklist and GRADE, respectively. Results: In 19 eligible studies, there were non-significant between-group differences in the concentrations of cell adhesion molecules, barring higher P-selectin in patients with schizophrenia (standard mean difference, SMD = 2.05, 95 % CI 0.72 to 3.38, p = 0.003; I Conclusions: The results of our systematic review and meta-analysis do not support a significant role of immunoglobulin-like adhesion molecules, selectins, integrins, or cadherins in mediating the associations between schizophrenia, atherosclerosis, and cardiovascular disease. Further studies are warranted to investigate these associations in patients with different cardiovascular risk and the effects of antipsychotic treatments on cell adhesion molecules and surrogate markers of atherosclerosis (PROSPERO registration number: CRD42023463916).
MeSH term(s)	Humans ; Atherosclerosis ; Cadherins ; Cell Adhesion Molecules ; E-Selectin/analysis ; Integrins/analysis ; Intercellular Adhesion Molecule-1 ; P-Selectin/analysis ; Platelet Endothelial Cell Adhesion Molecule-1/analysis ; Schizophrenia ; Selectins ; Vascular Cell Adhesion Molecule-1/analysis
Chemical Substances	Cadherins ; Cell Adhesion Molecules ; E-Selectin ; Integrins ; Intercellular Adhesion Molecule-1 (126547-89-5) ; P-Selectin ; Platelet Endothelial Cell Adhesion Molecule-1 ; Selectins ; Vascular Cell Adhesion Molecule-1
Language	English
Publishing date	2023-12-26
Publishing country	Netherlands
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	639422-x
ISSN	1573-2509 ; 0920-9964
ISSN (online)	1573-2509
ISSN	0920-9964
DOI	10.1016/j.schres.2023.12.025
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Zs.A 2351: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 543: Show issues

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Article ; Online: Systemic inflammation index, disease severity, and mortality in patients with COVID-19: a systematic review and meta-analysis.

Mangoni, Arduino A / Zinellu, Angelo

Frontiers in immunology

2023 Volume 14, Page(s) 1212998

Abstract: Introduction: An excessive systemic pro-inflammatory state increases the risk of severe disease and mortality in patients with coronavirus disease 2019 (COVID-19). However, there is uncertainty regarding whether specific biomarkers of inflammation can ... ...

Abstract	Introduction: An excessive systemic pro-inflammatory state increases the risk of severe disease and mortality in patients with coronavirus disease 2019 (COVID-19). However, there is uncertainty regarding whether specific biomarkers of inflammation can enhance risk stratification in this group. We conducted a systematic review and meta-analysis to investigate an emerging biomarker of systemic inflammation derived from routine hematological parameters, the systemic inflammation index (SII), in COVID-19 patients with different disease severity and survival status. Methods: A systematic literature search was conducted in PubMed, Web of Science, and Scopus, between the 1 Results: In 39 studies, patients with a severe disease or non-survivor status had significantly higher SII values on admission compared to patients with a non-severe disease or survivor status (standard mean difference (SMD)=0.91, 95% CI 0.75 to 1.06, p<0.001; moderate certainty of evidence). The SII was also significantly associated with the risk of severe disease or death in 10 studies reporting odds ratios (1.007, 95% CI 1.001 to 1.014, p=0.032; very low certainty of evidence) and in six studies reporting hazard ratios (1.99, 95% CI 1.01 to 3.92, p=0.047; very low certainty of evidence). Pooled sensitivity, specificity, and area under the curve for severe disease or mortality were 0.71 (95% CI 0.67 to 0.75), 0.71 (95% CI 0.64 to 0.77), and 0.77 (95% CI 0.73 to 0.80), respectively. In meta-regression, significant correlations were observed between the SMD and albumin, lactate dehydrogenase, creatinine, and D-dimer. Discussion: Our systematic review and meta-analysis has shown that the SII on admission is significantly associated with severe disease and mortality in patients with COVID-19. Therefore, this inflammatory biomarker derived from routine haematological parameters can be helpful for early risk stratification in this group. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO, identifier CRD42023420517.
MeSH term(s)	Humans ; COVID-19 ; Inflammation ; Patient Acuity ; Biomarkers
Chemical Substances	Biomarkers
Language	English
Publishing date	2023-06-21
Publishing country	Switzerland
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1212998
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