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  1. Article ; Online: Ni clusters immobilized on oxygen-rich siloxene nanosheets for efficient electrocatalytic oxygen reduction toward H

    Hu, Haihui / Ma, Ke / Yang, Yuandong / Jin, Na / Zhang, Linjie / Qian, Jinjie / Han, Lili

    Dalton transactions (Cambridge, England : 2003)

    2024  Volume 53, Issue 10, Page(s) 4823–4832

    Abstract: Hydrogen peroxide (H ...

    Abstract Hydrogen peroxide (H
    Language English
    Publishing date 2024-03-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/d3dt04389d
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Immunoengineering Biomaterials for Musculoskeletal Tissue Repair across Lifespan.

    Han, Jin / Rindone, Alexandra N / Elisseeff, Jennifer H

    Advanced materials (Deerfield Beach, Fla.)

    2024  , Page(s) e2311646

    Abstract: Musculoskeletal diseases and injuries are among the leading causes of pain and morbidity worldwide. Broad efforts have focused on developing pro-regenerative biomaterials to treat musculoskeletal conditions; however, these approaches have yet to make a ... ...

    Abstract Musculoskeletal diseases and injuries are among the leading causes of pain and morbidity worldwide. Broad efforts have focused on developing pro-regenerative biomaterials to treat musculoskeletal conditions; however, these approaches have yet to make a significant clinical impact. Recent studies have demonstrated that the immune system is central in orchestrating tissue repair and that targeting pro-regenerative immune responses can improve biomaterial therapeutic outcomes. However, aging is a critical factor negatively affecting musculoskeletal tissue repair and immune function. Hence, understanding how age affects the response to biomaterials is essential for improving musculoskeletal biomaterial therapies. This review focuses on the intersection of the immune system and aging in responding to biomaterials for musculoskeletal tissue repair. The article introduces the general impacts of aging on tissue physiology, the immune system, and the response to biomaterials. Then, it explains how the adaptive immune system guides the response to injury and biomaterial implants in cartilage, muscle, and bone and discusses how aging impacts these processes in each tissue type. The review concludes by highlighting future directions for the development and translation of personalized immunomodulatory biomaterials for musculoskeletal tissue repair. This article is protected by copyright. All rights reserved.
    Language English
    Publishing date 2024-02-28
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1474949-X
    ISSN 1521-4095 ; 0935-9648
    ISSN (online) 1521-4095
    ISSN 0935-9648
    DOI 10.1002/adma.202311646
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  3. Article ; Online: Machine learning coupled with causal inference to identify COVID-19 related chemicals that pose a high concern to drinking water.

    Han, Min / Liang, Jun / Jin, Biao / Wang, Ziwei / Wu, Wanlu / Arp, Hans Peter H

    iScience

    2024  Volume 27, Issue 2, Page(s) 109012

    Abstract: Various synthetic substances were utilized in large quantities during the recent coronavirus pandemic, COVID-19. Some of these chemicals could potentially enter drinking water sources. Persistent, mobile, and toxic (PMT) substances have been recognized ... ...

    Abstract Various synthetic substances were utilized in large quantities during the recent coronavirus pandemic, COVID-19. Some of these chemicals could potentially enter drinking water sources. Persistent, mobile, and toxic (PMT) substances have been recognized as a threat to drinking water resources. It has not yet been assessed how many COVID-19 related substances could be considered PMT substances. One reason is the lack of high-quality experimental data for the identification of PMT substances. To solve this problem, we applied a machine learning model to identify the PMT substances among COVID-19 related chemicals. The optimal model achieved an accuracy of 90.6% based on external test data. The model interpretation and causal inference indicated that our approach understood causation between PMT properties and molecular descriptors. Notably, the screening results showed that over 60% of the COVID-19 chemicals considered are candidate PMT substances, which should be prioritized to prevent undue pollution of water resources.
    Language English
    Publishing date 2024-01-24
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2024.109012
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  4. Article ; Online: Delirium and Delirium Prevention in the Emergency Department.

    Lee, Sangil / Howard, Matthew A / Han, Jin H

    Clinics in geriatric medicine

    2023  Volume 39, Issue 4, Page(s) 535–551

    Abstract: This article covers the epidemiology of delirium and the overlapping condition of altered mental status and encephalopathy that is relevant to those who practice in the emergency department. ...

    Abstract This article covers the epidemiology of delirium and the overlapping condition of altered mental status and encephalopathy that is relevant to those who practice in the emergency department.
    MeSH term(s) Humans ; Delirium/diagnosis ; Delirium/epidemiology ; Delirium/etiology ; Emergency Service, Hospital
    Language English
    Publishing date 2023-06-14
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1064151-8
    ISSN 1879-8853 ; 0749-0690
    ISSN (online) 1879-8853
    ISSN 0749-0690
    DOI 10.1016/j.cger.2023.05.006
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    Se 987: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: The senescence-associated secretory phenotype and its physiological and pathological implications.

    Wang, Boshi / Han, Jin / Elisseeff, Jennifer H / Demaria, Marco

    Nature reviews. Molecular cell biology

    2024  

    Abstract: Cellular senescence is a state of terminal growth arrest associated with the upregulation of different cell cycle inhibitors, mainly p16 and p21, structural and metabolic alterations, chronic DNA damage responses, and a hypersecretory state known as the ... ...

    Abstract Cellular senescence is a state of terminal growth arrest associated with the upregulation of different cell cycle inhibitors, mainly p16 and p21, structural and metabolic alterations, chronic DNA damage responses, and a hypersecretory state known as the senescence-associated secretory phenotype (SASP). The SASP is the major mediator of the paracrine effects of senescent cells in their tissue microenvironment and of various local and systemic biological functions. In this Review, we discuss the composition, dynamics and heterogeneity of the SASP as well as the mechanisms underlying its induction and regulation. We describe the various biological properties of the SASP, its beneficial and detrimental effects in different physiological and pathological settings, and its impact on overall health span. Finally, we discuss the use of the SASP as a biomarker and of SASP inhibitors as senomorphic interventions to treat cancer and other age-related conditions.
    Language English
    Publishing date 2024-04-23
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2031313-5
    ISSN 1471-0080 ; 1471-0072
    ISSN (online) 1471-0080
    ISSN 1471-0072
    DOI 10.1038/s41580-024-00727-x
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    Zs.A 5446: Show issues Location:
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  6. Article: [Incidence and case fatality rates of cardiovascular diseases in urban and rural community-dwelling populations in eastern, central and western regions of China].

    Li, X M / Li, M Y / Han, G L / You, K / Jin, H / Xiang, Q Y / Li, Y

    Zhonghua xin xue guan bing za zhi

    2024  Volume 52, Issue 2, Page(s) 191–198

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Humans ; Middle Aged ; Female ; Adult ; Cardiovascular Diseases/epidemiology ; Prospective Studies ; Rural Population ; Incidence ; Independent Living ; Urban Population ; China/epidemiology
    Language Chinese
    Publishing date 2024-02-07
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 603425-1
    ISSN 0253-3758
    ISSN 0253-3758
    DOI 10.3760/cma.j.cn112148-20231008-00255
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  7. Article: [Meta-analysis comparing long-term outcomes of intersphincteric resection versus abdominoperineal resection for low rectal cancer].

    Cao, K / Jin, Y / Shi, B H / Shi, X Y / Wang, Z J / Han, J G

    Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery

    2023  Volume 26, Issue 6, Page(s) 595–602

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Humans ; Prospective Studies ; Rectal Neoplasms/pathology ; Rectum/surgery ; Proctectomy ; Anal Canal/surgery ; Anal Canal/pathology ; Treatment Outcome
    Language Chinese
    Publishing date 2023-08-15
    Publishing country China
    Document type Meta-Analysis ; English Abstract ; Journal Article
    ISSN 1671-0274
    ISSN 1671-0274
    DOI 10.3760/cma.j.cn441530-20230315-00083
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  8. Article ; Online: Adjuvant screening of the Senecavirus A inactivated vaccine in mice and evaluation of its immunogenicity in pigs.

    Zhang, Jinyong / Wang, Peng / Li, Zhuoxin / Xie, Yubiao / Jin, Ningyi / Zhang, He / Lu, Huijun / Han, Jicheng

    BMC veterinary research

    2024  Volume 20, Issue 1, Page(s) 82

    Abstract: ... showed that the immune effects were largely consistent between the SVA-H group (200 µg) and SVA-L group ...

    Abstract Background: Senecavirus A (SVA) causes an emerging vesicular disease (VD) with clinical symptoms indistinguishable from other vesicular diseases, including vesicular stomatitis (VS), foot-and-mouth disease (FMD), and swine vesicular disease (SVD). Currently, SVA outbreaks have been reported in Canada, the U.S.A, Brazil, Thailand, Vietnam, Colombia, and China. Based on the experience of prevention and control of FMDV, vaccines are the best means to prevent SVA transmission.
    Results: After preparing an SVA inactivated vaccine (CH-GX-01-2019), we evaluated the immunogenicity of the SVA inactivated vaccine mixed with Imject® Alum (SVA + AL) or Montanide ISA 201 (SVA + 201) adjuvant in mice, as well as the immunogenicity of the SVA inactivated vaccine combined with Montanide ISA 201 adjuvant in post-weaned pigs. The results of the mouse experiment showed that the immune effects in the SVA + 201 group were superior to that in the SVA + AL group. Results from pigs immunized with SVA inactivated vaccine combined with Montanide ISA 201 showed that the immune effects were largely consistent between the SVA-H group (200 µg) and SVA-L group (50 µg); the viral load in tissues and blood was significantly reduced and no clinical symptoms occurred in the vaccinated pigs.
    Conclusions: Montanide ISA 201 is a better adjuvant choice than the Imject® Alum adjuvant in the SVA inactivated vaccine preparation, and the CH-GX-01-2019 SVA inactivated vaccine can provide effective protection for pigs.
    MeSH term(s) Animals ; Mice ; Swine ; Vaccines, Inactivated ; Adjuvants, Immunologic ; Mineral Oil ; Alum Compounds ; Mannitol/analogs & derivatives ; Picornaviridae ; Oleic Acids
    Chemical Substances aluminum sulfate (34S289N54E) ; Vaccines, Inactivated ; Monatide (IMS 3015) ; Adjuvants, Immunologic ; montanide ISA-201 ; Mineral Oil (8020-83-5) ; Alum Compounds ; Mannitol (3OWL53L36A) ; Oleic Acids
    Language English
    Publishing date 2024-03-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2191675-5
    ISSN 1746-6148 ; 1746-6148
    ISSN (online) 1746-6148
    ISSN 1746-6148
    DOI 10.1186/s12917-024-03949-5
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  9. Article ; Online: From organ preservation to selective surgery: How immunotherapy changes colorectal surgery?

    Yao, Shiya / Lan, Huanrong / Han, Yuejun / Mao, Chunsen / Yang, Mengxiang / Zhang, Xuan / Jin, Ketao

    Surgery open science

    2023  Volume 15, Page(s) 44–53

    Abstract: ... mismatch repair deficiency (MSI-H/dMMR), and based on this, we propose the concept of selective surgery ...

    Abstract The emergence of immunotherapy has revolutionized the traditional treatment paradigm of colorectal cancer (CRC). Among them, immune checkpoint blockade has become the first-line treatment for metastatic colorectal cancer (mCRC) and has made significant progress in the treatment of locally advanced colorectal cancer (LACRC). We reviewed a series of clinical trials that have made breakthrough progress. We will emphasize the breakthrough progress in achieving organ preservation in patients with high microsatellite instability or DNA mismatch repair deficiency (MSI-H/dMMR), and based on this, we propose the concept of selective surgery, which includes selectively removing or preserving lymph nodes, with the aim of proving our idea through more research in the future.
    Language English
    Publishing date 2023-08-09
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2589-8450
    ISSN (online) 2589-8450
    DOI 10.1016/j.sopen.2023.07.024
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  10. Article ; Online: Bioenzyme-nanoenzyme-chromogen all-in-one test strip for convenient and sensitive detection of malathion in water environment.

    Zhang, Hanwen / Jin, Jiabin / Wang, Xini / Han, Wei / Qin, Lei / Chen, Lin / Mao, Xiaoyan / Liu, Zhenjiang / Xiang, Xingwei

    The Science of the total environment

    2024  Volume 924, Page(s) 171512

    Abstract: ... chloride (Hemin) in the strip can catalyze the oxidation of H ...

    Abstract The presence of pesticide residues in aquatic environments poses a significant threat to both aquatic ecosystems and human health. The presence of these residues can result in significant harm to aquatic ecosystems and can negatively impact the health of aquatic organisms. Consequently, this issue requires urgent attention and effective measures to mitigate its impact. However, developing sensitive and rapid detection methods remains a challenge. In this study, an all-in-one test strip, which integrated bioenzymes, nanoenzymes, and a chromogen, was developed in combination with an enzyme labeling instrument for a highly sensitive and convenient sensing of malathion residues. The oxidase activity of heme chloride (Hemin) in the strip can catalyze the oxidation of H
    MeSH term(s) Humans ; Malathion ; Ecosystem ; Hydrogen Peroxide ; Limit of Detection ; Coloring Agents/chemistry ; Alkaline Phosphatase ; Pesticides ; Water
    Chemical Substances Malathion (U5N7SU872W) ; Hydrogen Peroxide (BBX060AN9V) ; Coloring Agents ; Alkaline Phosphatase (EC 3.1.3.1) ; Pesticides ; Water (059QF0KO0R)
    Language English
    Publishing date 2024-03-05
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2024.171512
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    Zs.A 949: Show issues Location:
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