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  1. Article ; Online: Endophytic Fungus from Sinopodophyllum emodi (Wall.) Ying that Produces Podophyllotoxin.

    Liang, Zizhen / Zhang, Jia / Zhang, Xuan / Li, Jinjie / Zhang, Xiaoqian / Zhao, Changqi

    Journal of chromatographic science

    2016  Volume 54, Issue 2, Page(s) 175–178

    Abstract: ... Alternaria tenuissima isolated from Sinopodophyllum emodi (Wall.) Ying. The identification of podophyllotoxin ...

    Abstract The aryltetralin lactone podophyllotoxin, which exhibits pronounced antineoplastic activity, is used as the precursor of the following three clinical anticancer drugs: Etoposide™, Etopophos™ and Teniposide™. The natural occurrence of this arylnaphthalene lignan is scarce and unable to meet the ever-rising demand in the medical industry. Thus, developing alternative sources for the production of podophyllotoxin is extremely urgent. This is the first report of the production of podophyllotoxin from endophytic Alternaria tenuissima isolated from Sinopodophyllum emodi (Wall.) Ying. The identification of podophyllotoxin was performed using high-performance liquid chromatography and liquid chromatography-mass spectrometry (MS)-MS and confirmed by comparison with authentic standards.
    MeSH term(s) Alternaria/chemistry ; Alternaria/isolation & purification ; Alternaria/metabolism ; Berberidaceae/microbiology ; Chromatography, High Pressure Liquid/methods ; Endophytes/chemistry ; Endophytes/isolation & purification ; Endophytes/metabolism ; Humans ; Podophyllotoxin/analysis ; Podophyllotoxin/metabolism
    Chemical Substances Podophyllotoxin (L36H50F353)
    Language English
    Publishing date 2016-02
    Publishing country United States
    Document type Evaluation Studies ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80141-0
    ISSN 1945-239X ; 0021-9665
    ISSN (online) 1945-239X
    ISSN 0021-9665
    DOI 10.1093/chromsci/bmv124
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 895: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Book: Zhong yi she xiang shu ma she ying

    Liang, Rong

    2015  

    Author's details Liang Rong, Li Shaowen zhu bian
    MeSH term(s) Tongue/pathology ; Photography/methods ; Medicine, Chinese Traditional
    Language Chinese
    Size 9, 116 pages :, illustrations
    Edition Di 1 ban.
    Document type Book
    ISBN 9787117209687 ; 7117209682
    Database Catalogue of the US National Library of Medicine (NLM)

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  3. Book: Han Ying Zhong yi xue jing yao

    Liang, Xiaochun

    2015  

    Title variant Essentials of traditional Chinese medicine :
    Author's details Liang Xiaochun, Sun Hua zhu bian
    MeSH term(s) Medicine, Chinese Traditional ; Drugs, Chinese Herbal ; Acupuncture
    Language Chinese ; English
    Size 560 p. :, ill.
    Edition Di 1 ban.
    Publisher Zhongguo xie he yi ke da xue chu ban she
    Publishing place Beijing
    Document type Book
    Note Text in Chinese and English.
    ISBN 9787567900615 ; 7567900610
    Database Catalogue of the US National Library of Medicine (NLM)

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  4. Article ; Online: Mitochondrial genome of Ying hybrid carp (Russian scattered scale mirror carp ♀ × carp-goldfish nucleocytoplasmic hybrid ♂).

    Liu, Xiangjiang / Liang, Yongjun / Lu, Cuiyun / Chang, Yumei / Li, Chitao / Qin, Xiangfeng / Quan, Shuyue / Wang, Zeyu / Zou, Guiwei / Hu, Guangfu

    Mitochondrial DNA. Part B, Resources

    2016  Volume 1, Issue 1, Page(s) 925–926

    Abstract: The complete mitogenomes of Ying hybrid carp (Russian scattered scale mirror carp ♀ × Carp-goldfish ...

    Abstract The complete mitogenomes of Ying hybrid carp (Russian scattered scale mirror carp ♀ × Carp-goldfish nucleocytoplasmic hybrid ♂) was sequenced by PCR-based method. The total of the mtDNA was 16,581 bp, and consisted of 13 protein-coding genes, 22 tRNAs, 2rRNA genes, and 1 control region (D-loop region). The overall base composition was as follows: A: 31.9%, T: 24.8%, C: 27.5%, and G: 15.8%, respectively. The overall AT and GC skew were found to be 0.125 and -0.271, respectively. A majority of the genes used ATG as the start codon, except that the codon GTG was found to initiated the
    Language English
    Publishing date 2016-12-09
    Publishing country England
    Document type Journal Article
    ISSN 2380-2359
    ISSN (online) 2380-2359
    DOI 10.1080/23802359.2016.1247661
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Endophytic Fungus from Sinopodophyllum emodi (Wall.) Ying that Produces Podophyllotoxin

    Liang, Zizhen / Li, Jinjie / Zhang, Jia / Zhang, Xiaoqian / Zhang, Xuan / Zhao, Changqi

    Journal of chromatographic science. 2016 Feb., v. 54, no. 2

    2016  

    Abstract: ... Alternaria tenuissima isolated from Sinopodophyllum emodi (Wall.) Ying. The identification of podophyllotoxin ...

    Abstract The aryltetralin lactone podophyllotoxin, which exhibits pronounced antineoplastic activity, is used as the precursor of the following three clinical anticancer drugs: EtoposideTM, EtopophosTM and TeniposideTM. The natural occurrence of this arylnaphthalene lignan is scarce and unable to meet the ever-rising demand in the medical industry. Thus, developing alternative sources for the production of podophyllotoxin is extremely urgent. This is the first report of the production of podophyllotoxin from endophytic Alternaria tenuissima isolated from Sinopodophyllum emodi (Wall.) Ying. The identification of podophyllotoxin was performed using high-performance liquid chromatography and liquid chromatography–mass spectrometry (MS)-MS and confirmed by comparison with authentic standards.
    Keywords Alternaria tenuissima ; antineoplastic activity ; antineoplastic agents ; endophytes ; fungi ; high performance liquid chromatography ; industry ; lactones ; mass spectrometry ; podophyllotoxin ; Podophyllum hexandrum
    Language English
    Dates of publication 2016-02
    Size p. 175-178.
    Publishing place Oxford University Press
    Document type Article
    ZDB-ID 80141-0
    ISSN 1945-239X ; 0021-9665
    ISSN (online) 1945-239X
    ISSN 0021-9665
    DOI 10.1093/chromsci/bmv124
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 895: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Effects of Jin-Ying-Tang on Staphylococcus aureus-induced mastitis in rabbit.

    Wang, L U / He, Chang-Liang / He, Bing-Kun / Guo, Qing / Xiao, Chun-Gang / Yi, Qiong

    Immunopharmacology and immunotoxicology

    2012  Volume 34, Issue 5, Page(s) 786–793

    Abstract: The present study was performed to investigate the effects of Jin-Ying-Tang (JYT), a Chinese herbal ...

    Abstract The present study was performed to investigate the effects of Jin-Ying-Tang (JYT), a Chinese herbal formula containing Lonicera japonica, Herba taraxaci, Fructus trichosanthis, Fructus forsythia, Radix et rhizoma rhei, Astragalus membranaceus, Angelica sinensis, on rabbit mastitis induced by Staphylococcus aureus. Suckling rabbits were challenged with 1.5 × 10(7) colony forming unit (CFU) of S. aureus at the base of the third pair teats, and they were treated and pretreated with JYT to detect the formula effects. The results showed that JYT could reduce the occurrence of Staphylococcal mastitis in rabbit model. To further investigate the action mechanism of JYT, we examined the leukocyte counts and inflammatory mediator levels such as TNF-α and IL-6 in blood and infected tissue. From histological study and blood analysis, we found that JYT could suppress leukocyte infiltration in infected mammary gland tissue and significantly inhibit the total leukocyte counts and lymphocytes (LYM), monocytes (MON) and granulocytes (GRA) fractions of leukocyte counts in blood. Enzyme-linked immunosorbent assay (ELISA) results showed JYT significantly decreased the TNF-α and IL-6 concentrations in serum and mammary gland. The analysis of these data suggested that JYT effectively inhibited inflammatory responses to reduce the occurrence of mastitis in rabbit model.
    MeSH term(s) Animals ; Drugs, Chinese Herbal/pharmacology ; Female ; Interleukin-6/blood ; Leukocyte Count ; Mastitis/blood ; Mastitis/drug therapy ; Rabbits ; Staphylococcal Infections/blood ; Staphylococcal Infections/drug therapy ; Staphylococcus aureus ; Tumor Necrosis Factor-alpha/blood
    Chemical Substances Drugs, Chinese Herbal ; Interleukin-6 ; Tumor Necrosis Factor-alpha
    Language English
    Publishing date 2012-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 807033-7
    ISSN 1532-2513 ; 0892-3973
    ISSN (online) 1532-2513
    ISSN 0892-3973
    DOI 10.3109/08923973.2012.655423
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1481: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Book: Jing xue te yi xing yan jiu yu ying yong

    Liang, Fanrong

    2014  

    Author's details zhu bian Liang Fanrong
    MeSH term(s) Acupuncture Points ; Medicine, Chinese Traditional
    Language Chinese
    Size 15, 612 p., 31 p. of plates :, ill., port.
    Edition Di 1 ban.
    Publisher Ren min wei sheng chu ban she
    Publishing place Beijing
    Document type Book
    ISBN 9787117178044 ; 7117178043
    Database Catalogue of the US National Library of Medicine (NLM)

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  8. Article: In Memory of Professor WANG Ying-Lai.

    Lin, Qi-Shui / Li, Bo-Liang

    Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica

    2001  Volume 33, Issue 4, Page(s) 365–367

    Language English
    Publishing date 2001
    Publishing country China
    Document type Journal Article
    ZDB-ID 2175256-4
    ISSN 1745-7270 ; 0582-9879 ; 1672-9145
    ISSN (online) 1745-7270
    ISSN 0582-9879 ; 1672-9145
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book: Tou jing bu yi nan bing li ying xiang zhen duan

    Liang, Biling

    (Yi nan ying xiang zhen duan cong shu)

    2015  

    Author's details zhu bian Liang Biling, Tian Junzhang, Chen Yanping, Xie Chuanmiao
    Series title Yi nan ying xiang zhen duan cong shu
    MeSH term(s) Head/pathology ; Neck/pathology ; Diagnostic Imaging
    Language Chinese
    Size 16, 227 pages :, illustrations, portraits
    Edition Di 1 ban.
    Document type Book
    ISBN 9787117198806 ; 711719880X
    Database Catalogue of the US National Library of Medicine (NLM)

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  10. Article: Traditional Chinese medicine, Qing Ying Tang, ameliorates the severity of acute lung injury induced by severe acute pancreatitis in rats via the upregulation of aquaporin-1.

    Gao, Zhenming / Xu, Junfeng / Sun, Deguang / Zhang, Rixin / Liang, Rui / Wang, Liming / Fan, Rong

    Experimental and therapeutic medicine

    2014  Volume 8, Issue 6, Page(s) 1819–1824

    Abstract: Aquaporin-1 (AQP-1) is expressed in lung endothelial cells and regulates water transport; thus, AQP-1 plays an important role in a number of edema-associated lung diseases. Qing Yin Tang (QYT), a traditional Chinese medicine, has been shown to ... ...

    Abstract Aquaporin-1 (AQP-1) is expressed in lung endothelial cells and regulates water transport; thus, AQP-1 plays an important role in a number of edema-associated lung diseases. Qing Yin Tang (QYT), a traditional Chinese medicine, has been shown to effectively reduce the mortality rate of acute lung injury (ALI) induced by severe acute pancreatitis (SAP). The current study aimed to investigate the detailed mechanisms underlying the effects of QYT on ALI induced by SAP, particularly the effects on the expression levels of AQP-1 in the lung tissue. ALI was established in Wister rats who were subsequently divided into four groups: SHAM, ALI, dexamethasone (DEX) and QYT groups (n=8 per group). In the QYT group, 20 ml/kg QYT was administered by gavage immediately following the induction of SAP. Blood and lung tissues were collected 8 h following the induction of pancreatitis. The lung wet/dry ratio, as well as the levels of blood gases, serum amylase and tumor necrosis factor-α (TNF-α), were measured at 4, 8 and 12 h following SAP-associated ALI induction surgery. The expression levels of AQP-1 in the lung tissue were detected by quantitative polymerase chain reaction, immunohistochemistry and western blot analysis. No statistically significant differences were observed with regard to the levels of serum amylase, wet/dry ratio, partial pressure of oxygen, serum TNF-α and pathological changes in the pulmonary tissue between the QYT and DEX groups; however, a statistically significant difference was observed when compared with the ALI group. The expression levels of AQP-1 significantly increased (P<0.05) and lung edema was alleviated in the QYT and DEX groups, when compared with ALI group. Therefore, the expression level of AQP-1 is associated with pulmonary edema. QYT protects the lungs from injury induced by SAP via the upregulation of AQP-1, which suppresses TNF-α expression.
    Language English
    Publishing date 2014-09-22
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 2683844-8
    ISSN 1792-1015 ; 1792-0981
    ISSN (online) 1792-1015
    ISSN 1792-0981
    DOI 10.3892/etm.2014.1987
    Database MEDical Literature Analysis and Retrieval System OnLINE

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