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  1. Article ; Online: Using Unmanned Aircraft to Save Lives: Learning to Fly.

    Scalea, Joseph R

    JAMA surgery

    2020  Volume 155, Issue 4, Page(s) 355–356

    MeSH term(s) Aircraft ; Delivery of Health Care ; Diffusion of Innovation ; Equipment Design ; Humans ; Organ Transplantation
    Language English
    Publishing date 2020-01-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701841-6
    ISSN 2168-6262 ; 2168-6254
    ISSN (online) 2168-6262
    ISSN 2168-6254
    DOI 10.1001/jamasurg.2019.4925
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The Distancing of Surgeon From Patient in the Era of COVID-19: Bring on the Innovation.

    Scalea, Joseph R

    Annals of surgery

    2020  Volume 272, Issue 1, Page(s) e18–e19

    MeSH term(s) Betacoronavirus ; COVID-19 ; Clinical Protocols ; Coronavirus Infections/transmission ; Humans ; Infectious Disease Transmission, Patient-to-Professional/prevention & control ; Infectious Disease Transmission, Professional-to-Patient/prevention & control ; Pandemics ; Physician-Patient Relations ; Pneumonia, Viral/transmission ; SARS-CoV-2 ; Surgeons ; Triage ; Videoconferencing
    Keywords covid19
    Language English
    Publishing date 2020-04-16
    Publishing country United States
    Document type Journal Article ; Personal Narrative
    ZDB-ID 340-2
    ISSN 1528-1140 ; 0003-4932
    ISSN (online) 1528-1140
    ISSN 0003-4932
    DOI 10.1097/SLA.0000000000003962
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Technology for Technology's Sake No Longer.

    Scalea, Joseph R

    Annals of surgery

    2019  Volume 269, Issue 2, Page(s) e24

    MeSH term(s) Child ; Humans ; Kidney Transplantation ; Printing, Three-Dimensional ; Technology
    Language English
    Publishing date 2019-01-07
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 340-2
    ISSN 1528-1140 ; 0003-4932
    ISSN (online) 1528-1140
    ISSN 0003-4932
    DOI 10.1097/SLA.0000000000003132
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: An Evolution of Organ Allocation: Principles, Processes, and Innovations (Con).

    Cullinan, Darren R / Ahmed, Ola / Scalea, Joseph R / Chapman, William C

    Transplantation

    2023  Volume 107, Issue 11, Page(s) 2302–2310

    Language English
    Publishing date 2023-10-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208424-7
    ISSN 1534-6080 ; 0041-1337
    ISSN (online) 1534-6080
    ISSN 0041-1337
    DOI 10.1097/TP.0000000000004513
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The Distancing of Surgeon From Patient in the Era of COVID-19 ; Bring on the Innovation

    Scalea, Joseph R.

    Annals of Surgery

    2020  Volume 272, Issue 1, Page(s) e18–e19

    Keywords Surgery ; covid19
    Language English
    Publisher Ovid Technologies (Wolters Kluwer Health)
    Publishing country us
    Document type Article ; Online
    ZDB-ID 340-2
    ISSN 1528-1140 ; 0003-4932
    ISSN (online) 1528-1140
    ISSN 0003-4932
    DOI 10.1097/sla.0000000000003962
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Initial exploration of a novel fusion protein, IL-4/IL-34/IL-10, which promotes cardiac allograft survival mice through alloregulation.

    Lee, Young S / Cheng, I-Ting / Raquel, Godoy-Ruiz / Weber, David J / Scalea, Joseph R

    Innate immunity

    2023  Volume 29, Issue 7, Page(s) 150–158

    Abstract: Immune mediated graft loss still represents a major risk to transplant recipients. Creative approaches to immunosuppression that exploit the recipient's own alloregulatory mechanisms could reduce the need for pharmacologic immunosuppression and ... ...

    Abstract Immune mediated graft loss still represents a major risk to transplant recipients. Creative approaches to immunosuppression that exploit the recipient's own alloregulatory mechanisms could reduce the need for pharmacologic immunosuppression and potentially induce immune tolerance. In the process of studying recipient derived myeloid derived suppressor cells (MDSCs), we identified key alloregulatory MDSC mechanisms, mediated by isolatable proteins IL-4, IL-34, and IL-10. We sought to purify these proteins and fuse them for subsequent infusion into transplant recipients as a means of inducing an alloregulatory response. In this introductory investigation, we leveraged molecular engineering technology to create a fusion protein (FP) of three cytokine coding sequences of IL-4, IL-34, and IL-10 and demonstrated their expressions by Western Blot analysis. Following purification, we tested whether FP IL-4/IL-34/IL-10 (FP1) can protect heart transplant allografts. Injection of FP1 significantly prolonged allogeneic cardiac graft survival in a dose-dependent fashion and the increase of graft survival time exceeded survival attributable to IL-34 alone. In vitro, MDSCs cells were expanded by FP1 treatment. However, FP1 did not directly inhibit T cell proliferation in vitro. In conclusion, newly developed FP1 improves the graft survival in cardiac transplantation mouse model. Significant additional work to optimize FP1 or include other novel proteins could supplement current treatment options for transplant patients.
    MeSH term(s) Humans ; Animals ; Mice ; Interleukin-10/genetics ; Interleukin-4 ; Heart Transplantation ; Tissue Donors ; Allografts ; Mice, Inbred C57BL
    Chemical Substances Interleukin-10 (130068-27-8) ; Interleukin-4 (207137-56-2)
    Language English
    Publishing date 2023-10-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2381250-3
    ISSN 1753-4267 ; 1753-4259
    ISSN (online) 1753-4267
    ISSN 1753-4259
    DOI 10.1177/17534259231186239
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Good outcomes with a bad story.

    Scalea, Joseph R / Xie, Wen / Vrakas, Georgios / Gray, Stephen H

    American journal of surgery

    2021  Volume 221, Issue 4, Page(s) 675–676

    MeSH term(s) Creatinine ; Humans ; Kidney ; Pancreas Transplantation
    Chemical Substances Creatinine (AYI8EX34EU)
    Language English
    Publishing date 2021-01-11
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2953-1
    ISSN 1879-1883 ; 0002-9610
    ISSN (online) 1879-1883
    ISSN 0002-9610
    DOI 10.1016/j.amjsurg.2021.01.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Transplant Interrupted: Breaking Routine With Destiny.

    Scalea, Joseph R / Mezrich, Joshua D

    Annals of surgery

    2017  Volume 265, Issue 2, Page(s) 275–276

    Language English
    Publishing date 2017-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 340-2
    ISSN 1528-1140 ; 0003-4932
    ISSN (online) 1528-1140
    ISSN 0003-4932
    DOI 10.1097/SLA.0000000000001839
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  10. Article ; Online: Can remote endarterectomy expand access to kidney transplantation in patients with severe iliac calcification?

    Lin, Mary S / Carrier, Amber / Toursavadkohi, Shahab / Meier, Raphael P H / Sarkar, Rajabrata / Bromberg, Jonathan / Cox, Samantha R / Scalea, Joseph R

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

    2023  Volume 23, Issue 1, Page(s) 108–110

    Abstract: Severe iliac artery calcification in patients with end-stage renal disease is a common barrier to listing for kidney transplant. While few surgical solutions to iliac calcification have been reported, improving treatment may thus improve access to ... ...

    Abstract Severe iliac artery calcification in patients with end-stage renal disease is a common barrier to listing for kidney transplant. While few surgical solutions to iliac calcification have been reported, improving treatment may thus improve access to transplant care. Here we present two cases of a novel application of remote endarterectomy of the external iliac artery to facilitate listing for renal transplant. Both patients were listed following remote endarterectomy, followed by successful renal transplants using the treated vessels.
    MeSH term(s) Humans ; Kidney Transplantation ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/surgery ; Arteriosclerosis ; Endarterectomy ; Iliac Artery/surgery
    Language English
    Publishing date 2023-01-11
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2060594-8
    ISSN 1600-6143 ; 1600-6135
    ISSN (online) 1600-6143
    ISSN 1600-6135
    DOI 10.1111/ajt.17200
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