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  1. Article ; Online: Feasibility, safety and oncological short-term outcome of laparoscopic pancreaticoduodenectomy for periampullary cancer: Findings from a large sample from Vietnam.

    Pham, Hai Minh / Le Quan, Anh Tuan / Nguyen, Bac Hoang

    Medicine

    2024  Volume 103, Issue 15, Page(s) e37769

    Abstract: ... who underwent LPD from February 2017 to January 2022 at University Medical Center at Ho Chi Minh City, Vietnam ...

    Abstract Laparoscopic pancreaticoduodenectomy (LPD) is an alternative to open pancreaticoduodenectomy (OPD) for treatment of periampullary cancer in selected patients. However, this is a difficult procedure with a high complication rate. We conducted a prospective cohort study of 85 patients with suspected periampullary cancer who underwent LPD from February 2017 to January 2022 at University Medical Center at Ho Chi Minh City, Vietnam. Among these, 15 patients were excluded from the data analysis because of benign disease confirmed by postoperative pathological examination. Among 70 patients, the mean age was 58.9 ± 8.9 years old and 51.4% were female. The conversion rate to open surgery was 7.1% (n = 5). Among those underwent LPD, the mean operating time and estimated blood loss were 509 ± 94 minutes and 267 ± 102 mL, respectively. The median length of hospital stay was 8 days, interquartile range (IQR) 7-12 days. The percentage of cumulative morbidity, pancreatic fistula and major complication was 35.4%, 12.3%, and 13.8%, respectively. The median of comprehensive complication index (CCI) was 26.2 (IQR 20.9-29.6). Three patients required reoperation due to severe pancreatic fistula (n = 2) and necrotizing pancreatitis (n = 1). There was no death after ninety-day. The average number of harvested lymph nodes was 16.6 ± 5.1. The percentage of R0 resection was 100%. With properly selected patients, LPD can be a feasible, safe and effective approach with acceptable short-term outcomes.
    MeSH term(s) Humans ; Female ; Middle Aged ; Aged ; Male ; Pancreaticoduodenectomy/adverse effects ; Vietnam/epidemiology ; Feasibility Studies ; Pancreatic Fistula ; Prospective Studies ; Duodenal Neoplasms ; Laparoscopy/adverse effects
    Language English
    Publishing date 2024-04-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000037769
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Online: Vietnamese Poem Generation & The Prospect Of Cross-Language Poem-To-Poem Translation

    Huynh, Triet Minh / Bao, Quan Le

    2024  

    Abstract: Poetry generation has been a challenging task in the field of Natural Language Processing, as it requires the model to understand the nuances of language, sentiment, and style. In this paper, we propose using Large Language Models to generate Vietnamese ... ...

    Abstract Poetry generation has been a challenging task in the field of Natural Language Processing, as it requires the model to understand the nuances of language, sentiment, and style. In this paper, we propose using Large Language Models to generate Vietnamese poems of various genres from natural language prompts, thereby facilitating an intuitive process with enhanced content control. Our most efficacious model, the GPT-3 Babbage variant, achieves a custom evaluation score of 0.8, specifically tailored to the "luc bat" genre of Vietnamese poetry. Furthermore, we also explore the idea of paraphrasing poems into normal text prompts and yield a relatively high score of 0.781 in the "luc bat" genre. This experiment presents the potential for cross-Language poem-to-poem translation with translated poems as the inputs while concurrently maintaining complete control over the generated content.
    Keywords Computer Science - Computation and Language ; Computer Science - Artificial Intelligence
    Subject code 410
    Publishing date 2024-01-02
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Morphological Changes of 3T3 Cells under Simulated Microgravity.

    Tran, Minh Thi / Ho, Chi Nguyen Quynh / Hoang, Son Nghia / Doan, Chung Chinh / Nguyen, Minh Thai / Van, Huy Duc / Ly, Cang Ngoc / Le, Cuong Phan Minh / Hoang, Huy Nghia Quang / Nguyen, Han Thai Minh / Truong, Han Thi / To, Quan Minh / Nguyen, Tram Thi Thuy / Le, Long Thanh

    Cells

    2024  Volume 13, Issue 4

    Abstract: Background: Cells are sensitive to changes in gravity, especially the cytoskeletal structures that determine cell morphology. The aim of this study was to assess the effects of simulated microgravity (SMG) on 3T3 cell morphology, as demonstrated by a ... ...

    Abstract Background: Cells are sensitive to changes in gravity, especially the cytoskeletal structures that determine cell morphology. The aim of this study was to assess the effects of simulated microgravity (SMG) on 3T3 cell morphology, as demonstrated by a characterization of the morphology of cells and nuclei, alterations of microfilaments and microtubules, and changes in cycle progression.
    Methods: 3T3 cells underwent induced SMG for 72 h with Gravite
    Results: The results show that SMG led to decreased nuclear intensity, nuclear area, and nuclear shape and increased cell diameter in 3T3 cells. The 3T3 cells in the SMG group appeared to have a flat form and diminished microvillus formation, while cells in the control group displayed an apical shape and abundant microvilli. The 3T3 cells under SMG exhibited microtubule distribution surrounding the nucleus, compared to the perinuclear accumulation in control cells. Irregular forms of the contractile ring and polar spindle were observed in 3T3 cells under SMG. The changes in cytoskeleton structure were caused by alterations in the expression of major cytoskeletal proteins, including β-actin and α-tubulin 3. Moreover, SMG induced 3T3 cells into the arrest phase by reducing main cell cycle related genes, which also affected the formation of cytoskeleton structures such as microfilaments and microtubules.
    Conclusions: These results reveal that SMG generated morphological changes in 3T3 cells by remodeling the cytoskeleton structure and downregulating major structural proteins and cell cycle regulators.
    MeSH term(s) Mice ; Animals ; Weightlessness ; Cytoskeleton/metabolism ; Actin Cytoskeleton/metabolism ; Microtubules/metabolism ; 3T3 Cells
    Language English
    Publishing date 2024-02-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells13040344
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Quantification of parabens in marine fish samples by a rapid, simple, effective sample preparation method.

    Pham, Phuong Thi / Quan, Thuy Cam / Le, Quynh Thi / Bui, Minh Quang / Tran, Anh Hoang / Phung, Anh-Tuyet Thi / Hoang, Anh Quoc / Minh, Tu Binh / Tran-Lam, Thanh-Thien / Tran, Hai Nguyen / Tran, Tri Manh

    Environmental science and pollution research international

    2024  Volume 31, Issue 11, Page(s) 16571–16582

    Abstract: Parabens (p-hydroxybenzoic acid esters) commonly used preservatives (in cosmetics, pharmaceuticals, and foods) can pose potential effects on environmental health. In this study, seven parabens were quantified in marine fish samples using an ultra-high ... ...

    Abstract Parabens (p-hydroxybenzoic acid esters) commonly used preservatives (in cosmetics, pharmaceuticals, and foods) can pose potential effects on environmental health. In this study, seven parabens were quantified in marine fish samples using an ultra-high performance liquid chromatography triple quadrupole mass spectrometer (UHPLC-MS/MS) system. Parabens in the fish samples were extracted and purified by a rapid, simple, and effective procedure comprising sample homogenization with solvent, solid-phase extraction clean-up, and solvent evaporation. Results demonstrated that the recoveries of seven compounds (with relative standard deviation < 15%) were 88-103% in matrix-spike samples and 86-105% in surrogate standards. The method detection limits and method quantification limits of seven parabens were 0.015-0.030 and 0.045-0.090 ng/g-ww (wet weight), respectively. The optimized method was applied to measure the concentration of parabens in the 37 marine fish samples collected from Vietnam coastal waters. The concentration ranges of seven parabens found in round scad and greater lizardfish samples were 6.82-25.3 ng/g ww and 6.21-17.2 ng/g-ww, respectively. Among parabens, methylparaben accounted for the highest contribution in both fish species (43.2 and 44.9%, respectively). Based on the measured concentrations of parabens in marine fish samples, the estimated daily intake was calculated for children and adults with the corresponding values of 0.0477 µg/kg/day and 0.0119 µg/kg/day, respectively. However, the presence of parabens in Vietnamese marine fish may not pose a significant risk to human health.
    MeSH term(s) Adult ; Child ; Animals ; Humans ; Parabens/analysis ; Tandem Mass Spectrometry ; Fishes ; Preservatives, Pharmaceutical ; Chromatography, High Pressure Liquid/methods ; Solvents
    Chemical Substances Parabens ; Preservatives, Pharmaceutical ; Solvents
    Language English
    Publishing date 2024-02-06
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-024-32321-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: RNA therapeutics history and future perspectives.

    Duong, Hong-Quan / Hoang, Minh-Cong / Nguyen, Thi-Hue / Ngo, Van-Lang / Le, Van-Thu

    Progress in molecular biology and translational science

    2024  Volume 203, Page(s) 99–114

    Abstract: Ribonucleic acid (RNA) therapeutics have significantly used RNA-based drugs to the prevention and treatment of diseases as effective messenger RNA-based vaccines in response to the COVID-19 pandemic. The RNA therapeutics with five classes including ... ...

    Abstract Ribonucleic acid (RNA) therapeutics have significantly used RNA-based drugs to the prevention and treatment of diseases as effective messenger RNA-based vaccines in response to the COVID-19 pandemic. The RNA therapeutics with five classes including antisense oligonucleotide, small interfering RNA, microRNA, APTAMER and messenger RNAs are being quickly developed to treat various human diseases as neurological disease, cardiovascular disease, genetic and rare disease, cancer disease, coronavirus disease… which cannot be treated by other conventional drugs as small molecule-based drugs and antibodies. Therefore, the discovery of these RNA therapeutics created a new avenue for treatment of various human diseases. This chapter demonstrates the history of important discoveries in RNA biology and their impact on key developments in RNA therapeutics as well as the advantages of RNA therapeutics; RNA therapeutics describes the action mechanisms and examples of RNA-based drugs approved for treatment of various disease; and RNA therapeutics discusses delivery methods for RNA therapeutics to target organs and cells. In conclusion, this chapter is designed to offer an updated important development and advance of RNA therapeutics for the prevention and treatment of various human diseases.
    MeSH term(s) Humans ; RNA ; Pandemics ; MicroRNAs/genetics ; RNA, Small Interfering/genetics ; RNA, Small Interfering/therapeutic use ; Oligonucleotides, Antisense/therapeutic use ; RNA, Messenger
    Chemical Substances RNA (63231-63-0) ; MicroRNAs ; RNA, Small Interfering ; Oligonucleotides, Antisense ; RNA, Messenger
    Language English
    Publishing date 2024-01-24
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2471995-X
    ISSN 1878-0814 ; 0079-6603 ; 1877-1173
    ISSN (online) 1878-0814
    ISSN 0079-6603 ; 1877-1173
    DOI 10.1016/bs.pmbts.2024.01.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Results from 228 Patients with Hemifacial Spasm Undergoing Microvascular Decompression without Intraoperative Neuroelectrophysiology Monitoring.

    Truong, Van Tri / Ngo, Minh Quan / Phan, Duy / Le, Hung / Tran Hoang, Ngoc Anh

    World neurosurgery

    2024  

    Abstract: Background: Intraoperative neuroelectrophysiology monitoring (IONM) has been used to decrease complications and to increase the successful rate of microvascular decompression (MVD) MVD for hemifacial spasm (HFS). Still, it is not available at limited ... ...

    Abstract Background: Intraoperative neuroelectrophysiology monitoring (IONM) has been used to decrease complications and to increase the successful rate of microvascular decompression (MVD) MVD for hemifacial spasm (HFS). Still, it is not available at limited resource centers. We report the outcome of patients undergoing MVD for HFS without using IONM.
    Methods: The variables concerning the patients' demographics (age and gender), clinical characteristics, offending vessels (vertebral artery type and non-vertebral artery type), postoperative grade of HFS, and postoperative complications of HFS patients undergoing MVD were retrospectively reviewed and collected. The scoring system provided by the Japan Society for MVD was used to evaluate the postoperative outcome of HFS. Postoperative hearing ability was evaluated according to a subjective assessment of the patients.
    Results: A total of 228 patients were recruited. Their median age was 51.0 (44.0-57.0) years old. The total cure effect was observed in 207 (90.8%) patients within the first week after the surgery and in 200 (96.1%) patients in a 2-year follow-up. Permanent hearing disturbance happened in 2 patients (0.9%). No patient had permanent unilateral deafness (0%). No postoperative permanent facial paralysis was reported.
    Conclusions: MVD without IONM may be performed safely and effectively to treat patients with HFS.
    Language English
    Publishing date 2024-02-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2024.02.053
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: RNA therapeutics for β-thalassemia.

    Duong, Hong-Quan / Nguyen, Thi-Hue / Hoang, Minh-Cong / Ngo, Van-Lang / Le, Van-Thu

    Progress in molecular biology and translational science

    2024  Volume 204, Page(s) 97–107

    Abstract: β-thalassemia is an autosomal recessive disease, caused by one or more mutations in the β-globin gene that reduces or abolishes β-globin chain synthesis causing an imbalance in the ratio of α- and β-globin chain. Therefore, the ability to target ... ...

    Abstract β-thalassemia is an autosomal recessive disease, caused by one or more mutations in the β-globin gene that reduces or abolishes β-globin chain synthesis causing an imbalance in the ratio of α- and β-globin chain. Therefore, the ability to target mutations will provide a good result in the treatment of β-thalassemia. RNA therapeutics represents a promising class of drugs inclusive antisense oligonucleotides (ASO), small interfering RNA (siRNA), microRNA (miRNA) and APTAMER have investigated in clinical trials for treatment of human diseases as β-thalassemia; Especially, ASO therapeutics can completely treat β-thalassemia patients by the way of making ASO infiltrating through erythrocyte progenitor cells, migrating to the nucleus and hybridizing with abnormal splicing sites to suppress an abnormal splicing pattern of β-globin pre-mRNA. As a result, the exactly splicing process is restored to increase the expression of β-globin which increases the amount of mature hemoglobin of red blood cells of β-thalassemia patients. Furthermore, current study demonstrates that RNA-based therapeutics get lots of good results for β-thalassemia patients. Then, this chapter focuses on current advances of RNA-based therapeutics and addresses current challenges with their development and application for treatment of β-thalassemia patients.
    MeSH term(s) Humans ; beta-Thalassemia/genetics ; beta-Thalassemia/therapy ; RNA/metabolism ; RNA, Messenger/genetics ; RNA Splicing/genetics ; beta-Globins/genetics ; beta-Globins/metabolism
    Chemical Substances RNA (63231-63-0) ; RNA, Messenger ; beta-Globins
    Language English
    Publishing date 2024-01-24
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2471995-X
    ISSN 1878-0814 ; 0079-6603 ; 1877-1173
    ISSN (online) 1878-0814
    ISSN 0079-6603 ; 1877-1173
    DOI 10.1016/bs.pmbts.2023.12.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Examining the Influence of Exploration and Parental Education Attainment on Students' Acceptance of Collectivist Values.

    Jin, Ruining / Le, Tam-Tri / Nguyen, Minh-Hoang / Vuong, Quan-Hoang

    European journal of investigation in health, psychology and education

    2023  Volume 13, Issue 7, Page(s) 1269–1292

    Abstract: Exploration can help students access a wider range of information and make connections among values within the natural and social world. This study investigated the relationship between students' previous exploration of their surroundings and their ... ...

    Abstract Exploration can help students access a wider range of information and make connections among values within the natural and social world. This study investigated the relationship between students' previous exploration of their surroundings and their acceptance of collectivist values in the context of China. A sample of 343 college students was analyzed based on the Bayesian Mindsponge Framework to explore this relationship. The results revealed a positive association between students' prior exploration of surroundings and their degree of collectivist orientation. Furthermore, parental education attainment was found to negatively moderate this association, albeit with a small effect size. These findings contribute to the understanding of how information acquisition influences students' acceptance of collectivist values and highlight the potential role of the family infosphere in shaping this relationship.
    Language English
    Publishing date 2023-07-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 3041279-1
    ISSN 2254-9625 ; 2174-8144
    ISSN (online) 2254-9625
    ISSN 2174-8144
    DOI 10.3390/ejihpe13070094
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: MetaAttention model: a new approach for skin lesion diagnosis using AB features and attention mechanism.

    To, Hung Duy / Nguyen, Huy Gia / Le, Hang Thi Thuy / Le, Hung Minh / Quan, Tho Thanh

    Biomedical physics & engineering express

    2023  Volume 9, Issue 4

    Abstract: Ozone depletion has always been a hot crisis around the globe. Its consequence is the increase in ultraviolet radiation at the surface in many regions and countries, which then causes danger to the human immune system, eyes, and especially skin - the ... ...

    Abstract Ozone depletion has always been a hot crisis around the globe. Its consequence is the increase in ultraviolet radiation at the surface in many regions and countries, which then causes danger to the human immune system, eyes, and especially skin - the part that is directly exposed most to the sunlight. According to the World Health Organization, the number of cases of skin cancer is higher than that of breast, prostate, and lung cancer combined. Therefore, there has been a lot of research to apply deep learning models in solving the problem of skin cancer classification. This paper proposes a novel approach, named MetaAttention, aimed at improving the performance of transfer learning models for skin lesion classification. The method combines image features with patients' metadata features using the attention mechanism, incorporating clinical knowledge related to ABCD signals to better distinguish melanoma cell carcinoma disease, which has long been a significant challenge for researchers. The experimental results indicate that the proposed approach outperforms the state-of-the-art method, EfficientNet-B4, achieving an accuracy of 89.9% with Scale-dot product MetaAttention and 90.63% with Additive MetaAttention. The method has the potential to support dermatologists in diagnosing skin lesions effectively and efficiently. Furthermore, with larger datasets, our method could be further fine-tuned to achieve even better performance on a broader range of labels.
    MeSH term(s) Male ; Humans ; Melanoma/diagnosis ; Ultraviolet Rays ; Skin Diseases ; Skin Neoplasms/diagnosis ; Skin Neoplasms/pathology ; Skin/pathology
    Language English
    Publishing date 2023-05-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2057-1976
    ISSN (online) 2057-1976
    DOI 10.1088/2057-1976/acd1f0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Endocrine-disrupting chemicals in Vietnamese marine fish: Occurrence, distribution, and risk assessment.

    Tran-Lam, Thanh-Thien / Quan, Thuy Cam / Bui, Minh Quang / Dao, Yen Hai / Le, Giang Truong

    The Science of the total environment

    2023  Volume 908, Page(s) 168305

    Abstract: The release of endocrine-disrupting chemicals (EDCs) into the aquatic environment, specifically the oceans, is increasing, leading to adverse effects on the marine ecosystem. Using optimized QuEChERS extraction methods, the study created the first ... ...

    Abstract The release of endocrine-disrupting chemicals (EDCs) into the aquatic environment, specifically the oceans, is increasing, leading to adverse effects on the marine ecosystem. Using optimized QuEChERS extraction methods, the study created the first contamination profiles of 44 EDCs, including organic ultraviolet compounds, pharmaceutically active compounds, hormones, and phthalate esters, in 114 fish muscle samples from five species collected along the Vietnamese coast. The study found that largehead hairtail exhibited the highest total EDCs at 208.3 ng g
    MeSH term(s) Animals ; Ecosystem ; Endocrine Disruptors/analysis ; Fishes ; Phenols/analysis ; Risk Assessment ; Vietnam ; Water Pollutants, Chemical/analysis
    Chemical Substances Endocrine Disruptors ; Phenols ; Water Pollutants, Chemical
    Language English
    Publishing date 2023-11-05
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2023.168305
    Database MEDical Literature Analysis and Retrieval System OnLINE

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