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  1. Article ; Online: Ganoderma lucidum

    Liu, Yun-Yun / Cai, Dan / Tang, Xin-Ping / Cheng, Yong-Xian

    Molecules (Basel, Switzerland)

    2024  Volume 29, Issue 5

    Abstract: Ganoderma ... ...

    Abstract Ganoderma lucidum
    MeSH term(s) Reishi/chemistry ; Ganoderma/chemistry ; Anti-Inflammatory Agents/pharmacology ; Cell Line ; Macrophages ; Molecular Structure
    Chemical Substances Anti-Inflammatory Agents
    Language English
    Publishing date 2024-03-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules29051149
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  2. Article: [Preparation of Catalyst Cyclodextrin-Fe-TAML to Activate H

    Liu, Qing-Quan / Cai, Ben-Zhe / Cai, Xi-Yun

    Huan jing ke xue= Huanjing kexue

    2023  Volume 44, Issue 7, Page(s) 3978–3989

    Abstract: In order to improve the stability and catalytic activity of Fe-TAML, mono-6-oxy-cyclodextrin bonded Fe-TAML catalyst (CD-Fe-TAML) was prepared by bonding Fe-TAML with cyclodextrin (CD) through chlorosulfonylation reaction, metal chelation reaction, and ... ...

    Abstract In order to improve the stability and catalytic activity of Fe-TAML, mono-6-oxy-cyclodextrin bonded Fe-TAML catalyst (CD-Fe-TAML) was prepared by bonding Fe-TAML with cyclodextrin (CD) through chlorosulfonylation reaction, metal chelation reaction, and nucleophilic substitution reaction. The catalytic activity and stability of CD-Fe-TAML and the oxidation degradation efficiencies of 34 organic micropollutants such as antibiotics and pesticides by activation of H
    Language Chinese
    Publishing date 2023-07-12
    Publishing country China
    Document type English Abstract ; Journal Article
    ISSN 0250-3301
    ISSN 0250-3301
    DOI 10.13227/j.hjkx.202208235
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Effects of low-frequency ultrasound combined with anti-MRSA agents on the mouse model of pulmonary infection.

    Yan, Kaicheng / Yao, Jiahui / Liu, Lingling / Liang, Wenxin / Cai, Yun

    Microbiology spectrum

    2024  , Page(s) e0101623

    Abstract: The treatment of methicillin- ... ...

    Abstract The treatment of methicillin-resistant
    Language English
    Publishing date 2024-02-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.01016-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Knockdown of heat shock transcription factor 1 decreases temperature stress tolerance in Bemisia tabaci MED.

    Bai, Jing / Liu, Yun-Cai / Wei, Ran / Wang, Yu-Cheng / Gong, Wei-Rong / Du, Yu-Zhou

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 16059

    Abstract: The primary function of heat shock transcription factor (HSF) in the heat shock response is to activate the transcription of genes encoding heat shock proteins (HSPs). The phloem-feeding insect Bemisia tabaci (Gennadius) is an important pest of cotton, ... ...

    Abstract The primary function of heat shock transcription factor (HSF) in the heat shock response is to activate the transcription of genes encoding heat shock proteins (HSPs). The phloem-feeding insect Bemisia tabaci (Gennadius) is an important pest of cotton, vegetables and ornamentals that transmits several plant viruses and causes enormous agricultural losses. In this study, the gene encoding HSF (Bthsf1) was characterized in MED B. tabaci. The full-length cDNA encoded a protein of 652 amino acids with an isoelectric point of 5.55. The BtHSF1 deduced amino acid sequence showed strong similarity to HSF in other insects. Expression analyses using quantitative real-time PCR indicated that Bthsf1 was significantly up-regulated in B. tabaci adults and pupae during thermal stress. Although Bthsf1 was induced by both hot and cold stress, the amplitude of expression was greater in the former. Bthsf1 had distinct, significant differences in expression pattern during different duration of high but not low temperature stress. Oral ingestion of dsBthsf1 repressed the expression of Bthsf1 and four heat shock proteins (Bthsp90, Bthsp70-3, Bthsp20 and Bthsp19.5) in MED B. tabaci during hot and cold stress. In conclusion, our results show that Bthsf1 is differentially expressed during high and low temperature stress and regulates the transcription of multiple hsps in MED B. tabaci.
    MeSH term(s) Amino Acids/metabolism ; Animals ; DNA, Complementary/metabolism ; Heat Shock Transcription Factors/genetics ; Heat Shock Transcription Factors/metabolism ; Heat-Shock Proteins/genetics ; Heat-Shock Proteins/metabolism ; Hemiptera/physiology ; Temperature ; Transcription Factors/genetics ; Transcription Factors/metabolism
    Chemical Substances Amino Acids ; DNA, Complementary ; Heat Shock Transcription Factors ; Heat-Shock Proteins ; Transcription Factors
    Language English
    Publishing date 2022-09-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-19788-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: The digital economy and job quality: Facilitator or inhibitor? --Evidence from micro-individuals.

    Cai, Yun / Liu, Shuqing / Zhang, Xia

    Heliyon

    2024  Volume 10, Issue 4, Page(s) e26536

    Abstract: The improvement of workers' employment quality is an important manifestation of high-quality economic development. Based on 13,969 valid samples from the China Family Panel Studies (CFPS) data, the paper examines the impact of urban digital economy ... ...

    Abstract The improvement of workers' employment quality is an important manifestation of high-quality economic development. Based on 13,969 valid samples from the China Family Panel Studies (CFPS) data, the paper examines the impact of urban digital economy development level on individual employment quality from a micro perspective using a multilevel regression model. The study finds that the level of urban digital economy development significantly promotes individual employment quality. For every 1 unit increase in the level of urban digital economy development, the quality of individual employment will increase by 1.033 units. And air quality positively moderates the relationship between urban digital economy development level and individual employment quality, i.e., in cities with good air quality, the urban digital economy development level has a more important role in promoting the quality of individual employment. Further heterogeneity analysis reveals that the level of digital economy development in cities has a more pronounced effect on the employment quality of males, younger workers (40 years old and below), and party members. To be more specific, every increase of one unit in the development level of urban digital economy will increase the employment quality by 1.649, 0.787, and 0.897 units, respectively. The above findings are useful for the formulation of policies to achieve high quality of employment and the implementation of environmental management plans.
    Language English
    Publishing date 2024-02-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e26536
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: LncRNA DLG5-AS1 facilitates breast cancer cell proliferation and invasion by promoting EZH2-mediated transcriptional silencing of SFRP1.

    Cai, Yun / Liu, Yi / Sun, Ye / Ren, Yu

    Archives of biochemistry and biophysics

    2024  , Page(s) 110018

    Abstract: Rapid proliferation and metastasis of breast cancer contributed to poor clinical prognosis. Accumulating evidence revealed that the dysregulation of long noncoding RNAs (lncRNAs) was associated with breast cancer progression. However, the role of lncRNA ... ...

    Abstract Rapid proliferation and metastasis of breast cancer contributed to poor clinical prognosis. Accumulating evidence revealed that the dysregulation of long noncoding RNAs (lncRNAs) was associated with breast cancer progression. However, the role of lncRNA DLG5-AS1 in breast cancer has not been established. Here, we investigated the mechanisms of DLG5-AS1 in the development of breast cancer. We found that the expression of DLG5-AS1 was significantly upregulated in breast cancer tissues and cell lines. DLG5-AS1 interference markedly restrained AU565 cell proliferation, invasion, the expression of apoptosis related (caspase3 and caspase8) and Wnt/β-catenin pathway related proteins (wnt5a, β-Catenin and c-Myc), as well as promoted cell apoptosis, whereas DLG5-AS1 overexpression showed an opposite effects. In addition, DLG5-AS1 could directly bind with miR-519b-3p. We also found that enhancer of zeste homolog 2 (EZH2) is a direct target of miR-519b-3p, and DLG5-AS1 upregulated EZH2 expression by inhibiting the expression of miR-519b-3p. EZH2 restrained secreted frizzled related protein 1 (SFRP1) expression through inducing H3 histone methylation in its promoter. MiR-519b-3p overexpression or SFRP1 knockdown memorably reversed the effects of DLG5-AS1 overexpression on cell functions and Wnt/β-Catenin pathway related protein expression. Finally, in vivo experiments demonstrated that silencing of DLG5-AS1 inhibited xenograft tumor development in mice. Taken together, these findings demonstrated that DLG5-AS1 facilitated cell proliferation and invasion by promoting EZH2-mediated transcriptional silencing of SFRP1 in breast cancer.
    Language English
    Publishing date 2024-04-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 523-x
    ISSN 1096-0384 ; 0003-9861
    ISSN (online) 1096-0384
    ISSN 0003-9861
    DOI 10.1016/j.abb.2024.110018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.237: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Antiproliferative and Proapoptotic Effects of Phenanthrene Derivatives Isolated from

    Zhou, Fei / Feng, Rui / Dai, Ou / Yang, Lian / Liu, Yu / Tian, Yun-Cai / Peng, Cheng / Xiong, Liang

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 11

    Abstract: Lung cancer continues to be the world's leading cause of cancer death and the treatment of non-small cell lung cancer (NSCLC) has attracted much attention. The tubers ... ...

    Abstract Lung cancer continues to be the world's leading cause of cancer death and the treatment of non-small cell lung cancer (NSCLC) has attracted much attention. The tubers of
    MeSH term(s) A549 Cells ; Apoptosis ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/metabolism ; Cell Proliferation ; Humans ; Lung Neoplasms/drug therapy ; Orchidaceae ; Phenanthrenes/pharmacology
    Chemical Substances Phenanthrenes
    Language English
    Publishing date 2022-05-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27113519
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 81: Show issues

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  8. Article ; Online: Antiproliferative and Proapoptotic Effects of Phenanthrene Derivatives Isolated from Bletilla striata on A549 Lung Cancer Cells

    Fei Zhou / Rui Feng / Ou Dai / Lian Yang / Yu Liu / Yun-Cai Tian / Cheng Peng / Liang Xiong

    Molecules, Vol 27, Iss 3519, p

    2022  Volume 3519

    Abstract: Lung cancer continues to be the world’s leading cause of cancer death and the treatment of non-small cell lung cancer (NSCLC) has attracted much attention. The tubers of Bletilla striata are regarded as “an excellent medicine for lung diseases” and as ... ...

    Abstract Lung cancer continues to be the world’s leading cause of cancer death and the treatment of non-small cell lung cancer (NSCLC) has attracted much attention. The tubers of Bletilla striata are regarded as “an excellent medicine for lung diseases” and as the first choice to treat several lung diseases. In this study, seventeen phenanthrene derivatives, including two new compounds ( 1 and 2 ), were isolated from the tubers of B. striata . Most compounds showed cytotoxicity against A549 cells. An EdU proliferation assay, a cell cycle assay, a wound healing assay, a transwell migration assay, a flow cytometry assay, and a western blot assay were performed to further investigate the effect of compound 1 on A549 cells. The results showed that compound 1 inhibited cell proliferation and migration and promoted cell apoptosis in A549 cells. The mechanisms might correlate with the regulation of the Akt, MEK/ERK, and Bcl-2/Bax signaling pathways. These results suggested that the phenanthrenes of B. striata might be important and effective substances in the treatment of NSCLC.
    Keywords Bletilla striata ; phenanthrenes ; A549 lung cancer cells ; antiproliferation ; proapoptosis ; Organic chemistry ; QD241-441
    Subject code 610
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  9. Article ; Online: Minor ergosteroids and a 19-nor labdane-type diterpenoid with anti-inflammatory effects from Ganoderma lucidum.

    Cai, Dan / Liu, Yun-Yun / Tang, Xin-Ping / Zhang, Mei / Cheng, Yong-Xian

    Phytochemistry

    2024  Volume 222, Page(s) 114052

    Abstract: A chemical investigation on the fruiting bodies of Ganoderma lucidum led to the isolation and identification of five undescribed ergosteroids including two des-D-steroids (3 and 4) and one rare 6/6/7/5-fused carbon skeletal ergosterol (5) along with one ... ...

    Abstract A chemical investigation on the fruiting bodies of Ganoderma lucidum led to the isolation and identification of five undescribed ergosteroids including two des-D-steroids (3 and 4) and one rare 6/6/7/5-fused carbon skeletal ergosterol (5) along with one 19-nor labdane-type diterpenoid (6). Their structures including their absolute configurations, were assigned by spectroscopic methods, ECD calculations, and X-ray diffraction analysis. In addition, the anti-inflammatory activities of all the isolates were evaluated. The results indicated that compound 1 can significantly down-regulate the protein expression of iNOS and COX-2 at 20 μM in LPS- stimulated RAW264.7 cells.
    Language English
    Publishing date 2024-03-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 208884-8
    ISSN 1873-3700 ; 0031-9422
    ISSN (online) 1873-3700
    ISSN 0031-9422
    DOI 10.1016/j.phytochem.2024.114052
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 1586: Show issues
    Z 8.5: Show issues

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  10. Article ; Online: Comparison of [

    Liu, Mengna / Chen, Xi / Ding, Haoyuan / Shu, Qiaoqiao / Zheng, Yun / Chen, Yue / Cai, Liang

    Molecular imaging and biology

    2024  

    Abstract: Purpose: This study aimed to explore the feasibility of [: Procedures: This prospective study included patients with NPC who underwent [: Results: Twenty-five participants (21 patients for initial stage and four patients for recurrence detection) ... ...

    Abstract Purpose: This study aimed to explore the feasibility of [
    Procedures: This prospective study included patients with NPC who underwent [
    Results: Twenty-five participants (21 patients for initial stage and four patients for recurrence detection) were enrolled in our study. The participants underwent [
    Conclusions: [
    Clinical trial registration no: ChiCTR2200065902.
    Language English
    Publishing date 2024-04-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2079160-4
    ISSN 1860-2002 ; 1536-1632
    ISSN (online) 1860-2002
    ISSN 1536-1632
    DOI 10.1007/s11307-024-01913-1
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6468: Show issues Location:
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