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Article: The effect of oral bacterial infection on DNA damage response in host cells.

Oh, Jung-Min / Kim, Hongtae

2023 Volume 13, Issue 7, Page(s) 3157–3168

Abstract: Maintaining and transferring intact genomes from one generation to another plays a pivotal role in all living organisms. DNA damage caused by numerous endogenous and exogenous factors must be adequately repaired, as unrepaired and accumulated DNA ... ...

Abstract	Maintaining and transferring intact genomes from one generation to another plays a pivotal role in all living organisms. DNA damage caused by numerous endogenous and exogenous factors must be adequately repaired, as unrepaired and accumulated DNA mutations can cause severe deleterious effects, such as cell death and cancer. To prevent adverse consequences, cells have established DNA damage response mechanisms that address different forms of DNA damage, including DNA double-strand breaks, mismatches, nucleotide excision, and base excision. Among several sources of exogenous DNA damage, bacterial infections cause inflammation in the host, generating reactive oxygen species (ROS) and causing oxidative DNA damage. Recent studies have revealed the importance of the oral microbiome in inflammation and several systemic host diseases. Dysbiosis of oral bacteria can induce chronic inflammation, which enhances ROS-induced DNA damage, and improperly repaired damage can lead to carcinogenesis. This review describes the various DNA repair pathways that are affected by chronic inflammation and the discovery of the DNA damage response induced by oral bacteria such as
Language	English
Publishing date	2023-07-15
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2589522-9
ISSN	2156-6976
ISSN	2156-6976
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Article ; Online: Prediction of dysphagia aspiration through machine learning-based analysis of patients' postprandial voices.

Kim, Jung-Min / Kim, Min-Seop / Choi, Sun-Young / Ryu, Ju Seok

Journal of neuroengineering and rehabilitation

2024 Volume 21, Issue 1, Page(s) 43

Abstract: Background: Conventional diagnostic methods for dysphagia have limitations such as long wait times, radiation risks, and restricted evaluation. Therefore, voice-based diagnostic and monitoring technologies are required to overcome these limitations. ... ...

Abstract	Background: Conventional diagnostic methods for dysphagia have limitations such as long wait times, radiation risks, and restricted evaluation. Therefore, voice-based diagnostic and monitoring technologies are required to overcome these limitations. Based on our hypothesis regarding the impact of weakened muscle strength and the presence of aspiration on vocal characteristics, this single-center, prospective study aimed to develop a machine-learning algorithm for predicting dysphagia status (normal, and aspiration) by analyzing postprandial voice limiting intake to 3 cc. Methods: Conducted from September 2021 to February 2023 at Seoul National University Bundang Hospital, this single center, prospective cohort study included 198 participants aged 40 or older, with 128 without suspected dysphagia and 70 with dysphagia-aspiration. Voice data from participants were collected and used to develop dysphagia prediction models using the Multi-Layer Perceptron (MLP) with MobileNet V3. Male-only, female-only, and combined models were constructed using 10-fold cross-validation. Through the inference process, we established a model capable of probabilistically categorizing a new patient's voice as either normal or indicating the possibility of aspiration. Results: The pre-trained models (mn40_as and mn30_as) exhibited superior performance compared to the non-pre-trained models (mn4.0 and mn3.0). Overall, the best-performing model, mn30_as, which is a pre-trained model, demonstrated an average AUC across 10 folds as follows: combined model 0.8361 (95% CI 0.7667-0.9056; max 0.9541), male model 0.8010 (95% CI 0.6589-0.9432; max 1.000), and female model 0.7572 (95% CI 0.6578-0.8567; max 0.9779). However, for the female model, a slightly higher result was observed with the mn4.0, which scored 0.7679 (95% CI 0.6426-0.8931; max 0.9722). Additionally, the other models (pre-trained; mn40_as, non-pre-trained; mn4.0 and mn3.0) also achieved performance above 0.7 in most cases, and the highest fold-level performance for most models was approximately around 0.9. The 'mn' in model names refers to MobileNet and the following number indicates the 'width_mult' parameter. Conclusions: In this study, we used mel-spectrogram analysis and a MobileNetV3 model for predicting dysphagia aspiration. Our research highlights voice analysis potential in dysphagia screening, diagnosis, and monitoring, aiming for non-invasive safer, and more effective interventions. Trial registration: This study was approved by the IRB (No. B-2109-707-303) and registered on clinicaltrials.gov (ID: NCT05149976).
MeSH term(s)	Humans ; Male ; Female ; Deglutition Disorders/diagnosis ; Deglutition Disorders/etiology ; Prospective Studies ; Respiratory Aspiration/diagnosis ; Respiratory Aspiration/etiology ; Machine Learning ; Algorithms
Language	English
Publishing date	2024-03-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2164377-5
ISSN	1743-0003 ; 1743-0003
ISSN (online)	1743-0003
ISSN	1743-0003
DOI	10.1186/s12984-024-01329-6
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Article: PARP inhibitors, use early in the first-line maintenance therapy setting but with caution.

Giudice, Elena / Kim, Yong Man / Lee, Jung-Min

Annals of translational medicine

2023 Volume 11, Issue 6, Page(s) 272

Language	English
Publishing date	2023-01-19
Publishing country	China
Document type	Editorial ; Comment
ZDB-ID	2893931-1
ISSN	2305-5847 ; 2305-5839
ISSN (online)	2305-5847
ISSN	2305-5839
DOI	10.21037/atm-2022-81
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Article ; Online: Psychometric Properties of the Korean Version of the Environmental Health Literacy Scale.

Kwak, Jung-Min / Kim, Ju-Hee

International journal of environmental research and public health

2022 Volume 19, Issue 7

Abstract: The environmental health literacy (EHL) scale evaluates media-specific and general EHL levels in three domains: knowledge, attitude, and behavior. This study aimed to adapt the EHL scale developed by Lichtveld et al. into the Korean language (K-EHL scale) ...

Abstract	The environmental health literacy (EHL) scale evaluates media-specific and general EHL levels in three domains: knowledge, attitude, and behavior. This study aimed to adapt the EHL scale developed by Lichtveld et al. into the Korean language (K-EHL scale) and to verify its reliability and validity. Survey data was collected from 492 adults (19-65 years) residing in Korea. The study process included translation procedures, content validity verification, pre-testing, the actual survey, and statistical analysis for validation and selection of the final items. The scale-level content validity index was 0.92, and one item was removed. Multiple exploratory factor analyses condensed the K-EHL into 2 factors and 38 items. The "Environmental health knowledge and attitude" factor (14 items) measures information, feelings, and thoughts about environmental health. The "Environmental health behavior" factor (24 items) comprises behaviors responding to environmental health. A construct validity (criterion and discriminant validity) was verified using confirmatory factor analysis for goodness of fit (CFI = 0.901, TLI = 0.863, GFI = 0.923, NFI = 0.862, and RMSEA = 0.08). Internal consistency reliability test results showed a Cronbach's α of 0.81 for the total items. This study is the first to introduce the EHL in Korea, and it also presents a validated evaluation tool. The K-EHL is expected to elucidate EHL levels in Korea. In the future, the EHL scale can be enhanced using this tool.
MeSH term(s)	Environmental Health ; Health Literacy ; Language ; Psychometrics ; Reproducibility of Results ; Republic of Korea ; Surveys and Questionnaires
Language	English
Publishing date	2022-03-29
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph19074079
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Article: The Fracture Risk Assessment Tool Probability and Trabecular Bone Score Mediate the Relationship between Sphingosine 1-phosphate Levels and Fracture Risk.

Lee, Seung Hun / Kim, Jae Seung / Koh, Jung-Min

Journal of bone metabolism

2023 Volume 30, Issue 4, Page(s) 355–364

Abstract: Background: The sphingosine 1-phosphate (S1P) concentration is a potential biomarker of osteoporotic fracture and is associated with both the fracture risk assessment tool (FRAX) probability and trabecular bone score (TBS), which are well-known ... ...

Abstract	Background: The sphingosine 1-phosphate (S1P) concentration is a potential biomarker of osteoporotic fracture and is associated with both the fracture risk assessment tool (FRAX) probability and trabecular bone score (TBS), which are well-known predictors of fracture. We sought to estimate the effect of the S1P concentration on fracture risk using the FRAX probability and TBS as mediators. Methods: Plasma S1P concentrations, FRAX variables, and TBSs were measured in 66 postmenopausal women with fractures and 273 postmenopausal women without fractures. Associations between S1P concentration, FRAX probability, TBS, and fracture risk were analyzed using correlation, logistic regression, and mediation analyses. Results: Subjects in the highest S1P concentration tertile had a higher fracture risk (odds ratio [OR], 5.09; 95% confidence interval [CI], 2.22-11.67) than those in the lowest S1P concentration tertile before adjustment. Subjects in the highest FRAX probability tertile had a higher fracture risk (OR, 14.59; 95% CI, 5.01-42.53) than those in the lowest FRAX probability tertile before adjustment. Subjects in the lowest TBS tertile had a higher fracture risk (OR, 4.76; 95% CI, 2.28-9.93) than those in the highest TBS tertile before adjustment. After adjustment for FRAX probability and TBS, the highest S1P concentration tertile was still associated with a higher fracture risk (OR, 3.13; 95% CI, 1.28-7.66). The FRAX probability and TBS accounted for 32.6% and 21.7%, respectively, of the relationship between the S1P concentration and fracture risk. Conclusions: The relationship between the circulating S1P concentration and fracture risk was partly mediated by the FRAX probability, bone microarchitecture, and other factors.
Language	English
Publishing date	2023-11-30
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2765291-9
ISSN	2287-7029 ; 2287-6375
ISSN (online)	2287-7029
ISSN	2287-6375
DOI	10.11005/jbm.2023.30.4.355
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Article: Smart cities and disaster risk reduction in South Korea by 2022: The case of daegu.

Kim, Jaekyoung / Lee, Jung-Min / Kang, Junsuk

Heliyon

2023 Volume 9, Issue 8, Page(s) e18794

Abstract: Smart cities have been introduced globally. It involves technical development and economic, social, and environmental objectives. In response to the Fourth Industrial Revolution (Industry 4.0) and global trends, Korea has prepared legal and institutional ...

Abstract	Smart cities have been introduced globally. It involves technical development and economic, social, and environmental objectives. In response to the Fourth Industrial Revolution (Industry 4.0) and global trends, Korea has prepared legal and institutional measures for smart city composition. This study reviewed the importance of key documents and agreements in Daegu Metropolitan City to reduce disaster risk for the vulnerable in the context of smart cities. 25 research studies were critically and systematically reviewed from the perspective of disaster risk reduction in smart cities. In its disaster safety areas, Daegu Metropolitan City aims to reduce property damage and casualties that may occur because of physical events such as collapse, water-related disasters, and heatwaves by up to 20%. Smart disaster mitigation involves data collection, sharing, and propagation. The entire process is handled on a safety platform called Data hub. According to the Daegu Metropolitan City government, solving social problems and managing disasters is key to a smart city, and it is striving to improve the efficiency of other cities. However, Daegu has limitations because it is a service-oriented smart city, and it is necessary to engage citizens to participate, raise awareness of the smart city, and educate them on the platform. The study results recommend future research that focus on disaster risk reduction and resilience in smart cities worldwide.
Language	English
Publishing date	2023-07-29
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e18794
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Article ; Online: The Effectiveness of Ultrasound Deep Heat Therapy for Adhesive Capsulitis: A Systematic Review and Meta-Analysis.

Sung, Jung-Ha / Lee, Jung-Min / Kim, Jung-Hyun

International journal of environmental research and public health

2022 Volume 19, Issue 3

Abstract: Background: Adhesive capsulitis occurs with synovial inflammation and capsular fibrosis in the glenohumeral joint, leading to restriction of joint motion and pain. Heat therapy modalities, which aim at modifying dense collagenous tissues are commonly ... ...

Abstract	Background: Adhesive capsulitis occurs with synovial inflammation and capsular fibrosis in the glenohumeral joint, leading to restriction of joint motion and pain. Heat therapy modalities, which aim at modifying dense collagenous tissues are commonly practiced interventions for patients with adhesive capsulitis; however, the effectiveness of ultrasound deep heat therapy (UST) on adhesive capsulitis is still unclear. Purpose: This systematic review and meta-analysis study was conducted to evaluate the effects of UST on the improvement of pain and glenohumeral joint function in adhesive capsulitis compared to (1) no treatment or placebo, and (2) any other therapeutic modalities. Methods: A literature search was carried out in January 2021 in Cochrane Central Register of Controlled Trials, PubMed, EMBASE, PEDro, Web of Science, and Google Scholar. The main outcomes of interest were self-reported pain scores, disability scores, and the range of motion. This study was conducted based on the guidelines of the PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analyses) protocols, using random-effects models. Results: Seven studies were included in the systematic review with five studies forming the basis for meta-analyses. The effects of UST in patients with adhesive capsulitis were compared with placebo, shockwave therapy, corticosteroid injection, platelet-rich plasma injection, or cryotherapy. The results indicated that UST significantly improved pain scores when performed together with exercise and/or other physical modalities compared to placebo; however, whether UST provides benefits for the improvement of disability and/or the range of motion was uncertain in the present results. Conclusions: The present findings suggest that UST as a co-intervention combined with other physical modalities is an effective means of improving the overall pain in patients with adhesive capsulitis.
MeSH term(s)	Bursitis/therapy ; Hot Temperature ; Humans ; Range of Motion, Articular ; Shoulder Joint ; Shoulder Pain/therapy ; Treatment Outcome
Language	English
Publishing date	2022-02-07
Publishing country	Switzerland
Document type	Journal Article ; Meta-Analysis ; Review ; Systematic Review
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph19031859
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Article ; Online: Highly chromophoric fluorescent-labeled methionyl-initiator tRNAs applicable in living cells.

Kim, Jung Min / Jung, Jinho

Biotechnology journal

2024 Volume 19, Issue 3, Page(s) e2300579

Abstract: Fluorescent initiator tRNAs (tRNAi) play a crucial role in studying protein synthesis, yet generating highly fluorescent tRNAi complexes remains challenging. We present an optimized strategy to effectively generate highly fluorescent initiator-tRNA ... ...

Abstract	Fluorescent initiator tRNAs (tRNAi) play a crucial role in studying protein synthesis, yet generating highly fluorescent tRNAi complexes remains challenging. We present an optimized strategy to effectively generate highly fluorescent initiator-tRNA complexes in living cells. Our strategy allows the generation of Fluo-Met-tRNAi
MeSH term(s)	RNA, Transfer, Met/chemistry ; RNA, Transfer, Met/genetics ; RNA, Transfer, Met/metabolism ; Protein Biosynthesis ; Methionine/genetics ; Methionine/metabolism ; Coloring Agents ; Racemethionine/metabolism
Chemical Substances	RNA, Transfer, Met ; Methionine (AE28F7PNPL) ; Coloring Agents ; Racemethionine (73JWT2K6T3)
Language	English
Publishing date	2024-03-17
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2221885-3
ISSN	1860-7314 ; 1860-6768
ISSN (online)	1860-7314
ISSN	1860-6768
DOI	10.1002/biot.202300579
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Article ; Online: Cytosolic zinc mediates the cytotoxicity of thiol-reactive electrophiles in rat vascular smooth muscle cells.

Park, Jung-Min / Park, Suin / Seo, Yoon-Seok / Kim, Jae-Hyeong / Lee, Moo-Yeol

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

2024 Volume 185, Page(s) 114446

Abstract: The aberrant increase or dysregulation of cytosolic ... ...

Abstract	The aberrant increase or dysregulation of cytosolic Zn
MeSH term(s)	Rats ; Animals ; Sulfhydryl Compounds/metabolism ; Zinc/metabolism ; Muscle, Smooth, Vascular/metabolism ; Cytosol ; Acids/metabolism ; Ethylenediamines
Chemical Substances	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine (R9PTU1U29I) ; Sulfhydryl Compounds ; Zinc (J41CSQ7QDS) ; Acids ; Ethylenediamines
Language	English
Publishing date	2024-01-18
Publishing country	England
Document type	Journal Article
ZDB-ID	782617-5
ISSN	1873-6351 ; 0278-6915
ISSN (online)	1873-6351
ISSN	0278-6915
DOI	10.1016/j.fct.2024.114446
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Article ; Online: The Effectiveness of Ultrasound Deep Heat Therapy for Adhesive Capsulitis

Jung-Ha Sung / Jung-Min Lee / Jung-Hyun Kim

International Journal of Environmental Research and Public Health, Vol 19, Iss 1859, p

A Systematic Review and Meta-Analysis

2022 Volume 1859

Abstract	Background: Adhesive capsulitis occurs with synovial inflammation and capsular fibrosis in the glenohumeral joint, leading to restriction of joint motion and pain. Heat therapy modalities, which aim at modifying dense collagenous tissues are commonly practiced interventions for patients with adhesive capsulitis; however, the effectiveness of ultrasound deep heat therapy (UST) on adhesive capsulitis is still unclear. Purpose: This systematic review and meta-analysis study was conducted to evaluate the effects of UST on the improvement of pain and glenohumeral joint function in adhesive capsulitis compared to (1) no treatment or placebo, and (2) any other therapeutic modalities. Methods: A literature search was carried out in January 2021 in Cochrane Central Register of Controlled Trials, PubMed, EMBASE, PEDro, Web of Science, and Google Scholar. The main outcomes of interest were self-reported pain scores, disability scores, and the range of motion. This study was conducted based on the guidelines of the PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analyses) protocols, using random-effects models. Results: Seven studies were included in the systematic review with five studies forming the basis for meta-analyses. The effects of UST in patients with adhesive capsulitis were compared with placebo, shockwave therapy, corticosteroid injection, platelet-rich plasma injection, or cryotherapy. The results indicated that UST significantly improved pain scores when performed together with exercise and/or other physical modalities compared to placebo; however, whether UST provides benefits for the improvement of disability and/or the range of motion was uncertain in the present results. Conclusions: The present findings suggest that UST as a co-intervention combined with other physical modalities is an effective means of improving the overall pain in patients with adhesive capsulitis.
Keywords	adhesive capsulitis ; frozen shoulder ; ultrasound therapy ; deep heat therapy ; systematic review ; meta-analysis ; Medicine ; R
Subject code	796
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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