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Article: Horses, pigeons, and the therapy of conversion: a psychological reading of Jonathan Edwards's theology.

Williams, D R

2001 Volume 74, Issue 4, Page(s) 337–352

MeSH term(s)	History, Modern 1601- ; Psychology/history ; United States
Language	English
Publishing date	2001-09-17
Publishing country	United States
Document type	Biography ; Historical Article ; Journal Article
ZDB-ID	2051494-3
ISSN	1475-4517 ; 0017-8160
ISSN (online)	1475-4517
ISSN	0017-8160
DOI	10.1017/s0017816000030108
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Article ; Online: Mineralocorticoid receptor and aldosterone: Interaction between NR3C2 genetic variants, sex and age in a mixed cohort.

Heydarpour, Mahyar / Parksook, Wasita W / Pojoga, Luminita H / Williams, Gordon H / Williams, Jonathan S

The Journal of clinical endocrinology and metabolism

2024

Abstract: ... dysregulation in hypertension development. This insight advances our comprehension of hypertension's ...

Abstract	Context: Hypertension, a prevalent cardiovascular risk, often involves dysregulated aldosterone and its interaction with the mineralocorticoid receptor (MR). Experimental designs in animal models and human cohorts have demonstrated a sex and age dependency of aldosterone secretion that expands our pathophysiologic understanding. Objective: This study explores the genetic variation of NR3C2, which encodes MR, in relation to aldosterone, considering age, sex, and race. Methods: Incorporating 720 Caucasians and 145 Africans from the HyperPATH cohort, we investigated the impact of rs4835490, a single nucleotide risk allele variant, on aldosterone levels and vasculature. Results: Notably, a significant association between rs4835490 and plasma aldosterone under liberal salt conditions emerged in individuals of European ancestry (P=0.0002). Homozygous carriers of the risk A allele exhibited elevated plasma aldosterone levels (AA=8.1±0.9 vs GG=4.9±0.5 ng/dl). Additionally, aldosterone activation through posture (P=0.025) and urinary excretion (P=0.0122) showed notable associations. Moreover, genetic interactions with race, sex, and age were observed. Caucasian females under 50 years displayed higher plasma aldosterone, urine aldosterone, and posture aldosterone with the AA genotype compared to females over 50 years, suggesting a potential connection with menopausal or estrogen influences. Interestingly, such age-dependent interactions were absent in the African cohort. Conclusions: our study highlights the significance of NR3C2 genetic variation and its interplay with age, sex, and race in aldosterone activation. The findings point towards an estrogen-modulating effect on MR activation, particularly in women underlining the role of aldosterone dysregulation in hypertension development. This insight advances our comprehension of hypertension's complexities and opens avenues for personalized interventions.
Language	English
Publishing date	2024-03-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	3029-6
ISSN	1945-7197 ; 0021-972X
ISSN (online)	1945-7197
ISSN	0021-972X
DOI	10.1210/clinem/dgae127
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Uh III Zs.134: Show issues

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Article ; Online: Blood Component Requirements and Erythrocyte Transfusion and Mortality Related to Hemoglobin Deficit in Phase III Trial of Hemoglobin-Based Oxygen Carrier: HBOC-201.

Jahr, Jonathan S / Williams, John P

American journal of therapeutics

2022 Volume 29, Issue 3, Page(s) e279–e286

Abstract: Background: Hemoglobin-based oxygen carriers (HBOCs) may cause coagulopathy, changes in total hemoglobin (THb), and affect mortality. Low total hemoglobin concentrations [THb] during hemorrhage may worsen outcomes.: Study question: The database of ... ...

Abstract	Background: Hemoglobin-based oxygen carriers (HBOCs) may cause coagulopathy, changes in total hemoglobin (THb), and affect mortality. Low total hemoglobin concentrations [THb] during hemorrhage may worsen outcomes. Study question: The database of the Hemopure HEM-0115 phase III trial was queried to determine the use of platelets, plasma, or cryoprecipitate and compare transfusion requirements and coagulation studies between patients randomized to erythrocyte transfusion or HBOC-201 infusion. Modeling of hemoglobin (Hb) changes produced by HBOC-201, erythrocyte, and blood product administration were related to [THb], coagulopathy, and mortality. Data sources: Hemopure HEM-0115 phase III trial database. Study design: Retrospective and Novel Hemoglobin Deficit Formulas Tested Against Existing Database. Results: The HBOC-201 database (n = 688) demonstrated less than 6% of subjects in both groups were administered non-Hb containing blood products (fresh frozen plasma, platelets, or cryoprecipitate) and low rates of coagulopathies in both erythrocyte and HBOC-201 arms. There were no differences in mortality in elective orthopedic patients administered up to 10 bags HBOC-201 (equivalent to 3 units erythrocytes). Low total [Hb] and lack of adequate oxygen carrying capacity was found to be an independent predictor of morbidity/mortality. Conclusions: The elective use of HBOC-201 for orthopedics versus erythrocytes demonstrated low incidence of blood product requirements in both cohorts and no differences in mortality up to the HBOC-201 equivalent of 3 units erythrocytes. High total Hb may be important to maintain in acute hemorrhage and [Hb] deficit, whereas later in recovery might not be as crucial. Future trauma trials may benefit from the use of HBOC-201 containing 13 g/dL in prehospital management, when erythrocytes are commonly not available.
MeSH term(s)	Blood Substitutes/adverse effects ; Erythrocyte Transfusion ; Hemoglobins/analysis ; Hemorrhage/epidemiology ; Humans ; Oxygen ; Retrospective Studies
Chemical Substances	Blood Substitutes ; Hemoglobins ; HBOC 201 (1XQE66T19H) ; Oxygen (S88TT14065)
Language	English
Publishing date	2022-04-14
Publishing country	United States
Document type	Clinical Trial, Phase III ; Journal Article ; Randomized Controlled Trial
ZDB-ID	1280786-2
ISSN	1536-3686 ; 1075-2765
ISSN (online)	1536-3686
ISSN	1075-2765
DOI	10.1097/MJT.0000000000001494
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Zs.A 4351: Show issues

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Article ; Online: Can a Purposeful Walk Intervention with a Distance Goal Using an Activity Monitor Improve Individuals' Daily Activity and Function Post Total Hip Replacement Surgery. A Randomized Pilot Trial.

Bahadori, Shayan / Williams, Jonathan Mark / Collard, Sarah / Swain, Ian

Cyborg and bionic systems (Washington, D.C.)

2023 Volume 4, Page(s) 69

Abstract: ... compared to those in the control group. The Cohen's effect sizes were larger for the changes in the gait ...

Abstract	Individuals have increasingly high expectations of return to activity following total hip replacement (THR) surgery. The current literature demonstrates marked improvements in pain following THR. However, there is limited evidence showing objective improvement in daily activity. This randomized pilot trial aimed to determine the effect of an intervention where outdoor walking distance is used as a goal to increase daily activity of older adults using a commercial activity monitor at 3 to 6 months post THR. Findings suggested that the participants in the intervention group had higher activity levels after THR, compared to those in the control group. The Cohen's effect sizes were larger for the changes in the gait, Hip Disability and Osteoarthritis Outcome Score, and Psychosocial Impact of Assistive Devices Scale data in the intervention group in contrast to the control group. However, further research with a larger sample size is required to provide tangible evidence on the significance of the effect of the purposeful walk compared to step count.
Language	English
Publishing date	2023-11-30
Publishing country	United States
Document type	Journal Article
ISSN	2692-7632
ISSN (online)	2692-7632
DOI	10.34133/cbsystems.0069
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Article ; Online: The reproduction number and its probability distribution for stochastic viral dynamics.

Williams, Bevelynn / Carruthers, Jonathan / Gillard, Joseph J / Lythe, Grant / Perelson, Alan S / Ribeiro, Ruy M / Molina-París, Carmen / López-García, Martín

Journal of the Royal Society, Interface

2024 Volume 21, Issue 210, Page(s) 20230400

Abstract: We consider stochastic models of individual infected cells. The reproduction number, ...

Abstract	We consider stochastic models of individual infected cells. The reproduction number,
MeSH term(s)	Probability ; Reproduction ; Virion
Language	English
Publishing date	2024-01-24
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2156283-0
ISSN	1742-5662 ; 1742-5689
ISSN (online)	1742-5662
ISSN	1742-5689
DOI	10.1098/rsif.2023.0400
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Article: Continuous-wave GaAs/AlGaAs quantum cascade laser at 5.7 THz.

Shahili, Mohammad / Addamane, Sadhvikas J / Kim, Anthony D / Curwen, Christopher A / Kawamura, Jonathan H / Williams, Benjamin S

Nanophotonics

2024 Volume 13, Issue 10, Page(s) 1735–1743

Abstract: Design strategies for improving terahertz (THz) quantum cascade lasers (QCLs) in the 5-6 THz range are investigated numerically and experimentally, with the goal of overcoming the degradation in performance that occurs as the laser frequency approaches ... ...

Abstract	Design strategies for improving terahertz (THz) quantum cascade lasers (QCLs) in the 5-6 THz range are investigated numerically and experimentally, with the goal of overcoming the degradation in performance that occurs as the laser frequency approaches the
Language	English
Publishing date	2024-01-16
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2674162-3
ISSN	2192-8614 ; 2192-8606
ISSN (online)	2192-8614
ISSN	2192-8606
DOI	10.1515/nanoph-2023-0726
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Article ; Online: Surgical management of the orbit in thyroid eye disease: lateral orbital decompression.

Williams, Jonathan S / Sahu, Priya D

Current opinion in otolaryngology & head and neck surgery

2021 Volume 29, Issue 4, Page(s) 289–293

Abstract: Purpose of review: Lateral orbital wall decompression is one of many well established techniques available to surgeons in management of patients with clinically significant thyroid eye disease (TED). Several different surgical approaches have been ... ...

Abstract	Purpose of review: Lateral orbital wall decompression is one of many well established techniques available to surgeons in management of patients with clinically significant thyroid eye disease (TED). Several different surgical approaches have been described in the literature and are reviewed herein. Recent findings: Lateral orbital wall decompression remains a popular technique for surgical management of TED, with a recent American Society of Ophthalmic Plastic and Reconstructive Surgery survey showing that 22.6% of respondents preferred a single-wall procedure, with 36.8% of that subset preferring lateral wall decompression alone. Surgical techniques for lateral orbital wall decompression differ based on several steps, such as the incisional approach, whether to take an ab-interno versus ab-externo approach, and whether to remove orbital fat to achieve further decompression. In addition, technological advances have produced an array of tools available to the orbital surgeon to achieve efficient and accurate bone removal. Summary: Lateral orbital wall decompression for TED, despite being an older technique, remains a popular and well established procedure for orbital decompression. Though no randomized controlled clinical trial supports one decompression technique over another for TED, lateral orbital wall decompression offers many benefits such as its ease of access and visualization of the orbital space.
MeSH term(s)	Decompression, Surgical ; Graves Ophthalmopathy/surgery ; Humans ; Orbit/surgery
Language	English
Publishing date	2021-06-28
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1232518-1
ISSN	1531-6998 ; 1068-9508
ISSN (online)	1531-6998
ISSN	1068-9508
DOI	10.1097/MOO.0000000000000728
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Zs.A 4814: Show issues

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Article ; Online: Role of Raptor Gene Variants in Hypertension: Influence on Blood Pressure Independent of Salt Intake in White Population.

Aljaibeji, Hayat / Heydarpour, Mahyar / Stanton, Ana Maria / Williams, Jonathan S / Pojoga, Luminita H / Romero, Jose R / Williams, Gordon H

Hypertension (Dallas, Tex. : 1979)

2024 Volume 81, Issue 5, Page(s) 1167–1177

Abstract: Background: The mTOR (mechanistic target of rapamycin) is an essential regulator of fundamental biological processes. mTOR forms 2 distinct complexes, mTORC1 (mTOR complex 1) when it binds with RAPTOR (Regulatory-associated Protein of mTOR) and mTORC2 ( ... ...

Abstract	Background: The mTOR (mechanistic target of rapamycin) is an essential regulator of fundamental biological processes. mTOR forms 2 distinct complexes, mTORC1 (mTOR complex 1) when it binds with RAPTOR (Regulatory-associated Protein of mTOR) and mTORC2 (mTOR complex 2) when it associates with RICTOR (Rapamycin-insesitive companion of mTOR). Due to the previous link between the mTOR pathway, aldosterone, and blood pressure (BP), we anticipated that variants in the mTOR complex might be associated with salt-sensitive BP. Methods: BP and other parameters were assessed after a one-week liberal Na Results: The analysis revealed a significant association between a single nucleotide variants within the Conclusions: The
MeSH term(s)	Female ; Humans ; Male ; Blood Pressure ; Carrier Proteins/genetics ; Hypertension/genetics ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Mechanistic Target of Rapamycin Complex 2/metabolism ; Nucleotides/metabolism ; Rapamycin-Insensitive Companion of mTOR Protein/metabolism ; Regulatory-Associated Protein of mTOR/genetics ; Regulatory-Associated Protein of mTOR/metabolism ; Sirolimus ; Sodium Chloride, Dietary/metabolism ; TOR Serine-Threonine Kinases/metabolism ; White People
Chemical Substances	Carrier Proteins ; Mechanistic Target of Rapamycin Complex 1 (EC 2.7.11.1) ; Mechanistic Target of Rapamycin Complex 2 (EC 2.7.11.1) ; Nucleotides ; Rapamycin-Insensitive Companion of mTOR Protein ; Regulatory-Associated Protein of mTOR ; Sirolimus (W36ZG6FT64) ; Sodium Chloride, Dietary ; TOR Serine-Threonine Kinases (EC 2.7.11.1) ; RPTOR protein, human
Language	English
Publishing date	2024-03-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	423736-5
ISSN	1524-4563 ; 0194-911X ; 0362-4323
ISSN (online)	1524-4563
ISSN	0194-911X ; 0362-4323
DOI	10.1161/HYPERTENSIONAHA.123.22273
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Article ; Online: Exploring the application of machine learning to expert evaluation of research impact.

Williams, Kate / Michalska, Sandra / Cohen, Eliel / Szomszor, Martin / Grant, Jonathan

PloS one

2023 Volume 18, Issue 8, Page(s) e0288469

Abstract: ... case study data from the UK's Research Excellence Framework (2014), we trained five machine learning models ...

Abstract	The objective of this study is to investigate the application of machine learning techniques to the large-scale human expert evaluation of the impact of academic research. Using publicly available impact case study data from the UK's Research Excellence Framework (2014), we trained five machine learning models on a range of qualitative and quantitative features, including institution, discipline, narrative style (explicit and implicit), and bibliometric and policy indicators. Our work makes two key contributions. Based on the accuracy metric in predicting high- and low-scoring impact case studies, it shows that machine learning models are able to process information to make decisions that resemble those of expert evaluators. It also provides insights into the characteristics of impact case studies that would be favoured if a machine learning approach was applied for their automated assessment. The results of the experiments showed strong influence of institutional context, selected metrics of narrative style, as well as the uptake of research by policy and academic audiences. Overall, the study demonstrates promise for a shift from descriptive to predictive analysis, but suggests caution around the use of machine learning for the assessment of impact case studies.
MeSH term(s)	Humans ; Machine Learning ; Health Facilities ; Narration
Language	English
Publishing date	2023-08-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0288469
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Article ; Online: CACNA1D

Stanton, Ana Maria / Heydarpour, Mahyar / Williams, Jonathan S / Williams, Gordon H / Adler, Gail K

Hypertension (Dallas, Tex. : 1979)

2023 Volume 80, Issue 12, Page(s) 2665–2673

Abstract: Background: Disease-causing mutations in : Methods: Data were obtained from the HyperPATH (International Hypertension Pathotypes) cohort, where participants completed a cross-over intervention of liberal and restricted sodium diets. Multi-Ethnic ... ...

Abstract	Background: Disease-causing mutations in Methods: Data were obtained from the HyperPATH (International Hypertension Pathotypes) cohort, where participants completed a cross-over intervention of liberal and restricted sodium diets. Multi-Ethnic Genotyping Array identified 104 Results: In the total population and hypertensives, but not normotensives, risk allele carriers (CC, GC), as compared with nonrisk allele homozygotes (GG), exhibited higher salt sensitivity of BP and, on liberal sodium diet, higher systolic BP, lower baseline and angiotensin II-stimulated aldosterone, and lower plasma renin activity. On restricted sodium diet, BP was similar across genotypes, suggesting sodium restriction corrected/neutralized the genotype effect on BP. Because increased aldosterone did not seem to drive the increased salt sensitivity of BP and increased BP on liberal sodium diet, we assessed renal plasma flow. Renal plasma flow increase from restricted to liberal sodium diets was blunted in risk allele homozygotes in the total population and in hypertensives. A replication study in another cohort HyperPATH B (International Hypertension Pathotypes Cohort B) confirmed BP-genotype associations. Conclusions: CACNA1D
MeSH term(s)	Female ; Humans ; Male ; Aldosterone ; Blood Pressure/genetics ; Calcium Channels, L-Type/genetics ; Diet, Sodium-Restricted ; Hypertension ; Polymorphism, Single Nucleotide ; Renin ; Sodium Chloride, Dietary/adverse effects ; White People/genetics
Chemical Substances	Aldosterone (4964P6T9RB) ; CACNA1D protein, human ; Calcium Channels, L-Type ; Renin (EC 3.4.23.15) ; Sodium Chloride, Dietary
Language	English
Publishing date	2023-10-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	423736-5
ISSN	1524-4563 ; 0194-911X ; 0362-4323
ISSN (online)	1524-4563
ISSN	0194-911X ; 0362-4323
DOI	10.1161/HYPERTENSIONAHA.123.21229
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