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  1. Article ; Online: Stabbed to the back! A C-clamp technique used to stabilize a C7 sagittal split fracture.

    Brembilla, Carlo / Cracchiolo, Giorgio / Fanti, Andrea / Bernucci, Claudio

    British journal of neurosurgery

    2022  , Page(s) 1–5

    Abstract: The management of stab wounds to the back is controversial. This case report entails a 17-year-old female that was assaulted from behind and stabbed to the lower cervical region with a knife. The patient reported mild lower limb hypoesthesia. ... ...

    Abstract The management of stab wounds to the back is controversial. This case report entails a 17-year-old female that was assaulted from behind and stabbed to the lower cervical region with a knife. The patient reported mild lower limb hypoesthesia. Neuroradiological exams showed a sagittal split fracture of C7, with a contextual split lesion of the spinal cord. The patient underwent surgical intervention for the stabilization of the sagittal split fracture via the C-clamp technique and dura mater plastic. In the current literature, the use of the C-clamp technique for the stabilization of a lower cervical fracture has never been reported.
    Language English
    Publishing date 2022-12-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 639029-8
    ISSN 1360-046X ; 0268-8697
    ISSN (online) 1360-046X
    ISSN 0268-8697
    DOI 10.1080/02688697.2022.2162851
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    Zs.A 2210: Show issues Location:
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  2. Article ; Online: Contribution of keratinocytes to dermal fibrosis.

    Russo, Barbara / Brembilla, Nicolò C / Chizzolini, Carlo

    Current opinion in rheumatology

    2022  Volume 34, Issue 6, Page(s) 337–342

    Abstract: Purpose of review: The cellular pathogenesis of fibrotic disorders including systemic sclerosis (SSc) remains largely speculative. Currently, the altered function of endothelial cells and fibroblasts under the influence of an inappropriate immune ... ...

    Abstract Purpose of review: The cellular pathogenesis of fibrotic disorders including systemic sclerosis (SSc) remains largely speculative. Currently, the altered function of endothelial cells and fibroblasts under the influence of an inappropriate immune response are considered central pathogenic events in SSc. Adding to this complexity, novel evidence here reviewed suggests that keratinocytes may concur in the development of skin fibrosis.
    Recent findings: Epidermal equivalents (EE) generated from primary SSc keratinocytes display a distinct gene expression program when compared to healthy donor (HD) EE. SSc-EE, among others, exhibited enhanced oxidative and metabolic response pathways. Immunohistochemical studies demonstrated similarities between SSc-EE and SSc epidermis including altered keratinocyte differentiation, enhanced expression of activation markers, and reduced rate of basal keratinocytes proliferation. SSc-EE supernatants more than HD-EE modified the inflammatory and extracellular matrix deposition/resorption program of dermal fibroblasts. Further evidence indicated that the relative lack rather than the excess of interleukin-25 in keratinocytes may contribute to enhanced dermal fibrotic changes. Overall, these data support keratinocyte-intrinsic SSc-related modifications.
    Summary: Improved methods for engineering epidermal and skin equivalents are helping to address the question whether keratinocyte alterations in SSc are primary and capable to dysregulate dermal homeostasis or secondary following dermal fibrotic changes.
    MeSH term(s) Endothelial Cells/metabolism ; Fibroblasts/pathology ; Fibrosis ; Humans ; Interleukin-17/metabolism ; Keratinocytes/metabolism ; Keratinocytes/pathology ; Scleroderma, Systemic/metabolism ; Skin/pathology
    Chemical Substances Interleukin-17
    Language English
    Publishing date 2022-08-16
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1045317-9
    ISSN 1531-6963 ; 1040-8711
    ISSN (online) 1531-6963
    ISSN 1040-8711
    DOI 10.1097/BOR.0000000000000895
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    Zs.A 3028: Show issues Location:
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  3. Article ; Online: Current Concepts on the Pathogenesis of Systemic Sclerosis.

    Truchetet, Marie Elise / Brembilla, Nicolò C / Chizzolini, Carlo

    Clinical reviews in allergy & immunology

    2021  Volume 64, Issue 3, Page(s) 262–283

    Abstract: From the clinical standpoint, systemic sclerosis (SSc) is characterized by skin and internal organ fibrosis, diffuse fibroproliferative vascular modifications, and autoimmunity. Clinical presentation and course are highly heterogenous and life expectancy ...

    Abstract From the clinical standpoint, systemic sclerosis (SSc) is characterized by skin and internal organ fibrosis, diffuse fibroproliferative vascular modifications, and autoimmunity. Clinical presentation and course are highly heterogenous and life expectancy variably affected mostly dependent on lung and heart involvement. SSc touches more women than men with differences in disease severity and environmental exposure. Pathogenetic events originate from altered homeostasis favored by genetic predisposition, environmental cues and a variety of endogenous and exogenous triggers. Epigenetic modifications modulate SSc pathogenesis which strikingly associate profound immune-inflammatory dysregulation, abnormal endothelial cell behavior, and cell trans-differentiation into myofibroblasts. SSc myofibroblasts show enhanced survival and enhanced extracellular matrix deposition presenting altered structure and altered physicochemical properties. Additional cell types of likely pathogenic importance are pericytes, platelets, and keratinocytes in conjunction with their relationship with vessel wall cells and fibroblasts. In SSc, the profibrotic milieu is favored by cell signaling initiated in the one hand by transforming growth factor-beta and related cytokines and in the other hand by innate and adaptive type 2 immune responses. Radical oxygen species and invariant receptors sensing danger participate to altered cell behavior. Conventional and SSc-specific T cell subsets modulate both fibroblasts as well as endothelial cell dysfunction. Beside autoantibodies directed against ubiquitous antigens important for enhanced clinical classification, antigen-specific agonistic autoantibodies may have a pathogenic role. Recent studies based on single-cell RNAseq and multi-omics approaches are revealing unforeseen heterogeneity in SSc cell differentiation and functional states. Advances in system biology applied to the wealth of data generated by unbiased screening are allowing to subgroup patients based on distinct pathogenic mechanisms. Deciphering heterogeneity in pathogenic mechanisms will pave the way to highly needed personalized therapeutic approaches.
    MeSH term(s) Male ; Humans ; Female ; Scleroderma, Systemic/etiology ; Autoantibodies ; Fibrosis ; Autoimmunity ; Cytokines ; Skin/pathology
    Chemical Substances Autoantibodies ; Cytokines
    Language English
    Publishing date 2021-09-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1239045-8
    ISSN 1559-0267 ; 1080-0549
    ISSN (online) 1559-0267
    ISSN 1080-0549
    DOI 10.1007/s12016-021-08889-8
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    Zs.A 1844: Show issues Location:
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  4. Article ; Online: Interplay Between Keratinocytes and Fibroblasts: A Systematic Review Providing a New Angle for Understanding Skin Fibrotic Disorders.

    Russo, Barbara / Brembilla, Nicolò C / Chizzolini, Carlo

    Frontiers in immunology

    2020  Volume 11, Page(s) 648

    Abstract: Background/Objective: ...

    Abstract Background/Objective:
    MeSH term(s) Animals ; Cicatrix, Hypertrophic/pathology ; Fibroblasts/physiology ; Fibrosis ; Humans ; Keloid/pathology ; Keratinocytes/physiology ; Scleroderma, Systemic/pathology ; Skin/pathology ; Wound Healing
    Language English
    Publishing date 2020-05-06
    Publishing country Switzerland
    Document type Research Support, Non-U.S. Gov't ; Systematic Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.00648
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  5. Article ; Online: Effects of the COVID-19 Outbreak in Northern Italy: Perspectives from the Bergamo Neurosurgery Department.

    Bernucci, Claudio / Brembilla, Carlo / Veiceschi, Pierlorenzo

    World neurosurgery

    2020  Volume 137, Page(s) 465–468.e1

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Elective Surgical Procedures ; Emergency Service, Hospital ; Humans ; Intensive Care Units ; Italy/epidemiology ; Neurosurgery ; Pandemics/prevention & control ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; SARS-CoV-2 ; Surgery Department, Hospital/organization & administration
    Keywords covid19
    Language English
    Publishing date 2020-04-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2020.03.179
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    Zs.A 1159: Show issues Location:
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  7. Article ; Online: Effects of the COVID-19 Outbreak in Northern Italy

    Bernucci, Claudio / Brembilla, Carlo / Veiceschi, Pierlorenzo

    World Neurosurgery

    Perspectives from the Bergamo Neurosurgery Department

    2020  Volume 137, Page(s) 465–468.e1

    Keywords Surgery ; Clinical Neurology ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2020.03.179
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  8. Article ; Online: The effectiveness of short hybrid stabilization with sublaminar bands and transpedicular screws in the treatment of thoracolumbar spine fractures.

    Brembilla, Carlo / Fanti, Andrea / Rampini, Angela D / Dorelli, Gianluigi / Sicignano, Angelo M / Cracchiolo, Giorgio / Bernucci, Claudio

    Journal of neurosurgical sciences

    2022  

    Abstract: Background: Long constructs have always been widely recommended for the treatment of thoracolumbar fractures, due to their biomechanical stability and minimal postoperative loss of correction. However, short constructs have significant advantages, since ...

    Abstract Background: Long constructs have always been widely recommended for the treatment of thoracolumbar fractures, due to their biomechanical stability and minimal postoperative loss of correction. However, short constructs have significant advantages, since they enable for better postoperative lumbar mobility and reduce the risk of adjacent segment degeneration. The purpose of this study is to evaluate the safety and efficacy of hybrid screw/sublaminar bands short constructs, used for the treatment of thoracolumbar fractures.
    Methods: From June 2015 until November 2017, 20 consecutive patients (14 male, 6 female) with an average age of 52.9 years, exhibiting at least one traumatic fracture in the thoracolumbar region, were treated with hybrid screw/sublaminar bands short constructs. The data for analysis included: duration of the intervention, intraoperative blood loss, complications, and clinical and radiographic postoperative results, compared with the standard for thoracolumbar fixation.
    Results: The use of this type of construct allowed for simple reduction, stabilization of the fractures, and restoration of the physiological spine curvatures. During the postoperative period none of the patients had neurological worsening. 18 out of 20 patients were followed up for two years. One patient sustained implant failure six months after surgery and underwent a surgical implant revision with traditional long fixation. After two years, stability and fusion were obtained in all patients, along with correct spine alignment.
    Conclusions: Hybrid screw/sublaminar bands short constructs seem to be effective in the treatment of thoracolumbar fractures, providing the same clinical results of the state-of-the-art pedicular screw/rod long constructs, but in addition they allow for better postoperative lumbar mobility and subsequently reduce the risk of adjacent segments degeneration. The results of this clinical case series might support the initiation of prospective randomized trials with more patients, a longer follow-up period, and control groups.
    Language English
    Publishing date 2022-06-28
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 193139-8
    ISSN 1827-1855 ; 0390-5616 ; 0026-4881
    ISSN (online) 1827-1855
    ISSN 0390-5616 ; 0026-4881
    DOI 10.23736/S0390-5616.22.05661-2
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    Uk I Zs.241: Show issues Location:
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  9. Article ; Online: Neurosurgeons on the front line: experience from the center of the storm in Italy.

    Bernucci, Claudio / Fanti, Andrea / Veiceschi, Pierlorenzo / Costi, Emanuele / Sicignano, Angelo Mirco / Brembilla, Carlo

    Neurosurgical focus

    2020  Volume 49, Issue 6, Page(s) E6

    Abstract: In this tumultuous time, the entire world has been shaken up by the COVID-19 outbreak. Italy has had one of the highest infection-related mortality rates. Bergamo, a city in eastern Lombardy, was among the most affected. Here, the authors describe the ... ...

    Abstract In this tumultuous time, the entire world has been shaken up by the COVID-19 outbreak. Italy has had one of the highest infection-related mortality rates. Bergamo, a city in eastern Lombardy, was among the most affected. Here, the authors describe the main healthcare actions taken at their institution to stem the crisis, with particular concern regarding the fate of their neurosurgery department. Among the different topics, the authors particularly focus on the retraining of neurosurgeons, organization of activities, and what should be the role of neurosurgeons during a pandemic.
    MeSH term(s) COVID-19/epidemiology ; COVID-19/therapy ; Hospital Departments/organization & administration ; Humans ; Italy ; Neurosurgery/organization & administration ; SARS-CoV-2
    Language English
    Publishing date 2020-11-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2026589-X
    ISSN 1092-0684 ; 1092-0684
    ISSN (online) 1092-0684
    ISSN 1092-0684
    DOI 10.3171/2020.9.FOCUS20577
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  10. Article ; Online: Letter to the Editor. Sagittal balance in adult spinal deformity.

    Brembilla, Carlo / Lanterna, Luigi Andrea / Costi, Emanuele / Bernucci, Claudio

    Journal of neurosurgery. Spine

    2018  Volume 29, Issue 3, Page(s) 347–348

    MeSH term(s) Adult ; Humans ; Lordosis/surgery ; Neurosurgical Procedures ; Postoperative Complications ; Prospective Studies ; Scoliosis/surgery
    Language English
    Publishing date 2018-06-01
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2158643-3
    ISSN 1547-5646 ; 1547-5654
    ISSN (online) 1547-5646
    ISSN 1547-5654
    DOI 10.3171/2018.4.SPINE18371
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