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  1. Article ; Online: Ocular Sarcoidosis.

    Rosenbaum, James T / Pasadhika, Sirichai

    Clinics in chest medicine

    2023  Volume 45, Issue 1, Page(s) 59–70

    Abstract: Sarcoidosis frequently affects the eye and can do so in many different ways. Sarcoidosis causing uveitis can have distinctive features that facilitate identifying sarcoidosis as the cause of the uveitis. Progress is being made in elucidating ocular ... ...

    Abstract Sarcoidosis frequently affects the eye and can do so in many different ways. Sarcoidosis causing uveitis can have distinctive features that facilitate identifying sarcoidosis as the cause of the uveitis. Progress is being made in elucidating ocular sarcoidosis, as for example, by transcriptomics, genetics, therapy, and imaging.
    MeSH term(s) Humans ; Sarcoidosis/diagnosis ; Sarcoidosis/therapy ; Sarcoidosis/complications ; Uveitis/diagnosis ; Uveitis/etiology ; Uveitis/therapy
    Language English
    Publishing date 2023-09-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 447455-7
    ISSN 1557-8216 ; 0272-5231
    ISSN (online) 1557-8216
    ISSN 0272-5231
    DOI 10.1016/j.ccm.2023.08.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The NLRP3 Conundrum.

    Rosenbaum, James T / Gill, Tejpal / Martin, Tammy M

    Arthritis & rheumatology (Hoboken, N.J.)

    2023  Volume 75, Issue 5, Page(s) 661–663

    MeSH term(s) Humans ; NLR Family, Pyrin Domain-Containing 3 Protein ; Inflammasomes ; Inflammation
    Chemical Substances NLR Family, Pyrin Domain-Containing 3 Protein ; Inflammasomes
    Language English
    Publishing date 2023-02-24
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2756371-6
    ISSN 2326-5205 ; 2326-5191
    ISSN (online) 2326-5205
    ISSN 2326-5191
    DOI 10.1002/art.42430
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 24: Show issues Location:
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  3. Article ; Online: Just another crappy commentary: the future of fecal microbiota transplantation.

    Rosenbaum, James T

    Expert review of clinical immunology

    2019  Volume 15, Issue 10, Page(s) 987–989

    MeSH term(s) Clostridium Infections/therapy ; Clostridium difficile ; Fecal Microbiota Transplantation/adverse effects ; Fecal Microbiota Transplantation/methods ; Humans
    Language English
    Publishing date 2019-10-08
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2274260-8
    ISSN 1744-8409 ; 1744-666X
    ISSN (online) 1744-8409
    ISSN 1744-666X
    DOI 10.1080/1744666X.2019.1656528
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The eye in spondyloarthritis

    Rosenbaum, James T

    Seminars in arthritis and rheumatism

    2019  Volume 49, Issue 3S, Page(s) S29–S31

    Abstract: Acute anterior uveitis is the most common extra-articular clinical manifestation of spondyloarthropathy. Rheumatologists should be aware of uveitis, know how it presents, understand the differential diagnosis of uveitis and arthritis, and be familiar ... ...

    Abstract Acute anterior uveitis is the most common extra-articular clinical manifestation of spondyloarthropathy. Rheumatologists should be aware of uveitis, know how it presents, understand the differential diagnosis of uveitis and arthritis, and be familiar with the role of systemic medications in the treatment or prevention of uveitis.
    MeSH term(s) Acute Disease ; Animals ; Diagnosis, Differential ; Glucocorticoids/therapeutic use ; Humans ; Spondylarthritis/complications ; Spondylarthritis/diagnosis ; Spondylarthritis/drug therapy ; Uveitis, Anterior/diagnosis ; Uveitis, Anterior/etiology ; Uveitis, Anterior/prevention & control
    Chemical Substances Glucocorticoids
    Language English
    Publishing date 2019-11-29
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 120247-9
    ISSN 1532-866X ; 0049-0172
    ISSN (online) 1532-866X
    ISSN 0049-0172
    DOI 10.1016/j.semarthrit.2019.09.014
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    Zs.A 790: Show issues Location:
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  5. Article ; Online: A Good Detective Never Misses a Clue: Why the Epidemiology of Scleritis Deserves Our Attention.

    Turk, Matthew A / Rosenbaum, James T

    Arthritis & rheumatology (Hoboken, N.J.)

    2021  Volume 73, Issue 7, Page(s) 1127–1128

    MeSH term(s) Attention ; Humans ; Risk Factors ; Scleritis/epidemiology
    Language English
    Publishing date 2021-06-01
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2756371-6
    ISSN 2326-5205 ; 2326-5191
    ISSN (online) 2326-5205
    ISSN 2326-5191
    DOI 10.1002/art.41724
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  6. Article ; Online: Scleritis and development of immune-mediated disease: A retrospective chart review.

    Morrison, Tessalyn / Gottman, Moriah / Do, Toan / Rosenbaum, James T / Ghetie, Daniela / Friedman, Marcia

    The Journal of rheumatology

    2024  

    Abstract: Objective: Scleritis may be idiopathic or caused by trauma, infections, or an immune-mediated condition. Our study aimed to understand the relationship between scleritis and immune-mediated disease, including presenting characteristics, serologies, and ... ...

    Abstract Objective: Scleritis may be idiopathic or caused by trauma, infections, or an immune-mediated condition. Our study aimed to understand the relationship between scleritis and immune-mediated disease, including presenting characteristics, serologies, and treatment course. Understanding these associations may allow clinicians to risk-stratify patients and predict their clinical and treatment course.
    Methods: We conducted a retrospective chart review of 341 scleritis patients seen at a tertiary care center between January 1, 2005, and December 31, 2020. Demographics, scleritis characteristics, treatment response, recurrence, and serologic data were compared among patients with idiopathic and immune-mediated disease-associated scleritis.
    Results: Among scleritis patients seen, 145 patients (43%) had an associated immune-mediated disease, most commonly rheumatoid arthritis (39%), vasculitis (21%), or inflammatory bowel disease (14%). In most cases, the immune-mediated disease diagnosis predated the scleritis presentation (65%), though vasculitis cases were more likely to develop during or after scleritis episodes. There were no significant differences in demographics or treatment failures among scleritis patients with and without associated immune-mediated conditions. Patients with immune-mediated diseases were more likely to have a recurrence of scleritis (62% vs 49%, p=0.02).
    Conclusion: At our ophthalmology center, 43% of patients with scleritis had an associated immunemediated disease, and most patients with immune-mediated disease were symptomatic from this disease prior to scleritis presentation. Rheumatoid arthritis was the most commonly associated condition and typically predated the scleritis, while vasculitis was more likely diagnosed during or after the scleritis episode. Scleritis among immune-mediated disease patients is more likely to recur compared to scleritis that is idiopathic.
    Language English
    Publishing date 2024-02-01
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 194928-7
    ISSN 1499-2752 ; 0315-162X
    ISSN (online) 1499-2752
    ISSN 0315-162X
    DOI 10.3899/jrheum.2023-0788
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  7. Article ; Online: Seasoning to Perfection: How to Optimize Anti-TNF Therapy.

    Rosenbaum, James T / Friedman, Marcia

    Ocular immunology and inflammation

    2021  Volume 30, Issue 4, Page(s) 767–768

    MeSH term(s) Adalimumab ; Humans ; Infliximab/therapeutic use ; Tumor Necrosis Factor Inhibitors ; Tumor Necrosis Factor-alpha ; Uveitis
    Chemical Substances Tumor Necrosis Factor Inhibitors ; Tumor Necrosis Factor-alpha ; Infliximab (B72HH48FLU) ; Adalimumab (FYS6T7F842)
    Language English
    Publishing date 2021-08-23
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 1193873-0
    ISSN 1744-5078 ; 0927-3948
    ISSN (online) 1744-5078
    ISSN 0927-3948
    DOI 10.1080/09273948.2021.1964032
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    Zs.A 4004: Show issues Location:
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  8. Article ; Online: Risk of arrhythmia among new users of hydroxychloroquine: comment on the article by Hoque et al.

    Desmarais, Julianna / Rosenbaum, James T / Link, Mark / Kovacs, Richard

    Arthritis & rheumatology (Hoboken, N.J.)

    2023  Volume 75, Issue 11, Page(s) 2065

    MeSH term(s) Humans ; Hydroxychloroquine/adverse effects ; Antirheumatic Agents/adverse effects ; Arrhythmias, Cardiac/chemically induced
    Chemical Substances Hydroxychloroquine (4QWG6N8QKH) ; Antirheumatic Agents
    Language English
    Publishing date 2023-08-30
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2756371-6
    ISSN 2326-5205 ; 2326-5191
    ISSN (online) 2326-5205
    ISSN 2326-5191
    DOI 10.1002/art.42618
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    Zs.A 24: Show issues Location:
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  9. Article ; Online: Putative Pathobionts in HLA-B27-Associated Spondyloarthropathy.

    Gill, Tejpal / Rosenbaum, James T

    Frontiers in immunology

    2021  Volume 11, Page(s) 586494

    Abstract: Spondyloarthritis (SpA) is a group of immune mediated inflammatory diseases with a strong association to the major histocompatibility (MHC) class I molecule, HLA-B27. Although the association between HLA-B27 and AS has been known for almost 50 years, the ...

    Abstract Spondyloarthritis (SpA) is a group of immune mediated inflammatory diseases with a strong association to the major histocompatibility (MHC) class I molecule, HLA-B27. Although the association between HLA-B27 and AS has been known for almost 50 years, the mechanisms underlying disease pathogenesis are elusive. Over the years, three hypotheses have been proposed to explain HLA-B27 and disease association: 1) HLA B27 presents arthritogenic peptides and thus creates a pathological immune response; 2) HLA-B27 misfolding causes endoplasmic reticulum (ER) stress which activates the unfolded protein response (UPR); 3) HLA-B27 dimerizes on the cell surface and acts as a target for natural killer (NK) cells. None of these hypotheses explains SpA pathogenesis completely. Evidence supports the hypothesis that HLA-B27-related diseases have a microbial pathogenesis. In animal models of various SpAs, a germ-free environment abrogates disease development and colonizing these animals with gut commensal microbes can restore disease manifestations. The depth of microbial influence on SpA development has been realized due to our ability to characterize microbial communities in the gut using next-generation sequencing approaches. In this review, we will discuss various putative pathobionts in the pathogenesis of HLA-B27-associated diseases. We pursue whether a single pathobiont or a disruption of microbial community and function is associated with HLA-B27-related diseases. Furthermore, rather than a specific pathobiont, metabolic functions of various disease-associated microbes might be key. While the use of germ-free models of SpA have facilitated understanding the role of microbes in disease development, future studies with animal models that mimic diverse microbial communities instead of mono-colonization are indispensable. We discuss the causal mechanisms underlying disease pathogenesis including the role of these pathobionts on mucin degradation, mucosal adherence, and gut epithelial barrier disruption and inflammation. Finally, we review the various uses of microbes as therapeutic modalities including pre/probiotics, diet, microbial metabolites and fecal microbiota transplant. Unravelling these complex host-microbe interactions will lead to the development of new targets/therapies for alleviation of SpA and other HLA-B27 associated diseases.
    MeSH term(s) Animals ; Gastrointestinal Microbiome/immunology ; HLA-B27 Antigen/genetics ; Humans ; Spondylarthropathies/genetics ; Spondylarthropathies/immunology ; Spondylarthropathies/microbiology
    Chemical Substances HLA-B27 Antigen
    Language English
    Publishing date 2021-01-18
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.586494
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  10. Article ; Online: Uveitis: contrasting the approaches in Japan and the United States.

    Rosenbaum, James T

    Japanese journal of ophthalmology

    2018  Volume 63, Issue 1, Page(s) 1–6

    Abstract: Purpose: To compare the approaches to uveitis in Japan and the United States.: Methods: This report is based on the author's personal experience, conversations with Japanese colleagues, and a literature search using the database of the US National ... ...

    Abstract Purpose: To compare the approaches to uveitis in Japan and the United States.
    Methods: This report is based on the author's personal experience, conversations with Japanese colleagues, and a literature search using the database of the US National Library of Medicine.
    Results: The frequencies of specific forms of uveitis vary between the two countries. Options for therapy are affected by government regulations and the impact of insurance carriers. In both countries, there is a stepwise approach to therapy beginning with topical corticosteroids and ultimately advancing to biologics. Despite the differences, the goals for therapy, disease control with minimal toxicity, are the same.
    Conclusions: Genetic, environmental, and regulatory differences impact the approach to uveitis. Despite these factors, the goal for therapy is essentially the same.
    MeSH term(s) Disease Management ; Humans ; Japan/epidemiology ; Morbidity ; United States/epidemiology ; Uveitis/diagnosis ; Uveitis/epidemiology ; Uveitis/therapy
    Language English
    Publishing date 2018-11-20
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 82032-5
    ISSN 1613-2246 ; 0021-5155
    ISSN (online) 1613-2246
    ISSN 0021-5155
    DOI 10.1007/s10384-018-0633-2
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