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Article ; Online: ¹⁵C(d,p)¹⁶C reaction and exotic behavior in ¹⁶C.

Wuosmaa, A H / Back, B B / Baker, S / Brown, B A / Deibel, C M / Fallon, P / Hoffman, C R / Kay, B P / Lee, H Y / Lighthall, J C / Macchiavelli, A O / Marley, S T / Pardo, R C / Rehm, K E / Schiffer, J P / Shetty, D V / Wiedeking, M

Physical review letters

2010 Volume 105, Issue 13, Page(s) 132501

Abstract: We have studied the ¹⁵C(d,p)¹⁶C reaction in inverse kinematics using the Helical Orbit Spectrometer ... at Argonne National Laboratory. Prior studies of electromagnetic-transition rates in ¹⁶C suggested an exotic ... a different probe of the wave functions of the relevant states in ¹⁶C. Shell-model calculations reproduce ...

Abstract	We have studied the ¹⁵C(d,p)¹⁶C reaction in inverse kinematics using the Helical Orbit Spectrometer at Argonne National Laboratory. Prior studies of electromagnetic-transition rates in ¹⁶C suggested an exotic decoupling of the valence neutrons from the core in that nucleus. Neutron-adding spectroscopic factors give a different probe of the wave functions of the relevant states in ¹⁶C. Shell-model calculations reproduce both the present transfer data and the previously measured transition rates, suggesting that ¹⁶C may be described without invoking very exotic phenomena.
Language	English
Publishing date	2010-09-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.105.132501
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Article: Ernst L. Wynder, M.D., Dr. Sc. h. c. (mult.), Dr. med. h.c.--1922-1999. Ein Nachruf.

Hoffman, D / Hoffman, I

Sozial- und Praventivmedizin

2000 Volume 45, Issue 2, Page(s) 61–63

Title translation	Ernst L. Wynder, M.D., Dr. Sc. h.c. (mult.), Dr. med. h.c.--1922-1999. A memorial.
MeSH term(s)	Germany ; History, 20th Century ; Preventive Medicine/history ; Smoking/history ; Social Medicine/history ; United States
Language	German
Publishing date	2000
Publishing country	Switzerland
Document type	Biography ; Historical Article ; Journal Article
ZDB-ID	125375-x
ISSN	1420-911X ; 0303-8408
ISSN (online)	1420-911X
ISSN	0303-8408
DOI	10.1007/bf01624613
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Article: Costs involved in compliance with new endoscope reprocessing guidelines.

Hoffman, David / Cool, Christina

Clinical endoscopy

2024

Abstract: Background/aims: In March 2022, the Association for the Advancement of Medical Instrumentation (AAMI) released the American National Standards Institute (ANSI)/AAMI ST91:2021, their latest update on comprehensive, flexible, and semirigid endoscope ... ...

Abstract	Background/aims: In March 2022, the Association for the Advancement of Medical Instrumentation (AAMI) released the American National Standards Institute (ANSI)/AAMI ST91:2021, their latest update on comprehensive, flexible, and semirigid endoscope reprocessing. These updated standards recommend the sterilization of high-risk endoscopes when possible and provide new recommendations for the precleaning, leak testing, manual cleaning, visual inspection, automated reprocessing, drying, storage, and transport of endoscopes. Methods: ANSI/AAMI ST91:2021 was compared with ANSI/AAMI ST91:2015 for major reprocessing differences that result in either time and/or cost increases. Time estimates were captured by explicit recommendation inclusion or taken from the literature. All the costs were estimated using publicly available resources. Results: The updated standards represent a potential 24.3-minute and 52.35 to 67.57 United States dollars increase per procedure in terms of reprocessing time and spending, respectively, not including capital investments. Capital costs per procedure were highly dependent on the procedure volume of the facility. Conclusions: The new AAMI standards recommend several major changes, such as sterilization, for facilities to reprocess and manage endoscopes between uses. As more facilities increase their reprocessing methods to reflect the updated standards, they do so at a cost and introduce several delays. As the reprocessing landscape evolves, facilities should consider their true costs and alternative solutions, such as single-use endoscopes.
Language	English
Publishing date	2024-01-26
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2643507-X
ISSN	2234-2443 ; 2234-2400
ISSN (online)	2234-2443
ISSN	2234-2400
DOI	10.5946/ce.2023.164
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Article: Protein kinase C activation attenuates N-methyl-D-aspartate-induced increases in intracellular calcium in cerebellar granule cells.

Snell, L D / Iorio, K R / Tabakoff, B / Hoffman, P L

Journal of neurochemistry

1994 Volume 62, Issue 5, Page(s) 1783–1789

Abstract: Activation of the N-methyl-D-aspartate (NMDA) subtype of glutamate receptor increases levels ... of intracellular calcium and can lead to stimulation of protein kinase C activity. Several reports have ... demonstrated that stimulation of protein kinase C can, in turn, increase electrophysiological responses to NMDA ...

Abstract	Activation of the N-methyl-D-aspartate (NMDA) subtype of glutamate receptor increases levels of intracellular calcium and can lead to stimulation of protein kinase C activity. Several reports have demonstrated that stimulation of protein kinase C can, in turn, increase electrophysiological responses to NMDA in certain cells or in oocytes expressing certain NMDA receptor subunits. In the present study, the effects of protein kinase C activation on NMDA receptor-mediated increases in intracellular Ca2+ level were investigated in primary cultures of rat cerebellar granule cells using fura-2 fluorescence spectroscopy. Pretreatment of the cells with the protein kinase C activator phorbol 12-myristate 13-acetate (PMA), but not the inactive analogue 4 alpha-phorbol 12-myristate 13-acetate, inhibited NMDA-induced increases in intracellular Ca2+ levels. Coincubation of cells with PMA and the kinase inhibitor staurosporine or calphostin C blocked the PMA effect. The potency of NMDA was reduced twofold, and the potency of the NMDA receptor co-agonist, glycine, to enhance the response to NMDA was decreased fourfold by pretreatment of cells with PMA. The effect on glycine was mimicked by pretreatment with okadaic acid, a protein phosphatase inhibitor. PMA treatment did not significantly alter Mg2+ inhibition of the NMDA response but decreased the potency of the competitive antagonist CGS-19755. These data suggest that, in cerebellar granule cells, the function of the NMDA receptor may be subject to feed-back inhibition by protein kinase C stimulation. Under physiological conditions, this inhibition may result from a decreased effectiveness of the endogenous co-agonists, glutamate and glycine.
MeSH term(s)	Alkaloids/pharmacology ; Animals ; Calcium/metabolism ; Cells, Cultured ; Cerebellum/cytology ; Cerebellum/drug effects ; Cerebellum/metabolism ; Dose-Response Relationship, Drug ; Enzyme Activation ; Glycine/pharmacology ; Intracellular Fluid/metabolism ; Kinetics ; Magnesium Sulfate/pharmacology ; N-Methylaspartate/antagonists & inhibitors ; N-Methylaspartate/pharmacology ; Naphthalenes ; Neurons/cytology ; Neurons/drug effects ; Neurons/metabolism ; Pipecolic Acids/pharmacology ; Polycyclic Compounds/pharmacology ; Protein Kinase C/antagonists & inhibitors ; Protein Kinase C/metabolism ; Rats ; Rats, Sprague-Dawley ; Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors ; Receptors, N-Methyl-D-Aspartate/physiology ; Staurosporine ; Tetradecanoylphorbol Acetate/pharmacology
Chemical Substances	Alkaloids ; Naphthalenes ; Pipecolic Acids ; Polycyclic Compounds ; Receptors, N-Methyl-D-Aspartate ; selfotel (4VGJ4A41L2) ; N-Methylaspartate (6384-92-5) ; Magnesium Sulfate (7487-88-9) ; Protein Kinase C (EC 2.7.11.13) ; Staurosporine (H88EPA0A3N) ; calphostin C (I271P23G24) ; Tetradecanoylphorbol Acetate (NI40JAQ945) ; Calcium (SY7Q814VUP) ; Glycine (TE7660XO1C)
Language	English
Publishing date	1994-05
Publishing country	England
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	80158-6
ISSN	1471-4159 ; 0022-3042 ; 1474-1644
ISSN (online)	1471-4159
ISSN	0022-3042 ; 1474-1644
DOI	10.1046/j.1471-4159.1994.62051783.x
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Article: Altered patterning of neural activity in a tauopathy mouse model.

Hoffman, C / Cheng, J / Morales, R / Ji, D / Dabaghian, Y

bioRxiv : the preprint server for biology

2024

Abstract: Alzheimer's disease (AD) is a complex neurodegenerative condition that manifests at multiple levels and involves a spectrum of abnormalities ranging from the cellular to cognitive. Here, we investigate the impact of AD-related tau-pathology on ... ...

Abstract	Alzheimer's disease (AD) is a complex neurodegenerative condition that manifests at multiple levels and involves a spectrum of abnormalities ranging from the cellular to cognitive. Here, we investigate the impact of AD-related tau-pathology on hippocampal circuits in mice engaged in spatial navigation, and study changes of neuronal firing and dynamics of extracellular fields. While most studies are based on analyzing instantaneous or time-averaged characteristics of neuronal activity, we focus on intermediate timescales-spike trains and waveforms of oscillatory potentials, which we consider as single entities. We find that, in healthy mice, spike arrangements and wave patterns (series of crests or troughs) are coupled to the animal's location, speed, and acceleration. In contrast, in tau-mice, neural activity is structurally disarrayed: brainwave cadence is detached from locomotion, spatial selectivity is lost, the spike flow is scrambled. Importantly, these alterations start early and accumulate with age, which exposes progressive disinvolvement the hippocampus circuit in spatial navigation. These features highlight qualitatively different neurodynamics than the ones provided by conventional analyses, and are more salient, thus revealing a new level of the hippocampal circuit disruptions.
Language	English
Publishing date	2024-03-27
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.03.23.586417
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Article: High-resolution magnetic resonance imaging of the efficacy of the cytosine analogue 1-[2-C-cyano-2-deoxy-beta-D-arabino-pentofuranosyl]-N(4)-palmitoyl cytosine (CS-682) in a liver-metastasis athymic nude mouse model.

Wu, Ming / Mazurchuk, Richard / Chaudhary, Neeta D / Spernyak, Joseph / Veith, Jean / Pera, Paula / Greco, William / Hoffman, Robert M / Kobayashi, Tomowo / Bernacki, Ralph J

Cancer research

2003 Volume 63, Issue 10, Page(s) 2477–2482

Abstract: ... used to assess CS-682, a novel 2'-deoxycytidine analogue of 1-[2-C-cyano-2-deoxy-beta-D-arabino ...

Abstract	High-resolution magnetic resonance (MR) imaging techniques in a liver metastatic mouse model were used to assess CS-682, a novel 2'-deoxycytidine analogue of 1-[2-C-cyano-2-deoxy-beta-D-arabino-pentofuranosyl]-N(4)-palmitoyl cytosine. The efficacy of CS-682 was visualized in real time by MR imaging of initial seeding and subsequent growth of liver metastases. The relative therapeutic efficacies of CS-682 and two agents used clinically, gemcitabine [2'-deoxy-2',2'-difluorocytidine monohydrochloride (DFDC)] and 5-fluorouracil (5-FU), were compared in this model. CS-682 was found to exhibit superior efficacy by delaying the onset and inhibiting the growth of liver metastasis compared with gemcitabine, 5-FU, and control. The overall occurrence of metastases was decreased 62% by CS-682, 18% by DFDC, and 35% by 5-FU. CS-682 increased the life span of the treated animals significantly, by 28 days above the 29-day median survival without treatment, compared with 11 days by DFDC and 14 days by 5-FU. The increased survival in CS-682-treated animals correlated with the antimetastatic activity of this compound. These preclinical findings support the potential clinical utility of CS-682 in the treatment of liver metastasis.
MeSH term(s)	Animals ; Antineoplastic Agents/pharmacology ; Arabinonucleosides/pharmacology ; Cell Division/drug effects ; Colonic Neoplasms/drug therapy ; Colonic Neoplasms/pathology ; Cytosine/analogs & derivatives ; Cytosine/pharmacology ; Deoxycytidine/analogs & derivatives ; Deoxycytidine/pharmacology ; Female ; Fluorouracil/pharmacology ; Humans ; Liver Neoplasms/pathology ; Liver Neoplasms/prevention & control ; Liver Neoplasms/secondary ; Magnetic Resonance Imaging/methods ; Mice ; Mice, Nude ; Xenograft Model Antitumor Assays
Chemical Substances	Antineoplastic Agents ; Arabinonucleosides ; Deoxycytidine (0W860991D6) ; Cytosine (8J337D1HZY) ; gemcitabine (B76N6SBZ8R) ; Fluorouracil (U3P01618RT) ; sapacitabine (W335P73C3L)
Language	English
Publishing date	2003-05-15
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	1432-1
ISSN	1538-7445 ; 0008-5472
ISSN (online)	1538-7445
ISSN	0008-5472
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Article ; Online: The ability of a portable near infrared instrument to evaluate the shelf-life of fresh and thawed goat muscles.

Cozzolino, D / Wu, W / Zhang, S / Beya, M / van Jaarsveld, P F / Hoffman, L C

Food research international (Ottawa, Ont.)

2024 Volume 180, Page(s) 114047

Abstract: ... semitendinosus (ST) and biceps femoris (BF)] stored for up to 8 days (4 °C). The NIR spectra of the muscle ...

Abstract	The objective of this study was to evaluate the use of a portable near infrared (NIR) instrument to monitor the shelf-life of four goat muscles [longissimus thoracis et lumborum (LTL), semimembranosus (SM), semitendinosus (ST) and biceps femoris (BF)] stored for up to 8 days (4 °C). The NIR spectra of the muscle samples were collected at day 0, and after 1, 4 and 8 days of storage using a MicroNIR instrument (900-1600 nm). The coefficient of determination in cross-validation (R
MeSH term(s)	Animals ; Goats ; Muscles ; Spectroscopy, Near-Infrared ; Hamstring Muscles ; Meat/analysis
Language	English
Publishing date	2024-01-28
Publishing country	Canada
Document type	Journal Article
ZDB-ID	1111695-x
ISSN	1873-7145 ; 0963-9969
ISSN (online)	1873-7145
ISSN	0963-9969
DOI	10.1016/j.foodres.2024.114047
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Article ; Online: GOES-R land surface products at Western Hemisphere eddy covariance tower locations.

Losos, Danielle / Hoffman, Sophie / Stoy, Paul C

Scientific data

2024 Volume 11, Issue 1, Page(s) 277

Abstract: The terrestrial carbon cycle varies dynamically on hourly to weekly scales, making it difficult to observe. Geostationary ("weather") satellites like the Geostationary Environmental Operational Satellite - R Series (GOES-R) deliver near-hemispheric ... ...

Abstract	The terrestrial carbon cycle varies dynamically on hourly to weekly scales, making it difficult to observe. Geostationary ("weather") satellites like the Geostationary Environmental Operational Satellite - R Series (GOES-R) deliver near-hemispheric imagery at a ten-minute cadence. The Advanced Baseline Imager (ABI) aboard GOES-R measures visible and near-infrared spectral bands that can be used to estimate land surface properties and carbon dioxide flux. However, GOES-R data are designed for real-time dissemination and are difficult to link with eddy covariance time series of land-atmosphere carbon dioxide exchange. We compiled three-year time series of GOES-R land surface attributes including visible and near-infrared reflectances, land surface temperature (LST), and downwelling shortwave radiation (DSR) at 314 ABI fixed grid pixels containing eddy covariance towers. We demonstrate how to best combine satellite and in-situ datasets and show how ABI attributes useful for ecosystem monitoring vary across space and time. By connecting observation networks that infer rapid changes to the carbon cycle, we can gain a richer understanding of the processes that control it.
Language	English
Publishing date	2024-03-07
Publishing country	England
Document type	Dataset ; Journal Article
ZDB-ID	2775191-0
ISSN	2052-4463 ; 2052-4463
ISSN (online)	2052-4463
ISSN	2052-4463
DOI	10.1038/s41597-024-03071-z
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Article ; Online: Des doigts gonflés et des ongles recourbés.

Hoffman, C / Amrane, S / Bagneres, D / Granel, B

La Revue de medecine interne

2021 Volume 42, Issue 11, Page(s) 816–819

Title translation	Swollen fingers and curved nails.
MeSH term(s)	Fingers ; Humans ; Nails
Language	French
Publishing date	2021-10-01
Publishing country	France
Document type	Letter
ZDB-ID	604679-4
ISSN	1768-3122 ; 0248-8663
ISSN (online)	1768-3122
ISSN	0248-8663
DOI	10.1016/j.revmed.2021.08.017
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Zs.B 2451: Show issues

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Article ; Online: Reconstructing cardiac electrical excitations from optical mapping recordings.

Marcotte, C D / Hoffman, M J / Fenton, F H / Cherry, E M

Chaos (Woodbury, N.Y.)

2023 Volume 33, Issue 9

Abstract: The reconstruction of electrical excitation patterns through the unobserved depth of the tissue is essential to realizing the potential of computational models in cardiac medicine. We have utilized experimental optical-mapping recordings of cardiac ... ...

Abstract	The reconstruction of electrical excitation patterns through the unobserved depth of the tissue is essential to realizing the potential of computational models in cardiac medicine. We have utilized experimental optical-mapping recordings of cardiac electrical excitation on the epicardial and endocardial surfaces of a canine ventricle as observations directing a local ensemble transform Kalman filter data assimilation scheme. We demonstrate that the inclusion of explicit information about the stimulation protocol can marginally improve the confidence of the ensemble reconstruction and the reliability of the assimilation over time. Likewise, we consider the efficacy of stochastic modeling additions to the assimilation scheme in the context of experimentally derived observation sets. Approximation error is addressed at both the observation and modeling stages through the uncertainty of observations and the specification of the model used in the assimilation ensemble. We find that perturbative modifications to the observations have marginal to deleterious effects on the accuracy and robustness of the state reconstruction. Furthermore, we find that incorporating additional information from the observations into the model itself (in the case of stimulus and stochastic currents) has a marginal improvement on the reconstruction accuracy over a fully autonomous model, while complicating the model itself and thus introducing potential for new types of model errors. That the inclusion of explicit modeling information has negligible to negative effects on the reconstruction implies the need for new avenues for optimization of data assimilation schemes applied to cardiac electrical excitation.
MeSH term(s)	Animals ; Dogs ; Reproducibility of Results ; Heart ; Heart Ventricles ; Endocardium ; Electricity
Language	English
Publishing date	2023-10-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	1472677-4
ISSN	1089-7682 ; 1054-1500
ISSN (online)	1089-7682
ISSN	1054-1500
DOI	10.1063/5.0156314
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