LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 172

Search options

  1. Article ; Online: The Effects of Time Framing on Compliance to Hypothetical Social-Distancing Policies Related to COVID-19.

    Harman, Michael J

    Behavior and social issues

    2021  Volume 30, Issue 1, Page(s) 632–647

    Abstract: The current study analyzed the effects of two frames for durations of time-calendar unit and calendar date-on measures of compliance to hypothetical social-distancing policies related to the COVID-19 pandemic. Participants reported the extent to which ... ...

    Abstract The current study analyzed the effects of two frames for durations of time-calendar unit and calendar date-on measures of compliance to hypothetical social-distancing policies related to the COVID-19 pandemic. Participants reported the extent to which they would comply with hypothetical social-distancing policies lasting different durations of time. Durations of time were framed as calendar units (e.g., days, weeks, months, years) and calendar dates (i.e., specific dates the policies would extent to). Levels of compliance across durations of time were used to calculate the area under the curve (AuC) for each condition. Social-distancing policies framed in calendar dates yielded significantly greater AuC values compared to social-distancing policies framed in calendar units. Participants' self-reported political affiliation yielded a significant main effect: Conservative participants' AuC values were significantly lower than liberal participants' AuC values. The framing of the duration of time was a significant variable in controlling rates of compliance to hypothetical social-distancing policies.
    Language English
    Publishing date 2021-01-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2065362-1
    ISSN 2376-6786 ; 1064-9506
    ISSN (online) 2376-6786
    ISSN 1064-9506
    DOI 10.1007/s42822-020-00041-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Consistent Visual Analysis of Multielement Data: A Preliminary Evaluation.

    Gifford, Margaret R / Tiger, Jeffrey H / Harman, Michael J / Kastner, Kendall M

    Behavior modification

    2024  Volume 48, Issue 2, Page(s) 128–149

    Abstract: Experimenters provided 33 graphical displays of hypothetical data depicted in a multielement experimental design to editorial board members of prominent, applied, behavior-analytic journals via an online survey. For each display, participants indicated ( ... ...

    Abstract Experimenters provided 33 graphical displays of hypothetical data depicted in a multielement experimental design to editorial board members of prominent, applied, behavior-analytic journals via an online survey. For each display, participants indicated (a) the presence or absence of experimental control and (b) the degree of experimental control (rated on a 1-100 scale). Each depiction varied systematically in (a) the number of data paths, (b) the number of data paths elevated above the control, (c) the mean difference between affected data paths and control conditions, and (d) the degree of variability within conditions. Correspondence among experts' ratings of experimental control was high across all presented graphical displays, supporting the reliability of visual analysis as an evaluative tool for these designs.
    MeSH term(s) Humans ; Reproducibility of Results ; Surveys and Questionnaires ; Research Design
    Language English
    Publishing date 2024-01-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 432229-0
    ISSN 1552-4167 ; 0145-4455
    ISSN (online) 1552-4167
    ISSN 0145-4455
    DOI 10.1177/01454455231212263
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 2195: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Atomistic, macromolecular model of the

    Addison, Bennett / Bu, Lintao / Bharadwaj, Vivek / Crowley, Meagan F / Harman-Ware, Anne E / Crowley, Michael F / Bomble, Yannick J / Ciesielski, Peter N

    Science advances

    2024  Volume 10, Issue 1, Page(s) eadi7965

    Abstract: Plant secondary cell walls (SCWs) are composed of a heterogeneous interplay of three major biopolymers: cellulose, hemicelluloses, and lignin. Details regarding specific intermolecular interactions and higher-order architecture of the SCW superstructure ... ...

    Abstract Plant secondary cell walls (SCWs) are composed of a heterogeneous interplay of three major biopolymers: cellulose, hemicelluloses, and lignin. Details regarding specific intermolecular interactions and higher-order architecture of the SCW superstructure remain ambiguous. Here, we use solid-state nuclear magnetic resonance (ssNMR) measurements to infer refined details about the structural configuration, intermolecular interactions, and relative proximity of all three major biopolymers within air-dried
    MeSH term(s) Populus ; Cellulose ; Magnetic Resonance Spectroscopy ; Biopolymers ; Plants ; Cell Wall
    Chemical Substances Cellulose (9004-34-6) ; Biopolymers
    Language English
    Publishing date 2024-01-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.adi7965
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Surgical management of Graves' disease: historical context and single institution experience.

    Russell, Michael J / Young, Simon / Martin, Richard / Harman, Richard

    The New Zealand medical journal

    2022  Volume 135, Issue 1549, Page(s) 43–49

    Abstract: Aim: To describe indications and outcomes of total thyroidectomy for Graves' disease in a large New Zealand endocrine surgery unit, and to compare these results to international studies.: Methods: We analysed a prospectively collected database to ... ...

    Abstract Aim: To describe indications and outcomes of total thyroidectomy for Graves' disease in a large New Zealand endocrine surgery unit, and to compare these results to international studies.
    Methods: We analysed a prospectively collected database to describe the indications and outcomes of surgery for Graves' disease between December 2001 and January 2021.
    Results: Among 64 patients who underwent total thyroidectomy at our tertiary centre for Graves' hyperthyroidism, Graves' ophthalmopathy and patient preference/aversion to radioactive iodine were the most common indications for surgery. Total thyroidectomy resulted in long-term control of thyrotoxicosis in all patients. There were no incidences of recurrent laryngeal nerve injury. One patient (1.6%) suffered permanent hypoparathyroidism.
    Conclusion: Total thyroidectomy is a safe and effective treatment for Graves' disease. In our population, total thyroidectomy functions as a second-line treatment for Graves' disease.
    MeSH term(s) Graves Disease/surgery ; Graves Ophthalmopathy ; Humans ; Iodine Radioisotopes/therapeutic use ; New Zealand ; Retrospective Studies ; Thyroid Neoplasms ; Thyroidectomy/methods ; Treatment Outcome
    Chemical Substances Iodine Radioisotopes
    Language English
    Publishing date 2022-02-04
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 390590-1
    ISSN 1175-8716 ; 0028-8446 ; 0110-7704
    ISSN (online) 1175-8716
    ISSN 0028-8446 ; 0110-7704
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.396: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Topiary: Pruning the manual labor from ancestral sequence reconstruction.

    Orlandi, Kona N / Phillips, Sophia R / Sailer, Zachary R / Harman, Joseph L / Harms, Michael J

    Protein science : a publication of the Protein Society

    2023  Volume 32, Issue 2, Page(s) e4551

    Abstract: Ancestral sequence reconstruction (ASR) is a powerful tool to study the evolution of proteins and thus gain deep insight into the relationships among protein sequence, structure, and function. A major barrier to its broad use is the complexity of the ... ...

    Abstract Ancestral sequence reconstruction (ASR) is a powerful tool to study the evolution of proteins and thus gain deep insight into the relationships among protein sequence, structure, and function. A major barrier to its broad use is the complexity of the task: it requires multiple software packages, complex file manipulations, and expert phylogenetic knowledge. Here we introduce topiary, a software pipeline that aims to overcome this barrier. To use topiary, users prepare a spreadsheet with a handful of sequences. Topiary then: (1) Infers the taxonomic scope for the ASR study and finds relevant sequences by BLAST; (2) Does taxonomically informed sequence quality control and redundancy reduction; (3) Constructs a multiple sequence alignment; (4) Generates a maximum-likelihood gene tree; (5) Reconciles the gene tree to the species tree; (6) Reconstructs ancestral amino acid sequences; and (7) Determines branch supports. The pipeline returns annotated evolutionary trees, spreadsheets with sequences, and graphical summaries of ancestor quality. This is achieved by integrating modern phylogenetics software (Muscle5, RAxML-NG, GeneRax, and PastML) with online databases (NCBI and the Open Tree of Life). In this paper, we introduce non-expert readers to the steps required for ASR, describe the specific design choices made in topiary, provide a detailed protocol for users, and then validate the pipeline using datasets from a broad collection of protein families. Topiary is freely available for download: https://github.com/harmslab/topiary.
    MeSH term(s) Phylogeny ; Software ; Amino Acid Sequence ; Proteins/genetics ; Proteins/chemistry ; Sequence Alignment ; Evolution, Molecular
    Chemical Substances Proteins
    Language English
    Publishing date 2023-01-08
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1106283-6
    ISSN 1469-896X ; 0961-8368
    ISSN (online) 1469-896X
    ISSN 0961-8368
    DOI 10.1002/pro.4551
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3407: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 1: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article: Comparing Multiple Methods to Measure Procedural Fidelity of Discrete-trial Instruction.

    Bergmann, Samantha / Niland, Haven / Gavidia, Valeria Laddaga / Strum, Marcus D / Harman, Michael J

    Education & treatment of children

    2023  , Page(s) 1–20

    Abstract: Procedural fidelity is the extent to which an intervention is implemented as designed and is an important component of research and practice. There are multiple ways to measure procedural fidelity, and few studies have explored how procedural fidelity ... ...

    Abstract Procedural fidelity is the extent to which an intervention is implemented as designed and is an important component of research and practice. There are multiple ways to measure procedural fidelity, and few studies have explored how procedural fidelity varies based on the method of measurement. The current study compared adherence to discrete-trial instruction protocols by behavior technicians with a child with autism when observers used different procedural-fidelity measures. We collected individual-component and individual-trial fidelity with an occurrence-nonoccurrence data sheet and compared these scores to global fidelity and all-or-nothing, 3-point Likert scale, and 5-point Likert scale measurement methods. The all-or-nothing method required all instances of a component or trial be implemented without error to be scored correct. The Likert scales used a rating system to score components and trials. At the component level, we found that the global, 3-point Likert, and 5-point Likert methods were likely to overestimate fidelity and mask component errors, and the all-or-nothing method was unlikely to mask errors. At the trial level, we found that the global and 5-point Likert methods approximated individual-trial fidelity, the 3-point Likert method overestimated fidelity, and the all-or-nothing method underestimated fidelity. The occurrence-nonoccurrence method required the most time to complete, and all-or-nothing by trial required the least. We discuss the implications of measuring procedural fidelity with different methods of measurement, including false positives and false negatives, and provide suggestions for practice and research.
    Supplementary information: The online version contains supplementary material available at 10.1007/s43494-023-00094-w.
    Language English
    Publishing date 2023-05-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2068647-X
    ISSN 1934-8924 ; 0748-8491
    ISSN (online) 1934-8924
    ISSN 0748-8491
    DOI 10.1007/s43494-023-00094-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: When do errors in reinforcer delivery affect learning? A parametric analysis of treatment integrity.

    Bergmann, Samantha / Kodak, Tiffany / Harman, Michael J

    Journal of the experimental analysis of behavior

    2021  Volume 115, Issue 2, Page(s) 561–577

    Abstract: Treatment integrity is the extent to which components of an intervention are implemented as intended (Gresham, 1989). Recent behavior-analytic literature has begun to evaluate the effects of reduced-treatment integrity on the efficacy and efficiency of ... ...

    Abstract Treatment integrity is the extent to which components of an intervention are implemented as intended (Gresham, 1989). Recent behavior-analytic literature has begun to evaluate the effects of reduced-treatment integrity on the efficacy and efficiency of skill-acquisition interventions. This study extended the current literature on the effects of errors of omission and commission of reinforcer delivery by replicating and extending Hirst and DiGennaro Reed (2015). Using a randomized-control group design, we compared undergraduate student participants' acquisition of conditional discriminations in a parametric analysis of different error values. A computer program erred in reinforcer delivery on 0%, 5%, 10%, 15%, 20%, 25% and 50% of trials. The purpose of the current study was to identify which levels of reduced integrity slowed or prevented acquisition. Our data replicated the findings of Hirst and DiGennaro Reed, and extended parametric analyses by identifying that errors in reinforcer delivery occurring on 15% or fewer trials (i.e., 85% integrity) were unlikely to prevent participants' responding from meeting the mastery criterion. These results could inform future research on how treatment-integrity errors change behavior-analytic procedures and the effects on skill acquisition for consumers of applied behavior analysis.
    MeSH term(s) Behavior Therapy ; Humans ; Learning
    Language English
    Publishing date 2021-01-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 219405-3
    ISSN 1938-3711 ; 0022-5002
    ISSN (online) 1938-3711
    ISSN 0022-5002
    DOI 10.1002/jeab.670
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 558: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article: The Effects of Competing Verbal Behavior on Performance in a Math Task.

    Harman, Michael J / Kodak, Tiffany / Bohl, Leah / Mayland, Theresa

    The Analysis of verbal behavior

    2021  Volume 37, Issue 1, Page(s) 57–76

    Abstract: The purposes of this study were to evaluate the effects of an auditory-distractor stimulus and vocal-blocking task on performance on a math task and measures of overt verbal operants. College students served as participants, and they were instructed to ... ...

    Abstract The purposes of this study were to evaluate the effects of an auditory-distractor stimulus and vocal-blocking task on performance on a math task and measures of overt verbal operants. College students served as participants, and they were instructed to solve an arithmetic problem while continuously emitting overt verbal behavior. The overt verbal behavior consisted of either talking aloud while solving the problem or reciting the alphabet. A third condition consisted of playing an auditory-distractor file containing the alphabet during the response interval while participants talked aloud. Data were collected on response accuracy, latency to respond, and frequency of echoic and self-echoic responses emitted during the response interval. The vocal-blocking task significantly affected performance on the math task when visual stimuli were absent. The decrease in performance coincided with significant decreases in participants' mean frequency of echoic and self-echoic responses. In sum, correctly responding to an arithmetic problem was significantly affected by the vocal-blocking task, indicating support for the necessity of verbal mediation during problem solving.
    Language English
    Publishing date 2021-06-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2604620-9
    ISSN 2196-8926 ; 0889-9401
    ISSN (online) 2196-8926
    ISSN 0889-9401
    DOI 10.1007/s40616-021-00145-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Increasing passive compliance to wearing a facemask in children with autism spectrum disorder.

    Lillie, Madelynn A / Harman, Michael J / Hurd, Maisie / Smalley, Miranda R

    Journal of applied behavior analysis

    2021  Volume 54, Issue 2, Page(s) 582–599

    Abstract: The current study taught 6 children with autism spectrum disorder (ASD) to increase passive compliance of wearing a facemask across sequentially increasing durations of time. A changing-criterion design embedded within a nonconcurrent multiple baseline ... ...

    Abstract The current study taught 6 children with autism spectrum disorder (ASD) to increase passive compliance of wearing a facemask across sequentially increasing durations of time. A changing-criterion design embedded within a nonconcurrent multiple baseline design was used to evaluate the effectiveness of a resetting differential reinforcement of other behavior (DRO) without escape extinction procedure on passive compliance. Terminal probe sessions determined DRO fading intervals. Results showed that 2 participants acquired mastery level passive compliance (30 min) without fading during the initial baseline sessions. The remaining 4 participants acquired mastery level passive compliance following fading intervals within the DRO intervention. Participants' passive compliance generalized across 2 novel settings. This study replicates previous studies and extends empirical support for the use of DRO without escape extinction interventions for increasing passive compliance with medical devices in children with ASD.
    MeSH term(s) Adolescent ; Autism Spectrum Disorder/psychology ; COVID-19/prevention & control ; Child ; Child, Preschool ; Female ; Humans ; Male ; Masks ; Patient Compliance/psychology
    Language English
    Publishing date 2021-03-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218065-0
    ISSN 1938-3703 ; 0021-8855
    ISSN (online) 1938-3703
    ISSN 0021-8855
    DOI 10.1002/jaba.829
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 1855: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Structure-Guided Chemical Optimization of Bicyclic Peptide (

    Harman, Maximilian A J / Stanway, Steven J / Scott, Heather / Demydchuk, Yuliya / Bezerra, Gustavo Arruda / Pellegrino, Simone / Chen, Liuhong / Brear, Paul / Lulla, Aleksei / Hyvönen, Marko / Beswick, Paul J / Skynner, Michael J

    Journal of medicinal chemistry

    2023  Volume 66, Issue 14, Page(s) 9881–9893

    Abstract: Angiotensin-converting enzyme 2 (ACE2) is a metalloprotease that cleaves angiotensin II, a peptide substrate involved in the regulation of hypertension. Here, we identified a series of constrained bicyclic peptides, ...

    Abstract Angiotensin-converting enzyme 2 (ACE2) is a metalloprotease that cleaves angiotensin II, a peptide substrate involved in the regulation of hypertension. Here, we identified a series of constrained bicyclic peptides,
    MeSH term(s) Humans ; Angiotensin-Converting Enzyme 2 ; Carboxypeptidases/chemistry ; Peptidyl-Dipeptidase A ; Bicycling ; Peptides/pharmacology ; Angiotensin II ; Peptide Fragments
    Chemical Substances Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) ; Carboxypeptidases (EC 3.4.-) ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; Peptides ; Angiotensin II (11128-99-7) ; Peptide Fragments
    Language English
    Publishing date 2023-07-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/acs.jmedchem.3c00710
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 151: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MB 1: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top