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Article: Cystic Echinococcosis in Hospitalized Children from Western Romania: A 25-Year Retrospective Study.

Paduraru, Ana Alexandra / Lupu, Maria Alina / Popoiu, Calin Marius / Stanciulescu, Maria Corina / Tirnea, Livius / Boia, Eugen Sorin / Olariu, Tudor Rares

Biomedicines

2024 Volume 12, Issue 2

Abstract: Cystic echinococcosis (CE) is a cosmopolitan parasitic disease caused ... ...

Abstract	Cystic echinococcosis (CE) is a cosmopolitan parasitic disease caused by
Language	English
Publishing date	2024-01-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines12020281
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Article ; Online: Exploring Pregnancy Outcomes Associated with SARS-CoV-2 Infection.

Timircan, Madalina / Bratosin, Felix / Vidican, Iulia / Suciu, Oana / Tirnea, Livius / Avram, Valentina / Marincu, Iosif

Medicina (Kaunas, Lithuania)

2021 Volume 57, Issue 8

Abstract: Background and ... ...

Abstract	Background and Objectives
MeSH term(s)	COVID-19 ; Cesarean Section ; Female ; Humans ; Infant, Newborn ; Infectious Disease Transmission, Vertical ; Pandemics ; Pregnancy ; Pregnancy Complications, Infectious/epidemiology ; Pregnancy Outcome/epidemiology ; Premature Birth/epidemiology ; Prospective Studies ; SARS-CoV-2
Language	English
Publishing date	2021-08-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina57080796
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Article ; Online: Predictive Factors for the First Recurrence of

Marincu, Iosif / Bratosin, Felix / Vidican, Iulia / Cerbu, Bianca / Turaiche, Mirela / Tirnea, Livius / Timircan, Madalina

Medicina (Kaunas, Lithuania)

2020 Volume 56, Issue 9

Abstract: Background and objectives: ...

Abstract	Background and objectives:
MeSH term(s)	Aged ; Anti-Bacterial Agents/therapeutic use ; Clostridium Infections/complications ; Clostridium Infections/diagnosis ; Clostridium Infections/drug therapy ; Cross Infection/complications ; Cross Infection/diagnosis ; Cross Infection/drug therapy ; Cross Infection/microbiology ; Enterocolitis/complications ; Enterocolitis/diagnosis ; Enterocolitis/drug therapy ; Enterocolitis/microbiology ; Female ; Fever/microbiology ; Gastrointestinal Diseases/complications ; Humans ; Immunocompromised Host ; Male ; Reinfection ; Retrospective Studies ; Risk Factors ; Romania
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2020-08-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina56090439
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Article ; Online: Exploring Pregnancy Outcomes Associated with SARS-CoV-2 Infection

Madalina Timircan / Felix Bratosin / Iulia Vidican / Oana Suciu / Livius Tirnea / Valentina Avram / Iosif Marincu

Medicina, Vol 57, Iss 796, p

2021 Volume 796

Abstract: Background and Objectives : The ongoing pandemic proved to be a tremendous challenge to all economic layers, healthcare, and people safety. As more than one year elapsed since the beginning of the COVID-19 pandemic, a multitude of medical studies ... ...

Abstract	Background and Objectives : The ongoing pandemic proved to be a tremendous challenge to all economic layers, healthcare, and people safety. As more than one year elapsed since the beginning of the COVID-19 pandemic, a multitude of medical studies involving the SARS-CoV-2 virus helped researchers and medical practitioners in understanding the effects it has on all sorts of patients until effective vaccines were finally developed and distributed for mass vaccination. Still, the SARS-CoV-2 and its new variants remain a potential threat towards all categories of patients, including a more delicate group represented by pregnant women. Thus, the current study aims to investigate the potential effects on obstetrical outcomes after a positive SARS-CoV-2 infection. Materials and Methods : This single-center prospective cohort study investigated the pregnancy outcomes in a total of 1039 eligible pregnant women between 30 August 2020 and 30 January 2021. Multiple patient characteristics and obstetrical outcomes were tested and analyzed in a multivariate regression model to establish potential risks determined by a COVID-19-positive pregnancy towards the mother and the newborn. Results : In the study sample, there were 938 pregnancies included without COVID-19 and 101 pregnant women identified with a positive COVID-19 infection. COVID-19 was significantly associated with a 2-fold increase in the risk of premature rupture of membranes and 1.5 times higher risk of preterm birth with emergency c-sections and lower APGAR scores. Also, significantly more newborns were given birth prematurely, with lower APGAR scores after the mothers were infected with SARS-CoV-2. Conclusions : A third-trimester infection with SARS-CoV-2 is a significant risk factor for preterm birth via an emergency cesarean section, a premature rupture of membranes, and a lower APGAR score in newborns, as compared with pregnancies where COVID-19 was not identified.
Keywords	adverse birth outcomes ; COVID-19 ; pregnancy outcomes ; SARS-CoV-2 ; preterm births ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2021-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Efficacy of Convalescent Plasma Use in Critically Ill COVID-19 Patients.

Tirnea, Livius / Bratosin, Felix / Vidican, Iulia / Cerbu, Bianca / Turaiche, Mirela / Timircan, Madalina / Margan, Madalin-Marius / Marincu, Iosif

Medicina (Kaunas, Lithuania)

2021 Volume 57, Issue 3

Abstract: Background and Objectives: ...

Abstract	Background and Objectives:
MeSH term(s)	Adult ; Anti-Bacterial Agents/therapeutic use ; Anticoagulants/therapeutic use ; Antiviral Agents/therapeutic use ; C-Reactive Protein/metabolism ; COVID-19/blood ; COVID-19/physiopathology ; COVID-19/therapy ; Critical Illness ; Glucocorticoids/therapeutic use ; Humans ; Immunization, Passive/methods ; Interleukin-6/blood ; Leukocyte Count ; Male ; Middle Aged ; Pilot Projects ; Romania ; SARS-CoV-2 ; Treatment Outcome
Chemical Substances	Anti-Bacterial Agents ; Anticoagulants ; Antiviral Agents ; Glucocorticoids ; Interleukin-6 ; C-Reactive Protein (9007-41-4)
Language	English
Publishing date	2021-03-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina57030257
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Article: Foodborne Botulism in Western Romania: Ten Years' Experience at a Tertiary Infectious Disease Hospital.

Marincu, Iosif / Bratosin, Felix / Vidican, Iulia / Cerbu, Bianca / Suciu, Oana / Turaiche, Mirela / Tirnea, Livius / Timircan, Madalina

Healthcare (Basel, Switzerland)

2021 Volume 9, Issue 9

Abstract: Objectives: The purpose of this study was to analyze epidemiological data concerning foodborne botulism in Western Romania over the last decade. Botulism, the toxin formed by the bacterium : Methods: Medical records were retrospectively analyzed from ...

Abstract	Objectives: The purpose of this study was to analyze epidemiological data concerning foodborne botulism in Western Romania over the last decade. Botulism, the toxin formed by the bacterium Methods: Medical records were retrospectively analyzed from 2010 to 2020 for all food botulism cases. A seroneutralization test was performed with type A, B and E anti-botulinum sera to establish the kind of toxin involved. Results: Overall, 18 cases of foodborne botulism were admitted to the hospital during this period and confirmed by laboratory analysis. Most of the participants in our study were men (61.1%), and 77.8% of the total lived in rural areas. All the participants showed classic symptoms of botulism, and dysphagia was present in all cases. The trivalent ABE antitoxin was administered by the hospital, and toxin type B was isolated in all patients. The main sources of the toxin were pork, ham and canned pork meat. Conclusions: Stronger efforts are needed to foster community awareness of foodborne botulism, particularly in home-preserved food.
Language	English
Publishing date	2021-09-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2721009-1
ISSN	2227-9032
ISSN	2227-9032
DOI	10.3390/healthcare9091149
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Article: Predictive Value of Comorbid Conditions for COVID-19 Mortality.

Marincu, Iosif / Bratosin, Felix / Vidican, Iulia / Bostanaru, Andra-Cristina / Frent, Stefan / Cerbu, Bianca / Turaiche, Mirela / Tirnea, Livius / Timircan, Madalina

Journal of clinical medicine

2021 Volume 10, Issue 12

Abstract: In this paper, we aim at understanding the broad spectrum of factors influencing the survival of infected patients and the correlations between these factors to create a predictive probabilistic score for surviving the COVID-19 disease. Initially, 510 ... ...

Abstract	In this paper, we aim at understanding the broad spectrum of factors influencing the survival of infected patients and the correlations between these factors to create a predictive probabilistic score for surviving the COVID-19 disease. Initially, 510 hospital admissions were counted in the study, out of which 310 patients did not survive. A prediction model was developed based on this data by using a Bayesian approach. Following the data collection process for the development study, the second cohort of patients totaling 541 was built to validate the risk matrix previously created. The final model has an area under the curve of 0.773 and predicts the mortality risk of SARS-CoV-2 infection based on nine disease groups while considering the gender and age of the patient as distinct risk groups. To ease medical workers' assessment of patients, we created a visual risk matrix based on a probabilistic model, ranging from a score of 1 (very low mortality risk) to 5 (very high mortality risk). Each score comprises a correlation between existing comorbid conditions, the number of comorbid conditions, gender, and age group category. This clinical model can be generalized in a hospital context and can be used to identify patients at high risk for whom immediate intervention might be required.
Language	English
Publishing date	2021-06-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm10122652
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Article: Clinical Presentation and Risk Factors of Infective Endocarditis in the Elderly: A Systematic Review.

Budea, Camelia Melania / Bratosin, Felix / Bogdan, Iulia / Bota, Adrian Vasile / Turaiche, Mirela / Tirnea, Livius / Stoica, Carmen Nicoleta / Csep, Andrei Nicolae / Feciche, Bogdan / Pescariu, Silvius Alexandru / Popa, Malina / Mavrea, Adelina / Bumbu, Bogdan Andrei / Bandi, Satya Sai Sri / Marincu, Iosif

Journal of personalized medicine

2023 Volume 13, Issue 2

Abstract: Infective endocarditis (IE) is a bacterial infection with high morbidity and mortality rates, particularly among the elderly. This systematic review was conducted to determine the clinical characteristics of IE in older adults and the risk factors that ... ...

Abstract	Infective endocarditis (IE) is a bacterial infection with high morbidity and mortality rates, particularly among the elderly. This systematic review was conducted to determine the clinical characteristics of IE in older adults and the risk factors that could lead to adverse outcomes. The research employed three databases (PubMed, Wiley, and Web of Science), with a primary search for studies that have described cases of IE in patients older than 65 years. From a total of 555 articles, 10 were selected for inclusion in the current study, comprising a total of 2222 patients with a confirmed diagnosis of IE. The primary findings were an increased incidence of staphylococcal and streptococcal infections (33.4% and32.0%, respectively), an increased prevalence of comorbidities, namely, cardiovascular disease, diabetes, and cancer, and a significantly greater mortality risk than the younger group. Regarding mortality risks, the pooled odds ratio for cardiac disorders was OR = 3.81, septic shock OR = 8.22, renal complications OR = 3.75, and advancing age OR = 3.54 were most frequently mentioned. Taking into consideration the fact that the majority of the elderly population suffers from significant complications and is unable to undergo surgery due to an increased risk of complications after the procedure, it is imperative that effective treatment methods should be investigated.
Language	English
Publishing date	2023-02-07
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm13020296
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Article ; Online: Predictive Factors for the First Recurrence of Clostridioides difficile Infection in the Elderly from Western Romania

Iosif Marincu / Felix Bratosin / Iulia Vidican / Bianca Cerbu / Mirela Turaiche / Livius Tirnea / Madalina Timircan

Medicina, Vol 56, Iss 439, p

2020 Volume 439

Abstract: Background and objectives: At present, Romania and parts of the European Union are facing an increasingly challenging public health problem consisting of nosocomial Clostridioides difficile infection (CDI), mostly in the elderly. Relapse cases have ... ...

Abstract	Background and objectives: At present, Romania and parts of the European Union are facing an increasingly challenging public health problem consisting of nosocomial Clostridioides difficile infection (CDI), mostly in the elderly. Relapse cases have become more frequent, which present higher morbidity and mortality rates than the initial CDI infection. The aim of this study is to determine the predictive factors for recurrence, with the purpose of reducing the exposure of patients diagnosed with CDI, as well as aiming to initiate early treatment. Materials and Methods: In this retrospective descriptive study, we analyze a database from the First Department of Infectious Diseases at the Dr. Victor Babes Clinical Hospital for Infectious Diseases and Pulmonology in Timisoara, looking for patient history of CDI recurrences. We analyzed CDI recurrence in patients aged ≥65 years from 1 January 2016 to 31 December 2019, identifying 77 cases of CDI recurrence. The determination of predictive factors for recurrence involved the formation of a randomized control group, consisting of 74 patients aged ≥65 years who were diagnosed with C. difficile enterocolitis, but did not suffer a recurrence and survived ≥2 weeks after symptom onset. Results: Immunocompromised status, pre-existing gastrointestinal disease, and fever on initial hospitalization for CDI were all found to be significant independent positive predictive factors for the condition recurring in elderly Romanian patients. Conclusions: As the geriatric population in Romania grows, the national health system becomes increasingly overburdened, both from a financial standpoint and a human resources perspective. The analysis of factors predictive for CDI recurrence is, thus, of the utmost importance, particularly for the early identification of patients most at risk of CDI recurrence. Our findings could help physicians to identify recurrence early, consequently benefitting patients by a rapid intervention with a potential decrease in the associated complications and ...
Keywords	infection recurrence ; geriatric population ; infectious diseases ; immunocompromised ; Clostridioides difficile ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2020-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Predictive Value of Comorbid Conditions for COVID-19 Mortality

Iosif Marincu / Felix Bratosin / Iulia Vidican / Andra-Cristina Bostanaru / Stefan Frent / Bianca Cerbu / Mirela Turaiche / Livius Tirnea / Madalina Timircan

Journal of Clinical Medicine, Vol 10, Iss 2652, p

2021 Volume 2652

Abstract	In this paper, we aim at understanding the broad spectrum of factors influencing the survival of infected patients and the correlations between these factors to create a predictive probabilistic score for surviving the COVID-19 disease. Initially, 510 hospital admissions were counted in the study, out of which 310 patients did not survive. A prediction model was developed based on this data by using a Bayesian approach. Following the data collection process for the development study, the second cohort of patients totaling 541 was built to validate the risk matrix previously created. The final model has an area under the curve of 0.773 and predicts the mortality risk of SARS-CoV-2 infection based on nine disease groups while considering the gender and age of the patient as distinct risk groups. To ease medical workers’ assessment of patients, we created a visual risk matrix based on a probabilistic model, ranging from a score of 1 (very low mortality risk) to 5 (very high mortality risk). Each score comprises a correlation between existing comorbid conditions, the number of comorbid conditions, gender, and age group category. This clinical model can be generalized in a hospital context and can be used to identify patients at high risk for whom immediate intervention might be required.
Keywords	mortality risk ; COVID-19 ; prediction model ; SARS-CoV-2 ; Medicine ; R
Subject code	310
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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