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  1. Article ; Online: CBT and CFT for Chronic Pain.

    Hadley, Graham / Novitch, Matthew B

    Current pain and headache reports

    2021  Volume 25, Issue 5, Page(s) 35

    Abstract: Purpose of review: Chronic pain is a widespread public and physical health crisis, as it is one of the most common reasons adults seek medical care and accounts for the largest medical reason for disability in the USA (Glombiewski et al., J Consult Clin ...

    Abstract Purpose of review: Chronic pain is a widespread public and physical health crisis, as it is one of the most common reasons adults seek medical care and accounts for the largest medical reason for disability in the USA (Glombiewski et al., J Consult Clin Psychol. 86(6):533-545, 2018; Schemer et al., Eur J Pain. 23(3):526-538, 2019). Chronic pain is associated with decreased functional status, opioid dependence and substance abuse disorders, mental health crises, and overall lower perceived quality of life (Korff et al., J Pain. 17(10):1068-1080, 2016). For example, the leading cause of chronic pain and the leading cause of long-term disability is low back pain (LBP) (Bjorck-van Dijken et al. J Rehabil Med. 40:864-9, 2008). Evidence suggests that persistent low back pain (pLBP) is a multidimensional biopsychosocial problem with various contributing factors (Cherkin et al., JAMA. 315(12):1240-1249, 2016). Emotional distress, pain-related fear, and protective movement behaviors are all unhelpful lifestyle factors that previously were more likely to go unaddressed when assessing and treating patient discomfort (Pincus et al., Spine. 38:2118-23, 2013). Those that are not properly assisted with these psychosocial issues are often unlikely to benefit from treatment in the primary care setting and thus are referred to multidisciplinary pain rehabilitation physicians. This itself increases healthcare costs, and treatments can be invasive and have risks of their own. Therefore, less expensive and more accessible management strategies targeting these psychosocial issues should be started to facilitate improvement early. As a biopsychosocial disorder, chronic pain is influenced by a range of factors including lifestyle, mental health status, familial culture, and socioeconomic status. Physicians have moved toward multi-modal pain approaches in order to combat this public health dilemma, ranging from medications with several different mechanisms of action, lifestyle changes, procedural pain control, and psychological interventions (Fashler et al., Pain Res Manag. 2016:5960987, 2016). Part of the rehabilitation process now more and more commonly includes cognitive behavioral and cognitive functional therapy. Cognitive functional therapy (CFT) and cognitive behavioral therapy (CBT) are both multidimensional psychological approaches to combat the mental portion of difficult pain control. While these therapies are quite different in their approach, they lend to the idea that chronic pain can and should be targeted using coping mechanisms, helping patients understand the pathophysiological process of pain, and altering behavior.
    Recent findings: CFT differs from CBT functionally, as instead of improving managing/coping mechanisms of pain control from a solely mental approach, CFT directly points out maladaptive behaviors and actively challenges the patient to change them in a cognitively integrated, progressive overloading functional manner (Bjorck-van Dijken et al. J Rehabil Med. 40:864-9, 2008). This allows CFT to be targeted to each individual patient, with the goal of personalized reconceptualization of the pain response. The end goal is to overcome the barriers that prevent functional status improvement, a healthy lifestyle, and reaching their personal goals. Chronic pain is a major public health issue. Cognitive functional therapy (CFT) and cognitive behavioral therapy (CBT) are both multidimensional psychological approaches to combat the mental portion of difficult pain control. While these therapies are quite different in their approach, they lend to the idea that chronic pain can and should be targeted using coping mechanisms, helping patients understand the pathophysiological process of pain, and altering behavior.
    MeSH term(s) Chronic Pain/rehabilitation ; Cognitive Behavioral Therapy/methods ; Humans
    Language English
    Publishing date 2021-04-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2055062-5
    ISSN 1534-3081 ; 1531-3433
    ISSN (online) 1534-3081
    ISSN 1531-3433
    DOI 10.1007/s11916-021-00948-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: The Emergence of a Forgotten Entity: Dermatomyositis-like Presentation of Lyme Disease in Rural Wisconsin.

    Novitch, Matthew / Wahab, Ahsan / Kakarala, Radhika / Mukerji, Ridhwi

    Cureus

    2018  Volume 10, Issue 5, Page(s) e2608

    Abstract: Dermatomyositis (DM) is one of the rare clinical manifestations of tickborne-related autoimmune presentations; we report an uncommon case of Borrelia-related DM-like presentation from rural Wisconsin. A 76-year-old female presented with fatigue, malaise, ...

    Abstract Dermatomyositis (DM) is one of the rare clinical manifestations of tickborne-related autoimmune presentations; we report an uncommon case of Borrelia-related DM-like presentation from rural Wisconsin. A 76-year-old female presented with fatigue, malaise, weight loss and progressive proximal muscle weakness after a flare-up of shoulder arthritis. She had a heliotrope rash and a Shawl sign in addition to generalized cutaneous erythema with edema. There was no history of tick bite, Lyme disease (LD) or DM. The physical exam revealed erythema migrans (EM) and DM-like musculocutaneous findings. Enzyme-linked immunosorbent assay and western blot were positive for LD. The patient received intravenous ceftriaxone and doxycycline for five days, leading to the resolution of EM lesions and improvement in her muscle weakness. In addition, DM-like features resolved with antiborrelial treatment and required no steroids or immunosuppressants. Workup including electromyography, skin or muscle biopsy could not be performed as the patient improved clinically. At six months post-treatment, she remained in remission.
    Language English
    Publishing date 2018-05-10
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.2608
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Potential opioid-related adverse events following spine surgery in elderly patients.

    Jones, Mark R / Brovman, Ethan Y / Novitch, Matthew B / Rao, Nikhilesh / Urman, Richard D

    Clinical neurology and neurosurgery

    2019  Volume 186, Page(s) 105550

    Abstract: Objective: Understanding the clinical and economic impact of opioid-related adverse drug events (ORADEs) within spine surgery may guide both the clinician's and hospital administration's approach to treating perioperative pain, thus improving patient ... ...

    Abstract Objective: Understanding the clinical and economic impact of opioid-related adverse drug events (ORADEs) within spine surgery may guide both the clinician's and hospital administration's approach to treating perioperative pain, thus improving patient care and reducing hospital costs. The objective of this analysis is to understand how potential ORADEs after spine surgery in elderly patients affect length of stay, hospital revenue and their association with comorbid conditions.
    Patients and methods: We conducted a retrospective study utilizing the Center for Medicare/Medicaid Services Administrative Database to analyze Medicare discharges between April 2016 and March 2017 involving 14 spine surgery DRGs for major spine procedures in order to identify potential ORADEs. An analysis was conducted using this database to identify the incidence of potential ORADEs as well as their impact on mean hospital length of stay and hospital revenue.
    Results: There were 177,432 discharges during the study period. The ORADE rate in patients undergoing spine surgery was 13.9% (24,642/177,432). The mean length of stay (LOS) for discharges with an ORADE was 3.13 days longer than without an ORADE (6.29 days with an ORADE vs 3.16 days without an ORADE). The adverse post-operative outcomes most strongly associated with potential ORADEs included shock, pneumonia, and septicemia. The mean hospital revenue per day with an ORADE was $3,076 less than without an ORADE ($7,263 with an ORADE vs $10,339 without an ORADE).
    Conclusion: Potential ORADEs in spine surgery in elderly patients are common and are associated with longer hospitalizations and decreased hospital revenue. Perioperative pain management strategies that reduce ORADEs may improve patient care and increase hospital revenue.
    MeSH term(s) Aged ; Aged, 80 and over ; Analgesics, Opioid/adverse effects ; Female ; Humans ; Length of Stay/trends ; Male ; Medicare/trends ; Pain, Postoperative/etiology ; Pain, Postoperative/prevention & control ; Retrospective Studies ; Spinal Diseases/drug therapy ; Spinal Diseases/surgery ; United States/epidemiology
    Chemical Substances Analgesics, Opioid
    Language English
    Publishing date 2019-10-03
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 193107-6
    ISSN 1872-6968 ; 0303-8467
    ISSN (online) 1872-6968
    ISSN 0303-8467
    DOI 10.1016/j.clineuro.2019.105550
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The Role of Complementary and Alternative Medicine Treatments in Fibromyalgia: a Comprehensive Review.

    Prabhakar, Amit / Kaiser, Jennifer M / Novitch, Matthew B / Cornett, Elyse M / Urman, Richard D / Kaye, Alan D

    Current rheumatology reports

    2019  Volume 21, Issue 5, Page(s) 14

    Abstract: Purpose of review: Fibromyalgia is a complex chronic pain syndrome that can have debilitating consequences for affected patients. When compared to the general population, patients with fibromyalgia experience lowered mechanical and thermal pain ... ...

    Abstract Purpose of review: Fibromyalgia is a complex chronic pain syndrome that can have debilitating consequences for affected patients. When compared to the general population, patients with fibromyalgia experience lowered mechanical and thermal pain thresholds, altered temporal summation of painful stimuli, and higher than normal pain ratings for known noxious stimuli.
    Recent findings: There is no definitive cure for fibromyalgia and treatment primarily focuses on both symptom management and improving patient quality of life. This treatment strategy involves a comprehensive multidisciplinary approach consisting of lifestyle modifications, pharmacologic measures, and other complementary approaches including but not limited to acupuncture, yoga, tai chi, and meditation. This manuscript will discuss the diagnosis and treatment of fibromyalgia, as well as complementary and alternative therapies that should be considered by healthcare providers.
    MeSH term(s) Complementary Therapies ; Fibromyalgia/psychology ; Fibromyalgia/therapy ; Humans ; Quality of Life/psychology
    Language English
    Publishing date 2019-03-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057357-1
    ISSN 1534-6307 ; 1523-3774
    ISSN (online) 1534-6307
    ISSN 1523-3774
    DOI 10.1007/s11926-019-0814-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Medication-Induced Tardive Dyskinesia: A Review and Update.

    Cornett, Elyse M / Novitch, Matthew / Kaye, Alan David / Kata, Vijay / Kaye, Adam M

    The Ochsner journal

    2017  Volume 17, Issue 2, Page(s) 162–174

    Abstract: Background: Tardive dyskinesia (TD) is a movement disorder that causes involuntary, repetitive body movements and is commonly seen in patients who are on long-term treatment with antipsychotic medications. However, several other classes of medications ... ...

    Abstract Background: Tardive dyskinesia (TD) is a movement disorder that causes involuntary, repetitive body movements and is commonly seen in patients who are on long-term treatment with antipsychotic medications. However, several other classes of medications with different mechanisms are also associated with TD.
    Methods: We conducted a PubMed search using keywords and combined word searches that involved medication-induced TD, as well as agents that are associated with causing or are used to treat medication-induced TD. We attempted to include as many recent (publication date of 2015 and later) articles as possible.
    Results: The reported incidence of TD seems to be reduced with the use of atypical antipsychotic drugs, yet the risk of developing TD remains with these medications. Furthermore, several other medication classes have a high prevalence of TD and yet are not commonly considered to be TD-inducing. This review highlights the need for a prevention-based focus of TD treatment that starts with a clinical consideration of pharmacologic choices related to each individual patient's history.
    Conclusion: This review offers the information current as of 2016 on the pathophysiology, etiology, and epidemiology of TD, as well as the medications associated with TD, mechanisms of medication-induced TD, and treatments for medication-induced TD.
    Language English
    Publishing date 2017-06-15
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1524-5012
    ISSN 1524-5012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Regional Catheters for Outpatient Surgery-a Comprehensive Review.

    Jones, Mark R / Petro, Julie A / Novitch, Matthew B / Faruki, Adeel A / Bice, Jeffrey B / Viswanath, Omar / Rana, Paragi H / Kaye, Alan D

    Current pain and headache reports

    2019  Volume 23, Issue 4, Page(s) 24

    Abstract: Purpose of review: This review summarizes and discusses the history of continuous catheter blockade (CCB), its current applications, clinical considerations, economic benefits, potential complications, patient education, and best practice techniques.: ...

    Abstract Purpose of review: This review summarizes and discusses the history of continuous catheter blockade (CCB), its current applications, clinical considerations, economic benefits, potential complications, patient education, and best practice techniques.
    Recent findings: Regional catheters for outpatient surgery have greatly impacted acute post-operative pain management and recovery. Prior to development, options for acute pain management were limited to the use of opioid pain medications, NSAIDS, neuropathic agents, and the like as local anesthetic duration of action is limited to 4-8 h. Moreover, delivery of opioids post-operatively has been associated with respiratory and central nervous depression, development of opioid use disorder, and many other potential adverse effects. CCB allows for faster recovery time, decreased rates of opioid abuse, and better pain control in patients post-operatively. Outpatient surgical settings continue to focus on efficiency, quality, and safety, including strategies to prevent post-operative nausea, vomiting, and pain. Regional catheters are a valuable tool and help achieve all of the well-established endpoints of enhanced recovery after surgery (ERAS). CCB is growing in popularity with wide indications for a variety of surgeries, and has demonstrated improved patient satisfaction, outcomes, and reductions in many unwanted adverse effects in the outpatient setting.
    MeSH term(s) Ambulatory Surgical Procedures/adverse effects ; Ambulatory Surgical Procedures/methods ; Anesthesia, Local/methods ; Anesthetics, Local/therapeutic use ; Catheters ; Humans ; Pain Management/methods ; Pain, Postoperative/etiology ; Pain, Postoperative/prevention & control
    Chemical Substances Anesthetics, Local
    Language English
    Publishing date 2019-03-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2055062-5
    ISSN 1534-3081 ; 1531-3433
    ISSN (online) 1534-3081
    ISSN 1531-3433
    DOI 10.1007/s11916-019-0762-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: New benzodiazepines for sedation.

    Cornett, Elyse M / Novitch, Matthew B / Brunk, Andrew J / Davidson, Kelly S / Menard, Bethany L / Urman, Richard D / Kaye, Alan D

    Best practice & research. Clinical anaesthesiology

    2018  Volume 32, Issue 2, Page(s) 149–164

    Abstract: There are currently new drugs being developed that have benzodiazepine properties. This review will examine remimazolam, 3-hydroxyphenazapam, adinazolam, clonazolam, and deschloroetizolam as well as other novel agents. All benzodiazepines are protein ... ...

    Abstract There are currently new drugs being developed that have benzodiazepine properties. This review will examine remimazolam, 3-hydroxyphenazapam, adinazolam, clonazolam, and deschloroetizolam as well as other novel agents. All benzodiazepines are protein bound and only moderately lipid soluble. In addition to their baseline properties, they can be enzymatically broken down into active metabolites. The mechanism of action of these medications is related to polysynaptic pathway inhibition via direct interaction with GABA and modifiable chloride channels. The main neurological areas of involvement are primarily the amygdala and reticular activating system. Benzodiazepines are used for sedation and for adjuvants to general anesthetics and not as primary induction agents. We describe the characteristics of newer drugs being developed, including their pharmacologic profile, side effects and efficacy, as well as the most recent clinical trials and future directions in benzodiazepine development.
    MeSH term(s) Anesthesia/methods ; Anesthesia/trends ; Benzodiazepines/administration & dosage ; Benzodiazepines/metabolism ; Humans ; Hypnotics and Sedatives/administration & dosage ; Hypnotics and Sedatives/metabolism
    Chemical Substances Hypnotics and Sedatives ; Benzodiazepines (12794-10-4)
    Language English
    Publishing date 2018-07-03
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2028818-9
    ISSN 1878-1608 ; 1521-6896 ; 1753-3740
    ISSN (online) 1878-1608 ; 1521-6896
    ISSN 1753-3740
    DOI 10.1016/j.bpa.2018.06.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Pharmacogenomics, concepts for the future of perioperative medicine and pain management: A review.

    Kaye, Alan D / Koress, Cody M / Novitch, Matthew B / Jung, Jai Won / Urits, Ivan / Viswanath, Omar / Renschler, Jordan S / Alpaugh, Edward S / Cornett, Elyse M

    Best practice & research. Clinical anaesthesiology

    2020  Volume 34, Issue 3, Page(s) 651–662

    Abstract: Pharmacogenomics is the study of how genetic differences between individuals affect pharmacokinetics and pharmacodynamics. These differences are apparent to clinicians when taking into account the wide range of responses to medications given in clinical ... ...

    Abstract Pharmacogenomics is the study of how genetic differences between individuals affect pharmacokinetics and pharmacodynamics. These differences are apparent to clinicians when taking into account the wide range of responses to medications given in clinical practice. A review of literature involving pharmacogenomics and pain management was performed. The implementation of preoperative pharmacogenomics will allow us to better care for our patients by delivering personalized, safer medicine. This review describes the current state of pharmacogenomics as it relates to many aspects of clinical practice and how clinicians can use these tools to improve patient outcomes.
    MeSH term(s) Forecasting ; Humans ; Pain Management/methods ; Pain Management/trends ; Pain, Postoperative/genetics ; Pain, Postoperative/physiopathology ; Pain, Postoperative/therapy ; Perioperative Care/methods ; Perioperative Care/trends ; Perioperative Medicine/methods ; Perioperative Medicine/trends ; Pharmacogenetics/methods ; Pharmacogenetics/trends
    Keywords covid19
    Language English
    Publishing date 2020-07-22
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2051316-1
    ISSN 1878-1608 ; 1753-3740 ; 1521-6896
    ISSN (online) 1878-1608
    ISSN 1753-3740 ; 1521-6896
    DOI 10.1016/j.bpa.2020.07.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Non-Opioid Perioperative Pain Strategies for the Clinician: A Narrative Review.

    Kaye, Alan David / Granier, Amanda L / Garcia, Andrew J / Carlson, Sam F / Fuller, Mitch C / Haroldson, Alex R / White, Shane W / Krueger, Owen L / Novitch, Matthew B / Cornett, Elyse M

    Pain and therapy

    2020  Volume 9, Issue 1, Page(s) 25–39

    Abstract: Alternative and non-opioid options for pain management are necessary in perioperative patient care. Opioids are no longer touted as cure-all medications, and furthermore, there have been tremendous advances in alternative therapies such as in ... ...

    Abstract Alternative and non-opioid options for pain management are necessary in perioperative patient care. Opioids are no longer touted as cure-all medications, and furthermore, there have been tremendous advances in alternative therapies such as in interventional pain, physical therapy, exercise, and nutritional counseling that have proven benefits to combat pain. The center for disease control now strongly recommends the use of multimodal analgesia and multidisciplinary approaches based on the individual needs of patients: personalized medicine. In this manuscript, the specifics of non-opioid pharmacological and non-pharmacological analgesic approaches will be discussed as well as their possible indications and uses to reduce the need for excessive use of opioids for adequate pain control.
    Language English
    Publishing date 2020-01-13
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2701614-6
    ISSN 2193-651X ; 2193-8237
    ISSN (online) 2193-651X
    ISSN 2193-8237
    DOI 10.1007/s40122-019-00146-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Opioid addiction, diversion, and abuse in chronic and cancer pain.

    Kata, Vijay / Novitch, Matthew B / Jones, Mark R / Anyama, Best O / Helander, Erik M / Kaye, Alan D

    Current opinion in supportive and palliative care

    2018  Volume 12, Issue 2, Page(s) 124–130

    Abstract: Purpose of review: The primary cause of overdose death in the United States is related to pharmaceutical opioids. A few particular populations that struggle with adverse outcomes related to opioid abuse are those in palliative care, those with chronic ... ...

    Abstract Purpose of review: The primary cause of overdose death in the United States is related to pharmaceutical opioids. A few particular populations that struggle with adverse outcomes related to opioid abuse are those in palliative care, those with chronic pain, and those receiving pain treatments secondary to cancer or chemotherapy.
    Recent findings: There have been massive efforts to decrease the use of opioid abuse in patient care in a gestalt manner, but palliative care provides unique challenges in applying these reduction tactics used by other specialties.
    Summary: We explore behavioral interventions, provider education, alternative pain management techniques, postmarketing surveillance, and abuse-deterrent formulas as emerging methods to counteract opioid abuse in these populations.
    MeSH term(s) Abuse-Deterrent Formulations/methods ; Analgesics, Opioid/administration & dosage ; Analgesics, Opioid/adverse effects ; Analgesics, Opioid/therapeutic use ; Cancer Pain/drug therapy ; Chronic Pain/drug therapy ; Delayed-Action Preparations ; Humans ; Opioid-Related Disorders/epidemiology ; Opioid-Related Disorders/mortality ; Pain Management/methods ; Palliative Care ; Practice Guidelines as Topic ; Practice Patterns, Physicians' ; Prescription Drug Diversion/prevention & control ; Prescription Drug Diversion/statistics & numerical data ; Product Surveillance, Postmarketing/methods ; United States
    Chemical Substances Abuse-Deterrent Formulations ; Analgesics, Opioid ; Delayed-Action Preparations
    Language English
    Publishing date 2018-02-21
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2633726-5
    ISSN 1751-4266 ; 1751-4258
    ISSN (online) 1751-4266
    ISSN 1751-4258
    DOI 10.1097/SPC.0000000000000333
    Database MEDical Literature Analysis and Retrieval System OnLINE

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