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  1. Article ; Online: The NHS SACT capacity crisis: Challenges and solutions.

    Dodhia, Vikash / Parkes, Joanne / Ghose, Aruni / Ng, Wendy

    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners

    2023  , Page(s) 10781552231185050

    Language English
    Publishing date 2023-06-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 1330764-2
    ISSN 1477-092X ; 1078-1552
    ISSN (online) 1477-092X
    ISSN 1078-1552
    DOI 10.1177/10781552231185050
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4488: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  2. Article ; Online: Assessing Radiological Response to Immunotherapy in Lung Cancer: An Evolving Arena.

    Rallis, Kathrine S / Makker, Shania / Ghose, Aruni / Sideris, Michail

    Cancer diagnosis & prognosis

    2024  Volume 4, Issue 1, Page(s) 1–8

    Abstract: In the past decade, immune checkpoint inhibitors (ICIs) have entered the treatment landscape of non-small-cell lung cancer, signalling a paradigm shift within the field characterized by significant survival benefits for patients with advanced and ... ...

    Abstract In the past decade, immune checkpoint inhibitors (ICIs) have entered the treatment landscape of non-small-cell lung cancer, signalling a paradigm shift within the field characterized by significant survival benefits for patients with advanced and metastatic disease, and especially those with non-targetable genetic oncogenic driver mutations. However, the shift towards immune-based treatments has created new challenges in oncology. Atypical immunotherapy response patterns, including pseudo-progression and hyperprogressive disease, as well as immune-related adverse events have generated the need for new methods to predict patient response to treatment. Hence, new versions of the traditional Response Evaluation Criteria for Solid Tumors (RECIST) have emerged to help characterise with better accuracy radiological findings concerning patient response classification to immunotherapy. This review discusses response evaluation criteria relevant to unique radiological findings observed in patients treated with immunotherapy for non-small-cell lung cancer.
    Language English
    Publishing date 2024-01-03
    Publishing country Greece
    Document type Journal Article ; Review
    ISSN 2732-7787
    ISSN (online) 2732-7787
    DOI 10.21873/cdp.10278
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Re: Pain and Health-related Quality of Life with Olaparib Versus Physician's Choice of Next-generation Hormonal Drug in Patients with Metastatic Castration-resistant Prostate Cancer with Homologous Recombination Repair Gene Alterations (PROfound): An Open-label, Randomised, Phase 3 Trial.

    Adeleke, Sola / Ghose, Aruni / Boussios, Stergios

    European urology

    2023  Volume 84, Issue 2, Page(s) 246–247

    MeSH term(s) Humans ; Male ; Pain ; Physicians ; Prostatic Neoplasms, Castration-Resistant/drug therapy ; Prostatic Neoplasms, Castration-Resistant/genetics ; Prostatic Neoplasms, Castration-Resistant/pathology ; Quality of Life ; Recombinational DNA Repair
    Chemical Substances olaparib (WOH1JD9AR8)
    Language English
    Publishing date 2023-04-07
    Publishing country Switzerland
    Document type Clinical Trial, Phase III ; Journal Article ; Randomized Controlled Trial ; Comment
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2023.03.023
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    Zs.A 1247: Show issues Location:
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    Zs.MO 294: Show issues

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  4. Article ; Online: A rare case of metaplastic breast carcinoma from India: Towards precision oncology.

    Banerjee, Soirindhri / Mahajan, Ishika / Ghose, Aruni / Boussios, Stergios / Chakraborty, Shivam

    Cancer reports (Hoboken, N.J.)

    2024  Volume 7, Issue 3, Page(s) e1997

    Abstract: Background: Metaplastic Breast Cancer (MpBC) is an exceedingly rare entity, accounting for less than 1% of all malignant breast tumours. Predominantly triple-negative, they are notorious for their chemoresistance, high rates of recurrence and decreased ... ...

    Abstract Background: Metaplastic Breast Cancer (MpBC) is an exceedingly rare entity, accounting for less than 1% of all malignant breast tumours. Predominantly triple-negative, they are notorious for their chemoresistance, high rates of recurrence and decreased disease-free survival (DFS). All this contributes significantly to BC mortality and results in poor prognostic implications. Limited evidence has led to a lacuna of specific treatment guidelines for this entity and hence remains an uncharted territory for clinicians.
    Case: We report a case of a 46 year old premenopausal female with left-sided metaplastic triple negative T3N2aM0 BC with mesenchymal differentiation (high grade) whom we treated with neoadjuvant chemotherapy, primary surgery in the form of extreme oncoplasty and adjuvant radiotherapy by Telecobalt machine. Contrary to the expected aggressive course of the disease and poor prognosis of treatment, the patient is presently in remission without progression for over 2 years of follow up.
    Conclusion: Limited experience in management of this pathological entity warrants the need for more research on it, with a special focus on targeted therapy. Discussing possibilities of a tailored approach, rather than a one-size-fits-all approach may aid in paving the path for the future of MpBC treatment.
    MeSH term(s) Female ; Humans ; Middle Aged ; Precision Medicine ; Breast Neoplasms/diagnosis ; Breast Neoplasms/therapy ; Prognosis ; Carcinoma, Squamous Cell/therapy ; Disease-Free Survival
    Language English
    Publishing date 2024-03-13
    Publishing country United States
    Document type Case Reports
    ISSN 2573-8348
    ISSN (online) 2573-8348
    DOI 10.1002/cnr2.1997
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Primary neuroendocrine breast cancer-an unusual occurrence.

    Vinod, Anjana / Mahajan, Ishika / Ghose, Aruni / Sreeram, Saraswathy

    Ecancermedicalscience

    2023  Volume 17, Page(s) 1520

    Abstract: Primary breast neuroendocrine neoplasms (BNENs) are a rare form of breast cancer, accounting for less than 0.1% of all breast malignancies. These neoplasms have a similar clinical presentation as conventional breast carcinomas, differing mainly in their ... ...

    Abstract Primary breast neuroendocrine neoplasms (BNENs) are a rare form of breast cancer, accounting for less than 0.1% of all breast malignancies. These neoplasms have a similar clinical presentation as conventional breast carcinomas, differing mainly in their histopathology and expression of neuroendocrine (NE) markers, chromogranin and synaptophysin. Owing to their rarity, current knowledge of these tumours comes mainly from corroborative case reports or retrospective case series. There is hence a lack of randomised data on the treatment of these entities and current protocol suggests similar treatment as that of conventional breast carcinomas. We report the case of a 48-year-old with a breast mass, which on further work-up was diagnosed as locally advanced carcinoma breast, that required a mastectomy and axillary node dissection on the same side and revealed NE differentiation on histopathological examination. Hence, immunohistochemical staining was indicated which confirmed NE differentiation. We discuss the current knowledge on incidence, demographics, diagnosis, histopathological and staining characteristics, prognostic factors and treatment modalities of BNENs.
    Language English
    Publishing date 2023-03-16
    Publishing country England
    Document type Case Reports
    ISSN 1754-6605
    ISSN 1754-6605
    DOI 10.3332/ecancer.2023.1520
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Self-breast examination for breast cancer screening: The Indian story.

    Ghose, Aruni / Basak, Swarnamudra / Agarwal, Tanya

    Indian journal of cancer

    2022  Volume 59, Issue 1, Page(s) 1–3

    MeSH term(s) Asians ; Breast Neoplasms/diagnosis ; Breast Neoplasms/epidemiology ; Breast Self-Examination ; Early Detection of Cancer ; Female ; Humans ; Mammography
    Language English
    Publishing date 2022-06-28
    Publishing country India
    Document type Editorial ; Comment
    ZDB-ID 410194-7
    ISSN 1998-4774 ; 0019-509X
    ISSN (online) 1998-4774
    ISSN 0019-509X
    DOI 10.4103/ijc.ijc_447_22
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    Zs.B 581: Show issues Location:
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  7. Article ; Online: Large Language Models in Oncology: Revolution or Cause for Concern?

    Caglayan, Aydin / Slusarczyk, Wojciech / Rabbani, Rukhshana Dina / Ghose, Aruni / Papadopoulos, Vasileios / Boussios, Stergios

    Current oncology (Toronto, Ont.)

    2024  Volume 31, Issue 4, Page(s) 1817–1830

    Abstract: The technological capability of artificial intelligence (AI) continues to advance with great strength. Recently, the release of large language models has taken the world by storm with concurrent excitement and concern. As a consequence of their ... ...

    Abstract The technological capability of artificial intelligence (AI) continues to advance with great strength. Recently, the release of large language models has taken the world by storm with concurrent excitement and concern. As a consequence of their impressive ability and versatility, their provide a potential opportunity for implementation in oncology. Areas of possible application include supporting clinical decision making, education, and contributing to cancer research. Despite the promises that these novel systems can offer, several limitations and barriers challenge their implementation. It is imperative that concerns, such as accountability, data inaccuracy, and data protection, are addressed prior to their integration in oncology. As the progression of artificial intelligence systems continues, new ethical and practical dilemmas will also be approached; thus, the evaluation of these limitations and concerns will be dynamic in nature. This review offers a comprehensive overview of the potential application of large language models in oncology, as well as concerns surrounding their implementation in cancer care.
    MeSH term(s) Humans ; Medical Oncology/methods ; Artificial Intelligence ; Neoplasms
    Language English
    Publishing date 2024-03-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1236972-x
    ISSN 1718-7729 ; 1198-0052
    ISSN (online) 1718-7729
    ISSN 1198-0052
    DOI 10.3390/curroncol31040137
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4305: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Herpes simplex virus-1 oesophagitis presenting with persistent hiccough in an immunocompetent host: A case report.

    Paul, Aritra / Ghose, Aruni

    Tropical doctor

    2021  Volume 51, Issue 4, Page(s) 601–602

    Abstract: Herpes simplex virus-1 (HSV-1) oesophagitis as an aetiology of persistent hiccough is a rarity in immunocompetent hosts and entails an exhaustive diagnostic work-up, since it does not present with any of the typical oesophagitis symptoms. Our patient ... ...

    Abstract Herpes simplex virus-1 (HSV-1) oesophagitis as an aetiology of persistent hiccough is a rarity in immunocompetent hosts and entails an exhaustive diagnostic work-up, since it does not present with any of the typical oesophagitis symptoms. Our patient presented with persistent hiccoughs that were resistant to treatment with baclofen. Oesophagogastroduodenoscopy with biopsy confirmed the diagnosis of HSV-1 oesophagitis. The hiccough subsided within 48 h of aciclovir therapy.
    MeSH term(s) Acyclovir/therapeutic use ; Antiviral Agents/therapeutic use ; Esophagitis/diagnosis ; Esophagitis/drug therapy ; Herpesvirus 1, Human ; Hiccup ; Humans
    Chemical Substances Antiviral Agents ; Acyclovir (X4HES1O11F)
    Language English
    Publishing date 2021-06-21
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 193169-6
    ISSN 1758-1133 ; 0049-4755
    ISSN (online) 1758-1133
    ISSN 0049-4755
    DOI 10.1177/00494755211022519
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1056: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  9. Article ; Online: Immunotherapy Combined With Standard Therapies in Head and Neck Squamous Cell Carcinoma - A Meta-analysis.

    Eden, Daisy / Ghose, Aruni / Moschetta, Michele / Pérez-Fidalgo, José Alejandro / Rassy, Elie / Boussios, Stergios

    Anticancer research

    2024  Volume 44, Issue 3, Page(s) 861–878

    Abstract: Head and neck squamous cell carcinoma (HNSCC) is a deadly disease with a poor prognosis due to late diagnosis and limited treatment options. Immunotherapy (IT) is emerging as a promising approach, especially after the failure of standard of care ... ...

    Abstract Head and neck squamous cell carcinoma (HNSCC) is a deadly disease with a poor prognosis due to late diagnosis and limited treatment options. Immunotherapy (IT) is emerging as a promising approach, especially after the failure of standard of care therapies (STs). The objective of this systematic review and meta-analysis was to evaluate whether the addition of IT to STs improves outcomes for patients with HNSCC, including overall survival (OS), progression-free survival (PFS), and quality of life (QoL). This review employed the Population Intervention Comparison and Outcome (PICO) framework to identify relevant search terms in electronic databases, and also included supplementary hand searches. Six primary research articles were selected using the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) flow chart, and were critically appraised. Data extraction from these studies was conducted, and a meta-analysis was performed to aid in the generation of forest plots. The addition of IT to standard anticancer therapies was found to enhance patient outcomes, such as OS, PFS, and QoL. The toxicity profile of IT was acceptable, with minimal treatment-related deaths. The most frequently observed adverse events (AE) were related to the skin, followed by hematological toxicities. Based on our analysis, the addition of IT to STs is a suitable treatment option and is supported by current research. However, further studies are needed to investigate factors that influence treatment effectiveness and to develop optimal therapies. To achieve this, we recommend a comprehensive treatment approach that involves the multidisciplinary team (MDT) and patient assessment tools.
    MeSH term(s) Humans ; Head and Neck Neoplasms/therapy ; Immunotherapy ; Quality of Life ; Squamous Cell Carcinoma of Head and Neck/therapy ; Standard of Care
    Language English
    Publishing date 2024-02-29
    Publishing country Greece
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 604549-2
    ISSN 1791-7530 ; 0250-7005
    ISSN (online) 1791-7530
    ISSN 0250-7005
    DOI 10.21873/anticanres.16880
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    Zs.A 1642: Show issues Location:
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  10. Article ; Online: Advanced Breast Cancer Care: The Current Situation and Global Disparities.

    Ghose, Aruni / Stanway, Susannah / Sirohi, Bhawna / Mutebi, Miriam / Adomah, Sarah

    Seminars in oncology nursing

    2023  Volume 40, Issue 1, Page(s) 151551

    Abstract: Objectives: Advanced breast cancer (ABC) is an incurable disease. The number of people living with ABC has increased globally. Disparities in ABC care exist at both individual and system levels. ABC cases in most low- and middle-income countries (LMICs) ...

    Abstract Objectives: Advanced breast cancer (ABC) is an incurable disease. The number of people living with ABC has increased globally. Disparities in ABC care exist at both individual and system levels. ABC cases in most low- and middle-income countries (LMICs) are underreported due to a lack of national cancer registries. Harmonized guidelines for resource stratification and capacity building in LMICs are under way.
    Data sources: MEDLINE, Cochrane, and Google Scholar databases were used.
    Conclusion: To improve ABC outcomes and resolve disparities, more robust health systems or pathways need to be developed across the cancer continuum in addition to social education.
    Implications for nursing practice: So far, the ABC specialist nurse role has been variable globally, and to conquer such variability, an international online nurse education and training program is in practice.
    MeSH term(s) Female ; Humans ; Breast Neoplasms/therapy ; Healthcare Disparities ; Global Health
    Language English
    Publishing date 2023-12-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632682-1
    ISSN 1878-3449 ; 0749-2081
    ISSN (online) 1878-3449
    ISSN 0749-2081
    DOI 10.1016/j.soncn.2023.151551
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