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  1. AU=Rauner Martina
  2. AU="Richlen, Mindy L"
  3. AU="Merghani, Nada M"
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  1. Artikel ; Online: Denosumab - protection for bone and beyond?

    Hofbauer, Lorenz C / Rauner, Martina

    The Journal of clinical endocrinology and metabolism

    2024  

    Sprache Englisch
    Erscheinungsdatum 2024-03-29
    Erscheinungsland United States
    Dokumenttyp Editorial ; Comment
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgae207
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Editorial

    Rauner, Martina

    Osteologie

    2021  Band 30, Heft 4, Seite(n) 283

    Sprache Deutsch
    Dokumenttyp Artikel
    ZDB-ID 1116704-X
    ISSN 1019-1291
    Datenquelle Current Contents Medizin

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  3. Artikel: Editorial

    Rauner, Martina

    Osteologie

    2021  Band 30, Heft 04, Seite(n) 283–283

    Abstract: Liebe Freunde der Osteologie, liebe Kolleginnen und Kollegen, Das Fachgebiet der Osteoimmunologie beschäftigt sich mit den Interaktionen des Immunsystems mit dem Knochen. Bereits in den 1990ern, kurz nach der ... ...

    Abstract Liebe Freunde der Osteologie, liebe Kolleginnen und Kollegen, Das Fachgebiet der Osteoimmunologie beschäftigt sich mit den Interaktionen des Immunsystems mit dem Knochen. Bereits in den 1990ern, kurz nach der Entdeckung von RANKL, dem Schlüsselprotein zur Differenzierung von Osteoklasten, etablierte sich dieses Themengebiet innerhalb der Osteologie. Schon damals hatte man erkannt, dass RANKL nicht nur von Osteoblasten produziert und für die Kommunikation zu Osteoklasten verwendet wird, sondern auch von aktivierten T-Zellen, die so zur vermehrten Generation von Osteoklasten und damit zum Knochenabbau im Kontext der chronischen Entzündung beitragen können. Somit ist die Osteoimmunologie klinisch von hoher Relevanz.
    Sprache Deutsch
    Erscheinungsdatum 2021-11-01
    Verlag Georg Thieme Verlag
    Erscheinungsort Stuttgart ; New York
    Dokumenttyp Artikel
    ZDB-ID 2113634-8
    ISSN 2567-5818 ; 1019-1291
    ISSN (online) 2567-5818
    ISSN 1019-1291
    DOI 10.1055/a-1206-3507
    Datenquelle Thieme Verlag

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  4. Artikel ; Konferenzbeitrag: The role of iron in heterotopic ossification

    Spangenberg, Sven / Hofbauer, Lorenz / Rauner, Martina / Baschant, Ulrike

    Osteologie

    2024  Band 33, Heft 02

    Veranstaltung/Kongress OSTEOLOGIE 2024, Wiesbaden, 2024-03-14
    Sprache Deutsch
    Erscheinungsdatum 2024-03-13
    Verlag Georg Thieme Verlag
    Erscheinungsort Stuttgart ; New York
    Dokumenttyp Artikel ; Konferenzbeitrag
    ZDB-ID 2113634-8
    ISSN 2567-5818 ; 1019-1291
    ISSN (online) 2567-5818
    ISSN 1019-1291
    DOI 10.1055/s-0044-1782061
    Datenquelle Thieme Verlag

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  5. Buch ; Online ; Dissertation / Habilitation: Role of DKK-1 in bone fragility and miRNA crosstalk in T1D

    Daamouch, Souad [Verfasser] / Rauner, Martina [Gutachter] / Knopf, Franziska [Gutachter]

    2024  

    Verfasserangabe Souad Daamouch ; Gutachter: Martina Rauner, Franziska Knopf
    Schlagwörter Medizin, Gesundheit ; Medicine, Health
    Thema/Rubrik (Code) sg610
    Sprache Englisch
    Verlag Technische Universität Dresden
    Erscheinungsort Dresden
    Dokumenttyp Buch ; Online ; Dissertation / Habilitation
    Datenquelle Digitale Dissertationen im Internet

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  6. Artikel ; Online: Deconstructing cellular senescence in bone and beyond.

    Hofbauer, Lorenz C / Lademann, Franziska / Rauner, Martina

    The Journal of clinical investigation

    2023  Band 133, Heft 8

    Abstract: Osteocytes are specialized bone cells that orchestrate skeletal remodeling. Senescent osteocytes are characterized by an activation of cyclin-dependent kinase inhibitor p16Ink4a and have been implicated in the pathogenesis of several bone loss disorders. ...

    Abstract Osteocytes are specialized bone cells that orchestrate skeletal remodeling. Senescent osteocytes are characterized by an activation of cyclin-dependent kinase inhibitor p16Ink4a and have been implicated in the pathogenesis of several bone loss disorders. In this issue of the JCI, Farr et al. have now shown that systemic removal of senescent cells (termed senolysis) prevented age-related bone loss at the spine and femur and mitigated bone marrow adiposity through a robust effect on osteoblasts and osteoclasts, whereas cell-specific senolysis in osteocytes alone was only partially effective. Surprisingly, transplantation of senescent fibroblasts into the peritoneum of young mice caused host osteocyte senescence associated with bone loss. This refined concept of osteocyte senescence and the effects of remote senolysis may help to develop improved senolytic strategies against multisystem aging in bone and beyond.
    Mesh-Begriff(e) Mice ; Animals ; Cellular Senescence/physiology ; Bone and Bones ; Aging/pathology ; Osteoblasts ; Osteoclasts ; Osteocytes ; Bone Diseases, Metabolic
    Sprache Englisch
    Erscheinungsdatum 2023-04-17
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI169069
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: Effects of adipocyte-specific Dkk1 deletion on bone homeostasis and obesity-induced bone loss in male mice.

    Daamouch, Souad / Thiele, Sylvia / Hofbauer, Lorenz / Rauner, Martina

    Endocrine connections

    2023  Band 12, Heft 11

    Abstract: The link between obesity and low bone strength has become a significant medical concern. The canonical Wnt signaling pathway is a key regulator of mesenchymal stem cell differentiation into either osteoblasts or adipocytes with active Wnt signaling ... ...

    Abstract The link between obesity and low bone strength has become a significant medical concern. The canonical Wnt signaling pathway is a key regulator of mesenchymal stem cell differentiation into either osteoblasts or adipocytes with active Wnt signaling promoting osteoblastogenesis. Our previous research indicated that Dickkopf-1 (Dkk1), a Wnt inhibitor, is upregulated in bone tissue in obesity and that osteoblast-derived Dkk1 drives obesity-induced bone loss. However, Dkk1 is also produced by adipocytes, but the impact of adipogenic Dkk1 on bone remodeling and its role in obesity-induced bone loss remain unclear. Thus, in this study, we investigated the influence of adipogenic Dkk1 on bone homeostasis and obesity-induced bone loss in mice. To that end, deletion of Dkk1 in adipocytes was induced by tamoxifen administration into 8-week-old male Dkk1fl/fl;AdipoQcreERT2 mice. Bone and fat mass were analyzed at 12 and 20 weeks of age. Obesity was induced in 8-week-old male Dkk1fl/fl;AdipoQcre mice with a high-fat diet (HFD) rich in saturated fats for 12 weeks. We observed that 12-week-old male mice without adipogenic Dkk1 had a significant increase in trabecular bone volume in the vertebrae and femoral bones. While histological and serological bone formation markers were not different, the number of osteoclasts and adipocytes was decreased in the vertebral bones of Dkk1fl/fl;AdipoQcre-positive mice. Despite the increased bone mass in 12-week-old male mice, at 20 weeks of age, there was no difference in the bone volume between the controls and Dkk1fl/fl;AdipoQcre-positive mice. Also, Dkk1fl/fl;AdipoQcre-positive mice were not protected from HFD-induced bone loss. Even though mRNA expression levels of Sost, another important Wnt inhibitor, in bone from Dkk1-deficient mice fed with HFD were decreased compared to Dkk1-sufficient mice on an HFD, this did not prevent the HFD-induced suppression of bone formation. In conclusion, adipogenic Dkk1 may play a transient role in bone mass regulation during adolescence, but it does not contribute to bone homeostasis or obesity-induced bone loss later in life.
    Sprache Englisch
    Erscheinungsdatum 2023-09-27
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2668428-7
    ISSN 2049-3614
    ISSN 2049-3614
    DOI 10.1530/EC-23-0251
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Konferenzbeitrag: Exploring the role of Transferrin receptor 1 for iron uptake in bone

    Passin, Vanessa / Ledesma-Colunga, Maria / Hofbauer, Lorenz Christian / Rauner, Martina

    Osteologie

    2024  Band 33, Heft 02

    Veranstaltung/Kongress OSTEOLOGIE 2024, Wiesbaden, 2024-03-14
    Sprache Deutsch
    Erscheinungsdatum 2024-03-13
    Verlag Georg Thieme Verlag
    Erscheinungsort Stuttgart ; New York
    Dokumenttyp Artikel ; Konferenzbeitrag
    ZDB-ID 2113634-8
    ISSN 2567-5818 ; 1019-1291
    ISSN (online) 2567-5818
    ISSN 1019-1291
    DOI 10.1055/s-0044-1782062
    Datenquelle Thieme Verlag

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  9. Artikel ; Online: Deconstructing cellular senescence in bone and beyond

    Lorenz C. Hofbauer / Franziska Lademann / Martina Rauner

    The Journal of Clinical Investigation, Vol 133, Iss

    2023  Band 8

    Abstract: Osteocytes are specialized bone cells that orchestrate skeletal remodeling. Senescent osteocytes are characterized by an activation of cyclin-dependent kinase inhibitor p16Ink4a and have been implicated in the pathogenesis of several bone loss disorders. ...

    Abstract Osteocytes are specialized bone cells that orchestrate skeletal remodeling. Senescent osteocytes are characterized by an activation of cyclin-dependent kinase inhibitor p16Ink4a and have been implicated in the pathogenesis of several bone loss disorders. In this issue of the JCI, Farr et al. have now shown that systemic removal of senescent cells (termed senolysis) prevented age-related bone loss at the spine and femur and mitigated bone marrow adiposity through a robust effect on osteoblasts and osteoclasts, whereas cell-specific senolysis in osteocytes alone was only partially effective. Surprisingly, transplantation of senescent fibroblasts into the peritoneum of young mice caused host osteocyte senescence associated with bone loss. This refined concept of osteocyte senescence and the effects of remote senolysis may help to develop improved senolytic strategies against multisystem aging in bone and beyond.
    Schlagwörter Medicine ; R
    Sprache Englisch
    Erscheinungsdatum 2023-04-01T00:00:00Z
    Verlag American Society for Clinical Investigation
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel: 100 YEARS OF VITAMIN D: Light and health: a century after the therapeutic use of UV light and vitamin D, hormones advanced medical care.

    Köhrle, Josef / Rauner, Martina / Lanham-New, Susan A

    Endocrine connections

    2022  Band 11, Heft 1

    Sprache Englisch
    Erscheinungsdatum 2022-01-31
    Erscheinungsland England
    Dokumenttyp Editorial
    ZDB-ID 2668428-7
    ISSN 2049-3614
    ISSN 2049-3614
    DOI 10.1530/EC-21-0609
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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