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Article ; Online: Geographic Medical Overview of Noncommunicable Diseases (Cardiovascular Diseases and Diabetes) in the Territory of the AP Vojvodina (Northern Serbia)

Emina Kričković / Tin Lukić / Dejana Jovanović-Popović

Healthcare, Vol 11, Iss 1, p

2022 Volume 48

Abstract: The objective of this study was a geographic medical analysis of noncommunicable diseases (cardiovascular diseases from 2010 to 2020 and diabetes from 2010 to 2019) in the AP Vojvodina (northern Serbia) in order to identify the most and least burdened ... ...

Abstract	The objective of this study was a geographic medical analysis of noncommunicable diseases (cardiovascular diseases from 2010 to 2020 and diabetes from 2010 to 2019) in the AP Vojvodina (northern Serbia) in order to identify the most and least burdened counties as well as to present trends in the mentioned diseases. The Mann-Kendall trend test, a cluster analysis, and Getis–Ord Gi* method for hot spot analysis were applied in this analysis. Regarding acute coronary syndrome and myocardial infarction, the North Backa County had a lower mortality rate although the number of newly reported cases was above average. The largest number of new cases of unstable angina pectoris was in the North Backa, North Banat, and Middle Banat Counties, while the West Backa County was identified as a county with a higher mortality rate. The cluster analysis showed that the number of death cases from diabetes in the Srem County is significantly higher than that in the other counties. Likewise, the West Backa County had a high number of new diabetes patients, but also a much lower mortality rate. Chronic noncommunicable diseases are predominant in newly diagnosed incidences and death cases in the AP Vojvodina. Studies of this kind promote public health and healthcare systems in the researched area and in the Republic of Serbia, as well as in other countries.
Keywords	noncommunicable diseases ; AP Vojvodina ; cardiovascular diseases ; diabetes ; population health ; geographic medical overview ; Medicine ; R
Subject code	610
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Non-convulsive status epilepticus as an initial manifestation of herpes simplex virus encephalitis.

Jeremić, Marta / Arsenijević, Mirjana / Jovanović, Dejana / Berisavac, Ivana

Epileptic disorders : international epilepsy journal with videotape

2021 Volume 23, Issue 5, Page(s) 749–753

Abstract: Herpes simplex encephalitis (HSVE), manifesting with non-convulsive status epilepticus (NCSE), normocellular CSF findings and CT features of acute ischemic stroke, is a rare finding that can be hard to diagnose accurately. We present a case of HSVE and ... ...

Abstract	Herpes simplex encephalitis (HSVE), manifesting with non-convulsive status epilepticus (NCSE), normocellular CSF findings and CT features of acute ischemic stroke, is a rare finding that can be hard to diagnose accurately. We present a case of HSVE and compare our results to those of previously published cases with the same pathology, in order to provide information to support more rapid and effective diagnosis and treatment. A Pubmed search of reported cases was conducted and five cases of HSVE manifesting with NCSE were found. Each of the cases, including ours, was compared in terms of clinical manifestations and CSF, CT and EEG findings. The clinical manifestations in our patient correlated with those of the other cases. EEG showing sharp fronto-temporo-centro-parietal waves was only observed in our patient. Similar CT manifestations were found in one other patient, normocellular CSF was registered in three other cases and positive PCR for HSV in four patients. Information about the possible clinical manifestations and CT, EEG and CSF findings in patients with HSVE manifesting with NCSE is crucial for a fast diagnosis and successful treatment, leading to higher survival rates and fewer complications and neurological deficits.
MeSH term(s)	Brain Ischemia ; Encephalitis, Herpes Simplex/complications ; Encephalitis, Herpes Simplex/diagnosis ; Humans ; Simplexvirus ; Status Epilepticus/etiology ; Stroke
Language	English
Publishing date	2021-09-23
Publishing country	France
Document type	Case Reports ; Journal Article
ZDB-ID	2086797-9
ISSN	1950-6945 ; 1294-9361
ISSN (online)	1950-6945
ISSN	1294-9361
DOI	10.1684/epd.2021.1320
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Zs.A 5740: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Increased Severity of New-onset Type 1 Diabetes in Children and Adolescents during the COVID-19 Pandemic: Experience from a Tertiary Care Center in Serbia

Jovanovic, Damjan / Blagojevic, Jelena / Stanisavljevic, Dejana / Jesic, Maja

medRxiv

Abstract: Background and objectives: Public health measures, parental fear of infection, and redeployment of medical resources in response to the COVID-19 pandemic might have led to a decrease in pediatric healthcare access. As a result, a delay in type 1 diabetes ...

Abstract	Background and objectives: Public health measures, parental fear of infection, and redeployment of medical resources in response to the COVID-19 pandemic might have led to a decrease in pediatric healthcare access. As a result, a delay in type 1 diabetes diagnosis might have occurred, leading to the worsening of its clinical presentation in the pediatric population. This study aimed to examine the clinical and biochemical features of new-onset DM1 in children and adolescents during the COVID-19 pandemic, comparing it to the pre-pandemic period. Materials and methods: The clinical and biochemical features of diabetes observed during the COVID-19 period from April 1, 2020, until December 31, 2022, were compared with the period from April 1, 2017, until December 31, 2019. In the COVID-19 pandemic group, the clinical and biochemical features were compared between children with and without SARS-CoV-2 infection at diagnosis or before the diagnosis of DM1. Results: During the COVID-19 pandemic, observed frequencies of DKA and severe DKA at diagnosis were 47.6% and 20.7%, both significantly higher than during the pre-pandemic period (an absolute increase of 15% and 11.3%, respectively). In the COVID-19 group, blood pH levels were significantly lower than in the pre-pandemic group, while HbA1c levels were higher. Clinical and biochemical features of diabetes in children with SARS-CoV-2 infection at or before the diagnosis were not significantly different compared to children without an infection. Conclusion: We report a significant worsening of the clinical presentation of new-onset type 1 diabetes and an increase in the frequency of DKA and severe DKA at diagnosis during the COVID-19 pandemic. Further studies are necessary to gain quantitative insight into pediatric healthcare availability in Serbia.
Keywords	covid19
Language	English
Publishing date	2023-11-20
Publisher	Cold Spring Harbor Laboratory Press
Document type	Article ; Online
DOI	10.1101/2023.11.20.23298741
Database	COVID19

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Article ; Online: Single nucleotide translation without ribosomes.

Jash, Biswarup / Tremmel, Peter / Jovanovic, Dejana / Richert, Clemens

Nature chemistry

2021 Volume 13, Issue 8, Page(s) 751–757

Abstract: The translation of messenger RNA sequences into polypeptide sequences according to the genetic code is central to life. How this process, which relies on the ribosomal machinery, arose from much simpler precursors is unclear. Here, we demonstrate that ... ...

Abstract	The translation of messenger RNA sequences into polypeptide sequences according to the genetic code is central to life. How this process, which relies on the ribosomal machinery, arose from much simpler precursors is unclear. Here, we demonstrate that single nucleotides charged with an amino acid couple with amino acids linked to the 5'-terminus of an RNA primer in reactions directed by the nucleotides of an RNA template in dilute aqueous solution at 0 °C. When a mixture of U-Val, A-Gly and G-Leu competed for coupling to Gly-RNA, base pairing dictated which dipeptide sequence formed preferentially. The resulting doubly anchored dipeptides can retain their link to the primer for further extension or can be fully released under mild acidic conditions. These results show that a single-nucleotide-based form of translation exists that requires no more than oligoribonucleotides and anchored amino acids.
MeSH term(s)	Amino Acids/chemistry ; Nucleotides/chemistry ; Oligopeptides/chemical synthesis ; Peptide Biosynthesis ; RNA/chemistry
Chemical Substances	Amino Acids ; Nucleotides ; Oligopeptides ; RNA (63231-63-0)
Language	English
Publishing date	2021-07-26
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2464596-5
ISSN	1755-4349 ; 1755-4330
ISSN (online)	1755-4349
ISSN	1755-4330
DOI	10.1038/s41557-021-00749-4
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Article: Cerebral Amyloid Angiopathy-Related Inflammation (CAA-rI): Three Heterogeneous Case Reports and a Focused Literature Review.

Bozovic, Ivo / Jeremic, Marta / Pavlovic, Aleksandra / Jovanovic, Carna / Kresojevic, Nikola / Vojvodic, Nikola / Jovanovic, Dejana / Sokic, Dragoslav / Mijajlovic, Milija

Brain sciences

2023 Volume 13, Issue 5

Abstract: Cerebral amyloid angiopathy-related inflammation (CAA-rI) is a largely reversible, subacute encephalopathy, which is considered as a rare variant of cerebral amyloid angiopathy (CAA). Although the diagnosis of this inflammatory vasculopathy is generally ... ...

Abstract	Cerebral amyloid angiopathy-related inflammation (CAA-rI) is a largely reversible, subacute encephalopathy, which is considered as a rare variant of cerebral amyloid angiopathy (CAA). Although the diagnosis of this inflammatory vasculopathy is generally clinico-pathologic, a probable or possible diagnosis can often be established based on current clinico-radiological diagnostic criteria. This is important since CAA-rI is considered as a treatable disorder, which most commonly occurs in the elderly population. Behavioral changes and cognitive deterioration are highlighted as the most common clinical signs of CAA-rI, followed by a heterogeneous spectrum of typical and atypical clinical presentations. However, despite the well-established clinical and radiological features incorporated in the current diagnostic criteria for this CAA variant, this rare disorder is still insufficiently recognized and treated. Here, we have shown three patients diagnosed with probable CAA-rI, with significant heterogeneity in the clinical and neuroradiological presentations, followed by different disease courses and outcomes after the introduction of immunosuppressive treatment. Moreover, we have also summarized up-to-date literature data about this rare, yet underdiagnosed, immune-mediated vasculopathy.
Language	English
Publishing date	2023-04-29
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2651993-8
ISSN	2076-3425
ISSN	2076-3425
DOI	10.3390/brainsci13050747
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Article ; Online: Guillain-Barré syndrome during pregnancy: A case series.

Ždraljević, Mirjana / Radišić, Vanja / Perić, Stojan / Kačar, Aleksandra / Jovanović, Dejana / Berisavac, Ivana

The journal of obstetrics and gynaecology research

2021 Volume 48, Issue 2, Page(s) 477–482

Abstract: Guillain-Barré syndrome (GBS) in pregnancy may be a serious disease associated with high maternal and perinatal morbidity and mortality. Herein, we present the long-term maternal and fetal outcomes of five pregnant GBS patients from our center. The mean ... ...

Abstract	Guillain-Barré syndrome (GBS) in pregnancy may be a serious disease associated with high maternal and perinatal morbidity and mortality. Herein, we present the long-term maternal and fetal outcomes of five pregnant GBS patients from our center. The mean age of pregnant GBS patients was 29.8 ± 3.1. Two patients had a severe disability at admission. Three patients were treated with intravenous immunoglobulins, while the remaining two were treated with symptomatic therapy. One year after disease onset, one patient had a mild disability, while the remaining four had normal neurological findings. All babies born were healthy and developed normally. GBS in pregnancy may affect both maternal and neonatal outcomes. Early diagnosis and treatment are essential for the outcome. Most patients and their babies have a favorable long-term outcome.
MeSH term(s)	Female ; Fetus ; Guillain-Barre Syndrome/diagnosis ; Guillain-Barre Syndrome/drug therapy ; Humans ; Immunoglobulins, Intravenous/therapeutic use ; Infant, Newborn ; Parturition ; Pregnancy
Chemical Substances	Immunoglobulins, Intravenous
Language	English
Publishing date	2021-11-30
Publishing country	Australia
Document type	Case Reports
ZDB-ID	1327307-3
ISSN	1447-0756 ; 1341-8076
ISSN (online)	1447-0756
ISSN	1341-8076
DOI	10.1111/jog.15116
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Article ; Online: Cerebral venous thrombosis: a retrospective unicentric analysis of clinical and neuroimaging characteristics.

Petrović, Jovan / Švabić, Tamara / Zidverc-Trajković, Jasna / Stanarčević, Predrag / Jovanović, Dejana / Mijajlović, Milija

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

2021 Volume 43, Issue 3, Page(s) 1839–1847

Abstract: Thrombosis of dural sinuses and/or cerebral veins (CVT) is an uncommon form of stroke, usually affecting young individuals. It has a variable clinical presentation ranging from mild cases presenting only headaches, to severe cases featuring ... ...

Abstract	Thrombosis of dural sinuses and/or cerebral veins (CVT) is an uncommon form of stroke, usually affecting young individuals. It has a variable clinical presentation ranging from mild cases presenting only headaches, to severe cases featuring encephalopathy, coma or status epilepticus. A retrospective cross-sectional study of patients treated in the outpatient department and in-hospital during the period from 2014 to 2020 at the Neurology Clinic-University Clinical Centre of Serbia was conducted. Forty-nine patients (24 men; 25 women) were included in the study. Twenty-three patients (46.9%) suffered a subacute form of CVT (48 h-4 weeks), 19 (38.8%) presented with an acute form (< 48 h) and 7 (14.3%) with a chronic form (> 4 weeks). Around 75% of patients reported headaches during disease course. Focal neurological deficit (FND) was observed in 27 (55.1%) patients. Patients who did not report headaches (22.4%) presented with more severe symptoms (seizures and coma). More than 70% of patients had no radiologically evident brain parenchymal lesion. The most frequent locations of CVT were transverse sinus (79.6%), sigmoid sinus (44.9%) and superior sagittal sinus (36.7%). Thrombosis of more than one sinus/vein occurred in 33 (67.3%) patients. Hereditary thrombophilia was observed in 9 (18.4%) patients, 11 (22.4%) patients had some type of infection and 20% of women reported OCT usage. As much as 25% of cases remained without evident risk factors. The most common symptom in our cohort was acute unilateral throbbing headache of high intensity, while patients without headaches had more severe symptoms.
MeSH term(s)	Cross-Sectional Studies ; Female ; Humans ; Intracranial Thrombosis/complications ; Intracranial Thrombosis/diagnostic imaging ; Intracranial Thrombosis/epidemiology ; Male ; Neuroimaging ; Retrospective Studies ; Sinus Thrombosis, Intracranial/complications ; Sinus Thrombosis, Intracranial/diagnostic imaging ; Sinus Thrombosis, Intracranial/epidemiology ; Venous Thrombosis/diagnostic imaging ; Venous Thrombosis/epidemiology
Language	English
Publishing date	2021-08-04
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2016546-8
ISSN	1590-3478 ; 1590-1874
ISSN (online)	1590-3478
ISSN	1590-1874
DOI	10.1007/s10072-021-05514-6
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Article: Is there a difference between GBS triggered by COVID-19 and those of other origins?

Radišić, Vanja / Ždraljević, Mirjana / Perić, Stojan / Mladenović, Branka / Ralić, Branislav / Jovanović, Dejana R / Berisavac, Ivana

The Egyptian journal of neurology, psychiatry and neurosurgery

2022 Volume 58, Issue 1, Page(s) 54

Abstract: Background: Since the outbreak of the coronavirus disease 2019 (COVID-19), an increasing number of Guillain-Barré syndrome (GBS) cases following the infection has been reported. The aim of our study was to detect patients with GBS treated in our ... ...

Abstract	Background: Since the outbreak of the coronavirus disease 2019 (COVID-19), an increasing number of Guillain-Barré syndrome (GBS) cases following the infection has been reported. The aim of our study was to detect patients with GBS treated in our hospital over a 1-year period and to compare the characteristics and outcomes of those triggered by COVID-19 with the rest of GBS patients. Our prospective study included 29 patients who were diagnosed with GBS from March 2020 to March 2021. Based on the preceding event, patients were stratified as post-COVID-19 and non-COVID-19. The GBS disability scale (GDS) was used to assess functional disability. Results: We identified 10 (34.5%) patients with post-COVID-19 GBS and 19 (65.5%) patients with non-COVID-19 GBS. The median time from the preceding event to the symptoms onset was longer in post-COVID-19 than in non-COVID-19 GBS patients ( Conclusions: There was no difference in clinical and electrophysiological features, disease course, and outcome in post-COVID-19 compared with non-COVID-19 GBS patients.
Language	English
Publishing date	2022-05-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2686351-0
ISSN	1687-8329 ; 1110-1083
ISSN (online)	1687-8329
ISSN	1110-1083
DOI	10.1186/s41983-022-00486-6
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Article ; Online: Environment and security

Jovanović-Popović Dejana

Zbornik Matice Srpske za Drustvene Nauke, Vol 2013, Iss 142, Pp 103-

The concept of ecological and environmental security

2013 Volume 118

Abstract: The terms environmental and ecological security are often used interchangeably by both scientists and politicians, especially in Serbia. Whereas environmental security refers fundamentally to the threat of environmental degradation to political stability, ...

Abstract	The terms environmental and ecological security are often used interchangeably by both scientists and politicians, especially in Serbia. Whereas environmental security refers fundamentally to the threat of environmental degradation to political stability, ecological security refers to the creation of a condition where physical surroundings of a community provides for all its needs without diminishing natural resources. Accordingly, ecological security is embedded in the concept of sustainable development. Various trends in the development of security concept and environmental changes are presented in this paper. Finally, scientific explanations of the terms environmental and ecological security are given.
Keywords	ecological security ; environmental security ; sustainable development ; conflicts ; Social sciences (General) ; H1-99 ; Social Sciences ; H ; DOAJ:Social Sciences
Language	Serbian
Publishing date	2013-01-01T00:00:00Z
Publisher	Matica srpska, Novi Sad
Document type	Article ; Online
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Article ; Online: Prognostic Value of Mitral Regurgitation in Patients with Primary Hypertrophic Cardiomyopathy.

Tesic, Milorad / Travica, Lazar / Giga, Vojislav / Jovanovic, Ivana / Trifunovic Zamaklar, Danijela / Popovic, Dejana / Mladenovic, Djordje / Radomirovic, Marija / Vratonjic, Jelena / Boskovic, Nikola / Dedic, Srdjan / Nedeljkovic Arsenovic, Olga / Aleksandric, Srdjan / Juricic, Stefan / Beleslin, Branko / Djordjevic Dikic, Ana

Medicina (Kaunas, Lithuania)

2023 Volume 59, Issue 10

Abstract: Background and ... ...

Abstract	Background and Objectives
MeSH term(s)	Humans ; Mitral Valve Insufficiency/complications ; Mitral Valve Insufficiency/diagnostic imaging ; Prognosis ; Prospective Studies ; Echocardiography ; Cardiomyopathy, Hypertrophic/complications ; Cardiomyopathy, Hypertrophic/diagnostic imaging
Language	English
Publishing date	2023-10-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina59101798
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