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  1. Book: Automated hematology analyzers

    Brugnara, Carlo

    state of the art

    (Clinics in laboratory medicine ; 35,1)

    2015  

    Author's details ed. Carlo Brugnara
    Series title Clinics in laboratory medicine ; 35,1
    Collection
    Language English
    Size XIV, 224 S. : Ill., graph. Darst.
    Publisher Elsevier
    Publishing place Philadelphia, Pa
    Publishing country United States
    Document type Book
    HBZ-ID HT018604546
    ISBN 978-0-323-35658-9 ; 0-323-35658-3
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 1695 -35,1- not available for loan Zeitschriften-Lesesaal

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  2. Article ; Online: Immune Therapies in the Treatment of Multiple Myeloma.

    Brugnara, Carlo

    American journal of hematology

    2023  

    Language English
    Publishing date 2023-01-19
    Publishing country United States
    Document type Editorial
    ZDB-ID 196767-8
    ISSN 1096-8652 ; 0361-8609
    ISSN (online) 1096-8652
    ISSN 0361-8609
    DOI 10.1002/ajh.26851
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Immune therapies in the treatment of multiple myeloma.

    Brugnara, Carlo

    American journal of hematology

    2023  Volume 98 Suppl 2, Page(s) S3

    MeSH term(s) Humans ; Multiple Myeloma/therapy ; Immunotherapy
    Language English
    Publishing date 2023-01-24
    Publishing country United States
    Document type Editorial
    ZDB-ID 196767-8
    ISSN 1096-8652 ; 0361-8609
    ISSN (online) 1096-8652
    ISSN 0361-8609
    DOI 10.1002/ajh.26843
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The Erythrocyte, a Novel Disease-Mediator for COVID-19 Vasculopathy?

    Brugnara, Carlo

    JACC. Basic to translational science

    2022  Volume 7, Issue 3, Page(s) 205–206

    Language English
    Publishing date 2022-03-28
    Publishing country United States
    Document type Editorial ; Comment
    ISSN 2452-302X
    ISSN (online) 2452-302X
    DOI 10.1016/j.jacbts.2022.01.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Less (Fe) is more (Hb) in SCA.

    Brugnara, Carlo

    Blood

    2021  Volume 137, Issue 11, Page(s) 1446–1447

    MeSH term(s) Anemia, Sickle Cell ; Humans
    Language English
    Publishing date 2021-03-18
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2020010131
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Diagnostics with modern genomics.

    Brugnara, Carlo

    American journal of hematology

    2021  Volume 96, Issue 11, Page(s) E447

    MeSH term(s) Animals ; Genetic Testing ; Genetic Therapy ; Genomics ; Hematologic Diseases/genetics ; Hematologic Diseases/therapy ; High-Throughput Nucleotide Sequencing ; Humans
    Language English
    Publishing date 2021-10-04
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 196767-8
    ISSN 1096-8652 ; 0361-8609
    ISSN (online) 1096-8652
    ISSN 0361-8609
    DOI 10.1002/ajh.26353
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Sickle cell dehydration: Pathophysiology and therapeutic applications.

    Brugnara, Carlo

    Clinical hemorheology and microcirculation

    2018  Volume 68, Issue 2-3, Page(s) 187–204

    Abstract: Cell dehydration is a distinguishing characteristic of sickle cell disease and an important contributor to disease pathophysiology. Due to the unique dependence of Hb S polymerization on cellular Hb S concentration, cell dehydration promotes ... ...

    Abstract Cell dehydration is a distinguishing characteristic of sickle cell disease and an important contributor to disease pathophysiology. Due to the unique dependence of Hb S polymerization on cellular Hb S concentration, cell dehydration promotes polymerization and sickling. In double heterozygosis for Hb S and C (SC disease) dehydration is the determining factor in disease pathophysiology. Three major ion transport pathways are involved in sickle cell dehydration: the K-Cl cotransport (KCC), the Gardos channel (KCNN4) and Psickle, the polymerization induced membrane permeability, most likely mediated by the mechano-sensitive ion channel PIEZO1. Each of these pathways exhibit unique characteristics in regulation by oxygen tension, intracellular and extracellular environment, and functional expression in reticulocytes and mature red cells. The unique dependence of K-Cl cotransport on intracellular Mg and the abnormal reduction of erythrocyte Mg content in SS and SC cells had led to clinical studies assessing the effect of oral Mg supplementation. Inhibition of Gardos channel by clotrimazole and senicapoc has led to Phase 1,2,3 trials in patients with sickle cell disease. While none of these studies has resulted in the approval of a novel therapy for SS disease, they have highlighted the key role played by these pathways in disease pathophysiology.
    MeSH term(s) Anemia, Sickle Cell/complications ; Anemia, Sickle Cell/physiopathology ; Anemia, Sickle Cell/therapy ; Humans ; Intermediate-Conductance Calcium-Activated Potassium Channels/metabolism ; Symporters/metabolism ; K Cl- Cotransporters
    Chemical Substances Intermediate-Conductance Calcium-Activated Potassium Channels ; KCNN4 protein, human ; Symporters
    Language English
    Publishing date 2018-03-31
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1381750-4
    ISSN 1875-8622 ; 1386-0291
    ISSN (online) 1875-8622
    ISSN 1386-0291
    DOI 10.3233/CH-189007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The American Journal of Hematology turns 40.

    Brugnara, Carlo

    American journal of hematology

    2016  Volume 91, Issue 1, Page(s) 4

    MeSH term(s) Editorial Policies ; Hematology/history ; History, 20th Century ; History, 21st Century ; Journalism, Medical/history ; Periodicals as Topic/history
    Language English
    Publishing date 2016-01
    Publishing country United States
    Document type Editorial ; Historical Article
    ZDB-ID 196767-8
    ISSN 1096-8652 ; 0361-8609
    ISSN (online) 1096-8652
    ISSN 0361-8609
    DOI 10.1002/ajh.24237
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: HbSC disease: A time for progress.

    Minniti, Caterina / Brugnara, Carlo / Steinberg, Martin H

    American journal of hematology

    2022  Volume 97, Issue 11, Page(s) 1390–1393

    MeSH term(s) Hemoglobin SC Disease ; Hemoglobin, Sickle ; Humans
    Chemical Substances Hemoglobin, Sickle
    Language English
    Publishing date 2022-09-08
    Publishing country United States
    Document type Editorial
    ZDB-ID 196767-8
    ISSN 1096-8652 ; 0361-8609
    ISSN (online) 1096-8652
    ISSN 0361-8609
    DOI 10.1002/ajh.26702
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: American Journal of Hematology, getting ready for the 40th birthday in 2016.

    Brugnara, Carlo

    American journal of hematology

    2015  Volume 90, Issue 1, Page(s) 1

    MeSH term(s) Editorial Policies ; Periodicals as Topic/trends ; United States
    Language English
    Publishing date 2015-01
    Publishing country United States
    Document type Editorial
    ZDB-ID 196767-8
    ISSN 1096-8652 ; 0361-8609
    ISSN (online) 1096-8652
    ISSN 0361-8609
    DOI 10.1002/ajh.23906
    Database MEDical Literature Analysis and Retrieval System OnLINE

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