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Article ; Online: The Essential Element Manganese, Oxidative Stress, and Metabolic Diseases: Links and Interactions.

Li, Longman / Yang, Xiaobo

Oxidative medicine and cellular longevity

2018 Volume 2018, Page(s) 7580707

Abstract: Manganese (Mn) is an essential element that is involved in the synthesis and activation of many enzymes and in the regulation of the metabolism of glucose and lipids in humans. In addition, Mn is one of the required components for Mn superoxide dismutase ...

Abstract	Manganese (Mn) is an essential element that is involved in the synthesis and activation of many enzymes and in the regulation of the metabolism of glucose and lipids in humans. In addition, Mn is one of the required components for Mn superoxide dismutase (MnSOD) that is mainly responsible for scavenging reactive oxygen species (ROS) in mitochondrial oxidative stress. Both Mn deficiency and intoxication are associated with adverse metabolic and neuropsychiatric effects. Over the past few decades, the prevalence of metabolic diseases, including type 2 diabetes mellitus (T2MD), obesity, insulin resistance, atherosclerosis, hyperlipidemia, nonalcoholic fatty liver disease (NAFLD), and hepatic steatosis, has increased dramatically. Previous studies have found that ROS generation, oxidative stress, and inflammation are critical for the pathogenesis of metabolic diseases. In addition, deficiency in dietary Mn as well as excessive Mn exposure could increase ROS generation and result in further oxidative stress. However, the relationship between Mn and metabolic diseases is not clear. In this review, we provide insights into the role Mn plays in the prevention and development of metabolic diseases.
MeSH term(s)	Diabetes Mellitus, Type 2/metabolism ; Diabetes Mellitus, Type 2/pathology ; Humans ; Manganese/metabolism ; Metabolic Diseases/metabolism ; Metabolic Diseases/pathology ; Mitochondria/metabolism ; Non-alcoholic Fatty Liver Disease/metabolism ; Non-alcoholic Fatty Liver Disease/pathology ; Obesity/metabolism ; Obesity/pathology ; Oxidative Stress ; Reactive Oxygen Species/metabolism ; Superoxide Dismutase/metabolism
Chemical Substances	Reactive Oxygen Species ; Manganese (42Z2K6ZL8P) ; Superoxide Dismutase (EC 1.15.1.1)
Language	English
Publishing date	2018-04-05
Publishing country	United States
Document type	Journal Article ; Review
ISSN	1942-0994
ISSN (online)	1942-0994
DOI	10.1155/2018/7580707
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Article ; Online: Genetic manipulation of gut microbes enables single-gene interrogation in a complex microbiome.

Jin, Wen-Bing / Li, Ting-Ting / Huo, Da / Qu, Sophia / Li, Xin V / Arifuzzaman, Mohammad / Lima, Svetlana F / Shi, Hui-Qing / Wang, Aolin / Putzel, Gregory G / Longman, Randy S / Artis, David / Guo, Chun-Jun

Cell

2022 Volume 185, Issue 3, Page(s) 547–562.e22

Abstract: Hundreds of microbiota genes are associated with host biology/disease. Unraveling the causal contribution of a microbiota gene to host biology remains difficult because many are encoded by nonmodel gut commensals and not genetically targetable. A general ...

Abstract	Hundreds of microbiota genes are associated with host biology/disease. Unraveling the causal contribution of a microbiota gene to host biology remains difficult because many are encoded by nonmodel gut commensals and not genetically targetable. A general approach to identify their gene transfer methodology and build their gene manipulation tools would enable mechanistic dissections of their impact on host physiology. We developed a pipeline that identifies the gene transfer methods for multiple nonmodel microbes spanning five phyla, and we demonstrated the utility of their genetic tools by modulating microbiome-derived short-chain fatty acids and bile acids in vitro and in the host. In a proof-of-principle study, by deleting a commensal gene for bile acid synthesis in a complex microbiome, we discovered an intriguing role of this gene in regulating colon inflammation. This technology will enable genetically engineering the nonmodel gut microbiome and facilitate mechanistic dissection of microbiota-host interactions.
MeSH term(s)	Animals ; Bile Acids and Salts/metabolism ; CRISPR-Cas Systems/genetics ; Clostridium/genetics ; Colitis/chemically induced ; Colitis/microbiology ; Colitis/pathology ; Dextran Sulfate ; Drug Resistance, Microbial/genetics ; Female ; Gastrointestinal Microbiome/genetics ; Gene Expression Regulation, Bacterial ; Gene Transfer Techniques ; Genes, Bacterial ; Germ-Free Life ; Inflammation/pathology ; Intestines/pathology ; Male ; Metabolome/genetics ; Metagenomics ; Mice, Inbred C57BL ; Mice, Knockout ; Mutagenesis, Insertional/genetics ; Mutation/genetics ; RNA, Ribosomal, 16S/genetics ; Transcription, Genetic ; Mice
Chemical Substances	Bile Acids and Salts ; RNA, Ribosomal, 16S ; Dextran Sulfate (9042-14-2)
Language	English
Publishing date	2022-01-19
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	187009-9
ISSN	1097-4172 ; 0092-8674
ISSN (online)	1097-4172
ISSN	0092-8674
DOI	10.1016/j.cell.2021.12.035
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Zs.A 1167: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Baseline serum and stool microbiome biomarkers predict clinical efficacy and tissue molecular response after ritlecitinib induction therapy in ulcerative colitis.

Hassan-Zahraee, Mina / Ye, Zhan / Xi, Li / Dushin, Elizabeth / Lee, Julie / Romatowski, Jacek / Leszczyszyn, Jaroslaw / Danese, Silvio / Sandborn, William J / Banfield, Christopher / Gale, Jeremy D / Peeva, Elena / Longman, Randy S / Hyde, Craig L / Hung, Kenneth E

Journal of Crohn's & colitis

2023

Abstract: Background and aims: Ritlecitinib, an oral JAK3/TEC family kinase inhibitor, was well- tolerated and efficacious in the phase 2b VIBRATO study in participants with moderate-to-severe ulcerative colitis (UC). The aim of this study was to identify ... ...

Abstract	Background and aims: Ritlecitinib, an oral JAK3/TEC family kinase inhibitor, was well- tolerated and efficacious in the phase 2b VIBRATO study in participants with moderate-to-severe ulcerative colitis (UC). The aim of this study was to identify baseline serum and microbiome markers that predict subsequent clinical efficacy and to develop noninvasive serum signatures as potential real-time noninvasive surrogates of clinical efficacy after ritlecitinib. Methods: Tissue and peripheral blood proteomics, transcriptomics, and fecal metagenomics were performed on samples before and after 8-week oral ritlecitinib induction therapy (20 mg, 70 mg, 200 mg, or placebo once daily, N=39, 41, 33, and 18, respectively). Linear mixed models were used to identify baseline and longitudinal protein markers associated with efficacy. The combined predictivity of these proteins was evaluated using a logistic model with permuted efficacy data. Differential expression of fecal metagenomic was used to differentiate responders and nonresponders. Results: Peripheral blood serum proteomics identified 4 baseline serum markers (LTA, CCL21, HLA-E, MEGF10) predictive of modified clinical remission (MR), endoscopic improvement (EI), histologic remission (HR), and integrative score of tissue molecular improvement. In responders, 37 serum proteins significantly changed at Week 8 compared with baseline (FDR<0.05); of these, changes in 4 (IL4R, TNFRSF4, SPINK4, and LAIR-1) predicted concurrent EI and HR responses. Fecal metagenomics analysis revealed baseline and treatment response signatures that correlated with EI, MR, and tissue molecular improvement. Conclusions: Blood and microbiome biomarkers stratify endoscopic, histologic, and tissue molecular response to ritlecitinib, which may help guide future precision medicine approaches to UC treatment.
Language	English
Publishing date	2023-12-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2390120-2
ISSN	1876-4479 ; 1873-9946
ISSN (online)	1876-4479
ISSN	1873-9946
DOI	10.1093/ecco-jcc/jjad213
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Zs.A 6634: Show issues

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Article ; Online: Causal Relationship Between Complement C3, C4, and Nonalcoholic Fatty Liver Disease: Bidirectional Mendelian Randomization Analysis.

Li, Longman / Huang, Lulu / Yang, Aimin / Feng, Xiuming / Mo, Zengnan / Zhang, Haiying / Yang, Xiaobo

Phenomics (Cham, Switzerland)

2021 Volume 1, Issue 5, Page(s) 211–221

Abstract: The complement system is activated during the development of nonalcoholic fatty liver disease (NAFLD). We aimed to evaluate the causal relationship between serum C3 and C4 levels and NAFLD. After exclusion criteria, a total of 1600 Chinese Han men from ... ...

Abstract	The complement system is activated during the development of nonalcoholic fatty liver disease (NAFLD). We aimed to evaluate the causal relationship between serum C3 and C4 levels and NAFLD. After exclusion criteria, a total of 1600 Chinese Han men from the Fangchenggang Area Male Health and Examination Survey cohort were enrolled in cross-sectional analysis, while 572 participants were included in the longitudinal analysis (average follow-up of 4 years). We performed a bidirectional Mendelian randomization (MR) analysis using two C3-related, eight C4-related and three NAFLD-related gene loci as instrumental variables to evaluate the causal associations between C3, C4, and NAFLD risk in cross-sectional analysis. Per SD increase in C3 levels was significantly associated with higher risk of NAFLD (OR = 1.65, 95% CI 1.40, 1.94) in cross-sectional analysis while C4 was not (OR = 1.04, 95% CI 0.89, 1.21). Longitudinal analysis produced similar results (HR Supplementary information: The online version contains supplementary material available at 10.1007/s43657-021-00023-0.
Language	English
Publishing date	2021-09-23
Publishing country	Switzerland
Document type	Journal Article
ISSN	2730-5848
ISSN (online)	2730-5848
DOI	10.1007/s43657-021-00023-0
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Article ; Online: Tuina for shoulder pain after stroke: A protocol for systematic review and meta-analysis.

Sun, Weichen / Ji, Guangcheng / Lu, Longman / Sun, Jiabao / Guo, Haoze / Yao, Yao / Gao, Shan / Li, Jing / Chen, Jinjin / Song, Bailin

Medicine

2022 Volume 101, Issue 46, Page(s) e31828

Abstract: Background: Post-stroke shoulder pain is a relatively common complication in stroke patients, with an incidence of 16% to 84% and poor outcomes with anti-inflammatory or sedative medications. This study will evaluate the results of a randomized ... ...

Abstract	Background: Post-stroke shoulder pain is a relatively common complication in stroke patients, with an incidence of 16% to 84% and poor outcomes with anti-inflammatory or sedative medications. This study will evaluate the results of a randomized controlled trial to determine the effectiveness and safety of Tuina in the treatment of post-stroke shoulder pain. Methods: The Chinese and English search strategies were used to search China National Knowledge Infrastructure, Chinese Scientific Journal Database, Cochrane Central Register of Controlled Trials, EMBASE, MEDLINE, PubMed, Wanfang Database, and Web of Science were used to search seven databases. All eligible studies published on or before September 15, 2022, will be selected. To improve the validity of this study, only clinical randomized controlled trials related to the use of Tuina for post-stroke shoulder pain will be included. The screening will be performed by 2 independent reviewers and data synthesis, bias analysis, subgroup analysis, and meta-analysis will be performed using RevMan (V.5.4) software. Results: The study will provide a high-quality evaluation of the effectiveness and safety of Tuina in the treatment of post-stroke shoulder pain. Conclusion: This systematic review will provide evidence to determine whether Tuina is an effective and safe intervention for treating patients with post-stroke shoulder pain.PROSPERO registration number: CRD42022360401.
MeSH term(s)	Humans ; Shoulder Pain/etiology ; Shoulder Pain/therapy ; Systematic Reviews as Topic ; Meta-Analysis as Topic ; Medicine, Chinese Traditional/methods ; Acupuncture Therapy/methods ; Stroke/complications ; Randomized Controlled Trials as Topic
Language	English
Publishing date	2022-11-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000031828
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Article ; Online: Associations Between Blood Pressure and Accelerated DNA Methylation Aging.

Xiao, Lili / Zan, Gaohui / Liu, Chaoqun / Xu, Xia / Li, Longman / Chen, Xing / Zhang, Zhiyong / Yang, Xiaobo

Journal of the American Heart Association

2022 Volume 11, Issue 3, Page(s) e022257

Abstract: Background Individuals of the same chronological age may exhibit diverse susceptibilities to death. However, few studies have investigated the associations between blood pressure and the accelerated aging. Methods and Results A cross-sectional study was ... ...

Abstract	Background Individuals of the same chronological age may exhibit diverse susceptibilities to death. However, few studies have investigated the associations between blood pressure and the accelerated aging. Methods and Results A cross-sectional study was conducted in 288 adults aged ≥50 years. We assessed the DNA methylation-based measures of biological age using CpG sites on the Illumina HumanMethylationEPIC BeadChip. Epigenetic age acceleration metrics were derived by regressing residuals (ΔAge) and ratios (aging rate) of DNA methylation age on chronological age. Dose-response relationships between blood pressure and epigenetic age acceleration were quantified using multiple linear regression and restricted cubic regression models. We found that each 10-mm Hg increase in systolic blood pressure was associated with 0.608 (95% CI, 0.231-0.984) years increase in ΔAge and 0.007 (95% CI, 0.002-0.012) increase in aging rate; meanwhile, for pulse pressure, the increase was 1.12 (95% CI, 0.625-1.61) years for ΔAge and 0.013 (95% CI, 0.007-0.020) for aging rate. Subgroup analysis showed that the significant associations of systolic blood pressure and pulse pressure with epigenetic age acceleration appeared to be limited to women, although interactions between blood pressure and sex were not significant (
MeSH term(s)	Adult ; Aging/genetics ; Blood Pressure/genetics ; Cross-Sectional Studies ; DNA Methylation ; Epigenesis, Genetic ; Female ; Humans ; Hypertension/diagnosis ; Hypertension/epidemiology ; Hypertension/genetics ; Male ; Middle Aged
Language	English
Publishing date	2022-01-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2653953-6
ISSN	2047-9980 ; 2047-9980
ISSN (online)	2047-9980
ISSN	2047-9980
DOI	10.1161/JAHA.121.022257
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Article ; Online: Establishment of a risk score model for bladder urothelial carcinoma based on energy metabolism‐related genes and their relationships with immune infiltration

Caihong Huang / Yexin Li / Qiang Ling / Chunmeng Wei / Bo Fang / Xingning Mao / Rirong Yang / LuLu Zhang / Shengzhu Huang / Jiwen Cheng / Naikai Liao / Fubo Wang / Linjian Mo / Zengnan Mo / Longman Li

FEBS Open Bio, Vol 13, Iss 4, Pp 736-

2023 Volume 750

Abstract: Bladder urothelial carcinoma (BLCA) is a common malignant tumor of the human urinary system, and a large proportion of BLCA patients have a poor prognosis. Therefore, there is an urgent need to find more efficient and sensitive biomarkers for the ... ...

Abstract	Bladder urothelial carcinoma (BLCA) is a common malignant tumor of the human urinary system, and a large proportion of BLCA patients have a poor prognosis. Therefore, there is an urgent need to find more efficient and sensitive biomarkers for the prognosis of BLCA patients in clinical practice. RNA sequencing (RNA‐seq) data and clinical information were obtained from The Cancer Genome Atlas, and 584 energy metabolism‐related genes (EMRGs) were obtained from the Reactome pathway database. Cox regression analysis and least absolute shrinkage and selection operator analysis were applied to assess prognostic genes and build a risk score model. The estimate and cibersort algorithms were used to explore the immune microenvironment, immune infiltration, and checkpoints in BLCA patients. Furthermore, we used the Human Protein Atlas database and our single‐cell RNA‐seq datasets of BLCA patients to verify the expression of 13 EMRGs at the protein and single‐cell levels. We constructed a risk score model; the area under the curve of the model at 5 years was 0.792. The risk score was significantly correlated with the immune markers M0 macrophages, M2 macrophages, CD8 T cells, follicular helper T cells, regulatory T cells, and dendritic activating cells. Furthermore, eight immune checkpoint genes were significantly upregulated in the high‐risk group. The risk score model can accurately predict the prognosis of BLCA patients and has clinical application value. In addition, according to the differences in immune infiltration and checkpoints, BLCA patients with the most significant benefit can be selected for immune checkpoint inhibitor therapy.
Keywords	bladder urothelial carcinoma ; energy metabolism ; immune ; prognosis ; risk score model ; Biology (General) ; QH301-705.5
Subject code	616 ; 610
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
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Article: Associations Between Serum Multiple Metals Exposures and Metabolic Syndrome: a Longitudinal Cohort Study

Feng, Xiuming / Li, Longman / Huang, Lulu / Zhang, Haiying / Mo, Zengnan / Yang, Xiaobo

Biological trace element research. 2021 July, v. 199, no. 7

2021

Abstract: Although many studies have confirmed metabolic syndrome (MetS) is correlated with metal exposures, few studies have elucidated the associations of multiple metals with MetS risk. We aim to explore the relationship between serum 22 metals and MetS. We ... ...

Abstract	Although many studies have confirmed metabolic syndrome (MetS) is correlated with metal exposures, few studies have elucidated the associations of multiple metals with MetS risk. We aim to explore the relationship between serum 22 metals and MetS. We determined serum 22 metals using ICP-MS and used LASSO regression to select metals independently related with MetS to construct multiple-metals model. We further explored the dose-response relationship between positive metals and MetS by the restricted cubic spline regression. After screening by LASSO regression, serum 11 metals were selected to construct multiple-metals model in cross-sectional analysis, while 5 metals in longitudinal analysis. In the 11-metal model, only tin and zinc were associated with MetS in cross-sectional analysis (ORₜᵢₙ = 2.22, 95% CI:1.43, 3.45; ORzᵢₙc = 2.17, 95% CI: 1.42, 3.32; both Pₜᵣₑₙd < 0.05). Besides, the same results were found in the 5-metal model in longitudinal analysis (HRₜᵢₙ = 1.66, 95% CI: 0.87, 3.17; HRzᵢₙc = 1.83, 95% CI: 1.07, 3.14; both Pₜᵣₑₙd < 0.05). Moreover, there were positive linear relationships between serum tin and zinc concentrations and the increasing risk of MetS (both Pₒᵥₑᵣₐₗₗ < 0.05, Pₙₒₙ₋ₗᵢₙₑₐᵣᵢₜy > 0.05). Furthermore, the interaction between high tin and high zinc was also associated with increasing MetS risk (Pᵢₙₜₑᵣₐcₜᵢₒₙ < 0.05). We found that serum tin and zinc were independently and interactively associated with MetS in the southern Chinese men. Our results suggested that high tin and zinc may be the risk factors of MetS.
Keywords	blood serum ; cohort studies ; cross-sectional studies ; dose response ; longitudinal studies ; metabolic syndrome ; models ; research ; tin ; zinc
Language	English
Dates of publication	2021-07
Size	p. 2444-2455.
Publishing place	Springer US
Document type	Article
ZDB-ID	445336-0
ISSN	1559-0720 ; 0163-4984
ISSN (online)	1559-0720
ISSN	0163-4984
DOI	10.1007/s12011-020-02371-w
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Causal relationships between blood calcium, iron, magnesium, zinc, selenium, phosphorus, copper, and lead levels and multisystem disease outcomes in over 400,000 Caucasian participants.

Huang, Lulu / Yang, Wenjun / Li, Longman / Feng, Xiuming / Cheng, Hong / Ge, Xiaoting / Liu, Chaoqun / Chen, Xing / Mo, Zengnan / Yang, Xiaobo

Clinical nutrition (Edinburgh, Scotland)

2022 Volume 41, Issue 5, Page(s) 1015–1024

Abstract: Background & aims: Metal elements have been associated with a wide range of clinical outcomes. The available epidemiological evidence for these associations is often inconsistent and suffers from confounding and reverse causation. We aimed to explore ... ...

Abstract	Background & aims: Metal elements have been associated with a wide range of clinical outcomes. The available epidemiological evidence for these associations is often inconsistent and suffers from confounding and reverse causation. We aimed to explore the broad clinical effects of varying blood metal element levels and possible underlying mechanisms. Methods: We performed a two-sample Mendelian randomization (MR) analysis by using metal element-associated genetic loci as instrumental variable to evaluate the causal associations between blood metal element levels and 1050 disease outcomes in a UK Biobank cohort. A total of 408,910 White British participants were enrolled in the analysis. We further used the metal element-related genes and disease-related genes to construct a protein-protein interaction (PPI) network. Results: Eight metal elements were associated with 63 diseases in total. Notably, we found nine pairs of suggestive evidence between two different metal elements for the same disease. Selenium and lead share some of the associated clinical outcomes, including diabetes mellitus, type 2 diabetes, lymphoid leukemia, and acute pharyngitis. Lead and zinc share the associated disease of acquired hypothyroidism. Iron and copper share the associated disease of arthropathies. Copper and zinc share the associated disease of occlusion of cerebral arteries. Calcium and zinc share the associated disease of arthropathies. In addition, the PPI network provided potential links between metal elements and disease outcomes at the genetic level. Conclusions: Our MR study of eight metal elements comprehensively characterized their shared and unique clinical effects, highlighting their potential causal roles in multiple diseases. Given the modifiable nature of blood metal elements and the potential for clinical interventions, these findings warrant further investigation.
MeSH term(s)	Calcium ; Copper ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/genetics ; Humans ; Iron ; Lead ; Magnesium ; Phosphorus ; Selenium ; Trace Elements ; Zinc
Chemical Substances	Trace Elements ; Phosphorus (27YLU75U4W) ; Lead (2P299V784P) ; Copper (789U1901C5) ; Iron (E1UOL152H7) ; Selenium (H6241UJ22B) ; Magnesium (I38ZP9992A) ; Zinc (J41CSQ7QDS) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2022-03-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604812-2
ISSN	1532-1983 ; 0261-5614
ISSN (online)	1532-1983
ISSN	0261-5614
DOI	10.1016/j.clnu.2022.02.020
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Article ; Online: Establishment of a risk score model for bladder urothelial carcinoma based on energy metabolism-related genes and their relationships with immune infiltration.

Huang, Caihong / Li, Yexin / Ling, Qiang / Wei, Chunmeng / Fang, Bo / Mao, Xingning / Yang, Rirong / Zhang, LuLu / Huang, Shengzhu / Cheng, Jiwen / Liao, Naikai / Wang, Fubo / Mo, Linjian / Mo, Zengnan / Li, Longman

FEBS open bio

2023 Volume 13, Issue 4, Page(s) 736–750

Abstract	Bladder urothelial carcinoma (BLCA) is a common malignant tumor of the human urinary system, and a large proportion of BLCA patients have a poor prognosis. Therefore, there is an urgent need to find more efficient and sensitive biomarkers for the prognosis of BLCA patients in clinical practice. RNA sequencing (RNA-seq) data and clinical information were obtained from The Cancer Genome Atlas, and 584 energy metabolism-related genes (EMRGs) were obtained from the Reactome pathway database. Cox regression analysis and least absolute shrinkage and selection operator analysis were applied to assess prognostic genes and build a risk score model. The estimate and cibersort algorithms were used to explore the immune microenvironment, immune infiltration, and checkpoints in BLCA patients. Furthermore, we used the Human Protein Atlas database and our single-cell RNA-seq datasets of BLCA patients to verify the expression of 13 EMRGs at the protein and single-cell levels. We constructed a risk score model; the area under the curve of the model at 5 years was 0.792. The risk score was significantly correlated with the immune markers M0 macrophages, M2 macrophages, CD8 T cells, follicular helper T cells, regulatory T cells, and dendritic activating cells. Furthermore, eight immune checkpoint genes were significantly upregulated in the high-risk group. The risk score model can accurately predict the prognosis of BLCA patients and has clinical application value. In addition, according to the differences in immune infiltration and checkpoints, BLCA patients with the most significant benefit can be selected for immune checkpoint inhibitor therapy.
MeSH term(s)	Humans ; Carcinoma, Transitional Cell ; Urinary Bladder Neoplasms/genetics ; Urinary Bladder ; Energy Metabolism/genetics ; Algorithms ; Tumor Microenvironment/genetics
Language	English
Publishing date	2023-03-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2651702-4
ISSN	2211-5463 ; 2211-5463
ISSN (online)	2211-5463
ISSN	2211-5463
DOI	10.1002/2211-5463.13580
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