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  1. Book ; Online: Extranodales Marginalzonen-Lymphom (MALT LYMPHOM)

    Raderer, Markus / Buske, Christian / Dreyling, Martin / Eich, Hans Theodor / Kiesewetter, Barbara / Klapper, Wolfram / Zucca, Emanuele

    Leitlinie : Empfehlungen der Fachgesellschaft zur Diagnostik und Therapie hämatologischer und onkologischer Erkrankungen

    (Onkopedia Leitlinien)

    2021  

    Institution Deutsche Gesellschaft für Hämatologie und Medizinische Onkologie
    Österreichische Gesellschaft für Hämatologie & Medizinische Onkologie
    Schweizerische Gesellschaft für Medizinische Onkologie
    Schweizerische Gesellschaft für Hämatologie
    Author's details DGHO - Deutsche Gesellschaft für Hämatologie und Medizinische Onkologie e.V., OeGHO - Österreichische Gesellschaft für Hämatologie & Medizinische Onkologie, SSMO/SSOM/SGMO - Schweizerische Gesellschaft für Medizinische Onkologie, SGH-SSH - Schweizerische Gesellschaft für Hämatologie/Société Suisse d'Hématologie ; Autoren: Markus Raderer, Christian Buske, Martin Dreyling, Hans Theodor Eich, Barbara Kiesewetter, Wolfram Klapper, Emanuele Zucca ; Vorherige Autoren: Mario Bargetzi, Peter Koch, Gabriele Reinartz, Michael Steurer, Bernhard Wörmann
    Series title Onkopedia Leitlinien
    Subject code 610
    Language German
    Size 1 Online-Ressource (38 Seiten), Diagramme
    Edition Stand: Januar 2021
    Publisher DGHO - Deutsche Gesellschaft für Hämatologie und Medizinische Onkologie e.V
    Publishing place Berlin
    Publishing country Germany
    Document type Book ; Online
    Note Open Access
    HBZ-ID HT021146745
    DOI 10.4126/FRL01-006430342
    Database Repository for Life Sciences

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  2. Book ; Online: Extranodales Marginalzonen-Lymphom (MALT LYMPHOM)

    Raderer, Markus / Buske, Christian / Dreyling, Martin / Eich, Hans Theodor / Kiesewetter, Barbara / Klapper, Wolfram / Zucca, Emanuele

    Leitlinie : Empfehlungen der Fachgesellschaft zur Diagnostik und Therapie hämatologischer und onkologischer Erkrankungen

    (Onkopedia Leitlinien)

    2019  

    Institution Deutsche Gesellschaft für Hämatologie und Medizinische Onkologie
    Österreichische Gesellschaft für Hämatologie & Medizinische Onkologie
    Schweizerische Gesellschaft für Medizinische Onkologie
    Schweizerische Gesellschaft für Hämatologie
    Author's details DGHO - Deutsche Gesellschaft für Hämatologie und Medizinische Onkologie e.V., OeGHO - Österreichische Gesellschaft für Hämatologie & Medizinische Onkologie, SSMO/SSOM/SGMO - Schweizerische Gesellschaft für Medizinische Onkologie, SGH-SSH - Schweizerische Gesellschaft für Hämatologie/Société Suisse d'Hématologie ; Autoren: Markus Raderer, Christian Buske, Martin Dreyling, Hans Theodor Eich, Barbara Kiesewetter, Wolfram Klapper, Emanuele Zucca ; Autoren früherer Versionen: Mario Bargetzi, Peter Koch, Gabriele Reinartz, Michael Steurer, Bernhard Wörmann
    Series title Onkopedia Leitlinien
    Subject code 610
    Language German
    Size 1 Online-Ressource (37 Seiten), Diagramme
    Edition Stand: 06/2019
    Publisher DGHO - Deutsche Gesellschaft für Hämatologie und Medizinische Onkologie e.V
    Publishing place Berlin
    Publishing country Germany
    Document type Book ; Online
    Note Open Access
    HBZ-ID HT020348763
    DOI 10.4126/FRL01-006418723
    Database Repository for Life Sciences

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  3. Article ; Online: Aktuelle Entwicklungen in der Behandlung neuroendokriner Tumoren.

    Kiesewetter-Wiederkehr, Barbara / Melhorn, Philipp / Scheuba, Christian / Raderer, Markus

    Radiologie (Heidelberg, Germany)

    2024  

    Abstract: Background: Well-differentiated neuroendocrine tumors (NET) are rare malignancies that are clinically very heterogeneous. Accordingly, their treatment is also complex and dependent on various factors. With currently available systemic therapies, the ... ...

    Title translation Current developments in the treatment of neuroendocrine tumors.
    Abstract Background: Well-differentiated neuroendocrine tumors (NET) are rare malignancies that are clinically very heterogeneous. Accordingly, their treatment is also complex and dependent on various factors. With currently available systemic therapies, the prognosis is often favorable.
    Objectives: This article aims to provide an overview of current treatment strategies for NET, addressing the most important NET locations.
    Methods: The current European guidelines and further relevant literature on the treatment of NET were reviewed for this purpose.
    Results: The therapeutic spectrum for NET is extremely broad: For NET of the stomach/duodenum, appendix, and rectum, endoscopic or surgical resection is often sufficient, and metastatic tumors are rare. NET of the pancreas, small intestine and lung should also undergo potentially curative resection in the early stages. In the metastatic stage, locoregional treatments such as surgery and liver tumor embolization play a role. Major advances have been made in drug therapy, with somatostatin analogs (octreotide and lanreotide), an mTOR inhibitor (everolimus), and a tyrosine kinase inhibitor (sunitinib) being widely used. Peptide receptor radionuclide therapy (PRRT) is also an invaluable option. In some cases, classic chemotherapy is indicated.
    Conclusions: Many effective therapies are now available for NET. It is important to select the right therapy at the right time for each patient through interdisciplinary management.
    Language German
    Publishing date 2024-04-22
    Publishing country Germany
    Document type English Abstract ; Journal Article ; Review
    ISSN 2731-7056
    ISSN (online) 2731-7056
    DOI 10.1007/s00117-024-01303-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Clinical relevance of molecular aspects in extranodal marginal zone lymphoma: a critical appraisal.

    Raderer, Markus / Kiesewetter, Barbara / Du, Ming-Qing

    Therapeutic advances in medical oncology

    2023  Volume 15, Page(s) 17588359231183565

    Abstract: Extranodal marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT lymphoma) is among the more common types of lymphoma accounting for up to 8% of newly diagnosed lymphoma cases. As opposed to other B-cell lymphomas, however, no ... ...

    Abstract Extranodal marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT lymphoma) is among the more common types of lymphoma accounting for up to 8% of newly diagnosed lymphoma cases. As opposed to other B-cell lymphomas, however, no predominant genetic hallmark has been defined in MALT lymphoma, but different localizations appear to be affected by different, sometimes distinct changes. Nonetheless, a high proportion of these genetic changes reported in MALT lymphomas dysregulate the pathways leading to NF-kB activation. t(11;18)(q21;q21)/BIRC3::MALT1 appears to be MALT lymphoma specific and is found in 24% of gastric and 40% of pulmonary MALT lymphomas. The translocation is associated with more disseminated disease in gastric MALT lymphoma and is found in a large percentage of patients whose lymphoma is unresponsive to antibiotic eradication of
    Language English
    Publishing date 2023-06-22
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2503443-1
    ISSN 1758-8359 ; 1758-8340
    ISSN (online) 1758-8359
    ISSN 1758-8340
    DOI 10.1177/17588359231183565
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  5. Article: What you always wanted to know about gastric MALT-lymphoma: a focus on recent developments.

    Raderer, Markus / Kiesewetter, Barbara

    Therapeutic advances in medical oncology

    2021  Volume 13, Page(s) 17588359211033825

    Abstract: The stomach is the most common site of origin for extranodal lymphomas, with extranodal marginal zone B-cell of the mucosa associated lymphoid tissue (MALT-lymphoma) being the predominant subtype. MALT-lymphoma develops in mucosa associated lymphoid ... ...

    Abstract The stomach is the most common site of origin for extranodal lymphomas, with extranodal marginal zone B-cell of the mucosa associated lymphoid tissue (MALT-lymphoma) being the predominant subtype. MALT-lymphoma develops in mucosa associated lymphoid structures acquired by infection or chronic antigenic stimuli and may therefore arise in almost any organ of the human body. In spite of histopathologic similarities between various organs upon first glance, recent findings suggest pronounced differences between different sites, with a variety of features specific to gastric MALT-lymphoma. The objective of this review is to sum up the current knowledge on pathogenesis, molecular pathology, clinical presentation and therapeutic approaches to gastric MALT-lymphoma with in-depth discussion of recent developments.
    Language English
    Publishing date 2021-07-23
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2503443-1
    ISSN 1758-8359 ; 1758-8340
    ISSN (online) 1758-8359
    ISSN 1758-8340
    DOI 10.1177/17588359211033825
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  6. Article: From biology to clinical practice: antiproliferative effects of somatostatin analogs in neuroendocrine neoplasms.

    Melhorn, Philipp / Mazal, Peter / Wolff, Ladislaia / Kretschmer-Chott, Elisabeth / Raderer, Markus / Kiesewetter, Barbara

    Therapeutic advances in medical oncology

    2024  Volume 16, Page(s) 17588359241240316

    Abstract: Somatostatin analogs (SSA), specifically octreotide and lanreotide, have demonstrated antiproliferative effects in patients with neuroendocrine tumors (NET), a group of rare malignancies of diverse origin and presentation. A prominent feature of NET ... ...

    Abstract Somatostatin analogs (SSA), specifically octreotide and lanreotide, have demonstrated antiproliferative effects in patients with neuroendocrine tumors (NET), a group of rare malignancies of diverse origin and presentation. A prominent feature of NET cells is the expression of G protein-coupled receptors called somatostatin receptors (SSTR). Although these SSTR are not uniformly present in NET, they can be instrumental in the diagnosis and treatment of NET. Apart from their application in nuclear imaging and radionuclide therapy, SSA have proven invaluable in the treatment of hormonal syndromes associated with certain NET (antisecretory effects of SSA), but it took more than two decades to convincingly demonstrate the antiproliferative effects of SSA in metastatic NET with the two pivotal studies PROMID and CLARINET. The current review summarizes three decades of SSA treatment and provides an overview of the clinical trial landscape for SSA monotherapy and combination therapy, including clinical implications and quality of life aspects, as well as ongoing fields of research.
    Language English
    Publishing date 2024-03-24
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2503443-1
    ISSN 1758-8359 ; 1758-8340
    ISSN (online) 1758-8359
    ISSN 1758-8340
    DOI 10.1177/17588359241240316
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  7. Article ; Online: The more the merrier? Evidence and efficacy of immune checkpoint- and tyrosine kinase inhibitor combinations in advanced solid cancers.

    Starzer, Angelika M / Wolff, Ladislaia / Popov, Petar / Kiesewetter, Barbara / Preusser, Matthias / Berghoff, Anna S

    Cancer treatment reviews

    2024  Volume 125, Page(s) 102718

    Abstract: Immune checkpoint inhibitors (ICI) and tyrosine kinase inhibitors (TKI) have gained therapeutical significance in cancer therapy over the last years. Due to the high efficacy of each substance group, additive or complementary effects are considered, and ... ...

    Abstract Immune checkpoint inhibitors (ICI) and tyrosine kinase inhibitors (TKI) have gained therapeutical significance in cancer therapy over the last years. Due to the high efficacy of each substance group, additive or complementary effects are considered, and combinations are the subject of multiple prospective trials in different tumor entities. The majority of available data results from clinical phase I and II trials. Although regarded as well-tolerated therapies ICI-TKI combinations have higher toxicities compared to monotherapies of one of the substance classes and some combinations were shown to be excessively toxic leading to discontinuation of trials. So far, ICI-TKI combinations with nivolumab + cabozantinib, pembrolizumab + axitinib, avelumab + axitinib, pembrolizumab + lenvatinib have been approved in advanced renal cell (RCC), with pembrolizumab + lenvatinib in endometrial carcinoma and with camrelizumab + rivoceranib in hepatocellular carcinoma (HCC). Several ICI-TKI combinations are currently investigated in phase I to III trials in various other cancer entities. Further, the optimal sequence of ICI-TKI combinations is an important subject of investigation, as cross-resistances between the substance classes were observed. This review reports on clinical trials with ICI-TKI combinations in different cancer entities, their efficacy and toxicity.
    MeSH term(s) Humans ; Carcinoma, Hepatocellular ; Tyrosine Kinase Inhibitors ; Axitinib ; Prospective Studies ; Liver Neoplasms ; Carcinoma, Renal Cell ; Kidney Neoplasms ; Phenylurea Compounds ; Quinolines
    Chemical Substances Tyrosine Kinase Inhibitors ; lenvatinib (EE083865G2) ; Axitinib (C9LVQ0YUXG) ; Phenylurea Compounds ; Quinolines
    Language English
    Publishing date 2024-03-15
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 125102-8
    ISSN 1532-1967 ; 0305-7372
    ISSN (online) 1532-1967
    ISSN 0305-7372
    DOI 10.1016/j.ctrv.2024.102718
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1022: Show issues Location:
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  8. Article ; Online: How can we assess and measure prognosis for MALT lymphoma? A review of current findings and strategies.

    Kiesewetter, Barbara / Raderer, Markus

    Expert review of hematology

    2021  Volume 14, Issue 4, Page(s) 391–399

    Abstract: Introduction: : MALT (mucosa associated lymphoid tissue) lymphoma is a distinct type of B-cell lymphoma characterized by extranodal manifestation and an indolent clinical course with 10-year survival rates up to 90%. However, transformation to ... ...

    Abstract Introduction: : MALT (mucosa associated lymphoid tissue) lymphoma is a distinct type of B-cell lymphoma characterized by extranodal manifestation and an indolent clinical course with 10-year survival rates up to 90%. However, transformation to aggressive lymphoma may occur and treatment is indicated in case of symptomatic or progressive disease.
    Areas covered: : This review covers clinical and biological features potentially related to prognosis and outcome of MALT lymphoma patients, as well as available prognostic tools and risk stratification systems with a focus on the MALT-IPI (international prognostic index) and the POD24 (progression of disease at 24 months) cohort. In addition, we address the role of watch-and-wait, the importance of defining the optimal time point for treatment initiation and the relevance of depth of remission, which appear to be some of the central questions for physicians involved in the care of MALT lymphoma patients. A computerized database search using PubMed® was performed to identify available publications on prognostic factors and risk stratification tools in MALT lymphoma.
    Expert opinion: : Despite the development of disease-specific risk stratification systems, there is no clear concept how to measure prognosis and tailor treatment. Careful observation of the individual clinical course is essential to assess the optimal time point of treatment initiation and avoid overtreatment, particularly in patients with disseminated disease. In addition, early detection of patients with histological transformation is necessary, as these patients face a poor prognosis.
    MeSH term(s) Humans ; Lymphoma, B-Cell, Marginal Zone/diagnosis ; Lymphoma, B-Cell, Marginal Zone/therapy ; Prognosis ; Stomach Neoplasms/pathology ; Survival Rate
    Language English
    Publishing date 2021-04-02
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2516804-6
    ISSN 1747-4094 ; 1747-4086
    ISSN (online) 1747-4094
    ISSN 1747-4086
    DOI 10.1080/17474086.2021.1909468
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6943: Show issues Location:
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  9. Article ; Online: How I treat MALT lymphoma: 'a subjective interpretation of the gospel according to Isaacson….'

    Raderer, Markus / Kiesewetter, Barbara

    ESMO open

    2020  Volume 5, Issue 4

    Abstract: Mucosa-associated lymphoid tissue lymphoma (MALT lymphoma) is an indolent B-cell lymphoma characterised by a fascinating interplay between chronic antigenic stimulation, an immune response insufficient for elimination of the antigen and a mucosal ' ... ...

    Abstract Mucosa-associated lymphoid tissue lymphoma (MALT lymphoma) is an indolent B-cell lymphoma characterised by a fascinating interplay between chronic antigenic stimulation, an immune response insufficient for elimination of the antigen and a mucosal 'battleground'. The archetype of this association is infection of the gastric mucosa with
    MeSH term(s) Gastric Mucosa ; Helicobacter Infections ; Helicobacter pylori ; Humans ; Lymphoma, B-Cell, Marginal Zone ; Stomach Neoplasms
    Language English
    Publishing date 2020-07-18
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2059-7029
    ISSN (online) 2059-7029
    DOI 10.1136/esmoopen-2020-000812
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  10. Article ; Online: Positron emission tomography/magnetic resonance imaging (PET/MRI) vs. gastroscopy: Can it improve detection of extranodal marginal zone lymphomas of the stomach following

    Raderer, Markus / Kiesewetter, Barbara / Mayerhoefer, Marius E

    Expert review of hematology

    2022  Volume 15, Issue 7, Page(s) 565–571

    Abstract: Introduction: The stomach is the most common site of origin for extranodal marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT lymphoma). Antibiotic eradication of : Areas covered: The objective of this review is to provide ... ...

    Abstract Introduction: The stomach is the most common site of origin for extranodal marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT lymphoma). Antibiotic eradication of
    Areas covered: The objective of this review is to provide an update on results obtained using noninvasive methods, including magnetic resonance imaging (MRI), positron emission tomography combined with computed tomography (PET/CT), and most recently, PET/MRI for the assessment of disease extent and response to treatment in patients with gastric MALT lymphoma.
    Expert opinion: While CT is the officially recommended imaging technique, few studies in small cohorts have suggested that diffusion-weighted MRI shows higher sensitivity, also relative to 18 F-FDG PET/CT, for both gastric and nongastric MALT lymphomas. A recent prospective study using PET/MRI with the novel CXCR4-targeting radiotracer 68 Ga-Pentixafor suggested that, for patients with gastric MALT lymphoma after
    MeSH term(s) Gastroscopy ; Helicobacter pylori ; Humans ; Lymphoma, B-Cell, Marginal Zone/diagnostic imaging ; Lymphoma, B-Cell, Marginal Zone/drug therapy ; Lymphoma, Non-Hodgkin ; Magnetic Resonance Imaging ; Positron Emission Tomography Computed Tomography ; Positron-Emission Tomography ; Stomach/pathology ; Stomach Neoplasms
    Language English
    Publishing date 2022-06-21
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 2516804-6
    ISSN 1747-4094 ; 1747-4086
    ISSN (online) 1747-4094
    ISSN 1747-4086
    DOI 10.1080/17474086.2022.2089110
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6943: Show issues Location:
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