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Article ; Online: Immunoglobulin deficiencies: the B-lymphocyte side of DiGeorge Syndrome.

Patel, Kiran / Akhter, Javeed / Kobrynski, Lisa / Benjamin Gathmann, M A / Gathman, Benjamin / Davis, Onika / Sullivan, Kathleen E

The Journal of pediatrics

2012 Volume 161, Issue 5, Page(s) 950–953

Abstract: DiGeorge syndrome is associated with a T-lymphocyte immunodeficiency. The prevalence of hypogammaglobulinemia has not been reported. We found that 3% of patients with DiGeorge syndrome were receiving immunoglobulin replacement therapy and 6% of patients ... ...

Abstract	DiGeorge syndrome is associated with a T-lymphocyte immunodeficiency. The prevalence of hypogammaglobulinemia has not been reported. We found that 3% of patients with DiGeorge syndrome were receiving immunoglobulin replacement therapy and 6% of patients over the age of 3 years had hypogammaglobulinemia. We conclude that DiGeorge syndrome is associated with significant humoral immune deficiency.
MeSH term(s)	Adolescent ; Adult ; B-Lymphocytes/cytology ; Child ; Child, Preschool ; Cohort Studies ; DiGeorge Syndrome/diagnosis ; DiGeorge Syndrome/genetics ; Europe ; Humans ; IgA Deficiency/blood ; IgA Deficiency/diagnosis ; Immunoglobulin A/metabolism ; Immunoglobulin G/metabolism ; Immunoglobulin M/metabolism ; Immunoglobulins/metabolism ; Infant ; Infant, Newborn ; Middle Aged ; Prevalence ; Registries ; T-Lymphocytes/cytology ; United States
Chemical Substances	Immunoglobulin A ; Immunoglobulin G ; Immunoglobulin M ; Immunoglobulins
Language	English
Publishing date	2012-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	3102-1
ISSN	1097-6833 ; 0022-3476
ISSN (online)	1097-6833
ISSN	0022-3476
DOI	10.1016/j.jpeds.2012.06.018
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Article: Fallbericht: nichtorganischer Vaginismus

Özdemir, Umut C. / Gathmann, Sandra / Flöter, Annika

PiD - Psychotherapie im Dialog

(Sexualität)

2022 Volume 23, Issue 02, Page(s) 89–92

Abstract: ... zukünftigen Großeltern gestellt – so auch der Patientin Frau B. und ihrem Ehemann. Was die Angehörigen jedoch ...

Series title	Sexualität
Abstract	Wann kommt endlich der Nachwuchs? Diese Frage wird vielen jungen Ehepaaren von den erwartungsvollen zukünftigen Großeltern gestellt – so auch der Patientin Frau B. und ihrem Ehemann. Was die Angehörigen jedoch nicht wissen: Die beiden hatten in 3 Jahren Ehe noch keinen penetrativen Geschlechtsverkehr.:
Language	German
Publishing date	2022-05-18
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2015119-6
ISSN	1439-913X ; 1438-7026
ISSN (online)	1439-913X
ISSN	1438-7026
DOI	10.1055/a-1487-9111
Database	Thieme publisher's database

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Article ; Online: Effects of low-level visual information and perceptual load on P1 and N170 responses to emotional expressions.

Schindler, Sebastian / Bruchmann, Maximilian / Gathmann, Bettina / Moeck, Robert / Straube, Thomas

Cortex; a journal devoted to the study of the nervous system and behavior

2020 Volume 136, Page(s) 14–27

Abstract: Emotional facial expressions lead to modulations of early event-related potentials (ERPs). However, it has so far remained unclear how far these modulations represent face-specific effects rather than differences in low-level visual features, and to ... ...

Abstract	Emotional facial expressions lead to modulations of early event-related potentials (ERPs). However, it has so far remained unclear how far these modulations represent face-specific effects rather than differences in low-level visual features, and to which extent they depend on available processing resources. To examine these questions, we conducted two preregistered independent experiments (N = 40 in each experiment) using different variants of a novel task that manipulates peripheral perceptual load across levels but keeps overall visual stimulation constant. At the display center, we presented task-irrelevant angry, neutral, and happy faces and their Fourier phase-scrambled versions, which preserved low-level visual features. The results of both studies showed load-independent P1 and N170 emotional expression effects. Importantly, by using Bayesian analyses we could confirm that these facial expression effects were face-independent for the P1 but not for the N170 component. We conclude that firstly, ERP modulations during the P1 interval strongly depend on low-level visual information, while the N170 modulation requires the processing of figural facial expression features. Secondly, both P1 and N170 modulations appear to be immune to a large range of variations in perceptual load.
MeSH term(s)	Bayes Theorem ; Electroencephalography ; Emotions ; Evoked Potentials ; Facial Expression ; Humans
Language	English
Publishing date	2020-12-23
Publishing country	Italy
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	280622-8
ISSN	1973-8102 ; 0010-9452
ISSN (online)	1973-8102
ISSN	0010-9452
DOI	10.1016/j.cortex.2020.12.011
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Article ; Online: Association between resting-state connectivity patterns in the defensive system network and treatment response in spider phobia-a replication approach.

Leehr, Elisabeth J / Seeger, Fabian R / Böhnlein, Joscha / Gathmann, Bettina / Straube, Thomas / Roesmann, Kati / Junghöfer, Markus / Schwarzmeier, Hanna / Siminski, Niklas / Herrmann, Martin J / Langhammer, Till / Goltermann, Janik / Grotegerd, Dominik / Meinert, Susanne / Winter, Nils R / Dannlowski, Udo / Lueken, Ulrike

Translational psychiatry

2024 Volume 14, Issue 1, Page(s) 137

Abstract: Although highly effective on average, exposure-based treatments do not work equally well for all patients with anxiety disorders. The identification of pre-treatment response-predicting patient characteristics may enable patient stratification. ... ...

Abstract	Although highly effective on average, exposure-based treatments do not work equally well for all patients with anxiety disorders. The identification of pre-treatment response-predicting patient characteristics may enable patient stratification. Preliminary research highlights the relevance of inhibitory fronto-limbic networks as such. We aimed to identify pre-treatment neural signatures differing between exposure treatment responders and non-responders in spider phobia and to validate results through rigorous replication. Data of a bi-centric intervention study comprised clinical phenotyping and pre-treatment resting-state functional connectivity (rsFC) data of n = 79 patients with spider phobia (discovery sample) and n = 69 patients (replication sample). RsFC data analyses were accomplished using the Matlab-based CONN-toolbox with harmonized analyses protocols at both sites. Treatment response was defined by a reduction of >30% symptom severity from pre- to post-treatment (Spider Phobia Questionnaire Score, primary outcome). Secondary outcome was defined by a reduction of >50% in a Behavioral Avoidance Test (BAT). Mean within-session fear reduction functioned as a process measure for exposure. Compared to non-responders and pre-treatment, results in the discovery sample seemed to indicate that responders exhibited stronger negative connectivity between frontal and limbic structures and were characterized by heightened connectivity between the amygdala and ventral visual pathway regions. Patients exhibiting high within-session fear reduction showed stronger excitatory connectivity within the prefrontal cortex than patients with low within-session fear reduction. Whereas these results could be replicated by another team using the same data (cross-team replication), cross-site replication of the discovery sample findings in the independent replication sample was unsuccessful. Results seem to support negative fronto-limbic connectivity as promising ingredient to enhance response rates in specific phobia but lack sufficient replication. Further research is needed to obtain a valid basis for clinical decision-making and the development of individually tailored treatment options. Notably, future studies should regularly include replication approaches in their protocols.
MeSH term(s)	Animals ; Humans ; Spiders ; Magnetic Resonance Imaging ; Phobic Disorders/diagnostic imaging ; Phobic Disorders/therapy ; Anxiety Disorders ; Fear/physiology
Language	English
Publishing date	2024-03-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2609311-X
ISSN	2158-3188 ; 2158-3188
ISSN (online)	2158-3188
ISSN	2158-3188
DOI	10.1038/s41398-024-02799-x
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Article ; Online: Information und Beratung über Fragen des Naturhaushalts als wichtiger Baustein im Zulassungsverfahren für Pflanzenschutzmittel ; Information and advice on questions of the environment as an important building block in the registration process of plant protection products

Peters, Anna Désirée / Kula, Christine / Smith, Balthasar / Gathmann, Joachim

2021

Keywords	Text ; abstract_or_summary ; ddc:630
Language	German
Publisher	Julius Kühn-Institut
Publishing country	de
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Effects of low-level visual information and perceptual load on P1 and N170 responses to emotional expressions

Schindler, Sebastian / Bruchmann, Maximilian / Gathmann, Bettina / Moeck, Robert / Straube, Thomas

Cortex

2021 Volume 136, Page(s) 14–27

Abstract: Abstract not released by publisher. ...

Title translation	Auswirkungen von Low-Level-Visualisierungsinformationen und Wahrnehmungsbelastung auf P1- und N170-Reaktionen auf emotionale Ausdrücke (DeepL)
Abstract	Abstract not released by publisher.
Keywords	Cognitive Processes ; Emotion Recognition ; Emotionserkennung ; Face Perception ; Facial Expressions ; Gesichterwahrnehmung ; Gesichtsausdruck ; Kognitive Prozesse ; Visual Evoked Potentials ; Visuell evozierte Potenziale
Language	English
Document type	Article
ZDB-ID	280622-8
ISSN	1973-8102 ; 0010-9452
ISSN (online)	1973-8102
ISSN	0010-9452
DOI	10.1016/j.cortex.2020.12.011
Database	PSYNDEX

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Article ; Online: One executive function never comes alone: monitoring and its relation to working memory, reasoning, and different executive functions.

Gathmann, Bettina / Brand, Matthias / Schiebener, Johannes

Cognitive processing

2017 Volume 18, Issue 1, Page(s) 13–29

Abstract: Monitoring is involved in many daily tasks and is described in several theoretical approaches of executive functioning. This study investigated the relative relationship of cognitive processes that are theoretically relevant to monitoring, such as ... ...

Abstract	Monitoring is involved in many daily tasks and is described in several theoretical approaches of executive functioning. This study investigated the relative relationship of cognitive processes that are theoretically relevant to monitoring, such as concept formation, reasoning, working memory, and general cognitive control functions. Data from 699 participants who performed the Balanced Switching Task, aiming at capturing monitoring, were used. Subsamples also performed standard tasks assessing the processes assumed to be related to monitoring. Structural equation modeling revealed that general cognitive control processes are particularly relevant. They mediate the relationship between working memory, reasoning, and monitoring. Updating and maintaining information, as well as concluding from information which strategies can guide behavior toward predefined goals, is required for the ability to exert general cognitive control, which again may be relevant for implementing strategies in a goal-directed way. Together, these processes seem to be necessary to adequately monitor behavior in complex tasks.
MeSH term(s)	Adult ; Executive Function/physiology ; Humans ; Memory, Short-Term/physiology ; Thinking/physiology
Language	English
Publishing date	2017-02
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2075054-7
ISSN	1612-4790 ; 1612-4782
ISSN (online)	1612-4790
ISSN	1612-4782
DOI	10.1007/s10339-016-0773-6
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Article ; Online: Mechanisms of action underlying virtual reality exposure treatment in spider phobia: Pivotal role of within-session fear reduction.

Roesmann, Kati / Leehr, Elisabeth J / Böhnlein, Joscha / Gathmann, Bettina / Herrmann, Martin J / Junghöfer, Markus / Schwarzmeier, Hanna / Seeger, Fabian R / Siminski, Niklas / Straube, Thomas / Dannlowski, Udo / Lueken, Ulrike

Journal of anxiety disorders

2023 Volume 100, Page(s) 102790

Abstract: Although virtual-reality exposure treatment (VRET) for anxiety disorders is an efficient treatment option for specific phobia, mechanisms of action for immediate and sustained treatment response need to be elucidated. Towards this aim, core therapy ... ...

Abstract	Although virtual-reality exposure treatment (VRET) for anxiety disorders is an efficient treatment option for specific phobia, mechanisms of action for immediate and sustained treatment response need to be elucidated. Towards this aim, core therapy process variables were assessed as predictors for short- and long-term VR treatment outcomes. In a bi-centric study, n = 186 patients with spider phobia completed a baseline-assessment, a one-session VRET, a post-therapy assessment, and a 6-month-follow-up assessment (ClinicalTrials.gov, ID: NCT03208400). Short- and long-term outcomes regarding self-reported symptoms in the spider phobia questionnaire (SPQ) and final patient-spider distance in the behavioral avoidance test (BAT) were predicted via logistic regression models with the corresponding baseline score, age, initial fear activation, within-session fear reduction and fear expectancy violation as predictors. To predict long-term remission status at 6-month-follow-up, dimensional short-term changes in the SPQ and BAT were additionally included. Higher within-session fear reductions predicted better treatment outcomes (long-term SPQ; short- and long-term BAT). Lower initial fear activation tended to be associated with better long-term outcomes (SPQ), while fear expectancy violation was not associated with any outcome measure. Short-term change in the SPQ predicted remission status. Findings highlight that in VRET for spider phobia, the experience of fear reduction is central for short- and long-term treatment success and should be focused by therapists.
MeSH term(s)	Animals ; Humans ; Anxiety Disorders ; Fear ; Phobic Disorders/therapy ; Spiders ; Treatment Outcome ; Virtual Reality Exposure Therapy/methods
Language	English
Publishing date	2023-10-14
Publishing country	Netherlands
Document type	Clinical Trial ; Journal Article
ZDB-ID	619417-5
ISSN	1873-7897 ; 0887-6185
ISSN (online)	1873-7897
ISSN	0887-6185
DOI	10.1016/j.janxdis.2023.102790
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Article: How susceptible are different lepidopteran/coleopteran maize pests to Bt-proteins: a systematic review protocol

Gathmann, Achim / Priesnitz, Kai U

Environmental evidence. 2014 Dec., v. 3, no. 1

2014

Abstract: ... events represent a high-dose to specific target organisms, b) resistance has developed while monitoring ...

Abstract	BACKGROUND: Lepidopteran and coleopteran species are the most important pests in maize. They can be controlled using genetically modified crops expressing insecticidal Bt-proteins. The long term success of this technology demands a pest resistance management. Important information for a successful management of resistance is the baseline susceptibility of the different targeted pests towards the different Bt-proteins. The data on baseline susceptibility should enable risk assessors and managers to assess whether a) Bt-maize events represent a high-dose to specific target organisms, b) resistance has developed while monitoring the commercial introduction of Bt-maize events and c) potential knowledge gaps can be identified. METHODS: This protocol describes our suggested methods for conducting a systematic review to give an overview of the European target pests in maize and their susceptibility to insecticidal Bt-proteins. Both published and unpublished data shall be collated. Different sources of information will be searched in order to maximize the coverage of the search. All identified publications will be stored in a database. Relevant information for the review will be identified in a three step approach based on inclusion criteria. This data set will be an important basis to model and assess the potential for evolution of resistance of different crop-Bt-protein-species combinations.
Keywords	Coleoptera ; Lepidoptera ; corn ; data collection ; databases ; evolution ; pest resistance ; protocols ; resistance management ; risk ; systematic review
Language	English
Dates of publication	2014-12
Size	p. 12.
Publishing place	BioMed Central
Document type	Article
ZDB-ID	2662506-4
ISSN	2047-2382
ISSN	2047-2382
DOI	10.1186/2047-2382-3-12
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Brain activation during disorder-related script-driven imagery in panic disorder: a pilot study.

Burkhardt, Alexander / Buff, Christine / Brinkmann, Leonie / Feldker, Katharina / Gathmann, Bettina / Hofmann, David / Straube, Thomas

Scientific reports

2019 Volume 9, Issue 1, Page(s) 2415

Abstract: Despite considerable effort, the neural correlates of altered threat-related processing in panic disorder (PD) remain inconclusive. Mental imagery of disorder-specific situations proved to be a powerful tool to investigate dysfunctional threat processing ...

Abstract	Despite considerable effort, the neural correlates of altered threat-related processing in panic disorder (PD) remain inconclusive. Mental imagery of disorder-specific situations proved to be a powerful tool to investigate dysfunctional threat processing in anxiety disorders. The current functional magnetic resonance imaging (fMRI) study aimed at investigating brain activation in PD patients during disorder-related script-driven imagery. Seventeen PD patients and seventeen healthy controls (HC) were exposed to newly developed disorder-related and neutral narrative scripts while brain activation was measured with fMRI. Participants were encouraged to imagine the narrative scripts as vividly as possible and they rated their script-induced emotional states after the scanning session. PD patients rated disorder-related scripts as more arousing, unpleasant and anxiety-inducing as compared to HC. Patients relative to HC showed elevated activity in the right amygdala and the brainstem as well as decreased activity in the rostral anterior cingulate cortex, and the medial and lateral prefrontal cortex to disorder-related vs. neutral scripts. The results suggest altered amygdala/ brainstem and prefrontal cortex engagement and point towards the recruitment of brain networks with opposed activation patterns in PD patients during script-driven imagery.
MeSH term(s)	Adult ; Amygdala/diagnostic imaging ; Amygdala/physiopathology ; Anxiety Disorders/diagnostic imaging ; Anxiety Disorders/physiopathology ; Brain/diagnostic imaging ; Brain/physiopathology ; Brain Mapping ; Emotions/physiology ; Fear/physiology ; Fear/psychology ; Female ; Gyrus Cinguli/diagnostic imaging ; Gyrus Cinguli/physiopathology ; Humans ; Imagery, Psychotherapy/methods ; Imagination/physiology ; Magnetic Resonance Imaging ; Male ; Panic Disorder/diagnostic imaging ; Panic Disorder/physiopathology ; Pilot Projects ; Prefrontal Cortex/diagnostic imaging ; Prefrontal Cortex/physiopathology ; Surveys and Questionnaires
Language	English
Publishing date	2019-02-20
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-019-38990-0
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