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Article ; Online: Speech and noise levels measured in occupied K-12 classrooms.

Wang, Lily M / Brill, Laura C

The Journal of the Acoustical Society of America

2021 Volume 150, Issue 2, Page(s) 864

Abstract: This project acquired sound levels logged across six school days and impulse responses in 220 classrooms across four K-12 grades. Seventy-four percent met reverberation time recommendations. Sound levels were processed to estimate occupied signal-to- ... ...

Abstract	This project acquired sound levels logged across six school days and impulse responses in 220 classrooms across four K-12 grades. Seventy-four percent met reverberation time recommendations. Sound levels were processed to estimate occupied signal-to-noise ratios (SNRs), using Gaussian mixture modeling and from daily equivalent and statistical levels. A third method, k-means clustering, estimated SNR more precisely, separating data on nine dimensions into one group with high levels across speech frequencies and one without. The SNRs calculated as the daily difference between the average levels for the speech and non-speech clusters are found to be lower than 15 dB in 27.3% of the classrooms and differ from using the other two methods. The k-means data additionally indicate that speech occurred 30.5%-81.2% of the day, with statistically larger percentages found in grade 3 compared to higher grades. Speech levels exceeded 65 dBA 35% of the day, and non-speech levels exceeded 50 dBA 32% of the day, on average, with grades 3 and 8 experiencing speech levels exceeding 65 dBA statistically more often than the other two grades. Finally, classroom speech and non-speech levels were significantly correlated, with a 0.29 dBA increase in speech levels for every 1 dBA in non-speech levels.
MeSH term(s)	Schools ; Signal-To-Noise Ratio ; Speech ; Speech Perception
Language	English
Publishing date	2021-09-02
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	219231-7
ISSN	1520-8524 ; 0001-4966
ISSN (online)	1520-8524
ISSN	0001-4966
DOI	10.1121/10.0005815
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Article ; Online: Single-Cell RNA-seq reveals transcriptomic modulation of Alzheimer's disease by activated protein C.

Fatmi, Mohammad Kasim / Wang, Hao / Slotabec, Lily / Wen, Changhong / Seale, Blaise / Zhao, Bi / Li, Ji

Aging

2024 Volume 16, Issue 4, Page(s) 3137–3159

Abstract: Single-Cell RNA sequencing reveals changes in cell population in Alzheimer's disease (AD) model 5xFAD (5x Familial AD mutation) versus wild type (WT) mice. The returned sequencing data was processed through the 10x ... ...

Abstract	Single-Cell RNA sequencing reveals changes in cell population in Alzheimer's disease (AD) model 5xFAD (5x Familial AD mutation) versus wild type (WT) mice. The returned sequencing data was processed through the 10x Genomics
MeSH term(s)	Mice ; Animals ; Alzheimer Disease/genetics ; Alzheimer Disease/metabolism ; Protein C/genetics ; Protein C/metabolism ; Single-Cell Gene Expression Analysis ; Gene Expression Regulation ; Cognition ; Microglia/metabolism ; Disease Models, Animal ; Mice, Transgenic ; Amyloid beta-Peptides/metabolism ; Membrane Glycoproteins/metabolism ; Receptors, Immunologic/genetics
Chemical Substances	Protein C ; Amyloid beta-Peptides ; Trem2 protein, mouse ; Membrane Glycoproteins ; Receptors, Immunologic
Language	English
Publishing date	2024-02-21
Publishing country	United States
Document type	Journal Article
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.205624
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Article: Corrigendum: The influence of physiological and pathological perturbations on blood-brain barrier function.

Zhao, Nan / Chung, Tracy D / Guo, Zhaobin / Jamieson, John J / Liang, Lily / Linville, Raleigh M / Pessell, Alex F / Wang, Linus / Searson, Peter C

Frontiers in neuroscience

2024 Volume 17, Page(s) 1328902

Abstract: This corrects the article DOI: 10.3389/fnins.2023.1289894.]. ...

Abstract	[This corrects the article DOI: 10.3389/fnins.2023.1289894.].
Language	English
Publishing date	2024-03-21
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2411902-7
ISSN	1662-453X ; 1662-4548
ISSN (online)	1662-453X
ISSN	1662-4548
DOI	10.3389/fnins.2023.1328902
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Article ; Online: Prescription and Dispensation of QT-Prolonging Medications in Individuals Receiving Hemodialysis.

Wang, Virginia / Wang, Chin-Hua Lily / Assimon, Magdalene M / Pun, Patrick H / Winkelmayer, Wolfgang C / Flythe, Jennifer E

JAMA network open

2024 Volume 7, Issue 4, Page(s) e248732

Abstract: Importance: Individuals with dialysis-dependent kidney failure have numerous risk factors for medication-related adverse events, including receipt of care by multiple clinicians and initiation of some QT-prolonging medications with known risk of ... ...

Abstract	Importance: Individuals with dialysis-dependent kidney failure have numerous risk factors for medication-related adverse events, including receipt of care by multiple clinicians and initiation of some QT-prolonging medications with known risk of torsades de pointes (TdP), which is associated with higher risk of sudden cardiac death. Little is known about the prescription and dispensation patterns of QT-prolonging medications among people receiving dialysis, hindering efforts to reduce drug-related harm from these and other medications in this high-risk population. Objective: To examine prescription and dispensation patterns of QT-prolonging medications with known TdP risk and selected interacting medications prescribed to individuals receiving hemodialysis. Design, setting, and participants: This cross-sectional study included patients 60 years or older who were enrolled in Medicare Parts A, B, and D receiving in-center hemodialysis from January 1 to December 31, 2019. Analyses were conducted from October 20, 2022, to June 16, 2023. Exposures: New-user prescriptions for the 7 most frequently filled QT-prolonging medications characterized by the timing of the new prescription relative to acute care encounters, the type of prescribing clinician and pharmacy that dispensed the medication, and concomitant use of selected medications known to interact with the 7 most frequently filled QT-prolonging medications with known TdP risk. Main outcomes and measures: The main outcomes were the frequencies of the most commonly filled and new-use episodes of QT-prolonging medications; the timing of medication fills relative to acute care events; prescribers and dispensing pharmacy characteristics for new use of medications; and the frequency and types of new-use episodes with concurrent use of potentially interacting medications. Results: Of 20 761 individuals receiving hemodialysis in 2019 (mean [SD] age, 74 [7] years; 51.1% male), 10 992 (52.9%) filled a study drug prescription. Approximately 80% (from 78.6% for odansetron to 93.9% for escitalopram) of study drug new-use prescriptions occurred outside of an acute care event. Between 36.8% and 61.0% of individual prescriptions originated from general medicine clinicians. Between 16.4% and 26.2% of these prescriptions occurred with the use of another QT-prolonging medication. Most potentially interacting drugs were prescribed by different clinicians (46.3%-65.5%). Conclusions and relevance: In this cross-sectional study, QT-prolonging medications for individuals with dialysis-dependent kidney failure were commonly prescribed by nonnephrology clinicians and from nonacute settings. Prescriptions for potentially interacting medications often originated from different prescribers. Strategies aimed at minimizing high-risk medication-prescribing practices in the population undergoing dialysis are needed.
MeSH term(s)	Humans ; Renal Dialysis ; Male ; Cross-Sectional Studies ; Female ; Aged ; Middle Aged ; United States ; Torsades de Pointes/chemically induced ; Long QT Syndrome/chemically induced ; Aged, 80 and over ; Drug Prescriptions/statistics & numerical data ; Kidney Failure, Chronic/therapy
Language	English
Publishing date	2024-04-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	2574-3805
ISSN (online)	2574-3805
DOI	10.1001/jamanetworkopen.2024.8732
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Article ; Online: MethReg: estimating the regulatory potential of DNA methylation in gene transcription.

Silva, Tiago C / Young, Juan I / Martin, Eden R / Chen, X Steven / Wang, Lily

Nucleic acids research

2022 Volume 50, Issue 9, Page(s) e51

Abstract: Epigenome-wide association studies often detect many differentially methylated sites, and many are located in distal regulatory regions. To further prioritize these significant sites, there is a critical need to better understand the functional impact of ...

Abstract	Epigenome-wide association studies often detect many differentially methylated sites, and many are located in distal regulatory regions. To further prioritize these significant sites, there is a critical need to better understand the functional impact of CpG methylation. Recent studies demonstrated that CpG methylation-dependent transcriptional regulation is a widespread phenomenon. Here, we present MethReg, an R/Bioconductor package that analyzes matched DNA methylation and gene expression data, along with external transcription factor (TF) binding information, to evaluate, prioritize and annotate CpG sites with high regulatory potential. At these CpG sites, TF-target gene associations are often only present in a subset of samples with high (or low) methylation levels, so they can be missed by analyses that use all samples. Using colorectal cancer and Alzheimer's disease datasets, we show MethReg significantly enhances our understanding of the regulatory roles of DNA methylation in complex diseases.
MeSH term(s)	CpG Islands/genetics ; DNA Methylation/genetics ; Epigenesis, Genetic ; Genome-Wide Association Study ; Transcription, Genetic
Language	English
Publishing date	2022-01-31
Publishing country	England
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	186809-3
ISSN	1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
ISSN (online)	1362-4962 ; 1362-4954
ISSN	0301-5610 ; 0305-1048
DOI	10.1093/nar/gkac030
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Article ; Online: Differential impacts of healthy cognitive aging on directed and random exploration.

Mizell, Jack-Morgan / Wang, Siyu / Frisvold, Alec / Alvarado, Lily / Farrell-Skupny, Alex / Keung, Waitsang / Phelps, Caroline E / Sundman, Mark H / Franchetti, Mary-Kathryn / Chou, Ying-Hui / Alexander, Gene E / Wilson, Robert C

Psychology and aging

2024 Volume 39, Issue 1, Page(s) 88–101

Abstract	Deciding whether to explore unknown opportunities or exploit well-known options is a ubiquitous part of our everyday lives. Extensive work in college students suggests that young people make explore-exploit decisions using a mixture of information seeking and random behavioral variability. Whether, and to what extent, older adults use the same strategies is unknown. To address this question, 51 older adults (ages 65-74) and 32 younger adults (ages 18-25) completed the Horizon Task, a gambling task that quantifies information seeking and behavioral variability as well as how these strategies are controlled for the purposes of exploration. Qualitatively, we found that older adults performed similar to younger adults on this task, increasing both their information seeking and behavioral variability when it was adaptive to explore. Quantitively, however, there were substantial differences between the age groups, with older adults showing less information seeking overall and less reliance on variability as a means to explore. In addition, we found a subset of approximately 26% of older adults whose information seeking was close to zero, avoiding informative options even when they were clearly the better choice. Unsurprisingly, these "information avoiders" performed worse on the task. In contrast, task performance in the remaining "information seeking" older adults was comparable to that of younger adults suggesting that age-related differences in explore-exploit decision making may be adaptive except when they are taken to extremes. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
MeSH term(s)	Humans ; Aged ; Adolescent ; Young Adult ; Adult ; Cognitive Aging ; Aging ; Gambling ; Healthy Aging ; Students
Language	English
Publishing date	2024-02-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	635596-1
ISSN	1939-1498 ; 0882-7974
ISSN (online)	1939-1498
ISSN	0882-7974
DOI	10.1037/pag0000791
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Article ; Online: Multilingual Speech Acquisition by Vietnamese-English-Speaking Children and Adult Family Members.

McLeod, Sharynne / Verdon, Sarah / Margetson, Kate / Tran, Van H / Wang, Cen / Phạm, Ben / To, Lily / Huynh, Kylie

Journal of speech, language, and hearing research : JSLHR

2023 Volume 66, Issue 7, Page(s) 2184–2229

Abstract: ... by family members, (c) including dialectal variants in the definition of accuracy, and (d) clustering participants ...

Abstract	Purpose: This article presents a large-scale example of culturally responsive assessment and analysis of multilingual Vietnamese-English-speaking children and their family members using the VietSpeech Protocol involving (a) examining all spoken languages, (b) comparing ambient phonology produced by family members, (c) including dialectal variants in the definition of accuracy, and (d) clustering participants with similar language experience. Method: The VietSpeech participants ( Results: Children's Vietnamese consonant accuracy was significantly higher when dialectal variants were accepted (percentage of consonants correct-dialect [PCC-D]: Conclusions: Children's speech acquisition was influenced by cross-linguistic, dialectal, maturational, language experience, and environmental (ambient phonology) factors. Adults' pronunciation was influenced by dialectal and cross-linguistic factors. This study highlights the importance of including all spoken languages, adult family members, dialectal variants, and language proficiency to inform differential diagnosis of speech sound disorders and identify clinical markers in multilingual populations. Supplemental material: https://doi.org/10.23641/asha.23290055.
MeSH term(s)	Adult ; Child ; Female ; Humans ; Australia ; Language ; Mothers ; Phonetics ; Southeast Asian People ; Speech ; Speech Production Measurement ; Multilingualism ; Child, Preschool
Language	English
Publishing date	2023-06-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1364086-0
ISSN	1558-9102 ; 1092-4388
ISSN (online)	1558-9102
ISSN	1092-4388
DOI	10.1044/2023_JSLHR-21-00669
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Article ; Online: Noninvasive monitoring of the vagus nerve during thyroid surgery using cutaneous adhesive and needle electrodes: What is the optimal configuration?

Karcioglu, Amanda Silver / Trinh, Lily N / Mcllroy, Dioan / Okose, Okenwa C / Wang, Bo / Behr, Ian J / Cheung, Anthony Y / Srikanthan, Adithya / Russell, Marika D / Kamani, Dipti / Abdelhamid Ahmed, Amr H / Randolph, Gregory W

Head & neck

2024

Abstract: Objective: Endotracheal tube (ETT) surface electrodes are used to monitor the vagus nerve (VN), recurrent laryngeal nerve (RLN), and external branch of the superior laryngeal nerve (EBSLN) during thyroid and parathyroid surgery. Alternative nerve ... ...

Abstract	Objective: Endotracheal tube (ETT) surface electrodes are used to monitor the vagus nerve (VN), recurrent laryngeal nerve (RLN), and external branch of the superior laryngeal nerve (EBSLN) during thyroid and parathyroid surgery. Alternative nerve monitoring methods are desirable when intubation under general anesthesia is not desirable or possible. In this pilot study, we compared the performance of standard ETT electrodes to four different noninvasive cutaneous recording electrode types (two adhesive electrodes and two needle electrodes) in three different orientations. Methods: The VN was stimulated directly during thyroid and parathyroid surgery using a Prass stimulator probe. Electromyographic (EMG) responses for each patient were recorded using an ETT plus one of the following four cutaneous electrode types: large-foot adhesive, small-foot adhesive, long-needle and short-needle. Each of the four electrode types was placed in three orientations: (1) bilateral, (2) ipsilateral mediolateral, and (3) ipsilateral craniocaudal. Results: Four surgical cases were utilized for data collection with the repetitive measures obtained in each subject. Bilateral electrode orientation was superior to ipsilateral craniocaudal and ipsilateral mediolateral orientations. Regardless of electrodes type, all amplitudes in the bilateral orientation were >100 μV. When placed bilaterally, the small-foot adhesive and the long-needle electrodes obtained the highest EMG amplitudes as a percentage of ETT amplitudes. Conclusion: Cutaneous electrodes could potentially be used to monitor the VN during thyroid and parathyroid procedures. Different electrode types vary in their ability to record amplitudes and latencies. Bilateral orientation improves EMG responses in all electrode types. Additional validation of cutaneous electrodes as an alternative noninvasive method to monitor the VN is needed.
Language	English
Publishing date	2024-01-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	645165-2
ISSN	1097-0347 ; 0148-6403 ; 1043-3074
ISSN (online)	1097-0347
ISSN	0148-6403 ; 1043-3074
DOI	10.1002/hed.27669
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Article ; Online: letter to the editor.

Assimon, Magdalene M / Pun, Patrick H / Wang, Lily / Al-Khatib, Sana M / Brookhart, M Alan / Weber, David J / Winkelmayer, Wolfgang C / Flythe, Jennifer E

Kidney international

2022 Volume 102, Issue 5, Page(s) 1191–1192

Language	English
Publishing date	2022-10-28
Publishing country	United States
Document type	Letter ; Research Support, N.I.H., Extramural ; Comment
ZDB-ID	120573-0
ISSN	1523-1755 ; 0085-2538
ISSN (online)	1523-1755
ISSN	0085-2538
DOI	10.1016/j.kint.2022.08.009
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Article ; Online: Exploring therapeutic strategies for infantile neuronal axonal dystrophy (INAD/PARK14).

Lin, Guang / Tepe, Burak / McGrane, Geoff / Tipon, Regine C / Croft, Gist / Panwala, Leena / Hope, Amanda / Liang, Agnes J H / Zuo, Zhongyuan / Byeon, Seul Kee / Wang, Lily / Pandey, Akhilesh / Bellen, Hugo J

eLife

2023 Volume 12

Abstract: Infantile neuroaxonal dystrophy (INAD) is caused by recessive variants ... ...

Abstract	Infantile neuroaxonal dystrophy (INAD) is caused by recessive variants in
MeSH term(s)	Mice ; Animals ; Neurons/metabolism ; Parkinsonian Disorders/metabolism ; Drosophila/metabolism ; Ceramides/metabolism ; Neuroaxonal Dystrophies/genetics ; Neuroaxonal Dystrophies/metabolism ; Neuroaxonal Dystrophies/pathology ; Group VI Phospholipases A2/metabolism ; Eye Proteins/metabolism ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism
Chemical Substances	Ceramides ; Pla2g6 protein, mouse (EC 3.1.1.4) ; Group VI Phospholipases A2 (EC 3.1.1.4) ; inaD protein, Drosophila ; Eye Proteins ; Drosophila Proteins
Language	English
Publishing date	2023-01-16
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.82555
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