LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 19

Search options

  1. Book: Myeloma

    Tanner, Jerome E.

    (The biology of cancer)

    2008  

    Author's details Jerome Edward Tanner
    Series title The biology of cancer
    Language English
    Size 119 S. : Ill.
    Publisher Chelsea House
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT016191096
    ISBN 978-0-7910-8824-1 ; 0-7910-8824-3
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

  2. Article ; Online: The Fatty Acid Lipid Metabolism Nexus in COVID-19.

    Tanner, Jerome E / Alfieri, Caroline

    Viruses

    2021  Volume 13, Issue 1

    Abstract: Enteric symptomology seen in early-stage severe acute respiratory syndrome (SARS)-2003 and COVID-19 is evidence of virus replication occurring in the intestine, liver and pancreas. Aberrant lipid metabolism in morbidly obese individuals adversely affects ...

    Abstract Enteric symptomology seen in early-stage severe acute respiratory syndrome (SARS)-2003 and COVID-19 is evidence of virus replication occurring in the intestine, liver and pancreas. Aberrant lipid metabolism in morbidly obese individuals adversely affects the COVID-19 immune response and increases disease severity. Such observations are in line with the importance of lipid metabolism in COVID-19, and point to the gut as a site for intervention as well as a therapeutic target in treating the disease. Formation of complex lipid membranes and palmitoylation of coronavirus proteins are essential during viral replication and assembly. Inhibition of fatty acid synthase (FASN) and restoration of lipid catabolism by activation of AMP-activated protein kinase (AMPK) impede replication of coronaviruses closely related to SARS-coronavirus-2 (CoV-2). In vitro findings and clinical data reveal that the FASN inhibitor, orlistat, and the AMPK activator, metformin, may inhibit coronavirus replication and reduce systemic inflammation to restore immune homeostasis. Such observations, along with the known mechanisms of action for these types of drugs, suggest that targeting fatty acid lipid metabolism could directly inhibit virus replication while positively impacting the patient's response to COVID-19.
    MeSH term(s) AMP-Activated Protein Kinases/metabolism ; AMP-Activated Protein Kinases/pharmacology ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; COVID-19/drug therapy ; COVID-19/metabolism ; COVID-19/virology ; Digestive System/drug effects ; Digestive System/virology ; Fatty Acid Synthases/antagonists & inhibitors ; Fatty Acid Synthases/metabolism ; Fatty Acids/metabolism ; Humans ; Lipid Metabolism ; Metformin/therapeutic use ; Obesity/drug therapy ; Obesity/metabolism ; Obesity/virology ; Orlistat/therapeutic use ; SARS-CoV-2/drug effects ; SARS-CoV-2/physiology ; Viral Proteins/metabolism ; Virus Assembly/drug effects ; Virus Replication/drug effects
    Chemical Substances Antiviral Agents ; Fatty Acids ; Viral Proteins ; Metformin (9100L32L2N) ; Orlistat (95M8R751W8) ; Fatty Acid Synthases (EC 2.3.1.85) ; AMP-Activated Protein Kinases (EC 2.7.11.31)
    Language English
    Publishing date 2021-01-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v13010090
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Genomic-Scale Interaction Involving Complementary Sequences in the Hepatitis C Virus 5'UTR Domain IIa and the RNA-Dependent RNA Polymerase Coding Region Promotes Efficient Virus Replication.

    Rance, Elodie / Tanner, Jerome E / Alfieri, Caroline

    Viruses

    2018  Volume 11, Issue 1

    Abstract: The hepatitis C virus (HCV) genome contains structured elements thought to play important regulatory roles in viral RNA translation and replication processes. We used in vitro RNA binding assays to map interactions involving the HCV 5'UTR and distal ... ...

    Abstract The hepatitis C virus (HCV) genome contains structured elements thought to play important regulatory roles in viral RNA translation and replication processes. We used in vitro RNA binding assays to map interactions involving the HCV 5'UTR and distal sequences in NS5B to examine their impact on viral RNA replication. The data revealed that 5'UTR nucleotides (nt) 95⁻110 in the internal ribosome entry site (IRES) domain IIa and matching nt sequence 8528⁻8543 located in the RNA-dependent RNA polymerase coding region NS5B, form a high-affinity RNA-RNA complex in vitro. This duplex is composed of both wobble and Watson-Crick base-pairings, with the latter shown to be essential to the formation of the high-affinity duplex. HCV genomic RNA constructs containing mutations in domain IIa nt 95⁻110 or within the genomic RNA location comprising nt 8528⁻8543 displayed, on average, 5-fold less intracellular HCV RNA and 6-fold less infectious progeny virus. HCV genomic constructs containing complementary mutations for IRES domain IIa nt 95⁻110 and NS5B nt 8528⁻8543 restored intracellular HCV RNA and progeny virus titers to levels obtained for parental virus RNA. We conclude that this long-range duplex interaction between the IRES domain IIa and NS5B nt 8528⁻8543 is essential for optimal virus replication.
    MeSH term(s) 5' Untranslated Regions ; Cell Line, Tumor ; Genome, Viral ; Genomics ; Hepacivirus/genetics ; Hepacivirus/physiology ; Humans ; Nucleic Acid Conformation ; Open Reading Frames ; Protein Binding ; Protein Biosynthesis ; RNA Replicase/genetics ; RNA, Viral/genetics ; Virus Replication/genetics
    Chemical Substances 5' Untranslated Regions ; RNA, Viral ; RNA Replicase (EC 2.7.7.48)
    Language English
    Publishing date 2018-12-28
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v11010017
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article: Construction and Characterization of a Humanized Anti-Epstein-Barr Virus gp350 Antibody with Neutralizing Activity in Cell Culture.

    Tanner, Jerome E / Hu, Jing / Alfieri, Caroline

    Cancers

    2018  Volume 10, Issue 4

    Abstract: Acute Epstein-Barr virus (EBV) infection in immunosuppressed transplant patients can give rise to a malignant B-cell proliferation known as post-transplant lymphoproliferative disease (PTLD). The EBV major virion surface glycoprotein (gp)350 is a ... ...

    Abstract Acute Epstein-Barr virus (EBV) infection in immunosuppressed transplant patients can give rise to a malignant B-cell proliferation known as post-transplant lymphoproliferative disease (PTLD). The EBV major virion surface glycoprotein (gp)350 is a principal target of naturally occurring neutralizing antibodies and is viewed as the best target to prevent acute infection and PTLD in at-risk transplant recipients. We have constructed a humanized (hu) version of the murine anti-gp350 neutralizing monoclonal antibody 72a1. The hu72a1 IgG1 antibody displayed no significant anti-mouse activity, recognized both gp350 and its splice variant gp220 as well as a gp350 peptide that was shown to constitute the principal EBV gp350 neutralizing epitope when tested in immunoassays. Hu72a1 antibody blocked in vitro EBV infection of B cells at a level which equaled that of a mouse-human chimeric 72a1 antibody construct. This work provides a further structural and immunological understanding of the 72a1 antibody interaction with EBV gp350, and constitutes a launch point for future anti-EBV therapeutic antibodies designed to block EBV infection and prevent PTLD while eliminating the deleterious antigenic murine features of the original 72a1 antibody.
    Language English
    Publishing date 2018-04-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers10040112
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article: Designing antibodies for oncology.

    Tanner, Jerome E

    Cancer metastasis reviews

    2005  Volume 24, Issue 4, Page(s) 585–598

    Abstract: The past five years have witnessed the emergence of monoclonal antibodies as important therapeutics for cancer treatment. Lower toxicity for antibodies versus small molecules, the potential for increased efficacy by conjugation to radioisotopes and ... ...

    Abstract The past five years have witnessed the emergence of monoclonal antibodies as important therapeutics for cancer treatment. Lower toxicity for antibodies versus small molecules, the potential for increased efficacy by conjugation to radioisotopes and cellular toxins, or the ability to exploit immune cell functions have led to clinical performances on par or superior to conventional drug therapies. This review outlines the various immunoglobulin design strategies currently available, techniques used to reduce Ig antigenicity and toxicity, and points to consider during the manufacture of antibodies for use in clinical oncology.
    MeSH term(s) Animals ; Antibodies, Monoclonal/chemistry ; Antibodies, Monoclonal/immunology ; Antibodies, Monoclonal/pharmacology ; Drug Design ; Humans ; Neoplasms/immunology ; Neoplasms/therapy
    Chemical Substances Antibodies, Monoclonal
    Language English
    Publishing date 2005-12
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 604857-2
    ISSN 1573-7233 ; 0167-7659
    ISSN (online) 1573-7233
    ISSN 0167-7659
    DOI 10.1007/s10555-005-6197-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article: Nucleosomes activate NF-kappaB in endothelial cells for induction of the proangiogenic cytokine IL-8.

    Tanner, Jerome E

    International journal of cancer

    2004  Volume 112, Issue 1, Page(s) 155–160

    Abstract: Solid tumors often exhibit regions undergoing apoptosis and necrosis, also referred to as "aponecrosis", juxtaposed to sites of active angiogenesis. We explored whether nucleosomes resulting from aponecrosis induced the angiogenic factor IL-8 in vascular ...

    Abstract Solid tumors often exhibit regions undergoing apoptosis and necrosis, also referred to as "aponecrosis", juxtaposed to sites of active angiogenesis. We explored whether nucleosomes resulting from aponecrosis induced the angiogenic factor IL-8 in vascular endothelial cells. Results indicate that nucleosomes induced IL-8. Nucleosomes increased IL-6 and IL-8 mRNA but not IL-10, TNF-alpha, VEGF or FGF-2 mRNA. Induction of IL-8 by nucleosomes in endothelial cells appeared to be the result of NF-kappaB/RelA transcription factor activation. The increased expression of IL-8 in vascular endothelial cells following nucleosome stimulation suggests that aponecrosis could play an important role in the promotion of tumor angiogenesis.
    MeSH term(s) Antineoplastic Agents/metabolism ; Cells, Cultured ; Endothelium, Vascular/physiology ; Fibroblast Growth Factor 2/genetics ; Fibroblast Growth Factor 2/metabolism ; Humans ; Interleukin-10/genetics ; Interleukin-10/metabolism ; Interleukin-6/genetics ; Interleukin-6/metabolism ; Interleukin-8/genetics ; Interleukin-8/metabolism ; NF-kappa B/metabolism ; Neovascularization, Physiologic ; Nucleosomes/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Tumor Necrosis Factor-alpha/genetics ; Tumor Necrosis Factor-alpha/metabolism ; Umbilical Veins/metabolism ; Vascular Endothelial Growth Factor A/genetics ; Vascular Endothelial Growth Factor A/metabolism
    Chemical Substances Antineoplastic Agents ; Interleukin-6 ; Interleukin-8 ; NF-kappa B ; Nucleosomes ; RNA, Messenger ; Tumor Necrosis Factor-alpha ; Vascular Endothelial Growth Factor A ; Fibroblast Growth Factor 2 (103107-01-3) ; Interleukin-10 (130068-27-8)
    Language English
    Publishing date 2004-10-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218257-9
    ISSN 1097-0215 ; 0020-7136
    ISSN (online) 1097-0215
    ISSN 0020-7136
    DOI 10.1002/ijc.20390
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article: Whole genome sequence analysis of apparent treatment resistant hypertension status in participants from the Trans-Omics for Precision Medicine program.

    Armstrong, Nicole D / Srinivasasainagendra, Vinodh / Ammous, Farah / Assimes, Themistocles L / Beitelshees, Amber L / Brody, Jennifer / Cade, Brian E / Ida Chen, Yii-Der / Chen, Han / de Vries, Paul S / Floyd, James S / Franceschini, Nora / Guo, Xiuqing / Hellwege, Jacklyn N / House, John S / Hwu, Chii-Min / Kardia, Sharon L R / Lange, Ethan M / Lange, Leslie A /
    McDonough, Caitrin W / Montasser, May E / O'Connell, Jeffrey R / Shuey, Megan M / Sun, Xiao / Tanner, Rikki M / Wang, Zhe / Zhao, Wei / Carson, April P / Edwards, Todd L / Kelly, Tanika N / Kenny, Eimear E / Kooperberg, Charles / Loos, Ruth J F / Morrison, Alanna C / Motsinger-Reif, Alison / Psaty, Bruce M / Rao, Dabeeru C / Redline, Susan / Rich, Stephen S / Rotter, Jerome I / Smith, Jennifer A / Smith, Albert V / Irvin, Marguerite R / Arnett, Donna K

    Frontiers in genetics

    2023  Volume 14, Page(s) 1278215

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2023-12-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2023.1278215
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article ; Online: Transfusion-related Epstein-Barr virus (EBV) infection: A multicenter prospective cohort study among pediatric recipients of hematopoietic stem cell transplants (TREASuRE study).

    Enok Bonong, Pascal R / Buteau, Chantal / Delage, Gilles / Tanner, Jerome E / Lacroix, Jacques / Duval, Michel / Laporte, Louise / Tucci, Marisa / Robitaille, Nancy / Spinella, Philip C / Cuvelier, Geoffrey / Vercauteren, Suzanne / Lewis, Victor / Fearon, Margaret / Drews, Steven J / Alfieri, Carolina / Trottier, Helen

    Transfusion

    2020  Volume 61, Issue 1, Page(s) 144–158

    Abstract: Background: Epstein-Barr virus (EBV) is carried in the blood of most adults, and transfusion-related infections have been reported. EBV is particularly deleterious in immunosuppressed transplant patients. The aim was to determine if EBV transmission ... ...

    Abstract Background: Epstein-Barr virus (EBV) is carried in the blood of most adults, and transfusion-related infections have been reported. EBV is particularly deleterious in immunosuppressed transplant patients. The aim was to determine if EBV transmission occurred through leukodepleted blood product transfusion in pediatric recipients of hematopoietic stem cell transplants (HSCT).
    Study design and methods: This prospective Canadian multi-center cohort study includes 156 allogeneic HSCT pediatric recipients. The association between EBV and transfusion was analyzed using Cox regressions. EBV infection, defined by a PCR+ test in the blood of seronegative recipients of an EBV-negative graft, was monitored in order to correlate the recipient EBV strain with that of the blood donors. EBV genotypes were determined by PCR amplification followed by DNA sequencing at two loci (EBNA3b and LMP1).
    Results: No statistically significant associations were found between transfusions and EBV. One case of post-transplant EBV infection was identified among the 21 EBV-seronegative recipients receiving an EBV-negative graft. A total of 22 blood donors were retraced to determine whether the recipient's EBV strain matched that of a donor. One donor strain showed 100% sequence homology at the EBNA3b locus, but differed by one or two point mutations and by a 132-bp deletion at the LMP1 locus. The blood donor in question was alone among the 22 donors to show amplifiable virus in plasma. Blood from this donor readily produced an immortalized lymphoblastoid cell line in culture.
    Conclusion: While considered a rare event, EBV transmission through transfusion may occur in the context of severe immunosuppression.
    MeSH term(s) Blood Donors/statistics & numerical data ; Blood Transfusion/methods ; Blood Transfusion/statistics & numerical data ; Canada/epidemiology ; Child ; Child, Preschool ; Cohort Studies ; Epstein-Barr Virus Infections/diagnosis ; Epstein-Barr Virus Infections/transmission ; Epstein-Barr Virus Infections/virology ; Epstein-Barr Virus Nuclear Antigens/genetics ; Female ; Genotype ; Hematopoietic Stem Cell Transplantation/adverse effects ; Herpesvirus 4, Human/genetics ; Herpesvirus 4, Human/immunology ; Humans ; Immunosuppression/adverse effects ; Male ; Prospective Studies ; Transfusion Reaction/virology ; Transplant Recipients/statistics & numerical data ; Viral Matrix Proteins/genetics
    Chemical Substances EBNA-3B antigen ; EBV-associated membrane antigen, Epstein-Barr virus ; Epstein-Barr Virus Nuclear Antigens ; Viral Matrix Proteins
    Language English
    Publishing date 2020-10-22
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 208417-x
    ISSN 1537-2995 ; 0041-1132
    ISSN (online) 1537-2995
    ISSN 0041-1132
    DOI 10.1111/trf.16149
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: Adaptively introgressed Neandertal haplotype at the OAS locus functionally impacts innate immune responses in humans.

    Sams, Aaron J / Dumaine, Anne / Nédélec, Yohann / Yotova, Vania / Alfieri, Carolina / Tanner, Jerome E / Messer, Philipp W / Barreiro, Luis B

    Genome biology

    2016  Volume 17, Issue 1, Page(s) 246

    Abstract: Background: The 2'-5' oligoadenylate synthetase (OAS) locus encodes for three OAS enzymes (OAS1-3) involved in innate immune response. This region harbors high amounts of Neandertal ancestry in non-African populations; yet, strong evidence of positive ... ...

    Abstract Background: The 2'-5' oligoadenylate synthetase (OAS) locus encodes for three OAS enzymes (OAS1-3) involved in innate immune response. This region harbors high amounts of Neandertal ancestry in non-African populations; yet, strong evidence of positive selection in the OAS region is still lacking.
    Results: Here we used a broad array of selection tests in concert with neutral coalescent simulations to demonstrate a signal of adaptive introgression at the OAS locus. Furthermore, we characterized the functional consequences of the Neandertal haplotype in the transcriptional regulation of OAS genes at baseline and infected conditions. We found that cells from people with the Neandertal-like haplotype express lower levels of OAS3 upon infection, as well as distinct isoforms of OAS1 and OAS2.
    Conclusions: We present evidence that a Neandertal haplotype at the OAS locus was subjected to positive selection in the human population. This haplotype is significantly associated with functional consequences at the level of transcriptional regulation of innate immune responses. Notably, we suggest that the Neandertal-introgressed haplotype likely reintroduced an ancestral splice variant of OAS1 encoding a more active protein, suggesting that adaptive introgression occurred as a means to resurrect adaptive variation that had been lost outside Africa.
    MeSH term(s) 2',5'-Oligoadenylate Synthetase/genetics ; Animals ; Evolution, Molecular ; Gene Expression Regulation, Enzymologic ; Genome, Human ; Haplotypes/genetics ; Humans ; Immunity, Innate/genetics ; Infections/genetics ; Infections/immunology ; Infections/pathology ; Neanderthals/genetics ; Neanderthals/immunology ; Polymorphism, Single Nucleotide ; Protein Isoforms/genetics ; Protein Isoforms/immunology ; Selection, Genetic/genetics ; Selection, Genetic/immunology
    Chemical Substances Protein Isoforms ; OAS1 protein, human (EC 2.7.7.-) ; OAS2 protein, human (EC 2.7.7.-) ; 2',5'-Oligoadenylate Synthetase (EC 2.7.7.84) ; OAS3 protein, human (EC 2.7.7.84)
    Language English
    Publishing date 2016-11-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2040529-7
    ISSN 1474-760X ; 1474-760X
    ISSN (online) 1474-760X
    ISSN 1474-760X
    DOI 10.1186/s13059-016-1098-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article: Reduction in intracellular HCV RNA and virus protein expression in human hepatoma cells following treatment with 2'-O-methyl-modified anti-core deoxyribozyme.

    Trepanier, Janie B / Tanner, Jerome E / Alfieri, Caroline

    Virology

    2008  Volume 377, Issue 2, Page(s) 339–344

    Abstract: HCV RNA is gaining greater consideration as a principal target for newer HCV antivirals because its destruction has the potential of eliminating the virus. These newer antivirals include deoxyribozymes (Dz), which are small single-stranded DNA molecules ... ...

    Abstract HCV RNA is gaining greater consideration as a principal target for newer HCV antivirals because its destruction has the potential of eliminating the virus. These newer antivirals include deoxyribozymes (Dz), which are small single-stranded DNA molecules that cleave homologous RNA targets. Using a liver cell model containing functional genomic-length HCV-1b RNA we tested whether 2'-O-methyl-modified Dz, designed to recognize a highly-conserved RNA sequence located within the core-E1 coding region, could recognize and cleave its target sequence in the structural context of a functional HCV RNA molecule. Dz858-4-OMe contains four 2'-O-methyl nucleotide derivatives consecutively located on the distal ends of its two annealing arms. Intracellular HCV RNA, core protein and HCV antigen expression were reduced by 63%, 87% and 84%, respectively, when HCV RNA was challenged 6 h post-transfection with Dz858-4-OMe. The observed reduction of intracellular HCV RNA and protein by Dz858-4-OMe suggests that it may constitute an attractive HCV antiviral.
    MeSH term(s) Carcinoma, Hepatocellular/pathology ; Carcinoma, Hepatocellular/virology ; DNA, Catalytic/genetics ; DNA, Catalytic/pharmacology ; Gene Expression Regulation, Viral/drug effects ; Hepacivirus/drug effects ; Hepacivirus/genetics ; Hepacivirus/metabolism ; Humans ; RNA, Viral/drug effects ; RNA, Viral/genetics ; RNA, Viral/metabolism ; Viral Proteins/drug effects ; Viral Proteins/metabolism
    Chemical Substances DNA, Catalytic ; RNA, Viral ; Viral Proteins
    Language English
    Publishing date 2008-08-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 200425-2
    ISSN 1096-0341 ; 0042-6822
    ISSN (online) 1096-0341
    ISSN 0042-6822
    DOI 10.1016/j.virol.2008.04.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top