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  1. Article ; Online: 65/m mit Sepsis auf der Intensivstation : Vorbereitungskurs Anästhesiologische Intensivmedizin: Fall 5.

    Kapp, Anne-Christine / Fischer, Dania

    Die Anaesthesiologie

    2022  Volume 71, Issue Suppl 1, Page(s) 24–28

    Title translation 65/m-Sepsis on the intensive care ward : Preparation course anesthesiological intensive care medicine: case 5.
    MeSH term(s) Critical Care ; Hospitals ; Humans ; Sepsis/diagnosis
    Language German
    Publishing date 2022-06-30
    Publishing country Germany
    Document type Journal Article
    ISSN 2731-6866
    ISSN (online) 2731-6866
    DOI 10.1007/s00101-022-01155-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Das Immunsystem des kritisch Kranken.

    Vogeler, Marie / Schenz, Judith / Müller, Eckhard / Weigand, Markus / Fischer, Dania

    Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS

    2024  Volume 59, Issue 2, Page(s) 96–112

    Abstract: Critically ill patients often experience a dysregulated immune response, leading to immune dysfunction. Sepsis, trauma, severe infections, and certain medical conditions can trigger a state of systemic inflammation, known as the cytokine storm. This ... ...

    Title translation The Immune System of the Critically Ill Patient.
    Abstract Critically ill patients often experience a dysregulated immune response, leading to immune dysfunction. Sepsis, trauma, severe infections, and certain medical conditions can trigger a state of systemic inflammation, known as the cytokine storm. This hyperactive immune response can cause collateral damage to healthy tissues and organs, exacerbating the patient's condition. On the other hand, some critically ill patients may suffer from immune paralysis which can increase the risk of nosocomial infections.Fever is an evolutionary adaptation that evolved as an effective defense mechanism to fight invading pathogens. By raising body temperature, fever enhances the immune response, inhibits pathogen growth, promotes recovery, and aids in the formation of immune memory. Understanding the role of fever in the context of immune defense is crucial for optimizing medical interventions and supporting the body's natural ability to combat infections.Future Directions: Advancements in immunology research and technology hold promise for better understanding the immune system's complexities in critically ill patients. Personalized medicine approaches may be developed to tailor therapies to individual patients based on their immune profile, optimizing treatment outcomes. Based on recent studies prognostic parameters such as lymphocyte count, IL-10 concentration and mHLA-DR expression can be used to stratify the immunological response pattern in septic patients.Conclusion: The immune system's response in critically ill patients is a multifaceted process, involving intricate interactions between various immune cells, cytokines, and organs. Striking the delicate balance between immune activation and suppression remains a significant challenge in clinical practice. Continued research and therapeutic innovations are vital to improve patient outcomes and reduce the burden of critical illness on healthcare systems.
    MeSH term(s) Humans ; Critical Illness ; Immune System ; Sepsis/therapy
    Language German
    Publishing date 2024-02-14
    Publishing country Germany
    Document type English Abstract ; Journal Article
    ZDB-ID 1065682-0
    ISSN 1439-1074 ; 0939-2661
    ISSN (online) 1439-1074
    ISSN 0939-2661
    DOI 10.1055/a-2070-3516
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 257: Show issues Location:
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  3. Article: Das Immunsystem des kritisch Kranken

    Vogeler, Marie / Schenz, Judith / Müller, Eckhard / Weigand, Markus / Fischer, Dania

    AINS - Anästhesiologie · Intensivmedizin · Notfallmedizin · Schmerztherapie

    2024  Volume 59, Issue 02, Page(s) 96–112

    Keywords kritische Erkrankung ; Sepsis ; Immunoseneszenz ; Fieber ; Sekundärinfektionen ; critical illness ; sepsis ; immune senescence ; fever ; immunosuppression
    Language German
    Publishing date 2024-02-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 1065682-0
    ISSN 1439-1074 ; 0939-2661
    ISSN (online) 1439-1074
    ISSN 0939-2661
    DOI 10.1055/a-2070-3516
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 257: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 96: Show issues
    Zs.A 257/X: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Plasma Transfusion Practice in Adult Surgical Patients: Systematic Review of the Literature.

    Adam, Elisabeth Hannah / Fischer, Dania

    Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie

    2020  Volume 47, Issue 5, Page(s) 347–359

    Abstract: Background: Plasma transfusions are most commonly used therapeutically for bleeding or prophylactically in non-bleeding patients prior to invasive procedures or surgery. Although plasma transfusions generally seem to decline, plasma usage for ... ...

    Abstract Background: Plasma transfusions are most commonly used therapeutically for bleeding or prophylactically in non-bleeding patients prior to invasive procedures or surgery. Although plasma transfusions generally seem to decline, plasma usage for indications that lack evidence of efficacy prevail.
    Summary: There is wide international, interinstitutional, and interindividual variance regarding the compliance with guidelines based on published references, supported by appropriate testing. There is furthermore a profound lack of evidence from randomized controlled trials comparing the effect of plasma transfusion with that of other therapeutic interventions for most indications, including massive bleeding. The expected benefit of a plasma transfusion needs to be balanced carefully against the associated risk of adverse events. In light of the heterogeneous nature of bleeding conditions and their rapid evolvement over time, fibrinogen and factor concentrate therapy, directed at specific phases of coagulation identified by alternative laboratory assays, may offer advantages over conventional blood product ratio-driven resuscitation. However, their outcome benefit has not been demonstrated in well-powered prospective trials. This systematic review will detail the current evidence base for plasma transfusion in adult surgical patients.
    Language English
    Publishing date 2020-09-18
    Publishing country Switzerland
    Document type Systematic Review
    ZDB-ID 2100848-6
    ISSN 1660-3818 ; 1660-3796
    ISSN (online) 1660-3818
    ISSN 1660-3796
    DOI 10.1159/000511271
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 959: Show issues Location:
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  5. Article: Interpreting Iron Homeostasis in Congenital and Acquired Disorders.

    Scaramellini, Natalia / Fischer, Dania / Agarvas, Anand R / Motta, Irene / Muckenthaler, Martina U / Mertens, Christina

    Pharmaceuticals (Basel, Switzerland)

    2023  Volume 16, Issue 3

    Abstract: Mammalian cells require iron to satisfy their metabolic needs and to accomplish specialized functions, such as hematopoiesis, mitochondrial biogenesis, energy metabolism, or oxygen transport. Iron homeostasis is balanced by the interplay of proteins ... ...

    Abstract Mammalian cells require iron to satisfy their metabolic needs and to accomplish specialized functions, such as hematopoiesis, mitochondrial biogenesis, energy metabolism, or oxygen transport. Iron homeostasis is balanced by the interplay of proteins responsible for iron import, storage, and export. A misbalance of iron homeostasis may cause either iron deficiencies or iron overload diseases. The clinical work-up of iron dysregulation is highly important, as severe symptoms and pathologies may arise. Treating iron overload or iron deficiency is important to avoid cellular damage and severe symptoms and improve patient outcomes. The impressive progress made in the past years in understanding mechanisms that maintain iron homeostasis has already changed clinical practice for treating iron-related diseases and is expected to improve patient management even further in the future.
    Language English
    Publishing date 2023-02-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph16030329
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Interpreting Iron Homeostasis in Congenital and Acquired Disorders

    Natalia Scaramellini / Dania Fischer / Anand R. Agarvas / Irene Motta / Martina U. Muckenthaler / Christina Mertens

    Pharmaceuticals, Vol 16, Iss 329, p

    2023  Volume 329

    Abstract: Mammalian cells require iron to satisfy their metabolic needs and to accomplish specialized functions, such as hematopoiesis, mitochondrial biogenesis, energy metabolism, or oxygen transport. Iron homeostasis is balanced by the interplay of proteins ... ...

    Abstract Mammalian cells require iron to satisfy their metabolic needs and to accomplish specialized functions, such as hematopoiesis, mitochondrial biogenesis, energy metabolism, or oxygen transport. Iron homeostasis is balanced by the interplay of proteins responsible for iron import, storage, and export. A misbalance of iron homeostasis may cause either iron deficiencies or iron overload diseases. The clinical work-up of iron dysregulation is highly important, as severe symptoms and pathologies may arise. Treating iron overload or iron deficiency is important to avoid cellular damage and severe symptoms and improve patient outcomes. The impressive progress made in the past years in understanding mechanisms that maintain iron homeostasis has already changed clinical practice for treating iron-related diseases and is expected to improve patient management even further in the future.
    Keywords iron ; iron metabolism ; rare disease ; hematology ; anemia ; iron overload ; Medicine ; R ; Pharmacy and materia medica ; RS1-441
    Subject code 570
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Book ; Online ; Thesis: Einfluss erythrozytärer Mikropartikel auf das Wachstum der Kolonkarzinomzelllinie HCT-116

    Thies, Fabian [Verfasser] / Fischer, Dania [Akademischer Betreuer] / Roos, Jessica [Akademischer Betreuer] / Fischer, Dania [Gutachter] / Đikić, Ivan [Gutachter]

    2022  

    Author's details Fabian Thies ; Gutachter: Dania Fischer, Ivan Đikić ; Dania Fischer, Jessica Roos
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek Johann Christian Senckenberg
    Publishing place Frankfurt am Main
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  8. Article: Coagulopathies in Intensive Care Medicine: Balancing Act between Thrombosis and Bleeding.

    Neuenfeldt, Friederike S / Weigand, Markus A / Fischer, Dania

    Journal of clinical medicine

    2021  Volume 10, Issue 22

    Abstract: Patient Blood Management advocates an individualized treatment approach, tailored to each patient's needs, in order to reduce unnecessary exposure to allogeneic blood products. The optimization of hemostasis and minimization of blood loss is of high ... ...

    Abstract Patient Blood Management advocates an individualized treatment approach, tailored to each patient's needs, in order to reduce unnecessary exposure to allogeneic blood products. The optimization of hemostasis and minimization of blood loss is of high importance when it comes to critical care patients, as coagulopathies are a common phenomenon among them and may significantly impact morbidity and mortality. Treating coagulopathies is complex as thrombotic and hemorrhagic conditions may coexist and the medications at hand to modulate hemostasis can be powerful. The cornerstones of coagulation management are an appropriate patient evaluation, including the individual risk of bleeding weighed against the risk of thrombosis, a proper diagnostic work-up of the coagulopathy's etiology, treatment with targeted therapies, and transfusion of blood product components when clinically indicated in a goal-directed manner. In this article, we will outline various reasons for coagulopathy in critical care patients to highlight the aspects that need special consideration. The treatment options outlined in this article include anticoagulation, anticoagulant reversal, clotting factor concentrates, antifibrinolytic agents, desmopressin, fresh frozen plasma, and platelets. This article outlines concepts with the aim of the minimization of complications associated with coagulopathies in critically ill patients. Hereditary coagulopathies will be omitted in this review.
    Language English
    Publishing date 2021-11-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm10225369
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Coagulopathies in Intensive Care Medicine

    Friederike S. Neuenfeldt / Markus A. Weigand / Dania Fischer

    Journal of Clinical Medicine, Vol 10, Iss 5369, p

    Balancing Act between Thrombosis and Bleeding

    2021  Volume 5369

    Abstract: Patient Blood Management advocates an individualized treatment approach, tailored to each patient’s needs, in order to reduce unnecessary exposure to allogeneic blood products. The optimization of hemostasis and minimization of blood loss is of high ... ...

    Abstract Patient Blood Management advocates an individualized treatment approach, tailored to each patient’s needs, in order to reduce unnecessary exposure to allogeneic blood products. The optimization of hemostasis and minimization of blood loss is of high importance when it comes to critical care patients, as coagulopathies are a common phenomenon among them and may significantly impact morbidity and mortality. Treating coagulopathies is complex as thrombotic and hemorrhagic conditions may coexist and the medications at hand to modulate hemostasis can be powerful. The cornerstones of coagulation management are an appropriate patient evaluation, including the individual risk of bleeding weighed against the risk of thrombosis, a proper diagnostic work-up of the coagulopathy’s etiology, treatment with targeted therapies, and transfusion of blood product components when clinically indicated in a goal-directed manner. In this article, we will outline various reasons for coagulopathy in critical care patients to highlight the aspects that need special consideration. The treatment options outlined in this article include anticoagulation, anticoagulant reversal, clotting factor concentrates, antifibrinolytic agents, desmopressin, fresh frozen plasma, and platelets. This article outlines concepts with the aim of the minimization of complications associated with coagulopathies in critically ill patients. Hereditary coagulopathies will be omitted in this review.
    Keywords coagulopathy ; coagulation ; bleeding ; critical care ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2021-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Book ; Online ; Thesis: Charakterisierung des Einflusses der kontinuierlichen Agitation während der Lagerung leukozytendepletierter Pool-Thrombozytenkonzentrate auf die Thrombozytenfunktion - eine in vitro Studie

    Kübel, Sarah [Verfasser] / Fischer, Dania [Gutachter] / Seifried, Erhard [Gutachter]

    2022  

    Author's details Sarah Kübel ; Gutachter: Dania Fischer, Erhard Seifried
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek Johann Christian Senckenberg
    Publishing place Frankfurt am Main
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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