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  1. Article ; Online: Pregnancy and Metabolic-Associated Fatty Liver Disease.

    Mandato, Claudia / Panera, Nadia / Alisi, Anna

    Endocrinology and metabolism clinics of North America

    2023  Volume 52, Issue 3, Page(s) 521–531

    Abstract: Metabolic-associated fatty liver disease (MAFLD), the term proposed to substitute nonalcoholic fatty liver disease, comprises not only liver features but also potentially associated metabolic dysfunctions. Since experimental studies in mice and ... ...

    Abstract Metabolic-associated fatty liver disease (MAFLD), the term proposed to substitute nonalcoholic fatty liver disease, comprises not only liver features but also potentially associated metabolic dysfunctions. Since experimental studies in mice and retrospective clinical studies in humans investigated the association between nonalcoholic fatty liver disease during pregnancy and the adverse clinical outcomes in mothers and offspring, it is plausible that MAFLD may cause similar or worse effects on mother and the offspring. Only a few studies have investigated the possible association of maternal MAFLD with more severe pregnancy-related complications. This article provides an overview of the evidence for this dangerous liaison.
    MeSH term(s) Female ; Pregnancy ; Humans ; Animals ; Mice ; Non-alcoholic Fatty Liver Disease/etiology ; Retrospective Studies ; Family
    Language English
    Publishing date 2023-03-22
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 92116-6
    ISSN 1558-4410 ; 0889-8529
    ISSN (online) 1558-4410
    ISSN 0889-8529
    DOI 10.1016/j.ecl.2023.02.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Is obesity in childhood protective for breast cancer in young women?

    D'Ermo, Giuseppe / Zaffina, Salvatore / Panera, Nadia / Alisi, Anna

    Translational cancer research

    2022  Volume 8, Issue 3, Page(s) 1012–1013

    Language English
    Publishing date 2022-01-15
    Publishing country China
    Document type Journal Article
    ZDB-ID 2901601-0
    ISSN 2219-6803 ; 2218-676X
    ISSN (online) 2219-6803
    ISSN 2218-676X
    DOI 10.21037/tcr.2019.04.11
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  3. Article ; Online: From pregnant women to infants: Non-alcoholic fatty liver disease is a poor inheritance.

    Mosca, Antonella / Panera, Nadia / Maggiore, Giuseppe / Alisi, Anna

    Journal of hepatology

    2020  Volume 73, Issue 6, Page(s) 1590–1592

    MeSH term(s) Female ; Humans ; Infant ; Non-alcoholic Fatty Liver Disease/diagnosis ; Non-alcoholic Fatty Liver Disease/epidemiology ; Non-alcoholic Fatty Liver Disease/genetics ; Obesity ; Pregnancy ; Pregnant Women
    Language English
    Publishing date 2020-09-18
    Publishing country Netherlands
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2020.06.043
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    Zs.A 2027: Show issues Location:
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  4. Article ; Online: Noninvasive diagnostic tools for pediatric NAFLD: where are we now?

    Mosca, Antonella / Panera, Nadia / Crudele, Annalisa / Alisi, Anna

    Expert review of gastroenterology & hepatology

    2020  Volume 14, Issue 11, Page(s) 1035–1046

    Abstract: Introduction: Nonalcoholic fatty liver disease (NAFLD) is a leading cause of liver disease in the pediatric population. It is a significant liver complication of obesity that also prominently affects children. Over the past decade, several noninvasive ... ...

    Abstract Introduction: Nonalcoholic fatty liver disease (NAFLD) is a leading cause of liver disease in the pediatric population. It is a significant liver complication of obesity that also prominently affects children. Over the past decade, several noninvasive methods have been investigated for replacing liver biopsy to identify which children with NAFLD have nonalcoholic steatohepatitis (NASH) and fibrosis. These methods that aim to differentiate the type and extent of liver damage are based on two main different methodologies: a 'biological' approach centered on the quantification of circulating biomarkers; and a 'physical' approach established by analyzing different imaging data.
    Areas covered: In this review, we illustrate the state of the art and recent discoveries on noninvasive methods for the diagnosis of NAFLD, NASH, and advanced fibrosis.
    Expert opinion: Currently, noninvasive tests cannot diagnose NASH or determine the degree of fibrosis. However, several lines of evidence have suggested that if these tests are used in a complementary way with other laboratory tests and imaging they have the potential to be used to monitor progression of disease and response to therapy in pediatric NAFLD. Future scientific research will focus on combining these methods with multiple potential predictors of genetic susceptibility.
    MeSH term(s) Adolescent ; Age of Onset ; Biomarkers/blood ; Biopsy ; Child ; Humans ; Liver Cirrhosis/blood ; Liver Cirrhosis/diagnostic imaging ; Liver Cirrhosis/epidemiology ; Liver Function Tests ; Non-alcoholic Fatty Liver Disease/blood ; Non-alcoholic Fatty Liver Disease/diagnostic imaging ; Non-alcoholic Fatty Liver Disease/epidemiology ; Predictive Value of Tests ; Risk Factors
    Chemical Substances Biomarkers
    Language English
    Publishing date 2020-09-07
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2481021-6
    ISSN 1747-4132 ; 1747-4124
    ISSN (online) 1747-4132
    ISSN 1747-4124
    DOI 10.1080/17474124.2020.1801413
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    Zs.A 6978: Show issues Location:
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  5. Article ; Online: The G-Quadruplex/Helicase World as a Potential Antiviral Approach Against COVID-19.

    Panera, Nadia / Tozzi, Alberto Eugenio / Alisi, Anna

    Drugs

    2020  Volume 80, Issue 10, Page(s) 941–946

    Abstract: G-Quadruplexes (G4s) are non-canonical secondary structures formed within guanine-rich regions of DNA or RNA. G4 sequences/structures have been detected in human and in viral genomes, including Coronaviruses Severe Acute Respiratory Syndrome Coronavirus ( ...

    Abstract G-Quadruplexes (G4s) are non-canonical secondary structures formed within guanine-rich regions of DNA or RNA. G4 sequences/structures have been detected in human and in viral genomes, including Coronaviruses Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and SARS-CoV-2. Here, we outline the existing evidence indicating that G4 ligands and inhibitors of SARS-CoV-2 helicase may exert some antiviral activity reducing viral replication and can represent a potential therapeutic approach to tackle the COVID-19 pandemic due to SARS-CoV-2 infection. We also discuss how repositioning of FDA-approved drugs against helicase activity of other viruses, could represent a rapid strategy to limit deaths associated with COVID-19 pandemic.
    MeSH term(s) Antiviral Agents/therapeutic use ; Betacoronavirus/genetics ; COVID-19 ; Coronavirus Infections/drug therapy ; Coronavirus Papain-Like Proteases ; Drug Repositioning ; G-Quadruplexes ; Genome, Viral/genetics ; Humans ; Methyltransferases/antagonists & inhibitors ; Pandemics ; Pneumonia, Viral/drug therapy ; RNA Helicases/antagonists & inhibitors ; SARS-CoV-2 ; Viral Nonstructural Proteins/antagonists & inhibitors ; Viral Nonstructural Proteins/metabolism
    Chemical Substances Antiviral Agents ; Viral Nonstructural Proteins ; Methyltransferases (EC 2.1.1.-) ; Nsp13 protein, SARS-CoV (EC 2.1.1.-) ; Coronavirus Papain-Like Proteases (EC 3.4.22.2) ; papain-like protease, SARS-CoV-2 (EC 3.4.22.2) ; RNA Helicases (EC 3.6.4.13)
    Keywords covid19
    Language English
    Publishing date 2020-05-25
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 120316-2
    ISSN 1179-1950 ; 0012-6667
    ISSN (online) 1179-1950
    ISSN 0012-6667
    DOI 10.1007/s40265-020-01321-z
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    Zs.A 762: Show issues Location:
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  6. Article: Genetics, epigenetics and transgenerational transmission of obesity in children.

    Panera, Nadia / Mandato, Claudia / Crudele, Annalisa / Bertrando, Sara / Vajro, Pietro / Alisi, Anna

    Frontiers in endocrinology

    2022  Volume 13, Page(s) 1006008

    Abstract: Sedentary lifestyle and consumption of high-calorie foods have caused a relentless increase of overweight and obesity prevalence at all ages. Its presently epidemic proportion is disquieting due to the tight relationship of obesity with metabolic ... ...

    Abstract Sedentary lifestyle and consumption of high-calorie foods have caused a relentless increase of overweight and obesity prevalence at all ages. Its presently epidemic proportion is disquieting due to the tight relationship of obesity with metabolic syndrome and several other comorbidities which do call for urgent workarounds. The usual ineffectiveness of present therapies and failure of prevention campaigns triggered overtime a number of research studies which have unveiled some relevant aspects of obesity genetic and epigenetic inheritable profiles. These findings are revealing extremely precious mainly to serve as a likely extra arrow to allow the clinician's bow to achieve still hitherto unmet preventive goals. Evidence now exists that maternal obesity/overnutrition during pregnancy and lactation convincingly appears associated with several disorders in the offspring independently of the transmission of a purely genetic predisposition. Even the pre-conception direct exposure of either father or mother gametes to environmental factors can reprogram the epigenetic architecture of cells. Such phenomena lie behind the transfer of the obesity susceptibility to future generations through a mechanism of epigenetic inheritance. Moreover, a growing number of studies suggests that several environmental factors such as maternal malnutrition, hypoxia, and exposure to excess hormones and endocrine disruptors during pregnancy and the early postnatal period may play critical roles in programming childhood adipose tissue and obesity. A deeper understanding of how inherited genetics and epigenetics may generate an obesogenic environment at pediatric age might strengthen our knowledge about pathogenetic mechanisms and improve the clinical management of patients. Therefore, in this narrative review, we attempt to provide a general overview of the contribution of heritable genetic and epigenetic patterns to the obesity susceptibility in children, placing a particular emphasis on the mother-child dyad.
    MeSH term(s) Pregnancy ; Humans ; Female ; Child ; Pediatric Obesity/epidemiology ; Pediatric Obesity/genetics ; Epigenomics ; Epigenesis, Genetic ; Overweight ; Metabolic Syndrome
    Language English
    Publishing date 2022-11-14
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2022.1006008
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  7. Article: The Role of the GH/IGF1 Axis on the Development of MAFLD in Pediatric Patients with Obesity.

    Mosca, Antonella / Della Volpe, Luca / Alisi, Anna / Panera, Nadia / Maggiore, Giuseppe / Vania, Andrea

    Metabolites

    2022  Volume 12, Issue 12

    Abstract: The anomalies of the Growth Hormone (GH)/Insulin-like Growth Factor-1 (IGF1) axis are associated with a higher prevalence of Metabolic Associated Fatty Liver Disease (MAFLD) and with a more rapid progression towards fibrosis, cirrhosis, and end-stage ... ...

    Abstract The anomalies of the Growth Hormone (GH)/Insulin-like Growth Factor-1 (IGF1) axis are associated with a higher prevalence of Metabolic Associated Fatty Liver Disease (MAFLD) and with a more rapid progression towards fibrosis, cirrhosis, and end-stage liver disease. A total of 191 adolescents with obesity [12−18 years] were consecutively enrolled between January 2014 and December 2020 and underwent liver biopsy to diagnose MAFLD severity. In all patients GH, IGF1 and Insulin-like Growth Factor-Binding Protein 3 (IGFBP3) were measured. Patients with inflammation and ballooning have significantly lower values of GH and IGF1 than those without (GH: 5.4 vs. 7.5 ng/mL; IGF1 245 vs. 284 ng/mL, p < 0.05). GH and IGF1 were also negatively correlated with fibrosis’ degree (r = −0.51, p = 0.001, and r = −0.45, p = 0.001, respectively). Only GH correlated with TNF-a (r = −0.29, p = 0.04) and lobular inflammation (r = −0.36, p = 0.02). At multivariate regression, both GH and IGF1 values, after adjustment for age, sex and BMI, were negatively associated with HOMA-IR but above all with fibrosis (GH→β = −2.3, p = 0.001, IGF1→β = −2.8, p = 0.001). Even in the pediatric population, a reduction of GH input in the liver directly promotes development of de novo hepatic lipogenesis, steatosis, fibrosis and inflammation. The possible role of recombinant GH administration in adolescents with obesity and severe MAFLD deserves to be studied.
    Language English
    Publishing date 2022-12-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662251-8
    ISSN 2218-1989
    ISSN 2218-1989
    DOI 10.3390/metabo12121221
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  8. Article ; Online: The G-Quadruplex/Helicase World as a Potential Antiviral Approach Against COVID-19

    Panera, Nadia / Tozzi, Alberto Eugenio / Alisi, Anna

    Drugs

    2020  Volume 80, Issue 10, Page(s) 941–946

    Keywords Pharmacology (medical) ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 120316-2
    ISSN 1179-1950 ; 0012-6667
    ISSN (online) 1179-1950
    ISSN 0012-6667
    DOI 10.1007/s40265-020-01321-z
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  9. Article ; Online: Letter to the Editor: Focal Adhesion Kinase/β-Catenin Network May Act as a Regulator of Hepatocellular Carcinoma Epigenetics.

    Romito, Ilaria / Panera, Nadia / D'Ermo, Giuseppe / Alisi, Anna

    Hepatology (Baltimore, Md.)

    2019  Volume 70, Issue 4, Page(s) 1494–1495

    MeSH term(s) Carcinoma, Hepatocellular/genetics ; Epigenesis, Genetic ; Focal Adhesion Protein-Tyrosine Kinases ; Humans ; Liver Neoplasms/genetics ; beta Catenin
    Chemical Substances beta Catenin ; Focal Adhesion Protein-Tyrosine Kinases (EC 2.7.10.2)
    Language English
    Publishing date 2019-08-19
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1002/hep.30849
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  10. Article: The G-Quadruplex/Helicase World as a Potential Antiviral Approach Against COVID-19

    Panera, Nadia / Tozzi, Alberto Eugenio / Alisi, Anna

    Drugs

    Abstract: G-Quadruplexes (G4s) are non-canonical secondary structures formed within guanine-rich regions of DNA or RNA. G4 sequences/structures have been detected in human and in viral genomes, including Coronaviruses Severe Acute Respiratory Syndrome Coronavirus ( ...

    Abstract G-Quadruplexes (G4s) are non-canonical secondary structures formed within guanine-rich regions of DNA or RNA. G4 sequences/structures have been detected in human and in viral genomes, including Coronaviruses Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and SARS-CoV-2. Here, we outline the existing evidence indicating that G4 ligands and inhibitors of SARS-CoV-2 helicase may exert some antiviral activity reducing viral replication and can represent a potential therapeutic approach to tackle the COVID-19 pandemic due to SARS-CoV-2 infection. We also discuss how repositioning of FDA-approved drugs against helicase activity of other viruses, could represent a rapid strategy to limit deaths associated with COVID-19 pandemic.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #361231
    Database COVID19

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