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Article ; Online: Leprosy: why does it persist among us?

Santos, Victor S / de Souza, Carlos D F / Martins-Filho, Paulo R S / Cuevas, Luis E

2020 Volume 18, Issue 7, Page(s) 613–615

MeSH term(s)	Global Health ; Humans ; Leprosy/epidemiology ; Leprosy/transmission ; Mycobacterium leprae/isolation & purification ; Public Health
Language	English
Publishing date	2020-04-17
Publishing country	England
Document type	Editorial
ZDB-ID	2181279-2
ISSN	1744-8336 ; 1478-7210
ISSN (online)	1744-8336
ISSN	1478-7210
DOI	10.1080/14787210.2020.1752194
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Article: Optical and Electrochemical Properties of a Nanostructured ZnO Thin Layer Deposited on a Nanoporous Alumina Structure via Atomic Layer Deposition.

Cuevas, Ana L / Dominguez, Antonia / Zamudio-García, Javier / Vega, Victor / González, Ana Silvia / Marrero-López, David / Prida, Victor M / Benavente, Juana

Materials (Basel, Switzerland)

2024 Volume 17, Issue 6

Abstract: This study explores the optical and electrochemical properties of a ZnO coating layer deposited on a nanoporous alumina structure (NPAS) for potential multifunctional applications. The NPAS, synthesized through an electrochemical anodization process, ... ...

Abstract	This study explores the optical and electrochemical properties of a ZnO coating layer deposited on a nanoporous alumina structure (NPAS) for potential multifunctional applications. The NPAS, synthesized through an electrochemical anodization process, displays well-defined nanochannels with a high aspect ratio (~3000). The ZnO coating, achieved via atomic layer deposition, enables the tuning of the pore diameter and porosity of the NPAS, thereby influencing both the optical and electrochemical interfacial properties. A comprehensive characterization using photoluminescence, spectroscopy ellipsometry and impedance spectroscopy (with the sample in contact with NaCl solutions) provides insights into optical and electrochemical parameters, including the refractive index, absorption coefficient, and electrolyte-ZnO/NPAS interface processes. This research demonstrates potential for tailoring the optical and interfacial properties of nanoporous structures by selecting appropriate coating materials, thus opening avenues for their utilization in various technological applications.
Language	English
Publishing date	2024-03-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma17061412
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Article: Synthesis of Pyrodextrins and Enzymatically Resistant Maltodextrins from Makal (

Barbosa-Martín, Enrique / Sauri-Duch, Enrique / Chel-Guerrero, Luis / Cuevas-Glory, Luis / Moo-Huchin, Víctor / Betancur-Ancona, David

Food technology and biotechnology

2024 Volume 62, Issue 1, Page(s) 26–34

Abstract: Research background: Enzymatically resistant maltodextrins (ERM) are a resistant starch type 4, synthesized from native starch. They are obtained by the sequential application of two processes: pyrodextrinization, which produces pyrodextrins, and ... ...

Abstract	Research background: Enzymatically resistant maltodextrins (ERM) are a resistant starch type 4, synthesized from native starch. They are obtained by the sequential application of two processes: pyrodextrinization, which produces pyrodextrins, and enzymatic hydrolysis, which produces ERM. In these processes atypical bonds are formed that confer pyrodextrins and ERM similar properties to dietary fiber, such as resistance to digestion. The aim of this work is to determine and evaluate some physicochemical properties of pyrodextrins and ERM obtained from native starch isolated from makal ( Experimental approach: Pyrodextrinization and complementary hydrolysis were conducted using factorial designs. For pyrodextrinization, factors and their levels were ( Results and conclusions: According to the factorial design, the best treatment conditions for pyrodextrinization were: ( Novelty and scientific contribution: The results show that the pyrodextrins and ERM obtained from makal can be used as ingredients for the development of functional foods, due to their high content of indigestible material and low degree of browning.
Language	English
Publishing date	2024-04-09
Publishing country	Croatia
Document type	Journal Article
ZDB-ID	1340467-2
ISSN	1330-9862
ISSN	1330-9862
DOI	10.17113/ftb.62.01.24.8163
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Article ; Online: Microbiota Metabolites in Health and Disease.

McCarville, Justin L / Chen, Grischa Y / Cuevas, Víctor D / Troha, Katia / Ayres, Janelle S

Annual review of immunology

2020 Volume 38, Page(s) 147–170

Abstract: Metabolism is one of the strongest drivers of interkingdom interactions-including those between microorganisms and their multicellular hosts. Traditionally thought to fuel energy requirements and provide building blocks for biosynthetic pathways, ... ...

Abstract	Metabolism is one of the strongest drivers of interkingdom interactions-including those between microorganisms and their multicellular hosts. Traditionally thought to fuel energy requirements and provide building blocks for biosynthetic pathways, metabolism is now appreciated for its role in providing metabolites, small-molecule intermediates generated from metabolic processes, to perform various regulatory functions to mediate symbiotic relationships between microbes and their hosts. Here, we review recent advances in our mechanistic understanding of how microbiota-derived metabolites orchestrate and support physiological responses in the host, including immunity, inflammation, defense against infections, and metabolism. Understanding how microbes metabolically communicate with their hosts will provide us an opportunity to better describe how a host interacts with all microbes-beneficial, pathogenic, and commensal-and an opportunity to discover new ways to treat microbial-driven diseases.
MeSH term(s)	Animals ; Disease Susceptibility/immunology ; Energy Metabolism ; Homeostasis ; Host-Pathogen Interactions ; Humans ; Immune System/immunology ; Immune System/metabolism ; Microbiota/immunology ; Symbiosis
Language	English
Publishing date	2020-05-18
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	604953-9
ISSN	1545-3278 ; 0732-0582
ISSN (online)	1545-3278
ISSN	0732-0582
DOI	10.1146/annurev-immunol-071219-125715
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Article ; Online: Pituitary Infiltration by Lymphoma.

Tovar-Méndez, Víctor Hugo / Cuenca, Dalia / Gómez-Pérez, Francisco J / Cuevas-Ramos, Daniel

Journal of the Endocrine Society

2022 Volume 6, Issue 12, Page(s) bvac161

Abstract: Lymphoma infiltration to the pituitary is rare. It represents less than 0.5% of all reported pituitary metastases (PMs). Here we present a case series of 3 patients with PMs from a systemic lymphoma. Also, we performed a literature review of the cases ... ...

Abstract	Lymphoma infiltration to the pituitary is rare. It represents less than 0.5% of all reported pituitary metastases (PMs). Here we present a case series of 3 patients with PMs from a systemic lymphoma. Also, we performed a literature review of the cases reported. We identified additional 31 cases in which non-Hodgkin lymphoma (NHL) was the most common (n = 28, 90%), with large B-cell NHL the most frequent histological subtype (n = 14, 45%). Central hypothyroidism (n = 21, 67%) was the most frequent pituitary deficiency followed by adrenal insufficiency (n = 19, 61%) and diabetes insipidus (DI; n = 18, 58%). Full endocrine recovery was found in only 12% (n = 4) of patients after treatment, and magnetic resonance imaging showed tumor regression in 22% of them. In our series, 2 patients were diagnosed with diffuse large B-cell lymphoma, and 1 had mixed cellularity of classic Hodgkin lymphoma. The mean age was 54 ± 6.92 years. Hypopituitarism and DI were present in all of them, with 100% of mortality because of advanced systemic disease.
Language	English
Publishing date	2022-10-27
Publishing country	United States
Document type	Case Reports
ISSN	2472-1972
ISSN (online)	2472-1972
DOI	10.1210/jendso/bvac161
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Article ; Online: Low-Power Lossless Data Compression for Wireless Brain Electrophysiology.

Cuevas-López, Aarón / Pérez-Montoyo, Elena / López-Madrona, Víctor J / Canals, Santiago / Moratal, David

Sensors (Basel, Switzerland)

2022 Volume 22, Issue 10

Abstract: Wireless electrophysiology opens important possibilities for neuroscience, especially for recording brain activity in more natural contexts, where exploration and interaction are not restricted by the usual tethered devices. The limiting factor is ... ...

Abstract	Wireless electrophysiology opens important possibilities for neuroscience, especially for recording brain activity in more natural contexts, where exploration and interaction are not restricted by the usual tethered devices. The limiting factor is transmission power and, by extension, battery life required for acquiring large amounts of neural electrophysiological data. We present a digital compression algorithm capable of reducing electrophysiological data to less than 65.5% of its original size without distorting the signals, which we tested in vivo in experimental animals. The algorithm is based on a combination of delta compression and Huffman codes with optimizations for neural signals, which allow it to run in small, low-power Field-Programmable Gate Arrays (FPGAs), requiring few hardware resources. With this algorithm, a hardware prototype was created for wireless data transmission using commercially available devices. The power required by the algorithm itself was less than 3 mW, negligible compared to the power saved by reducing the transmission bandwidth requirements. The compression algorithm and its implementation were designed to be device-agnostic. These developments can be used to create a variety of wired and wireless neural electrophysiology acquisition systems with low power and space requirements without the need for complex or expensive specialized hardware.
MeSH term(s)	Algorithms ; Animals ; Brain ; Data Compression ; Electrophysiological Phenomena ; Electrophysiology
Language	English
Publishing date	2022-05-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s22103676
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Article ; Online: High Rates of Extensively Drug-Resistant Pseudomonas aeruginosa in Children with Cystic Fibrosis.

Gutiérrez-Santana, Juan C / Gerónimo-Gallegos, Armando / Martínez-Corona, Mónica B / López-López, Marisol / Toscano-Garibay, Julia D / Cuevas-Schacht, Francisco / Coria-Jiménez, Victor R

Current microbiology

2022 Volume 79, Issue 11, Page(s) 353

Abstract: Pseudomonas aeruginosa has a high adaptive capacity, favoring the selection of antibiotic-resistant strains, which are currently considered a global health problem. The purpose of this work was to investigate the rate and distribution of extensively drug- ...

Abstract	Pseudomonas aeruginosa has a high adaptive capacity, favoring the selection of antibiotic-resistant strains, which are currently considered a global health problem. The purpose of this work was to investigate the rate and distribution of extensively drug-resistant (XDR) P. aeruginosa in pediatric patients with cystic fibrosis (CF) with recurrent infections and to distinguish the current efficacy of antibiotics commonly used in eradication therapy at a Mexican institute focused on children. A total of 118 P. aeruginosa isolates from 25 children with CF (2015-2019) underwent molecular identification, antimicrobial sensitivity tests, and Random Amplified Polymorphic DNA genotyping (RAPD-PCR). The bacterial isolates were grouped in 84 RAPD profiles, revealing a cross-infection between two sisters, whose resistance profile remained unchanged for more than 2 years. Furthermore, 77.1% (91/118) and 51.7% (61/118) of isolates showed in vitro susceptibility to ceftazidime and amikacin, respectively, antibiotics often used in eradication therapy at our institution. As well, 42.4% (50/118) were categorized as multi-drug resistant (MDR) and 12.7% (15/118) were XDR. Of these resistant isolates, 84.6% (55/65) were identified from patients with recurrent infections. The high frequency of XDR strains in children with CF should be considered a caution mark, as such resistance patterns are more commonly found in adult patients. Additionally, amikacin may soon prove ineffective. Careful use of available antibiotics is crucial before therapeutic possibilities are reduced and "antibiotic resistance crisis" worsens.
MeSH term(s)	Adult ; Amikacin/pharmacology ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Ceftazidime/pharmacology ; Ceftazidime/therapeutic use ; Child ; Cystic Fibrosis/complications ; Cystic Fibrosis/microbiology ; Humans ; Microbial Sensitivity Tests ; Pseudomonas Infections/drug therapy ; Pseudomonas Infections/microbiology ; Pseudomonas aeruginosa ; Random Amplified Polymorphic DNA Technique ; Reinfection
Chemical Substances	Anti-Bacterial Agents ; Amikacin (84319SGC3C) ; Ceftazidime (9M416Z9QNR)
Language	English
Publishing date	2022-10-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	134238-1
ISSN	1432-0991 ; 0343-8651
ISSN (online)	1432-0991
ISSN	0343-8651
DOI	10.1007/s00284-022-03048-4
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Article ; Online: High Rates of Extensively Drug-Resistant Pseudomonas aeruginosa in Children with Cystic Fibrosis

Gutiérrez-Santana, Juan C. / Gerónimo-Gallegos, Armando / Martínez-Corona, Mónica B. / López López, Marisol / Toscano-Garibay, Julia D. / Cuevas-Schacht, Francisco / Coria-Jiménez, Victor R.

Curr Microbiol. 2022 Nov., v. 79, no. 11 p.353-353

2022

Abstract	Pseudomonas aeruginosa has a high adaptive capacity, favoring the selection of antibiotic-resistant strains, which are currently considered a global health problem. The purpose of this work was to investigate the rate and distribution of extensively drug-resistant (XDR) P. aeruginosa in pediatric patients with cystic fibrosis (CF) with recurrent infections and to distinguish the current efficacy of antibiotics commonly used in eradication therapy at a Mexican institute focused on children. A total of 118 P. aeruginosa isolates from 25 children with CF (2015–2019) underwent molecular identification, antimicrobial sensitivity tests, and Random Amplified Polymorphic DNA genotyping (RAPD-PCR). The bacterial isolates were grouped in 84 RAPD profiles, revealing a cross-infection between two sisters, whose resistance profile remained unchanged for more than 2 years. Furthermore, 77.1% (91/118) and 51.7% (61/118) of isolates showed in vitro susceptibility to ceftazidime and amikacin, respectively, antibiotics often used in eradication therapy at our institution. As well, 42.4% (50/118) were categorized as multi-drug resistant (MDR) and 12.7% (15/118) were XDR. Of these resistant isolates, 84.6% (55/65) were identified from patients with recurrent infections. The high frequency of XDR strains in children with CF should be considered a caution mark, as such resistance patterns are more commonly found in adult patients. Additionally, amikacin may soon prove ineffective. Careful use of available antibiotics is crucial before therapeutic possibilities are reduced and “antibiotic resistance crisis” worsens.
Keywords	Pseudomonas aeruginosa ; adults ; amikacin ; antibiotic resistance ; ceftazidime ; cross infection ; cystic fibrosis ; genotyping ; multiple drug resistance ; random amplified polymorphic DNA technique ; therapeutics
Language	English
Dates of publication	2022-11
Size	p. 353.
Publishing place	Springer US
Document type	Article ; Online
ZDB-ID	134238-1
ISSN	1432-0991 ; 0343-8651
ISSN (online)	1432-0991
ISSN	0343-8651
DOI	10.1007/s00284-022-03048-4
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Article ; Online: Correction: Palmitate Conditions Macrophages for Enhanced Responses toward Inflammatory Stimuli via JNK Activation.

Riera-Borrull, Marta / Cuevas, Víctor D / Alonso, Bárbara / Vega, Miguel A / Joven, Jorge / Izquierdo, Elena / Corbí, Ángel L

Journal of immunology (Baltimore, Md. : 1950)

2019 Volume 203, Issue 2, Page(s) 580

Language	English
Publishing date	2019-06-07
Publishing country	United States
Document type	Journal Article ; Published Erratum
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
DOI	10.4049/jimmunol.1900602
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Article ; Online: Spatiotemporal clustering, social vulnerability and risk of congenital syphilis in northeast Brazil: an ecological study.

de Souza, Carlos D F / Machado, Michael F / Correia, Divanise S / do Carmo, Rodrigo F / Cuevas, Luis E / Santos, Victor S

Transactions of the Royal Society of Tropical Medicine and Hygiene

2020 Volume 114, Issue 9, Page(s) 657–665

Abstract: Background: To investigate the spatial distribution of congenital syphilis (CS) and its association to social vulnerability indexes in northeast Brazil.: Methods: This was an ecological study referring to all cases of CS and CS deaths recorded in the ...

Abstract	Background: To investigate the spatial distribution of congenital syphilis (CS) and its association to social vulnerability indexes in northeast Brazil. Methods: This was an ecological study referring to all cases of CS and CS deaths recorded in the northeast region of Brazil from 2008 to 2015. Data were obtained from three Brazilian information systems. We examined statistical correlations between CS indicators by state and municipality and their socioeconomic and social vulnerability characteristics. We used Bayesian empirical local models to identify fluctuations of the indicators. Spatial statistical tests were used to identify spatial clusters and the municipalities at high risk of CS. Results: The incidence of CS ranged from 2.1 cases/1000 live births (LB) in 2008 to 6.9/1000 LB in 2015, with an annual increase of 19.9% (p < 0.001). The mortality coefficient of CS ranged from 2.9/1000 LB in 2008 to 6.5/1000 LB in 2015, resulting in an annual increase of 15.1% (p < 0.001). Nine spatial clusters were identified. Cases of congenital syphilis occurred in well-defined spatiotemporal clusters and in areas with high levels of social vulnerability. Conclusions: CS incidence is associated with social vulnerability. CS control programmes should target spatial clusters and populations with high levels of social vulnerability.
MeSH term(s)	Bayes Theorem ; Brazil/epidemiology ; Cities ; Cluster Analysis ; Humans ; Incidence ; Syphilis, Congenital/epidemiology
Language	English
Publishing date	2020-06-15
Publishing country	England
Document type	Journal Article
ZDB-ID	441375-1
ISSN	1878-3503 ; 0035-9203
ISSN (online)	1878-3503
ISSN	0035-9203
DOI	10.1093/trstmh/traa034
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