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  1. Article: Targeting the Cerebrospinal Fluid Compartment in Glaucoma: Still the Dark Side of the Moon? Comment on Passaro et al. Glaucoma as a Tauopathy-Is It the Missing Piece in the Glaucoma Puzzle?

    Wostyn, Peter

    Journal of clinical medicine

    2024  Volume 13, Issue 3

    Abstract: I read with great interest the article by Passaro et al [ ... ]. ...

    Abstract I read with great interest the article by Passaro et al [...].
    Language English
    Publishing date 2024-01-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13030827
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Could Young Cerebrospinal Fluid Combat Glaucoma? Comment on Lee et al. Association between Optic Nerve Sheath Diameter and Lamina Cribrosa Morphology in Normal-Tension Glaucoma.

    Wostyn, Peter

    Journal of clinical medicine

    2023  Volume 12, Issue 9

    Abstract: I enjoyed reading the article by Lee et al. [ ... ]. ...

    Abstract I enjoyed reading the article by Lee et al. [...].
    Language English
    Publishing date 2023-05-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12093285
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Could Young Cerebrospinal Fluid Combat Glaucoma? Comment on Lee et al. Association between Optic Nerve Sheath Diameter and Lamina Cribrosa Morphology in Normal-Tension Glaucoma. J. Clin. Med. 2023, 12, 360

    Peter Wostyn

    Journal of Clinical Medicine, Vol 12, Iss 3285, p

    2023  Volume 3285

    Abstract: I enjoyed reading the article by Lee et al. [.] ...

    Abstract I enjoyed reading the article by Lee et al. [.]
    Keywords n/a ; Medicine ; R
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Anosmia as a predictor for post-COVID-19 fatigue syndrome.

    Wostyn, Peter

    The Lancet regional health. Europe

    2021  Volume 7, Page(s) 100162

    Language English
    Publishing date 2021-07-06
    Publishing country England
    Document type Journal Article
    ISSN 2666-7762
    ISSN (online) 2666-7762
    DOI 10.1016/j.lanepe.2021.100162
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Are Generalized Reduced Cerebrospinal Fluid Dynamics and Optic Nerve Sheath Compartmentation Sequential Steps in the Pathogenesis of Normal-Tension Glaucoma? [Letter].

    Wostyn, Peter

    Eye and brain

    2021  Volume 13, Page(s) 129–130

    Language English
    Publishing date 2021-05-11
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2587460-3
    ISSN 1179-2744
    ISSN 1179-2744
    DOI 10.2147/EB.S317786
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: COVID-19 and chronic fatigue syndrome: Is the worst yet to come?

    Wostyn, Peter

    Medical hypotheses

    2021  Volume 146, Page(s) 110469

    Abstract: There has been concern about possible long-term sequelae resembling myalgic encephalomyelitis/chronic fatigue syndrome in COVID-19 patients. Clarifying the mechanisms underlying such a "post-COVID-19 fatigue syndrome" is essential for the development of ... ...

    Abstract There has been concern about possible long-term sequelae resembling myalgic encephalomyelitis/chronic fatigue syndrome in COVID-19 patients. Clarifying the mechanisms underlying such a "post-COVID-19 fatigue syndrome" is essential for the development of preventive and early treatment methods for this syndrome. In the present paper, by integrating insights pertaining to the glymphatic system and the nasal cerebrospinal fluid outflow pathway with findings in patients with chronic fatigue syndrome, idiopathic intracranial hypertension, and COVID-19, I provide a coherent conceptual framework for understanding the pathophysiology of post-COVID-19 fatigue syndrome. According to this hypothesis, this syndrome may result from damage to olfactory sensory neurons, causing reduced outflow of cerebrospinal fluid through the cribriform plate, and further leading to congestion of the glymphatic system with subsequent toxic build-up within the central nervous system. I further postulate that patients with post-COVID-19 fatigue syndrome may benefit from cerebrospinal fluid drainage by restoring glymphatic transport and waste removal from the brain. Obviously, further research is required to provide further evidence for the presence of this post-viral syndrome, and to provide additional insight regarding the relative contribution of the glymphatic-lymphatic system to it. Other mechanisms may also be involved. If confirmed, the glymphatic-lymphatic system could represent a target in combating post-COVID-19 fatigue syndrome. Moreover, further research in this area could also provide new insights into the understanding of chronic fatigue syndrome.
    MeSH term(s) Brain/physiopathology ; COVID-19/cerebrospinal fluid ; COVID-19/etiology ; COVID-19/physiopathology ; Central Nervous System/physiopathology ; Ethmoid Bone/physiopathology ; Fatigue Syndrome, Chronic/cerebrospinal fluid ; Fatigue Syndrome, Chronic/etiology ; Fatigue Syndrome, Chronic/physiopathology ; Glymphatic System/physiopathology ; Humans ; Models, Neurological ; Olfactory Receptor Neurons/physiology ; Pandemics ; Pseudotumor Cerebri/cerebrospinal fluid ; Pseudotumor Cerebri/etiology ; Pseudotumor Cerebri/physiopathology ; SARS-CoV-2/pathogenicity ; Time Factors
    Language English
    Publishing date 2021-01-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2020.110469
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  7. Article ; Online: Do normal-tension and high-tension glaucoma result from brain and ocular glymphatic system disturbances, respectively?

    Wostyn, Peter

    Eye (London, England)

    2020  Volume 35, Issue 10, Page(s) 2905–2906

    MeSH term(s) Brain ; Eye ; Glaucoma ; Glymphatic System ; Humans
    Language English
    Publishing date 2020-10-12
    Publishing country England
    Document type Letter
    ZDB-ID 91001-6
    ISSN 1476-5454 ; 0950-222X
    ISSN (online) 1476-5454
    ISSN 0950-222X
    DOI 10.1038/s41433-020-01219-w
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  8. Article ; Online: The "ocular glymphatic clearance system": a key missing piece of the Alzheimer's disease-glaucoma puzzle found?

    Wostyn, Peter

    Eye (London, England)

    2020  Volume 35, Issue 4, Page(s) 1281

    MeSH term(s) Alzheimer Disease ; Brain ; Eye ; Glaucoma ; Glymphatic System ; Humans
    Language English
    Publishing date 2020-06-09
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 91001-6
    ISSN 1476-5454 ; 0950-222X
    ISSN (online) 1476-5454
    ISSN 0950-222X
    DOI 10.1038/s41433-020-1008-8
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  9. Article ; Online: Re: Stenger et al.: Focus on the optic nerve head in spaceflight-associated neuro-ocular syndrome (Ophthalmology. 2019;126:1604-1606).

    Wostyn, Peter

    Ophthalmology

    2020  Volume 127, Issue 6, Page(s) e40–e41

    MeSH term(s) Humans ; Optic Disk ; Space Flight ; Syndrome ; Vision, Ocular
    Language English
    Publishing date 2020-05-22
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 392083-5
    ISSN 1549-4713 ; 0161-6420
    ISSN (online) 1549-4713
    ISSN 0161-6420
    DOI 10.1016/j.ophtha.2020.01.043
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Could immersive sound improve glymphatic function in the awake brain?

    Wostyn, Peter / Goddaer, Piet

    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

    2023  Volume 20, Issue 1, Page(s) 181

    MeSH term(s) Humans ; Wakefulness ; Brain ; Sleep
    Language English
    Publishing date 2023-10-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2397213-0
    ISSN 1550-9397 ; 1550-9389
    ISSN (online) 1550-9397
    ISSN 1550-9389
    DOI 10.5664/jcsm.10846
    Database MEDical Literature Analysis and Retrieval System OnLINE

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