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Article: State Variability in Diagnosed Conditions for IDEA Part C Eligibility.

Barger, Brian / Squires, Jane / Greer, Maureen / Noyes-Grosser, Donna / Eile, Julia Martin / Rice, Catherine / Shaw, Evelyn / Surprenant, Kala Shah / Twombly, Elizabeth / London, Sarah / Zubler, Jennifer / Wolf, Rebecca B

Infants and young children

2020 Volume 32, Issue 4, Page(s) 231–244

Abstract: An infant or toddler can begin the process of receiving Part C early intervention services ... the initiation process varies widely. Lists of diagnosed conditions were collected from state Part C websites and ... Part C coordinators for a descriptive analysis. Across 49 states, the District of Columbia, and 4 ...

Abstract	An infant or toddler can begin the process of receiving Part C early intervention services by having a diagnosed condition with a high probability of developmental delay (Individuals with Disabilities Education Improvement Act, 2004). How states define those diagnosed conditions that begin the initiation process varies widely. Lists of diagnosed conditions were collected from state Part C websites and Part C coordinators for a descriptive analysis. Across 49 states, the District of Columbia, and 4 territories, a final list of 620 unique conditions was compiled. No single condition was listed by all jurisdictions. Hearing impairment was the condition listed by the most states (
Language	English
Publishing date	2020-04-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2093160-8
ISSN	0896-3746 ; 0896-3746
ISSN (online)	0896-3746
ISSN	0896-3746
DOI	10.1097/iyc.0000000000000151
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Article ; Online: The acceptability and effectiveness of a questionnaire for the identification of risk factors for HIV and hepatitis B and C: An observational study in general practice.

Aïm-Eusébi, Amélie / Prothon, Emmanuel / Majerholc, Catherine / Barger, Diana / Yazdanpanah, Yazdan / Aubert, Jean-Pierre

The European journal of general practice

2018 Volume 24, Issue 1, Page(s) 60–67

Abstract: ... hepatitis B virus (HBV), hepatitis C virus (HCV).: Objectives: To evaluate acceptability and ...

Abstract	Background: Many people in Europe remain undiagnosed for human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV). Objectives: To evaluate acceptability and effectiveness of a questionnaire designed to facilitate identification of risk factors for these viruses. Methods: We performed an observational study, in a prospectively enrolled cohort of patients in Paris (France) seen in 2014. Eighteen GPs administered a questionnaire to the first 50 patients, collecting information about risk factors. GPs were randomized into two groups: A (self-administered questionnaire) and B (GP-administered questionnaire). We used the overall response rate to assess the acceptability of the questionnaire. We used the rate of newly identified risk factors and compared the number of tests performed one year before and immediately after the intervention to assess the effectiveness of the questionnaire. Results: 842 patients were randomized: 349 (41.5%) in group A and 493 (58.5%) in group B. Acceptability was 88.5% (95%CI: 86.3-90.6); 93.1% (95%CI: 90.5-95.8) in-group A and 85.2% (95%CI: 82.1-88.3) in group B (P = 0.0004). Prevalence of risk factors was 51.8% (95%CI: 48.2-54.4) and 58.3% were newly identified (95%CI: 52.9-63.7). The number of HIV tests performed during the four weeks after intervention increased by 27% compared to the same period one year before (P = 0.22). It increased by 113% (P = 0.005) and 135% (P = 0.005) for HBV and HCV, respectively. Conclusion: The questionnaire proved acceptable and effective in identifying risk factors for HIV, HBV and HCV in general practice.
MeSH term(s)	Adolescent ; Adult ; Aged ; Cohort Studies ; Female ; France ; General Practice ; HIV Infections/diagnosis ; HIV Infections/epidemiology ; HIV Infections/etiology ; Hepatitis B/diagnosis ; Hepatitis B/epidemiology ; Hepatitis B/etiology ; Hepatitis C/diagnosis ; Hepatitis C/epidemiology ; Hepatitis C/etiology ; Humans ; Male ; Mass Screening/statistics & numerical data ; Middle Aged ; Prevalence ; Prospective Studies ; Risk Factors ; Surveys and Questionnaires ; Young Adult
Language	English
Publishing date	2018-12
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	1281338-2
ISSN	1751-1402 ; 1381-4788
ISSN (online)	1751-1402
ISSN	1381-4788
DOI	10.1080/13814788.2017.1400529
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Article: A Systematic Review of Part C Early Identification Studies.

Barger, Brian / Rice, Catherine / Simmons, Christina Anne / Wolf, Rebecca

Topics in early childhood special education

2016 Volume 38, Issue 1, Page(s) 4–16

Abstract: ... young children to connect with Part C services. Authors classified data collection settings as primary (settings ... who had received Part C services, (b) screening and/or referral and/or developmental assessment from 0 ... through age 2 years, and (c) were deemed eligible and/or received Part C services. Authors identified 43 ...

Abstract	Authors conducted a systematic literature review on early identification steps leading at-risk young children to connect with Part C services. Authors classified data collection settings as primary (settings for general population) or specialized (settings for children at risk of developmental delay) and according to the phases of early identification in the study: (a) original population of children aged 0 to 6 years who had received Part C services, (b) screening and/or referral and/or developmental assessment from 0 through age 2 years, and (c) were deemed eligible and/or received Part C services. Authors identified 43 articles including at least two phases of the early identification process. The literature about connecting children to Part C early intervention (EI) is sparse and fragmented; few studies document the full process from community monitoring to service receipt. Results indicate opportunities for development of systems to better track and improve the identification of young children in need of EI.
Language	English
Publishing date	2016-12-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2068127-6
ISSN	1538-4845 ; 0271-1214
ISSN (online)	1538-4845
ISSN	0271-1214
DOI	10.1177/0271121416678664
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Article ; Online: The acceptability and effectiveness of a questionnaire for the identification of risk factors for HIV and hepatitis B and C

Amélie Aïm-Eusébi / Emmanuel Prothon / Catherine Majerholc / Diana Barger / Yazdan Yazdanpanah / Jean-Pierre Aubert

European Journal of General Practice, Vol 24, Iss 1, Pp 60-

An observational study in general practice

2018 Volume 67

Abstract: ... hepatitis B virus (HBV), hepatitis C virus (HCV). Objectives: To evaluate acceptability and effectiveness ...

Abstract	Background: Many people in Europe remain undiagnosed for human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV). Objectives: To evaluate acceptability and effectiveness of a questionnaire designed to facilitate identification of risk factors for these viruses. Methods: We performed an observational study, in a prospectively enrolled cohort of patients in Paris (France) seen in 2014. Eighteen GPs administered a questionnaire to the first 50 patients, collecting information about risk factors. GPs were randomized into two groups: A (self-administered questionnaire) and B (GP-administered questionnaire). We used the overall response rate to assess the acceptability of the questionnaire. We used the rate of newly identified risk factors and compared the number of tests performed one year before and immediately after the intervention to assess the effectiveness of the questionnaire. Results: 842 patients were randomized: 349 (41.5%) in group A and 493 (58.5%) in group B. Acceptability was 88.5% (95%CI: 86.3–90.6); 93.1% (95%CI: 90.5–95.8) in-group A and 85.2% (95%CI: 82.1–88.3) in group B (P = 0.0004). Prevalence of risk factors was 51.8% (95%CI: 48.2–54.4) and 58.3% were newly identified (95%CI: 52.9–63.7). The number of HIV tests performed during the four weeks after intervention increased by 27% compared to the same period one year before (P = 0.22). It increased by 113% (P = 0.005) and 135% (P = 0.005) for HBV and HCV, respectively. Conclusion: The questionnaire proved acceptable and effective in identifying risk factors for HIV, HBV and HCV in general practice.
Keywords	General practice ; HIV ; viral hepatitis ; risk factors ; screening ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2018-01-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
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Article ; Online: Fast-tracking action on the Sustainable Development Goals by enhancing national institutional arrangements.

Akhtar-Schuster, Mariam / Stringer, Lindsay C / Barger, Nichole

PloS one

2024 Volume 19, Issue 3, Page(s) e0298855

Abstract: Six years remain to achieve the Sustainable Development Goals (SDGs). Despite some progress, institutional effectiveness for SDG achievement has not been delivered at a national level. Identification and establishment of an institutional framework to ... ...

Abstract	Six years remain to achieve the Sustainable Development Goals (SDGs). Despite some progress, institutional effectiveness for SDG achievement has not been delivered at a national level. Identification and establishment of an institutional framework to operationalise the 2030 Agenda within national plans, giving science-based coordination of SDG implementation a central role, is urgently required to accelerate progress. This paper tackles this challenge. Drawing on literature analysis, it asks: 1) What are the deficiencies in institutional national arrangements that hinder SDG implementation? 2) How can existing institutional deficiencies in SDG implementation be addressed? and 3) How can institutional changes support fast-tracking of SDG implementation processes at national level? Findings show that country-specific horizontal institutional arrangements are usually advanced. However, national visions to improve mainstreaming across decision-making at different levels to enable whole-of-government and whole-of-society approaches to SDG implementation are commonly under-developed. Deficiencies are due to poor systematic engagement of scientific and technical expertise in operational day-to-day communication, as well as in the design, validation, implementation, monitoring and reporting of domestic SDG-related multi-stakeholder actions. Vertical institutional arrangements are complex, and risk resource-consuming, uncoordinated implementation. Our analyses suggest countries may benefit from establishing a national, centralised independent scientific and technical coordinating body for SDG implementation at national level, within existing science-based institutional arrangements. Such a body would not be led by governmental processes but would provide technical support to government agencies. We argue that scientific and technical skills in data and information management and quality control are central to coordinated and evidence-informed support, and could help to accelerate national SDG implementation. Such a supporting body would also enable a more joined-up approach between stakeholders working in the areas of science and technology, government and practice, improving orchestrated science-based actions and their auditing across sectors and stakeholder communities at national and sub-national levels. It would further guide actions to reduce trade-offs within national sustainable development aspirations, and would facilitate consideration of diverse values in advancing towards a durable and just transformative future. Such efforts are vital given the rapidly closing window of time for SDG achievement.
MeSH term(s)	Humans ; Sustainable Development ; Government ; Government Agencies ; Ataxia ; Communication ; Goals
Language	English
Publishing date	2024-03-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0298855
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Article ; Online: The C-terminal domain of ERp29 mediates polyomavirus binding, unfolding, and infection.

Rainey-Barger, Emily K / Mkrtchian, Souren / Tsai, Billy

Journal of virology

2008 Volume 83, Issue 3, Page(s) 1483–1491

Abstract: ... that mediates its dimerization and a novel C-terminal all-helical domain (CTD) whose function is unclear ...

Abstract	Penetration of the endoplasmic reticulum (ER) membrane by polyomavirus (PyV) is a decisive step in virus entry. We showed previously that the ER-resident factor ERp29 induces the local unfolding of PyV to initiate the ER membrane penetration process. ERp29 contains an N-terminal thioredoxin domain (NTD) that mediates its dimerization and a novel C-terminal all-helical domain (CTD) whose function is unclear. The NTD-mediated dimerization of ERp29 is critical for its unfolding activity; whether the CTD plays any role in PyV unfolding is unknown. We now show that three hydrophobic residues within the last helix of the ERp29 CTD that were individually mutated to either lysine or alanine abolished ERp29's ability to stimulate PyV unfolding and infection. This effect was not due to global misfolding of the mutant proteins, as they dimerize and do not form aggregates or display increased protease sensitivity. Moreover, the mutant proteins stimulated secretion of the secretory protein thyroglobulin with an efficiency similar to that of wild-type ERp29. Using a cross-linking coimmunoprecipitation assay, we found that the physical interaction of the ERp29 CTD mutants with PyV is inefficient. Our data thus demonstrate that the ERp29 CTD plays a crucial role in PyV unfolding and infection, likely by serving as part of a substrate-binding domain.
MeSH term(s)	Animals ; Heat-Shock Proteins/chemistry ; Heat-Shock Proteins/genetics ; Heat-Shock Proteins/physiology ; Immunoprecipitation ; Membrane Fusion ; Mice ; Mutagenesis ; NIH 3T3 Cells ; Polyomavirus/physiology ; Polyomavirus Infections/virology
Chemical Substances	Erp29 protein, mouse ; Heat-Shock Proteins
Language	English
Publishing date	2008-11-19
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	80174-4
ISSN	1098-5514 ; 0022-538X
ISSN (online)	1098-5514
ISSN	0022-538X
DOI	10.1128/JVI.02057-08
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Article ; Online: Association of Depression With 10-Year and Lifetime Cardiovascular Disease Risk Among US Adults, National Health and Nutrition Examination Survey, 2005-2018.

Barger, Steven D / Struve, Gabrielle C

Preventing chronic disease

2022 Volume 19, Page(s) E28

Abstract: Introduction: Although an association between depression and incident cardiovascular disease (CVD) risk has been established, no US studies have quantified this association using standard primary care assessments or among younger adults who are not ... ...

Abstract	Introduction: Although an association between depression and incident cardiovascular disease (CVD) risk has been established, no US studies have quantified this association using standard primary care assessments or among younger adults who are not routinely screened for CVD risk. We estimated the association of mild and major depression with 1) 10-year atherosclerotic CVD (ASCVD) risk for people aged 40 to 79 years and 2) high lifetime CVD risk prevalence for people aged 20 to 39 years. Methods: We conducted a cross-sectional analysis of data from the 2005-2018 National Health and Nutrition Examination Survey for adults aged 20 to 39 years (n = 10,588) and adults aged 40 to 79 years (n = 16,848). We used the Patient Health Questionnaire-9 [PHQ-9] to classify no depression (PHQ-9 score, 0-4), mild depression (PHQ-9 score, 5-9) and major depression (PHQ-9 score ≥10). Results: Among women aged 40 to 79, ASCVD absolute risk was 6.0% for no depression, 6.9% for mild depression, and 7.6% for major depression (P < .001 vs no depression). Among men aged 40 to 79, the corresponding absolute ASCVD risks were 9.9%, 11.1%, and 11.3%, respectively (P < .001 vs no depression). High lifetime CVD risk prevalence for women aged 20 to 39 was 41.9% for no depression, 53.2% for mild depression, and 66.5% for major depression (P < .001 vs no depression). For men aged 20-39 the corresponding high lifetime risk percentages were 53.3%, 64.8%, and 74.4% respectively (P < .001 vs no depression). Conclusion: Mild and major depression are associated with elevated 10-year ASCVD risk and substantially elevated lifetime CVD risk among younger people ineligible for ASCVD risk assessment. Jointly addressing depression and CVD risk and extending prevention efforts to younger adults are warranted.
MeSH term(s)	Adult ; Cardiovascular Diseases/epidemiology ; Cross-Sectional Studies ; Depression/epidemiology ; Female ; Humans ; Male ; Nutrition Surveys ; Risk Assessment ; Risk Factors
Language	English
Publishing date	2022-05-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	2135684-1
ISSN	1545-1151 ; 1545-1151
ISSN (online)	1545-1151
ISSN	1545-1151
DOI	10.5888/pcd19.210418
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Article ; Online: Nuclear envelope assembly relies on CHMP-7 in the absence of BAF-LEM-mediated hole closure.

Barger, Sarah R / Penfield, Lauren / Bahmanyar, Shirin

Journal of cell science

2023 Volume 136, Issue 21

Abstract: ... emerin) function redundantly with BAF-1 (the C. elegans BAF protein) in NE closure. Compromising BAF-LEM ... helix domain of LEM-2 recruits CHMP-7 to the NE in C. elegans and a LEM-2-independent nucleoplasmic pool ...

Abstract	Barrier-to-autointegration factor (BAF) protein is a DNA-binding protein that crosslinks chromatin to allow mitotic nuclear envelope (NE) assembly. The LAP2-emerin-MAN1 (LEM)-domain protein LEMD2 and ESCRT-II/III hybrid protein CHMP7 close NE holes surrounding spindle microtubules (MTs). BAF binds LEM-domain family proteins to repair NE ruptures in interphase, but whether BAF-LEM binding participates in NE hole closure around spindle MTs is not known. Here, we took advantage of the stereotypical event of NE formation in fertilized Caenorhabditis elegans oocytes to show that BAF-LEM binding and LEM-2-CHMP-7 have distinct roles in NE closure around spindle MTs. LEM-2 and EMR-1 (homologs of LEMD2 and emerin) function redundantly with BAF-1 (the C. elegans BAF protein) in NE closure. Compromising BAF-LEM binding revealed an additional role for EMR-1 in the maintenance of the NE permeability barrier. In the absence of BAF-LEM binding, LEM-2-CHMP-7 was required for NE assembly and embryo survival. The winged helix domain of LEM-2 recruits CHMP-7 to the NE in C. elegans and a LEM-2-independent nucleoplasmic pool of CHMP-7 also contributes to NE stability. Thus, NE hole closure surrounding spindle MTs requires redundant mechanisms that safeguard against failure in NE assembly to support embryogenesis.
MeSH term(s)	Animals ; Nuclear Envelope/metabolism ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/metabolism ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; Cell Nucleus/metabolism
Chemical Substances	emerin ; Nuclear Proteins
Language	English
Publishing date	2023-11-13
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
ZDB-ID	2993-2
ISSN	1477-9137 ; 0021-9533
ISSN (online)	1477-9137
ISSN	0021-9533
DOI	10.1242/jcs.261385
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Article: Regulation of lipoprotein lipase by protein kinase C alpha in 3T3-F442A adipocytes.

Ranganathan, Gouri / Song, Wei / Dean, Nicholas / Monia, Brett / Barger, Steven W / Kern, Philip A

The Journal of biological chemistry

2002 Volume 277, Issue 41, Page(s) 38669–38675

Abstract: ... depletion of protein kinase C (PKC) isoforms with long term treatment of 3T3-F442A adipocytes with 12-O ...

Abstract	Lipoprotein lipase (LPL) is an important enzyme in adipocyte and lipid metabolism with complex cellular regulation. Previous studies demonstrated an inhibition of LPL activity and synthesis following depletion of protein kinase C (PKC) isoforms with long term treatment of 3T3-F442A adipocytes with 12-O-tetradecanoylphorbol-13-acetate. To identify the specific PKC isoforms involved, we treated cells with antisense oligonucleotides that block expression of specific PKC isoforms. An antisense oligonucleotide to PKC alpha inhibited LPL activity by 78 +/- 8%, whereas antisense oligonucleotides directed against PKC delta or PKC epsilon had no effect on LPL activity. The change in LPL activity was maximal at 72 h and was accompanied by a decrease in LPL protein and LPL synthetic rate but no change in LPL mRNA, suggesting regulation at the level of translation. However, PKC depletion resulted in no change in the polysome profile, indicating that translation initiation was not affected. However, the addition of cytoplasmic extracts from adipocytes treated with 12-O-tetradecanoylphorbol-13-acetate or PKC alpha antisense oligomers inhibited LPL translation in vitro. This inhibition of LPL translation in vitro was lost when the LPL mRNA transcript did not contain nucleotides 1599-3200, thus implicating the 3'-untranslated region of LPL in the regulation of translation by PKC depletion. Both LPL activity and Raf1 activity were decreased in parallel following depletion of either total PKC or specific inhibition of PKC alpha. An antisense oligonucleotide to RAF1, which inhibited RAF1 activity, also inhibited LPL activity by 48 +/- 10%, and this decrease in LPL activity was not accompanied by a change in LPL mRNA. Cells were treated with U0126, a specific inhibitor of the ERK-activating kinases MEK1 and MEK2. Although U0126 inhibited ERK1 and ERK2 phosphorylation, U0126 had no effect on LPL activity, indicating that MEK/ERK pathways were not involved in this mechanism of LPL regulation. Together, these data indicate that PKC alpha and RAF1 are important in the translational regulation of LPL in adipocytes and that the mechanism of regulation is probably through an ERK-independent pathway.
MeSH term(s)	Adipocytes/cytology ; Adipocytes/drug effects ; Adipocytes/enzymology ; Animals ; Butadienes/pharmacology ; Cell Line ; Enzyme Inhibitors/pharmacology ; Isoenzymes/genetics ; Isoenzymes/metabolism ; Lipoprotein Lipase/antagonists & inhibitors ; Lipoprotein Lipase/genetics ; Lipoprotein Lipase/metabolism ; MAP Kinase Signaling System/physiology ; Mice ; Mitogen-Activated Protein Kinases/metabolism ; Nitriles/pharmacology ; Oligonucleotides, Antisense/metabolism ; Polyribosomes/genetics ; Polyribosomes/metabolism ; Protein Biosynthesis ; Protein Kinase C/genetics ; Protein Kinase C/metabolism ; Protein Kinase C-alpha ; Proto-Oncogene Proteins c-raf/metabolism ; RNA, Messenger/metabolism ; Tetradecanoylphorbol Acetate/pharmacology
Chemical Substances	Butadienes ; Enzyme Inhibitors ; Isoenzymes ; Nitriles ; Oligonucleotides, Antisense ; RNA, Messenger ; U 0126 ; Proto-Oncogene Proteins c-raf (EC 2.7.11.1) ; Prkca protein, mouse (EC 2.7.11.13) ; Protein Kinase C (EC 2.7.11.13) ; Protein Kinase C-alpha (EC 2.7.11.13) ; Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; Lipoprotein Lipase (EC 3.1.1.34) ; Tetradecanoylphorbol Acetate (NI40JAQ945)
Language	English
Publishing date	2002-07-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1074/jbc.M206917200
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Article: Non-typhoidal

Barger, Branden T / Pakvasa, Mikhail / Lem, Melinda / Ramamurthi, Aishu / Lalezari, Shadi / Tang, Cathy

Case reports in plastic surgery & hand surgery

2023 Volume 10, Issue 1, Page(s) 2185621

Abstract: We present a case of a 32-year-old transgender male who underwent chest masculinization, complicated by purulent soft tissue infection of bilateral chest incisions. Cultures tested positive for non- ... ...

Abstract	We present a case of a 32-year-old transgender male who underwent chest masculinization, complicated by purulent soft tissue infection of bilateral chest incisions. Cultures tested positive for non-typhoidal
Language	English
Publishing date	2023-03-06
Publishing country	United States
Document type	Case Reports
ISSN	2332-0885
ISSN	2332-0885
DOI	10.1080/23320885.2023.2185621
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