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  1. Article: Intravenous versus Partial Oral Antibiotic Therapy in the Treatment of Uncomplicated Bloodstream Infection Due to

    Broermann, Lynn E / Al-Hasan, Majdi N / Withers, Sarah / Benbow, Kristina L / Ramsey, Taylor / McTavish, Meghan / Winders, Hana R

    Microorganisms

    2023  Volume 11, Issue 9

    Abstract: This retrospective cohort study examines effectiveness of partial oral antibiotic regimens in uncomplicated bloodstream infections (BSIs) due ... ...

    Abstract This retrospective cohort study examines effectiveness of partial oral antibiotic regimens in uncomplicated bloodstream infections (BSIs) due to
    Language English
    Publishing date 2023-09-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11092313
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Using Electronic Monitoring Devices to Assess Medication Adherence: a Research Methods Framework.

    McGrady, Meghan E / Ramsey, Rachelle R

    Journal of general internal medicine

    2020  Volume 35, Issue 9, Page(s) 2707–2714

    Abstract: While electronic adherence monitoring devices (EAMDs) are the preferred and most objective medication adherence measurement strategy for many populations and research questions, there is no comprehensive methodological framework for EAMD use. We ... ...

    Abstract While electronic adherence monitoring devices (EAMDs) are the preferred and most objective medication adherence measurement strategy for many populations and research questions, there is no comprehensive methodological framework for EAMD use. We synthesize recommendations from experts in adherence science and the scientific literature to create a temporal framework of EAMD research methods. The goal of this framework is to provide a step-by-step guide that will enable researchers to design, prepare, implement, and clean data from rigorous, high-quality studies using EAMDs to assess adherence. Resources including a checklist of methodological considerations and example protocols have been created to assist readers in using this framework.
    MeSH term(s) Electronics ; Humans ; Medication Adherence ; Qualitative Research ; Research Design
    Language English
    Publishing date 2020-05-21
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 639008-0
    ISSN 1525-1497 ; 0884-8734
    ISSN (online) 1525-1497
    ISSN 0884-8734
    DOI 10.1007/s11606-020-05905-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Systematic Evaluation of the Behavior Change Techniques and Quality of Commercially Available Cancer Self-Management Apps.

    McGrady, Meghan E / Schwartz, Laura E / Noser, Amy E / Klages, Kimberly L / Sweenie, Rachel / Breen, Gabriella / Ramsey, Rachelle R

    JCO oncology practice

    2022  Volume 19, Issue 2, Page(s) e228–e237

    Abstract: Purpose: Apps have the potential to aid in cancer self-management, but there is limited guidance available for selecting among currently available options. The purpose of this study is to evaluate the behavior change techniques (BCTs) and quality of ... ...

    Abstract Purpose: Apps have the potential to aid in cancer self-management, but there is limited guidance available for selecting among currently available options. The purpose of this study is to evaluate the behavior change techniques (BCTs) and quality of publicly available cancer self-management apps.
    Methods: Cancer self-management apps were identified from the Apple and Google Play stores in April 2022. Trained study team members coded the BCTs included in each app and rated its quality using the Mobile App Rating Scale (MARS). BCTs supported by previous literature were coded as cancer management BCTs.
    Results: The 39 apps meeting inclusion criteria included an average of 5.85 BCTs (standard deviation [SD], 3.49; range, 0-15) and 3.54 cancer management BCTs (SD, 1.90; range, 0-8). The most commonly included BCTs were educational or informational strategies:
    Conclusion: No cancer self-management apps were of excellent quality, and less than half included multiple cancer management BCTs beyond education. Clinical implications are discussed, and opportunities to improve the content and quality of apps to address the critical self-management needs of patients diagnosed with cancer are highlighted.
    MeSH term(s) Humans ; Self-Management/methods ; Behavior Therapy/methods ; Health Behavior ; Mobile Applications ; Neoplasms/therapy
    Language English
    Publishing date 2022-11-29
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 3028198-2
    ISSN 2688-1535 ; 2688-1527
    ISSN (online) 2688-1535
    ISSN 2688-1527
    DOI 10.1200/OP.22.00491
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Diversity, Equity, and Inclusion within Pediatric Adherence Science.

    Williford, Desireé N / Sweenie, Rachel / Ramsey, Rachelle R / McGrady, Meghan E / Crosby, Lori E / Modi, Avani C

    Journal of clinical psychology in medical settings

    2022  Volume 30, Issue 2, Page(s) 330–341

    Abstract: Given the long-standing history of systemic racism in psychological science, diversity, equity, and inclusion (DEI) efforts are increasingly vital to the advancement and improvement of the field. This commentary extends the seminal work of the article ... ...

    Abstract Given the long-standing history of systemic racism in psychological science, diversity, equity, and inclusion (DEI) efforts are increasingly vital to the advancement and improvement of the field. This commentary extends the seminal work of the article Upending Racism in Psychological Science: Strategies to Change How Our Science is Conducted, Reported, Reviewed, and Disseminated (Buchanan et al., Am Psychol, https://doi.org/10.31234/osf.io/6nk4x , 2020) by providing tangible applications and recommendations to improve DEI integration into pediatric adherence science. Real-world adherence examples are discussed regarding the challenges faced in systematically integrating DEI principles, potential solutions to overcoming barriers, and the implications of these efforts on scientific advancement in an effort to address and dismantle research practices that perpetuate inequity and White supremacy. Specifically, we provide discourse and practical guidance related to the conduct, reporting, reviewing, and dissemination of pediatric adherence science to promote dialog and produce actionable change toward the promotion of health equity and social justice.
    MeSH term(s) Humans ; Child ; Diversity, Equity, Inclusion ; Chlorhexidine ; Health Equity
    Chemical Substances Chlorhexidine (R4KO0DY52L)
    Language English
    Publishing date 2022-12-08
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1235893-9
    ISSN 1573-3572 ; 1068-9583
    ISSN (online) 1573-3572
    ISSN 1068-9583
    DOI 10.1007/s10880-022-09922-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Characterization of SARS-CoV-2 Aerosols Dispersed During Noninvasive Respiratory Support of Patients With COVID-19.

    Ramsey, Meghan E / Faugno, Anthony J / Puryear, Wendy B / Lee, Brian C / Foss, Alexa D / Lambert, Lester H / Nargi, Frances E / Bopp, Gregory P / Lee, Lauren P / Rudzinski, Christina M / Ervin, Benjamin L / Runstadler, Jonathan A / Hill, Nicholas S

    Respiratory care

    2022  Volume 68, Issue 1, Page(s) 8–17

    Abstract: Background: In the midst of the COVID-19 pandemic, noninvasive respiratory support (NRS) therapies such as high-flow nasal cannula (HFNC) and noninvasive ventilation (NIV) were central to respiratory care. The extent to which these treatments increase ... ...

    Abstract Background: In the midst of the COVID-19 pandemic, noninvasive respiratory support (NRS) therapies such as high-flow nasal cannula (HFNC) and noninvasive ventilation (NIV) were central to respiratory care. The extent to which these treatments increase the generation and dispersion of infectious respiratory aerosols is not fully understood. The objective of this study was to characterize SARS-CoV-2 aerosol dispersion from subjects with COVID-19 undergoing NRS therapy.
    Methods: Several different aerosol sampling devices were used to collect air samples in the vicinity of 31 subjects with COVID-19, most of whom were receiving NRS therapy, primarily HFNC. Aerosols were collected onto filters and analyzed for the presence of SARS-CoV-2 RNA. Additional measurements were collected in an aerosol chamber with healthy adult subjects using respiratory therapy devices under controlled and reproducible conditions.
    Results: Fifty aerosol samples were collected from subjects receiving HFNC or NIV therapy, whereas 6 samples were collected from subjects not receiving NRS. Only 4 of the 56 aerosol samples were positive for SARS-CoV-2 RNA, and all positive samples were collected using a high air flow scavenger mask collection device placed in close proximity to the subject. The chamber measurements with healthy subjects did not show any significant increase in aerosol dispersion caused by the respiratory therapy devices compared to baseline.
    Conclusions: Our findings demonstrate very limited detection of SARS-CoV-2-containing aerosols in the vicinity of subjects with COVID-19 receiving NRS therapies in the clinical setting. These results, combined with controlled chamber measurements showing that HFNC and NIV device usage was not associated with increased aerosol dispersion, suggest that NRS therapies do not result in increased dispersal of aerosols in the clinical setting.
    MeSH term(s) Adult ; Humans ; COVID-19/therapy ; SARS-CoV-2 ; Pandemics ; RNA, Viral ; Respiratory Aerosols and Droplets ; Noninvasive Ventilation/methods ; Cannula ; Oxygen Inhalation Therapy/methods
    Chemical Substances RNA, Viral
    Language English
    Publishing date 2022-12-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603252-7
    ISSN 1943-3654 ; 0098-9142 ; 0020-1324
    ISSN (online) 1943-3654
    ISSN 0098-9142 ; 0020-1324
    DOI 10.4187/respcare.10340
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  6. Article ; Online: Invasive Meningococcal Disease Among People Experiencing Homelessness-United States, 2016-2019.

    Rudmann, Keegan C / Brown, Nicole E / Rubis, Amy B / Burns, Meagan / Ramsey, April / De Las Nueces, Denise / Martin, Tasha / Barnes, Meghan / Davizon, Emily Spence / Retchless, Adam C / Potts, Caelin / Wang, Xin / Hariri, Susan / McNamara, Lucy A

    The Journal of infectious diseases

    2022  Volume 226, Issue Suppl 3, Page(s) S322–S326

    Abstract: Background: Recently, several invasive meningococcal disease (IMD) outbreaks caused by Neisseria meningitidis have occurred among people experiencing homelessness (PEH). However, overall IMD risk among PEH is not well described. We compared incidence ... ...

    Abstract Background: Recently, several invasive meningococcal disease (IMD) outbreaks caused by Neisseria meningitidis have occurred among people experiencing homelessness (PEH). However, overall IMD risk among PEH is not well described. We compared incidence and characteristics of IMD among PEH and persons not known to be experiencing homelessness (non-PEH) in the United States.
    Methods: We analyzed 2016-2019 IMD data from the National Notifiable Diseases Surveillance System and enhanced meningococcal disease surveillance. Incidence was calculated using US census data and point-in-time counts from the US Department of Housing and Urban Development.
    Results: Of cases from states participating in enhanced surveillance during 2016-2019 (n = 1409), 45 cases (3.2%) occurred among PEH. Annual incidence was higher among PEH (2.12 cases/100 000) than non-PEH (0.11 cases/100 000; relative risk, 19.8; 95% confidence interval [CI], 14.8-26.7). Excluding outbreak-associated cases (PEH n = 18, 40%; non-PEH n = 98, 7.2%), incidence among PEH remained elevated compared to incidence in non-PEH (relative risk, 12.8; 95% CI, 8.8-18.8). Serogroup C was identified in 68.2% of PEH cases compared to 26.4% in non-PEH (P < .0001).
    Conclusions: PEH are at increased risk for IMD. Further assessment is needed to determine the feasibility and potential impact of meningococcal vaccination for PEH in the United States.
    MeSH term(s) Homeless Persons ; Humans ; Incidence ; Meningococcal Infections/epidemiology ; Meningococcal Vaccines ; Neisseria meningitidis ; Serogroup ; United States/epidemiology
    Chemical Substances Meningococcal Vaccines
    Language English
    Publishing date 2022-08-08
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiac230
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  7. Article ; Online: Obstetric and Newborn Weak D-Phenotype RBC Testing and Rh Immune Globulin Management Recommendations.

    Ramsey, Glenn / Park, Yara A / Eder, Anne F / Bobr, Aleh / Karafin, Matthew S / Karp, Julie K / King, Karen E / Pagano, Monica B / Schwartz, Joseph / Szczepiorkowski, Zbigniew M / Souers, Rhona J / Thomas, Lamont / Delaney, Meghan

    Archives of pathology & laboratory medicine

    2021  

    Abstract: Context.—: Modern RHD genotyping can be used to determine when patients with serologic weak D phenotypes have RHD gene variants at risk for anti-D alloimmunization. However, serologic testing, RhD interpretations, and laboratory management of these ... ...

    Abstract Context.—: Modern RHD genotyping can be used to determine when patients with serologic weak D phenotypes have RHD gene variants at risk for anti-D alloimmunization. However, serologic testing, RhD interpretations, and laboratory management of these patients are quite variable.
    Objective.—: To obtain interlaboratory comparisons of serologic testing, RhD interpretations, Rh immune globulin (RhIG) management, fetomaternal hemorrhage testing, and RHD genotyping for weak D-reactive specimens.
    Design.—: We devised an educational exercise in which 81 transfusion services supporting obstetrics performed tube-method RhD typing on 2 unknown red blood cell challenge specimens identified as (1) maternal and (2) newborn. Both specimens were from the same weak D-reactive donor. The exercise revealed how participants responded to these different clinical situations.
    Results.—: Of reporting laboratories, 14% (11 of 80) obtained discrepant immediate-spin reactions on the 2 specimens. Nine different reporting terms were used to interpret weak D-reactive maternal RhD types to obstetricians. In laboratories obtaining negative maternal immediate-spin reactions, 28% (16 of 57) performed unwarranted antiglobulin testing, sometimes leading to recommendations against giving RhIG. To screen for excess fetomaternal hemorrhage after a weak D-reactive newborn, 47% (34 of 73) of reporting laboratories would have employed a contraindicated fetal rosette test, risking false-negative results, and inadequate RhIG coverage. Sixty percent (44 of 73) of laboratories would obtain RHD genotyping in some or all cases.
    Conclusions.—: For obstetric and neonatal patients with serologic weak D phenotypes, we found several critical problems in transfusion service laboratory practices. We provide recommendations for appropriate testing, consistent immunohematologic terminology, and RHD genotype-guided management of Rh immune globulin therapy and RBC transfusions.
    Language English
    Publishing date 2021-05-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 194119-7
    ISSN 1543-2165 ; 0363-0153 ; 0096-8528 ; 0003-9985
    ISSN (online) 1543-2165
    ISSN 0363-0153 ; 0096-8528 ; 0003-9985
    DOI 10.5858/arpa.2021-0250-CP
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  8. Article ; Online: International guidelines regarding the role of IVIG in the management of Rh- and ABO-mediated haemolytic disease of the newborn.

    Lieberman, Lani / Lopriore, Enrico / Baker, Jillian M / Bercovitz, Rachel S / Christensen, Robert D / Crighton, Gemma / Delaney, Meghan / Goel, Ruchika / Hendrickson, Jeanne E / Keir, Amy / Landry, Denise / La Rocca, Ursula / Lemyre, Brigitte / Maier, Rolf F / Muniz-Diaz, Eduardo / Nahirniak, Susan / New, Helen V / Pavenski, Katerina / Dos Santos, Maria Cristina Pessoa /
    Ramsey, Glenn / Shehata, Nadine

    British journal of haematology

    2022  Volume 198, Issue 1, Page(s) 183–195

    Abstract: Haemolytic disease of the newborn (HDN) can be associated with significant morbidity. Prompt treatment with intensive phototherapy (PT) and exchange transfusions (ETs) can dramatically improve outcomes. ET is invasive and associated with risks. ... ...

    Abstract Haemolytic disease of the newborn (HDN) can be associated with significant morbidity. Prompt treatment with intensive phototherapy (PT) and exchange transfusions (ETs) can dramatically improve outcomes. ET is invasive and associated with risks. Intravenous immunoglobulin (IVIG) may be an alternative therapy to prevent use of ET. An international panel of experts was convened to develop evidence-based recommendations regarding the effectiveness and safety of IVIG to reduce the need for ETs, improve neurocognitive outcomes, reduce bilirubin level, reduce the frequency of red blood cell (RBC) transfusions and severity of anaemia, and/or reduce duration of hospitalization for neonates with Rh or ABO-mediated HDN. We used a systematic approach to search and review the literature and then develop recommendations from published data. These recommendations conclude that IVIG should not be routinely used to treat Rh or ABO antibody-mediated HDN. In situations where hyperbilirubinaemia is severe (and ET is imminent), or when ET is not readily available, the role of IVIG is unclear. High-quality studies are urgently needed to assess the optimal use of IVIG in patients with HDN.
    MeSH term(s) Blood Group Incompatibility ; Erythroblastosis, Fetal/drug therapy ; Exchange Transfusion, Whole Blood ; Female ; Humans ; Immunoglobulins, Intravenous/therapeutic use ; Infant, Newborn ; Phototherapy
    Chemical Substances Immunoglobulins, Intravenous
    Language English
    Publishing date 2022-04-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.18170
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  9. Article ; Online: An Independent Evaluation of the Accuracy and Usability of Electronic Adherence Monitoring Devices.

    McGrady, Meghan E / Holbein, Christina E / Smith, Aimee W / Morrison, Caroline F / Hommel, Kevin A / Modi, Avani C / Pai, Ahna L H / Ramsey, Rachelle R

    Annals of internal medicine

    2018  Volume 169, Issue 6, Page(s) 419–422

    MeSH term(s) Drug Monitoring/instrumentation ; Electrical Equipment and Supplies ; Humans ; Medication Adherence
    Language English
    Publishing date 2018-05-22
    Publishing country United States
    Document type Evaluation Study ; Letter ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/M17-3306
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  10. Article: Management of Elbow Dislocations in the National Football League.

    Chang, Edward S / Bishop, Meghan E / Dodson, Christopher C / Deluca, Peter F / Ciccotti, Michael G / Cohen, Steven B / Ramsey, Matthew L

    Orthopaedic journal of sports medicine

    2018  Volume 6, Issue 2, Page(s) 2325967118755451

    Abstract: Background: Although much literature exists regarding the treatment and management of elbow dislocations in the general population, little information is available regarding management in the athletic population. Furthermore, no literature is available ... ...

    Abstract Background: Although much literature exists regarding the treatment and management of elbow dislocations in the general population, little information is available regarding management in the athletic population. Furthermore, no literature is available regarding the postinjury treatment and timing of return to play in the contact or professional athlete.
    Purpose: To review the clinical course of elbow dislocations in professional football players and determine the timing of return to full participation.
    Study design: Case series; Level of evidence, 4.
    Methods: All National Football League (NFL) athletes with elbow dislocations from 2000 through 2011 who returned to play during the season were identified from the NFL Injury Surveillance System (NFL ISS). Roster position, player activity, use of external bracing, and clinical course were reviewed. Mean number of days lost until full return to play was determined for players with elbow dislocations who returned in the same season.
    Results: From 2000 to 2011, a total of 62 elbow dislocations out of 35,324 injuries were recorded (0.17%); 40 (64.5%) dislocations occurred in defensive players, 12 (19.4%) were in offensive players; and 10 (16.1%) were during special teams play. Over half of the injuries (33/62, 53.2%) were sustained while tackling, and 4 (6.5%) patients required surgery. A total of 47 (75.8%) players who sustained this injury were able to return in the same season. For this group, the mean number of days lost in players treated conservatively (45/47) was 25.1 days (median, 23.0 days; range, 0.0-118 days), while that for players treated operatively (2/47) was 46.5 days (median, 46.5 days; range, 29-64 days). Mean return to play based on player position was 25.8 days for defensive players (n = 28; median, 21.5 days; range, 3.0-118 days), 24.1 days for offensive players (n = 11; median, 19 days; range, 2.0-59 days), and 25.6 days for special teams players (n = 8; median, 25.5 days; range, 0-44 days).
    Conclusion: Elbow dislocations comprise less than a half of a percent of all injuries sustained in the NFL. Most injuries occur during the act of tackling, with the majority of injured athletes playing a defensive position. Players treated nonoperatively missed a mean of 25.1 days, whereas those managed operatively missed a mean of 46.5 days.
    Language English
    Publishing date 2018-02-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2706251-X
    ISSN 2325-9671
    ISSN 2325-9671
    DOI 10.1177/2325967118755451
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