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  1. Article ; Online: S

    Alam, Md Jahin / Mohammad, Mir Sayeed / Hossain, Md Adnan Faisal / Showmik, Ishtiaque Ahmed / Raihan, Munshi Sanowar / Ahmed, Shahed / Mahmud, Talha Ibn

    Computers in biology and medicine

    2022  Volume 150, Page(s) 106148

    Abstract: ... especially schemes which adopt deep learning tactics. In this paper, a convolutional deep neural network, S ...

    Abstract Dermoscopic images ideally depict pigmentation attributes on the skin surface which is highly regarded in the medical community for detection of skin abnormality, disease or even cancer. The identification of such abnormality, however, requires trained eyes and accurate detection necessitates the process being time-intensive. As such, computerized detection schemes have become quite an essential, especially schemes which adopt deep learning tactics. In this paper, a convolutional deep neural network, S
    MeSH term(s) Humans ; Dermoscopy/methods ; Skin Neoplasms/diagnostic imaging ; Neural Networks, Computer ; Skin/diagnostic imaging ; Image Processing, Computer-Assisted/methods
    Language English
    Publishing date 2022-09-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 127557-4
    ISSN 1879-0534 ; 0010-4825
    ISSN (online) 1879-0534
    ISSN 0010-4825
    DOI 10.1016/j.compbiomed.2022.106148
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Development of Synergy-Based Combination of Methanolic Extract of Andrographis paniculata and Berberis aristata Against E. coli and S. aureus.

    Abass, Sageer / Zahiruddin, Sultan / Ali, Asghar / Irfan, Mohammad / Jan, Bisma / Haq, Qazi Mohd Rizwanul / Husain, Syed Akhtar / Ahmad, Sayeed

    Current microbiology

    2022  Volume 79, Issue 8, Page(s) 223

    Abstract: This study evaluates the antibacterial activity and phytochemical characterizations of Andrographis paniculata extract (APE) and Berberis aristata extract (BAE). The stem of Andrographis paniculata (AP) and root of Berberis aristata (BA) were extracted ... ...

    Abstract This study evaluates the antibacterial activity and phytochemical characterizations of Andrographis paniculata extract (APE) and Berberis aristata extract (BAE). The stem of Andrographis paniculata (AP) and root of Berberis aristata (BA) were extracted with methanol. The results confirmed that APE and BAE possess high phenolic and flavonoid content. The antioxidant activity of the APE and BAE showed an elevated potential to scavenge DPPH (2,2-diphenyl-1-picrylhydrazyl) radicals with IC
    MeSH term(s) Andrographis paniculata ; Anti-Bacterial Agents/pharmacology ; Berberis/chemistry ; Escherichia coli ; Methanol ; Methicillin-Resistant Staphylococcus aureus ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Staphylococcus aureus
    Chemical Substances Anti-Bacterial Agents ; Plant Extracts ; Methanol (Y4S76JWI15)
    Language English
    Publishing date 2022-06-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 134238-1
    ISSN 1432-0991 ; 0343-8651
    ISSN (online) 1432-0991
    ISSN 0343-8651
    DOI 10.1007/s00284-022-02911-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Development of Synergy-Based Combination of Methanolic Extract of Andrographis paniculata and Berberis aristata Against E. coli and S. aureus

    Abass, Sageer / Zahiruddin, Sultan / Ali, Asghar / Irfan, Mohammad / Jan, Bisma / Haq, Qazi Mohd Rizwanul / Husain, Syed Akhtar / Ahmad, Sayeed

    Current microbiology. 2022 Aug., v. 79, no. 8

    2022  

    Abstract: ... the findings showed that APE and BAE had antibacterial activities against E. coli and S. aureus. The growth ... of antibacterial compounds and can be used for treating infectious diseases caused by E. coli and S. aureus. ...

    Abstract This study evaluates the antibacterial activity and phytochemical characterizations of Andrographis paniculata extract (APE) and Berberis aristata extract (BAE). The stem of Andrographis paniculata (AP) and root of Berberis aristata (BA) were extracted with methanol. The results confirmed that APE and BAE possess high phenolic and flavonoid content. The antioxidant activity of the APE and BAE showed an elevated potential to scavenge DPPH (2,2-diphenyl-1-picrylhydrazyl) radicals with IC₅₀ of 95.03 μg/mL and 256.26 μg/mL, respectively. A total of 35 and 32 metabolites in APE and BAE, respectively, were identified through mass spectrometry analysis, whereas 17 and 12 metabolites in APE and BAE, respectively, were detected through high-performance thin-layer chromatography (HPTLC) fingerprinting profiling. Antibacterial activity of the extracts was performed by the well diffusion and microdilution method, and the findings showed that APE and BAE had antibacterial activities against E. coli and S. aureus. The growth curve and time-kill study showed that the extracts had a bacteriostatic effect. A combination study with the standard drug was carried out using the microdilution checkerboard method in which most of the combinations showed synergistic interactions. The findings of this study have shown that APE and BAE are good sources of antibacterial compounds and can be used for treating infectious diseases caused by E. coli and S. aureus.
    Keywords 2,2-diphenyl-1-picrylhydrazyl ; Andrographis paniculata ; Berberis aristata ; Escherichia coli ; antibacterial properties ; antioxidant activity ; drugs ; flavonoids ; growth curves ; mass spectrometry ; metabolites ; methanol ; microbiology ; thin layer chromatography
    Language English
    Dates of publication 2022-08
    Size p. 223.
    Publishing place Springer US
    Document type Article
    ZDB-ID 134238-1
    ISSN 1432-0991 ; 0343-8651
    ISSN (online) 1432-0991
    ISSN 0343-8651
    DOI 10.1007/s00284-022-02911-8
    Database NAL-Catalogue (AGRICOLA)

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  4. Book ; Online: Pipeline Engineering

    Rushd, Sayeed / Anwar Ismail, Mohamed

    Design, Failure, and Management

    2023  

    Keywords Structural engineering ; corrosion ; nanofluid ; surfactant ; fracture ; failure analysis ; modeling and simulation
    Language English
    Size 1 electronic resource (212 pages)
    Publisher IntechOpen
    Document type Book ; Online
    Note English
    HBZ-ID HT030380678
    ISBN 9781837680016 ; 1837680019
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Article ; Online: Study of Caspase 8 Inhibition for the Management of Alzheimer’s Disease

    Syed Sayeed Ahmad / Meetali Sinha / Khurshid Ahmad / Mohammad Khalid / Inho Choi

    Molecules, Vol 25, Iss 2071, p

    A Molecular Docking and Dynamics Simulation

    2020  Volume 2071

    Abstract: Alzheimer's disease (AD) is the most common type of dementia and usually manifests as diminished episodic memory and cognitive functions. Caspases are crucial mediators of neuronal death in a number of neurodegenerative diseases, and caspase 8 is ... ...

    Abstract Alzheimer's disease (AD) is the most common type of dementia and usually manifests as diminished episodic memory and cognitive functions. Caspases are crucial mediators of neuronal death in a number of neurodegenerative diseases, and caspase 8 is considered a major therapeutic target in the context of AD. In the present study, we performed a virtual screening of 200 natural compounds by molecular docking with respect to their abilities to bind with caspase 8. Among them, rutaecarpine was found to have the highest (negative) binding energy (−6.5 kcal/mol) and was further subjected to molecular dynamics (MD) simulation analysis. Caspase 8 was determined to interact with rutaecarpine through five amino acid residues, specifically Thr337, Lys353, Val354, Phe355, and Phe356, and two hydrogen bonds (ligand: H35-A: LYS353:O and A:PHE355: N-ligand: N5). Furthermore, a 50 ns MD simulation was conducted to optimize the interaction, to predict complex flexibility, and to investigate the stability of the caspase 8–rutaecarpine complex, which appeared to be quite stable. The obtained results propose that rutaecarpine could be a lead compound that bears remarkable anti-Alzheimer's potential against caspase 8.
    Keywords Alzheimer’s disease ; caspase 8 ; molecular dynamics ; RMSD ; RMSF ; Organic chemistry ; QD241-441
    Subject code 540
    Language English
    Publishing date 2020-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Chemical, Pharmacological and Computerized Molecular Analysis of Stem’s Extracts of Bauhinia scandens L. Provide Insights into the Management of Diarrheal and Microbial Infections

    Islam, Md Minarul / Alam, Rashedul / Chung, Hea-Jong / Emon, Nazim Uddin / Fazlul Kabir, Mohammad / Rudra, Sajib / Alam, Safaet / Ullah, Ahsan / Hong, Seong-Tshool / Aktar Sayeed, Mohammed

    Nutrients. 2022 Jan. 09, v. 14, no. 2

    2022  

    Abstract: ... preliminary and UPLC-QTOF–M.S. analysis) and to examine the pharmacological activities of Bauhinia scandens L ...

    Abstract Bauhinia scandens L. (Family: Fabaceae) is commonly used to treat cholera, diarrhea, asthma, and diabetes disorder in integrative medicine. This study aimed to screen the presence of phytochemicals (preliminary and UPLC-QTOF–M.S. analysis) and to examine the pharmacological activities of Bauhinia scandens L. stems (MEBS) stem extracts. Besides, in silico study was also implemented to elucidate the binding affinity and drug capability of the selected phytochemicals. In vivo anti diarrheal activity was investigated in mice models. In vitro, antibacterial and antifungal properties of MEBS against several pathogenic strains were evaluated using the disc diffusion method. In addition, in silico study has been employed using Discovery studio 2020, UCFS Chimera, PyRx autodock vina, and online tools. In the anti-diarrheal investigation, MEBS showed a significant dose-dependent inhibition rate in all three methods. The antibacterial and antifungal screening showed a remarkable zone of inhibition, of the diameter 14–26 mm and 12–28 mm, by MEBS. The present study revealed that MEBS has remarkable anti-diarrheal potential and is highly effective in wide-spectrum bacterial and fungal strains. Moreover, the in silico study validated the results of biological screenings. To conclude, MEBS is presumed to be a good source in treating diarrhea, bacterial and fungal infections.
    Keywords Bauhinia ; asthma ; cholera ; computer simulation ; diabetes ; diarrhea ; dose response ; drugs ; fungi ; medicine ; phytochemicals
    Language English
    Dates of publication 2022-0109
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2518386-2
    ISSN 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu14020265
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Health shocks, care-seeking behaviour and coping strategies of extreme poor households in Bangladesh’s Chittagong Hill tracts

    Ashraful Kabir / Rupa Datta / Sayeed Hasan Raza / Mathilde Rose Louise Maitrot

    BMC Public Health, Vol 19, Iss 1, Pp 1-

    2019  Volume 12

    Abstract: Abstract Background How and whether health shocks, care-seeking behaviour and coping strategies are interlinked and influence households resilience to ill-health remains an under-researched subject in the context of Bangladesh. This study investigates ... ...

    Abstract Abstract Background How and whether health shocks, care-seeking behaviour and coping strategies are interlinked and influence households resilience to ill-health remains an under-researched subject in the context of Bangladesh. This study investigates whether and how health shocks, care-seeking processes and coping strategies interplay and impact the resilience of extremely poor adivasi (ethnic minority) households in the Chittagong Hill Tracts (CHT), Bangladesh. Methods Our analysis draws from qualitative data collected through a range of methods (see Additional file 1). We conducted 25 in-depth interviews (IDIs) of two adivasi communities targeted by an extreme-poverty alleviation programme, 11 key informant interviews (KIIs) with project personnel (community workers, field officers, project managers), community leaders, and healthcare providers, and 9 focus group discussions (FGDs) with community members. Data triangulation was performed to further validate the data, and a thematic analysis approach was used to analyze the data. Results Health shocks were a defining characteristic of households’ experiences of extreme poverty in the studied region. Care-seeking behaviours are influenced by an array of cultural and economic factors. Households adopt a range of coping strategies during the treatment or care-seeking process, which are often insufficient to allow households to maintain a stable economic status. This is largely due to the fact that healthcare costs are borne by the household, primarily through out-of-pocket payments. Households meet healthcare cost by selling their means of livelihoods, borrowing cash, and marketing livestock. This process erodes their wellbeing and hinders they attempt at achieving resilience, despite their involvement in an extreme poverty-alleviation programme. Conclusions Livelihood supports or asset-transfers alone are insufficient to improve household resilience in this context. Therefore, we argue that extreme poor households’ healthcare needs should be central to the ...
    Keywords Adivasi (ethnic minority) ; Care-seeking behaviour ; Bangladesh ; Chittagong Hill tracts ; Coping strategies extreme poor households ; Health shocks ; Public aspects of medicine ; RA1-1270
    Subject code 360
    Language English
    Publishing date 2019-07-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Design and synthesis of (S)- and (R)-enantiomers of [4-(2-hydroxy-1-phenylethylimino)pent-2-ol]dimethyltin(iv) and 2,2-dimethyl-4-phenyl-1,3,2-oxazastannolidine: in vitro antitumor activity against human tumor cell lines and in vivo assay of (S)-enantiomers.

    Arjmand, Farukh / Sayeed, Fatima / Parveen, Shazia / Tabassum, Sartaj / Juvekar, Aarti S / Zingde, Surekha M

    Dalton transactions (Cambridge, England : 2003)

    2013  Volume 42, Issue 10, Page(s) 3390–3401

    Abstract: New dimethyltin derived antitumor drug candidates (S)- and (R)-[4-(2-hydroxy-1-phenylethylimino ... pent-2-ol]dimethyltin(iv), 1 and (S)- and (R)-[2,2-dimethyl-4-phenyl-1,3,2-oxazastannolidine], 2 ... derived from (R)- and (S)-enantiomers of [4-(2-hydroxy-1-phenylethylimino)pent-2-ol] and 2-amino-2 ...

    Abstract New dimethyltin derived antitumor drug candidates (S)- and (R)-[4-(2-hydroxy-1-phenylethylimino)pent-2-ol]dimethyltin(iv), 1 and (S)- and (R)-[2,2-dimethyl-4-phenyl-1,3,2-oxazastannolidine], 2 derived from (R)- and (S)-enantiomers of [4-(2-hydroxy-1-phenylethylimino)pent-2-ol] and 2-amino-2-phenylethanol, respectively, were synthesized and thoroughly characterized. Preliminary complex-DNA interaction studies employing various optical methods revealed that the (S)-enantiomer displayed a higher propensity towards the drug target DNA double helix. This was quantified by K(b) and K(sv) values of ligands L and L' and (S)-/(R)-1 and (S)-/(R)-2 complexes, which demonstrated a multifold increase in the case of the (S)-enantiomers in comparison to their (R)-enantiomeric forms. This clearly demonstrates the chiral preference of the (S)-enantiomer over the (R)-enantiomer, and its potency to act as a chemotherapeutic agent. Therefore, the in vitro antitumor activity of the (S)-enantiomer of 1 and 2 was evaluated by the sulforhodamine-B (SRB) assay to assess cellular proliferation against five different human cell lines viz., Hop62, DWD, K562, DU145 and MCF-7. The complex (S)-1 displayed a remarkably pronounced and specific activity for K562, while complex (S)-2 exhibited significant activity towards Hop62, DWD, DU145 and MCF-7. The in vivo antitumor activity of (S)-1 and (S)-2 was carried out, which revealed significant regression in human lung tumors.
    MeSH term(s) Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/therapeutic use ; Antineoplastic Agents/toxicity ; Cell Line, Tumor ; Cell Survival/drug effects ; Coordination Complexes/chemical synthesis ; Coordination Complexes/therapeutic use ; Coordination Complexes/toxicity ; DNA/chemistry ; DNA/metabolism ; DNA Cleavage/drug effects ; Drug Design ; Drug Screening Assays, Antitumor ; Humans ; K562 Cells ; Kinetics ; Lung Neoplasms/drug therapy ; MCF-7 Cells ; Mice ; Mice, Nude ; Organotin Compounds/chemical synthesis ; Organotin Compounds/therapeutic use ; Organotin Compounds/toxicity ; Osmolar Concentration ; Schiff Bases/chemistry ; Stereoisomerism ; Tin Compounds/chemical synthesis ; Tin Compounds/therapeutic use ; Tin Compounds/toxicity ; Transplantation, Heterologous
    Chemical Substances (4-(2-hydroxy-1-phenylethylimino)pent-2-ol)dimethyltin ; 2,2-dimethyl-4-phenyl-1,3,2-oxazastannolidine ; Antineoplastic Agents ; Coordination Complexes ; Organotin Compounds ; Schiff Bases ; Tin Compounds ; DNA (9007-49-2)
    Language English
    Publishing date 2013-03-14
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/c2dt32155f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Brain Calcifications Secondary to Idiopathic Hyperthyroidism and Hypoparathyroidism.

    Sayeed, Bushra Zafar / Sayeed, Faiza Zafar / Nashit, Muhammad / Bhatty, Shaheen

    Ochsner journal

    2024  Volume 24, Issue 1, Page(s) 53–57

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-03-07
    Publishing country United States
    Document type Case Reports
    ISSN 1524-5012
    ISSN 1524-5012
    DOI 10.31486/toj.23.0004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Interferon-γ and proliferation responses to Salmonella enterica Serotype Typhi proteins in patients with S. Typhi Bacteremia in Dhaka, Bangladesh.

    Sheikh, Alaullah / Khanam, Farhana / Sayeed, Md Abu / Rahman, Taibur / Pacek, Marcin / Hu, Yanhui / Rollins, Andrea / Bhuiyan, Md Saruar / Rollins, Sean / Kalsy, Anuj / Arifuzzaman, Mohammad / Leung, Daniel T / Sarracino, David A / Krastins, Bryan / Charles, Richelle C / Larocque, Regina C / Cravioto, Alejandro / Calderwood, Stephen B / Brooks, W Abdullah /
    Harris, Jason B / Labaer, Joshua / Qadri, Firdausi / Ryan, Edward T

    PLoS neglected tropical diseases

    2011  Volume 5, Issue 6, Page(s) e1193

    Abstract: ... Despite this, there are limited data on cellular immune responses in humans infected with wild type S ... a subset of S. Typhi proteins identified in previous antibody-based immuno-affinity screens and antigens ... conserved hypothetical protein-STY2195; we also generated and analyzed a crude membrane preparation of S ...

    Abstract Background: Salmonella enterica serotype Typhi is a human-restricted intracellular pathogen and the cause of typhoid fever. Cellular immune responses are required to control and clear Salmonella infection. Despite this, there are limited data on cellular immune responses in humans infected with wild type S. Typhi.
    Methodology/principal findings: For this work, we used an automated approach to purify a subset of S. Typhi proteins identified in previous antibody-based immuno-affinity screens and antigens known to be expressed in vivo, including StaF-putative fimbrial protein-STY0202, StbB-fimbrial chaperone-STY0372, CsgF-involved in curli production-STY1177, CsgD- putative regulatory protein-STY1179, OppA-periplasmic oligopeptide binding protein precursor-STY1304, PagC-outer membrane invasion protein-STY1878, and conserved hypothetical protein-STY2195; we also generated and analyzed a crude membrane preparation of S. Typhi (MP). In comparison to samples collected from uninfected Bangladeshi and North American participants, we detected significant interferon-γ responses in PBMCs stimulated with MP, StaF, StbB, CsgF, CsgD, OppA, STY2195, and PagC in patients bacteremic with S. Typhi in Bangladesh. The majority of interferon-γ expressing T cells were CD4 cells, although CD8 responses also occurred. We also assessed cellular proliferation responses in bacteremic patients, and confirmed increased responses in infected individuals to MP, StaF, STY2195, and PagC in convalescent compared to acute phase samples and compared to controls. StaF is a fimbrial protein homologous to E. coli YadK, and contains a Pfam motif thought to be involved in cellular adhesion. PagC is expressed in vivo under the control of the virulence-associated PhoP-regulon required for intra-macrophage survival of Salmonella. STY2195 is a conserved hypothetical protein of unknown function.
    Conclusion/significance: This is the first analysis of cellular immune responses to purified S. Typhi antigens in patients with typhoid fever. These results indicate that patients generate significant CD4 and CD8 interferon-γ responses to specific S. Typhi antigens during typhoid fever, and that these responses are elevated at the time of clinical presentation. These observations suggest that an interferon-γ based detection system could be used to diagnose individuals with typhoid fever during the acute stage of illness.
    MeSH term(s) Adolescent ; Adult ; Antigens, Bacterial/immunology ; Bacteremia/immunology ; Bacteremia/microbiology ; Bangladesh ; Cell Proliferation ; Cells, Cultured ; Child ; Child, Preschool ; Humans ; Infant ; Interferon-gamma/metabolism ; Leukocytes, Mononuclear/immunology ; Middle Aged ; Salmonella typhi/immunology ; Typhoid Fever/immunology ; Typhoid Fever/microbiology ; Young Adult
    Chemical Substances Antigens, Bacterial ; Interferon-gamma (82115-62-6)
    Language English
    Publishing date 2011-06-07
    Publishing country United States
    Document type Journal Article ; Research Support, American Recovery and Reinvestment Act ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2429704-5
    ISSN 1935-2735 ; 1935-2727
    ISSN (online) 1935-2735
    ISSN 1935-2727
    DOI 10.1371/journal.pntd.0001193
    Database MEDical Literature Analysis and Retrieval System OnLINE

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