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Book ; Online ; Thesis: Control of immunological synapse formation in regulatory T cells

Niemz, Jana Verfasser] / [Korte, Martin [Akademischer Betreuer]

2017

Author's details	Jana Niemz ; Betreuer: Martin Korte
Keywords	Biowissenschaften, Biologie ; Life Science, Biology
Subject code	sg570
Language	English
Publisher	Technische Universität Braunschweig
Publishing place	Braunschweig
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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Article: The Guanine-Nucleotide Exchange Factor Caldag Gefi Fine-Tunes Functional Properties of Regulatory T Cells.

Niemz, Jana / Kliche, Stefanie / Pils, Marina C / Morrison, Eliot / Manns, Annika / Freund, Christian / Crittenden, Jill R / Graybiel, Ann M / Galla, Melanie / Jänsch, Lothar / Huehn, Jochen

European journal of microbiology & immunology

2017 Volume 7, Issue 2, Page(s) 112–126

Abstract: Using quantitative phosphopeptide sequencing of unstimulated versus stimulated primary murine ... ...

Abstract	Using quantitative phosphopeptide sequencing of unstimulated versus stimulated primary murine Foxp3
Language	English
Publishing date	2017-05-22
Publishing country	Hungary
Document type	Journal Article
ZDB-ID	2652327-9
ISSN	2062-8633 ; 2062-509X
ISSN (online)	2062-8633
ISSN	2062-509X
DOI	10.1556/1886.2017.00007
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Yersinia pseudotuberculosis supports Th17 differentiation and limits de novo regulatory T cell induction by directly interfering with T cell receptor signaling.

Pasztoi, Maria / Bonifacius, Agnes / Pezoldt, Joern / Kulkarni, Devesha / Niemz, Jana / Yang, Juhao / Teich, René / Hajek, Janina / Pisano, Fabio / Rohde, Manfred / Dersch, Petra / Huehn, Jochen

Cellular and molecular life sciences : CMLS

2017 Volume 74, Issue 15, Page(s) 2839–2850

Abstract: Adaptive immunity critically contributes to control acute infection with enteropathogenic Yersinia pseudotuberculosis; however, the role of ... ...

Abstract	Adaptive immunity critically contributes to control acute infection with enteropathogenic Yersinia pseudotuberculosis; however, the role of CD4
MeSH term(s)	Animals ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/microbiology ; Cell Differentiation ; Female ; Forkhead Transcription Factors/immunology ; Host-Pathogen Interactions ; Intestines/immunology ; Intestines/microbiology ; Mice, Inbred BALB C ; Receptors, Antigen, T-Cell/immunology ; Signal Transduction ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/microbiology ; Th17 Cells/immunology ; Th17 Cells/microbiology ; Yersinia pseudotuberculosis/immunology ; Yersinia pseudotuberculosis/physiology ; Yersinia pseudotuberculosis Infections/immunology
Chemical Substances	Forkhead Transcription Factors ; Foxp3 protein, mouse ; Receptors, Antigen, T-Cell
Language	English
Publishing date	2017-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1358415-7
ISSN	1420-9071 ; 1420-682X
ISSN (online)	1420-9071
ISSN	1420-682X
DOI	10.1007/s00018-017-2516-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 195: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: Yersinia pseudotuberculosis supports Th17 differentiation and limits de novo regulatory T cell induction by directly interfering with T cell receptor signaling

Pasztoi, Maria / Agnes Bonifacius / Joern Pezoldt / Devesha Kulkarni / Jana Niemz / Juhao Yang / RenÃ© Teich / Janina Hajek / Fabio Pisano / Manfred Rohde / Petra Dersch / Jochen Huehn

Cellular and molecular life sciences. 2017 Aug., v. 74, no. 15

2017

Abstract: Adaptive immunity critically contributes to control acute infection with enteropathogenic Yersinia pseudotuberculosis; however, the role of CD4âº T cell subsets in establishing infection and allowing pathogen persistence remains elusive. Here, we ... ...

Abstract	Adaptive immunity critically contributes to control acute infection with enteropathogenic Yersinia pseudotuberculosis; however, the role of CD4âº T cell subsets in establishing infection and allowing pathogen persistence remains elusive. Here, we assessed the modulatory capacity of Y. pseudotuberculosis on CD4âº T cell differentiation. Using in vivo assays, we report that infection with Y. pseudotuberculosis resulted in enhanced priming of IL-17-producing T cells (Th17 cells), whereas induction of Foxp3âº regulatory T cells (Tregs) was severely disrupted in gut-draining mesenteric lymph nodes (mLNs), in line with altered frequencies of tolerogenic and proinflammatory dendritic cell (DC) subsets within mLNs. Additionally, by using a DC-free in vitro system, we could demonstrate that Y. pseudotuberculosis can directly modulate T cell receptor (TCR) downstream signaling within naÃ¯ve CD4âº T cells and Tregs via injection of effector molecules through the type III secretion system, thereby affecting their functional properties. Importantly, modulation of naÃ¯ve CD4âº T cells by Y. pseudotuberculosis resulted in an enhanced Th17 differentiation and decreased induction of Foxp3âº Tregs in vitro. These findings shed light to the adjustment of the Th17-Treg axis in response to acute Y. pseudotuberculosis infection and highlight the direct modulation of CD4âº T cell subsets by altering their TCR downstream signaling.
Keywords	CD4-positive T-lymphocytes ; Yersinia pseudotuberculosis ; acute course ; adaptive immunity ; cell differentiation ; chemical elements ; functional properties ; infectious diseases ; lymph nodes ; pathogen survival ; type III secretion system
Language	English
Dates of publication	2017-08
Size	p. 2839-2850.
Publishing place	Springer International Publishing
Document type	Article
ZDB-ID	1358415-7
ISSN	1420-9071 ; 1420-682X
ISSN (online)	1420-9071
ISSN	1420-682X
DOI	10.1007/s00018-017-2516-y
Database	NAL-Catalogue (AGRICOLA)

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Z 4' 47/14: Show issues

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Article ; Online: TCR signalling network organization at the immunological synapses of murine regulatory T cells.

van Ham, Marco / Teich, René / Philipsen, Lars / Niemz, Jana / Amsberg, Nicole / Wissing, Josef / Nimtz, Manfred / Gröbe, Lothar / Kliche, Stefanie / Thiel, Nadine / Klawonn, Frank / Hubo, Mario / Jonuleit, Helmut / Reichardt, Peter / Müller, Andreas J / Huehn, Jochen / Jänsch, Lothar

European journal of immunology

2017 Volume 47, Issue 12, Page(s) 2043–2058

Abstract: Regulatory T (Treg) cells require T-cell receptor (TCR) signalling to exert their immunosuppressive activity, but the precise organization of the TCR signalling network compared to conventional T (Tconv) cells remains elusive. By using accurate mass ... ...

Abstract	Regulatory T (Treg) cells require T-cell receptor (TCR) signalling to exert their immunosuppressive activity, but the precise organization of the TCR signalling network compared to conventional T (Tconv) cells remains elusive. By using accurate mass spectrometry and multi-epitope ligand cartography (MELC) we characterized TCR signalling and recruitment of TCR signalling components to the immunological synapse (IS) in Treg cells and Tconv cells. With the exception of Themis which we detected in lower amounts in Treg cells, other major TCR signalling components were found equally abundant, however, their phosphorylation-status notably discriminates Treg cells from Tconv cells. Overall, this study identified 121 Treg cell-specific phosphorylations. Short-term triggering of T cell subsets via CD3 and CD28 widely harmonized these variations with the exception of eleven TCR signalling components that mainly regulate cytoskeleton dynamics and molecular transport. Accordingly, conjugation with B cells indeed caused variant cellular morphology and revealed a Treg cell-specific recruitment of TCR signalling components such as PKCθ, PLCγ1 and ZAP70 as well as B cell-derived CD86 into the IS. Together, results from this study support the existence of a Treg cell-specific IS and suggest Treg cell-specific cytoskeleton dynamics as a novel determinant for the unique functional properties of Treg cells.
MeSH term(s)	Animals ; Cells, Cultured ; Female ; Immunological Synapses/immunology ; Mice, Inbred BALB C ; Microscopy, Fluorescence ; Phosphorylation ; Proteome/immunology ; Proteome/metabolism ; Proteomics/methods ; Receptors, Antigen, T-Cell/immunology ; Receptors, Antigen, T-Cell/metabolism ; Signal Transduction/immunology ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/metabolism ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/metabolism ; ZAP-70 Protein-Tyrosine Kinase/immunology ; ZAP-70 Protein-Tyrosine Kinase/metabolism
Chemical Substances	Proteome ; Receptors, Antigen, T-Cell ; ZAP-70 Protein-Tyrosine Kinase (EC 2.7.10.2) ; ZAP70 protein, human (EC 2.7.10.2)
Language	English
Publishing date	2017-09-12
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120108-6
ISSN	1521-4141 ; 0014-2980
ISSN (online)	1521-4141
ISSN	0014-2980
DOI	10.1002/eji.201747041
Database	MEDical Literature Analysis and Retrieval System OnLINE

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In stock of ZB MED Cologne/Königswinter

Zs.A 489: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 85: Show issues

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Article ; Online: Yersinia pseudotuberculosis supports Th17 differentiation and limits de novo regulatory T cell induction by directly interfering with T cell receptor signaling.

Pasztoi, Maria / Bonifacius, Agnes / Pezoldt, Joern / Kulkarni, Devesha / Niemz, Jana / Yang, Juhao / Teich, René / Hajek, Janina / Pisano, Fabio / Rohde, Manfred / Dersch, Petra / Huehn, Jochen

2017

Abstract: Adaptive immunity critically contributes to control acute infection with enteropathogenic Yersinia pseudotuberculosis; however, the role of CD4(+) T cell subsets in establishing infection and allowing pathogen persistence remains elusive. Here, we ... ...

Abstract	Adaptive immunity critically contributes to control acute infection with enteropathogenic Yersinia pseudotuberculosis; however, the role of CD4(+) T cell subsets in establishing infection and allowing pathogen persistence remains elusive. Here, we assessed the modulatory capacity of Y. pseudotuberculosis on CD4(+) T cell differentiation. Using in vivo assays, we report that infection with Y. pseudotuberculosis resulted in enhanced priming of IL-17-producing T cells (Th17 cells), whereas induction of Foxp3(+) regulatory T cells (Tregs) was severely disrupted in gut-draining mesenteric lymph nodes (mLNs), in line with altered frequencies of tolerogenic and proinflammatory dendritic cell (DC) subsets within mLNs. Additionally, by using a DC-free in vitro system, we could demonstrate that Y. pseudotuberculosis can directly modulate T cell receptor (TCR) downstream signaling within naïve CD4(+) T cells and Tregs via injection of effector molecules through the type III secretion system, thereby affecting their functional properties. Importantly, modulation of naïve CD4(+) T cells by Y. pseudotuberculosis resulted in an enhanced Th17 differentiation and decreased induction of Foxp3(+) Tregs in vitro. These findings shed light to the adjustment of the Th17-Treg axis in response to acute Y. pseudotuberculosis infection and highlight the direct modulation of CD4(+) T cell subsets by altering their TCR downstream signaling.
Subject code	570
Language	English
Publishing date	2017-04-04
Publishing country	de
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Yersinia pseudotuberculosis supports Th17 differentiation and limits de novo regulatory T cell induction by directly interfering with T cell receptor signaling.

Pasztoi, Maria / Bonifacius, Agnes / Pezoldt, Joern / Kulkarni, Devesha / Niemz, Jana / Yang, Juhao / Teich, René / Hajek, Janina / Pisano, Fabio / Rohde, Manfred / Dersch, Petra / Huehn, Jochen

2017

Abstract	Adaptive immunity critically contributes to control acute infection with enteropathogenic Yersinia pseudotuberculosis; however, the role of CD4(+) T cell subsets in establishing infection and allowing pathogen persistence remains elusive. Here, we assessed the modulatory capacity of Y. pseudotuberculosis on CD4(+) T cell differentiation. Using in vivo assays, we report that infection with Y. pseudotuberculosis resulted in enhanced priming of IL-17-producing T cells (Th17 cells), whereas induction of Foxp3(+) regulatory T cells (Tregs) was severely disrupted in gut-draining mesenteric lymph nodes (mLNs), in line with altered frequencies of tolerogenic and proinflammatory dendritic cell (DC) subsets within mLNs. Additionally, by using a DC-free in vitro system, we could demonstrate that Y. pseudotuberculosis can directly modulate T cell receptor (TCR) downstream signaling within naïve CD4(+) T cells and Tregs via injection of effector molecules through the type III secretion system, thereby affecting their functional properties. Importantly, modulation of naïve CD4(+) T cells by Y. pseudotuberculosis resulted in an enhanced Th17 differentiation and decreased induction of Foxp3(+) Tregs in vitro. These findings shed light to the adjustment of the Th17-Treg axis in response to acute Y. pseudotuberculosis infection and highlight the direct modulation of CD4(+) T cell subsets by altering their TCR downstream signaling.
Subject code	570
Language	English
Publishing date	2017-04-04
Publishing country	de
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells.

Ranjan, Satish / Goihl, Alexander / Kohli, Shrey / Gadi, Ihsan / Pierau, Mandy / Shahzad, Khurrum / Gupta, Dheerendra / Bock, Fabian / Wang, Hongjie / Shaikh, Haroon / Kähne, Thilo / Reinhold, Dirk / Bank, Ute / Zenclussen, Ana C / Niemz, Jana / Schnöder, Tina M / Brunner-Weinzierl, Monika / Fischer, Thomas / Kalinski, Thomas /

Schraven, Burkhart / Luft, Thomas / Huehn, Jochen / Naumann, Michael / Heidel, Florian H / Isermann, Berend

Nature communications

2017 Volume 8, Issue 1, Page(s) 311

Abstract: Graft-vs.-host disease (GvHD) is a major complication of allogenic hematopoietic stem-cell(HSC) transplantation. GvHD is associated with loss of endothelial thrombomodulin, but the relevance of this for the adaptive immune response to transplanted HSCs ... ...

Abstract	Graft-vs.-host disease (GvHD) is a major complication of allogenic hematopoietic stem-cell(HSC) transplantation. GvHD is associated with loss of endothelial thrombomodulin, but the relevance of this for the adaptive immune response to transplanted HSCs remains unknown. Here we show that the protease-activated protein C (aPC), which is generated by thrombomodulin, ameliorates GvHD aPC restricts allogenic T-cell activation via the protease activated receptor (PAR)2/PAR3 heterodimer on regulatory T-cells (T
MeSH term(s)	Animals ; Graft vs Host Disease/etiology ; Graft vs Host Disease/immunology ; Hematopoietic Stem Cell Transplantation/adverse effects ; Hematopoietic Stem Cell Transplantation/methods ; Humans ; Kaplan-Meier Estimate ; Mice, Inbred BALB C ; Mice, Inbred C3H ; Mice, Inbred C57BL ; Mice, Inbred NOD ; Mice, Knockout ; Mice, SCID ; Mice, Transgenic ; Protein C/immunology ; Protein C/metabolism ; Protein Multimerization ; Receptor, PAR-2/chemistry ; Receptor, PAR-2/immunology ; Receptor, PAR-2/metabolism ; Receptors, Proteinase-Activated/chemistry ; Receptors, Proteinase-Activated/immunology ; Receptors, Proteinase-Activated/metabolism ; Receptors, Thrombin/chemistry ; Receptors, Thrombin/immunology ; Receptors, Thrombin/metabolism ; Signal Transduction/immunology ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/metabolism ; Transplantation, Homologous
Chemical Substances	Protein C ; Receptor, PAR-2 ; Receptors, Proteinase-Activated ; Receptors, Thrombin ; protease-activated receptor 3
Language	English
Publishing date	2017-08-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2041-1723
ISSN (online)	2041-1723
DOI	10.1038/s41467-017-00169-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells

Satish Ranjan / Alexander Goihl / Shrey Kohli / Ihsan Gadi / Mandy Pierau / Khurrum Shahzad / Dheerendra Gupta / Fabian Bock / Hongjie Wang / Haroon Shaikh / Thilo Kähne / Dirk Reinhold / Ute Bank / Ana C. Zenclussen / Jana Niemz / Tina M. Schnöder / Monika Brunner-Weinzierl / Thomas Fischer / Thomas Kalinski /

Burkhart Schraven / Thomas Luft / Jochen Huehn / Michael Naumann / Florian H. Heidel / Berend Isermann

Nature Communications, Vol 8, Iss 1, Pp 1-

2017 Volume 16

Abstract: Graft-vs.-host disease is a complication of allogenic hematopoietic stem cell transplantation, and is associated with endothelial dysfunction. Here the authors show that activated protein C signals via PAR2/PAR3 to expand Treg cells, mitigating the ... ...

Abstract	Graft-vs.-host disease is a complication of allogenic hematopoietic stem cell transplantation, and is associated with endothelial dysfunction. Here the authors show that activated protein C signals via PAR2/PAR3 to expand Treg cells, mitigating the disease in mice.
Keywords	Science ; Q
Language	English
Publishing date	2017-08-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: TCR signalling network organization at the immunological synapses of murine regulatory T cells.

2017

Abstract	Regulatory T (Treg) cells require T-cell receptor (TCR) signalling to exert their immunosuppressive activity, but the precise organization of the TCR signalling network compared to conventional T (Tconv) cells remains elusive. By using accurate mass spectrometry and multi-epitope ligand cartography (MELC) we characterized TCR signalling and recruitment of TCR signalling components to the immunological synapse (IS) in Treg cells and Tconv cells. With the exception of Themis which we detected in lower amounts in Treg cells, other major TCR signalling components were found equally abundant, however, their phosphorylation-status notably discriminates Treg cells from Tconv cells. Overall, this study identified 121 Treg cell-specific phosphorylations. Short-term triggering of T cell subsets via CD3 and CD28 widely harmonized these variations with the exception of eleven TCR signalling components that mainly regulate cytoskeleton dynamics and molecular transport. Accordingly, conjugation with B cells indeed caused variant cellular morphology and revealed a Treg cell-specific recruitment of TCR signalling components such as PKCθ, PLCγ1 and ZAP70 as well as B cell-derived CD86 into the IS. Together, results from this study support the existence of a Treg cell-specific IS and suggest Treg cell-specific cytoskeleton dynamics as a novel determinant for the unique functional properties of Treg cells.
Subject code	570
Language	English
Publishing date	2017-08-17
Publishing country	de
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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