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  1. Article ; Online: Pressure regulates immune-cell function.

    Walmsley, Sarah R

    Nature

    2019  Volume 573, Issue 7772, Page(s) 41–42

    MeSH term(s) Immunity, Innate ; Physical Phenomena
    Language English
    Publishing date 2019-09-03
    Publishing country England
    Document type News ; Comment
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-019-02339-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Making a bed for viral infections.

    Mirchandani, Ananda S / Walmsley, Sarah R

    Science (New York, N.Y.)

    2020  Volume 370, Issue 6513, Page(s) 166–167

    MeSH term(s) Humans ; Inflammation ; Respiratory Mucosa ; Virus Diseases
    Language English
    Publishing date 2020-10-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.abe3685
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  3. Article ; Online: The emerging role for metabolism in fueling neutrophilic inflammation.

    Morrison, Tyler / Watts, Emily R / Sadiku, Pranvera / Walmsley, Sarah R

    Immunological reviews

    2022  Volume 314, Issue 1, Page(s) 427–441

    Abstract: Neutrophils are a critical element of host defense and are rapidly recruited to inflammatory sites. Such sites are frequently limited in oxygen and/or nutrient availability, presenting a metabolic challenge for infiltrating cells. Long believed to be ... ...

    Abstract Neutrophils are a critical element of host defense and are rapidly recruited to inflammatory sites. Such sites are frequently limited in oxygen and/or nutrient availability, presenting a metabolic challenge for infiltrating cells. Long believed to be uniquely dependent on glycolysis, it is now clear that neutrophils possess far greater metabolic plasticity than previously thought, with the capacity to generate energy stores and utilize extracellular proteins to fuel central carbon metabolism and biosynthetic activity. Out-with cellular energetics, metabolic programs have also been implicated in the production of neutrophils and their progenitors in the bone marrow compartment, activation of neutrophil antimicrobial responses, inflammatory and cell survival signaling cascades, and training of the innate immune response. Thus, understanding the mechanisms by which metabolic processes sustain changes in neutrophil effector functions and how these are subverted in disease states provides exciting new avenues for the treatment of dysfunctional neutrophilic inflammation which are lacking in clinical practice to date.
    MeSH term(s) Humans ; Inflammation ; Immunity, Innate ; Neutrophils
    Language English
    Publishing date 2022-11-03
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 391796-4
    ISSN 1600-065X ; 0105-2896
    ISSN (online) 1600-065X
    ISSN 0105-2896
    DOI 10.1111/imr.13157
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Hypoxia and the regulation of myeloid cell metabolic imprinting: consequences for the inflammatory response.

    Sadiku, Pranvera / Walmsley, Sarah R

    EMBO reports

    2019  Volume 20, Issue 5

    Abstract: Inflamed and infected tissue sites are characterised by oxygen and nutrient deprivation. The cellular adaptations to insufficient oxygenation, hypoxia, are mainly regulated by a family of transcription factors known as hypoxia-inducible factors (HIFs). ... ...

    Abstract Inflamed and infected tissue sites are characterised by oxygen and nutrient deprivation. The cellular adaptations to insufficient oxygenation, hypoxia, are mainly regulated by a family of transcription factors known as hypoxia-inducible factors (HIFs). The protein members of the HIF signalling pathway are critical regulators of both the innate and adaptive immune responses, and there is an increasing body of evidence to suggest that the elicited changes occur through cellular metabolic reprogramming. Here, we review the literature on innate immunometabolism to date and discuss the role of hypoxia in innate cell metabolic reprogramming, and how this determines immune responses.
    MeSH term(s) Adaptive Immunity/immunology ; Animals ; Cell Hypoxia/immunology ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/immunology ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Immunity, Innate/immunology ; Inflammation/immunology ; Inflammation/metabolism ; Myeloid Cells/immunology ; Myeloid Cells/metabolism ; Oxygen/metabolism ; Signal Transduction/immunology
    Chemical Substances Hypoxia-Inducible Factor 1, alpha Subunit ; Oxygen (S88TT14065)
    Language English
    Publishing date 2019-03-14
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2020896-0
    ISSN 1469-3178 ; 1469-221X
    ISSN (online) 1469-3178
    ISSN 1469-221X
    DOI 10.15252/embr.201847388
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Getting DAMP(s) Wets the Whistle for Neutrophil Recruitment.

    Watts, Emily R / Walmsley, Sarah R

    Immunity

    2018  Volume 48, Issue 5, Page(s) 846–848

    Abstract: Neutrophil recruitment in response to pathogen invasion is mediated through "self" tissue damage signals (DAMPs) and pathogen associated signals (PAMPs). In this issue of Immunity, Huang and Niethammer, (2018) demonstrate that DAMP signaling is a ... ...

    Abstract Neutrophil recruitment in response to pathogen invasion is mediated through "self" tissue damage signals (DAMPs) and pathogen associated signals (PAMPs). In this issue of Immunity, Huang and Niethammer, (2018) demonstrate that DAMP signaling is a prerequisite for neutrophil recruitment.
    MeSH term(s) Animals ; Immunity, Innate ; Neutrophil Infiltration ; Signal Transduction ; Zebrafish
    Language English
    Publishing date 2018-05-31
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2018.04.027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Inflammation and Hypoxia: HIF and PHD Isoform Selectivity.

    Watts, Emily R / Walmsley, Sarah R

    Trends in molecular medicine

    2018  Volume 25, Issue 1, Page(s) 33–46

    Abstract: Cells sense and respond to hypoxia through the activity of the transcription factor HIF (hypoxia-inducible factor) and its regulatory hydroxylases, the prolyl hydroxylase domain enzymes (PHDs). Multiple isoforms of HIFs and PHDs exist, and isoform- ... ...

    Abstract Cells sense and respond to hypoxia through the activity of the transcription factor HIF (hypoxia-inducible factor) and its regulatory hydroxylases, the prolyl hydroxylase domain enzymes (PHDs). Multiple isoforms of HIFs and PHDs exist, and isoform-selective roles have been identified in the context of the inflammatory environment, which is itself frequently hypoxic. Recent advances in the field have highlighted the complexity of this system, particularly with regards to the cell and context-specific activity of HIFs and PHDs. Because novel therapeutic agents which regulate this pathway are nearing the clinic, understanding the role of HIFs and PHDs in inflammation outcomes is an essential step in avoiding off-target effects and, crucially, in developing new anti-inflammatory strategies.
    MeSH term(s) Animals ; Humans ; Hypoxia/metabolism ; Hypoxia-Inducible Factor 1/metabolism ; Inflammation/metabolism ; Procollagen-Proline Dioxygenase/metabolism
    Chemical Substances Hypoxia-Inducible Factor 1 ; Procollagen-Proline Dioxygenase (EC 1.14.11.2)
    Language English
    Publishing date 2018-11-12
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2036490-8
    ISSN 1471-499X ; 1471-4914
    ISSN (online) 1471-499X
    ISSN 1471-4914
    DOI 10.1016/j.molmed.2018.10.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The emerging role for metabolism in fueling neutrophilic inflammation

    Morrison, Tyler / Watts, Emily R. / Sadiku, Pranvera / Walmsley, Sarah R.

    Immunological Reviews 2023 Mar., v. 314, no. 1, p. 427-441

    2023  , Page(s) 427–441

    Abstract: Neutrophils are a critical element of host defense and are rapidly recruited to inflammatory sites. Such sites are frequently limited in oxygen and/or nutrient availability, presenting a metabolic challenge for infiltrating cells. Long believed to be ... ...

    Abstract Neutrophils are a critical element of host defense and are rapidly recruited to inflammatory sites. Such sites are frequently limited in oxygen and/or nutrient availability, presenting a metabolic challenge for infiltrating cells. Long believed to be uniquely dependent on glycolysis, it is now clear that neutrophils possess far greater metabolic plasticity than previously thought, with the capacity to generate energy stores and utilize extracellular proteins to fuel central carbon metabolism and biosynthetic activity. Out‐with cellular energetics, metabolic programs have also been implicated in the production of neutrophils and their progenitors in the bone marrow compartment, activation of neutrophil antimicrobial responses, inflammatory and cell survival signaling cascades, and training of the innate immune response. Thus, understanding the mechanisms by which metabolic processes sustain changes in neutrophil effector functions and how these are subverted in disease states provides exciting new avenues for the treatment of dysfunctional neutrophilic inflammation which are lacking in clinical practice to date.
    Keywords biosynthesis ; bone marrow ; carbon metabolism ; cell viability ; energy ; glycolysis ; inflammation ; innate immunity ; neutrophils ; nutrient availability ; oxygen
    Language English
    Dates of publication 2023-03
    Size p. 427-441.
    Publishing place John Wiley & Sons, Inc
    Document type Article ; Online
    Note REVIEW
    ZDB-ID 391796-4
    ISSN 1600-065X ; 0105-2896
    ISSN (online) 1600-065X
    ISSN 0105-2896
    DOI 10.1111/imr.13157
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: Hypoxia and host pathogen responses.

    Walmsley, Sarah R / Rupp, Jan

    Microbes and infection

    2017  Volume 19, Issue 3, Page(s) 143

    MeSH term(s) Adaptation, Physiological ; Cell Hypoxia/immunology ; Cell Hypoxia/physiology ; Gene Expression Regulation ; Host-Pathogen Interactions/genetics ; Host-Pathogen Interactions/immunology ; Host-Pathogen Interactions/physiology ; Hypoxia-Inducible Factor 1/genetics ; Hypoxia-Inducible Factor 1/metabolism ; Immune System ; Mixed Function Oxygenases/genetics ; Mixed Function Oxygenases/metabolism ; Oxygen/metabolism
    Chemical Substances Hypoxia-Inducible Factor 1 ; Mixed Function Oxygenases (EC 1.-) ; Oxygen (S88TT14065)
    Language English
    Publishing date 2017-01-20
    Publishing country France
    Document type Editorial
    ZDB-ID 1465093-9
    ISSN 1769-714X ; 1286-4579
    ISSN (online) 1769-714X
    ISSN 1286-4579
    DOI 10.1016/j.micinf.2017.01.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The role of neutrophils in cancer.

    Grecian, Robert / Whyte, Moira K B / Walmsley, Sarah R

    British medical bulletin

    2018  Volume 128, Issue 1, Page(s) 5–14

    Abstract: Introduction: It has been known for some time that neutrophils are present in the tumour microenvironment, but only recently have their roles been explored.: Sources of data: Comprehensive literature search of neutrophils and cancer (PubMed, Google ... ...

    Abstract Introduction: It has been known for some time that neutrophils are present in the tumour microenvironment, but only recently have their roles been explored.
    Sources of data: Comprehensive literature search of neutrophils and cancer (PubMed, Google Scholar and CrossRef) for key articles (systematic reviews, meta-analyses, primary research). References from these articles cross-checked for additional relevant studies.
    Areas of agreement: Neutrophils are a heterogeneous population with both pro- and antitumour roles, and display plasticity. Several neutrophil subpopulations have been identified, defined by a combination of features (density, maturity, surface markers, morphology and anatomical site).
    Areas of controversy: Limitations in translating murine tumour models to human pathology and paucity of human data. Consensus in defining human neutrophil subpopulations.
    Growing points: Neutrophils as therapeutic targets and as possible playmakers in the biological response to newer targeted cancer drugs.
    Areas timely for developing research: Understanding the metabolic programming of neutrophils in the tumour microenvironment.
    MeSH term(s) Humans ; Immunity, Cellular/physiology ; Neoplasms/immunology ; Neoplasms/pathology ; Neutrophils/immunology ; Neutrophils/pathology ; Signal Transduction ; Tumor Microenvironment/immunology
    Language English
    Publishing date 2018-08-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 213294-1
    ISSN 1471-8391 ; 0007-1420
    ISSN (online) 1471-8391
    ISSN 0007-1420
    DOI 10.1093/bmb/ldy029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Inflammatory Disease Affecting the Central Nervous System in Dogs: A Retrospective Study in England (2010-2019).

    Gonçalves, Rita / De Decker, Steven / Walmsley, Gemma / Butterfield, Sarah / Maddox, Thomas W

    Frontiers in veterinary science

    2022  Volume 8, Page(s) 819945

    Abstract: The epidemiology of inflammatory diseases affecting the central nervous system (CNS) in dogs is largely unknown. We aimed to report the relative proportion of different causes of inflammatory disease affecting the CNS in dogs and identify predictors for ... ...

    Abstract The epidemiology of inflammatory diseases affecting the central nervous system (CNS) in dogs is largely unknown. We aimed to report the relative proportion of different causes of inflammatory disease affecting the CNS in dogs and identify predictors for infectious vs. immune-mediated conditions and predictors for the most common diseases affecting the brain and the spinal cord. This was a retrospective cohort study over a 10-year period in 2 referral institutions using multivariable and multinomial logistic regression for identification of risk factors. In total, 1,140 client-owned dogs diagnosed with inflammatory disease affecting the CNS were included. Fifteen different diagnoses were identified, with immune-mediated (83.6%) disease being more common than infectious conditions (16.4%). The most common immune-mediated conditions diagnosed were meningoencephalitis of unknown origin (47.5%) and steroid-responsive meningitis-arteritis (30.7%), and the most common infectious conditions were discospondylitis (9.3%) and otogenic intracranial infection (2.2%). Older age (
    Language English
    Publishing date 2022-01-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2834243-4
    ISSN 2297-1769
    ISSN 2297-1769
    DOI 10.3389/fvets.2021.819945
    Database MEDical Literature Analysis and Retrieval System OnLINE

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