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  1. Article ; Online: Multidimensional Response Surface Methodology for the Development of a Gene Editing Protocol for p67

    Whittaker, Thomas E / Moula, Shefta E / Bahal, Sameer / Bakri, Faris Ghalib / Hayajneh, Wail Ahmad / Daoud, Ammar Khaled / Naseem, Asma / Cavazza, Alessia / Thrasher, Adrian J / Santilli, Giorgia

    Human gene therapy

    2024  Volume 35, Issue 7-8, Page(s) 298–312

    Abstract: Replacing a faulty gene with a correct copy has become a viable therapeutic option as a result of recent progress in gene editing protocols. Targeted integration of therapeutic genes in hematopoietic stem cells has been achieved for multiple genes using ... ...

    Abstract Replacing a faulty gene with a correct copy has become a viable therapeutic option as a result of recent progress in gene editing protocols. Targeted integration of therapeutic genes in hematopoietic stem cells has been achieved for multiple genes using Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 system and Adeno-Associated Virus (AAV) to carry a donor template. Although this is a promising strategy to correct genetic blood disorders, it is associated with toxicity and loss of function in CD34
    MeSH term(s) Humans ; Granulomatous Disease, Chronic/genetics ; Granulomatous Disease, Chronic/therapy ; Gene Editing ; Genetic Therapy/methods ; Antigens, CD34/genetics ; Hematopoietic Stem Cells/metabolism ; CRISPR-Cas Systems
    Chemical Substances Antigens, CD34
    Language English
    Publishing date 2024-01-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1028152-6
    ISSN 1557-7422 ; 1043-0342
    ISSN (online) 1557-7422
    ISSN 1043-0342
    DOI 10.1089/hum.2023.114
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2988: Show issues Location:
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  2. Article ; Online: The Highest Cited Papers in Brucellosis: Identification Using Two Databases and Review of the Papers' Major Findings.

    Bakri, Faris Ghalib / AlQadiri, Hamzah M / Adwan, Marwan Hmoud

    BioMed research international

    2018  Volume 2018, Page(s) 9291326

    Abstract: Citation classics represent the highest impact work in a given field. We aim to identify and analyze the most frequently cited papers on brucellosis. We used the databases Scopus and Web of Science to determine the most frequently cited papers. The most ... ...

    Abstract Citation classics represent the highest impact work in a given field. We aim to identify and analyze the most frequently cited papers on brucellosis. We used the databases Scopus and Web of Science to determine the most frequently cited papers. The most cited fifty papers in each database were identified. We then ranked the papers according to the highest citation count recorded from any of the two databases. The most frequently cited paper received 964 citations and was by DelVecchio VG et al. reporting the complete genomic sequencing of
    MeSH term(s) Bibliometrics ; Brucellosis/epidemiology ; Databases as Topic ; Humans ; Journal Impact Factor ; Periodicals as Topic
    Keywords covid19
    Language English
    Publishing date 2018-04-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2698540-8
    ISSN 2314-6141 ; 2314-6133
    ISSN (online) 2314-6141
    ISSN 2314-6133
    DOI 10.1155/2018/9291326
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The Highest Cited Papers in Brucellosis

    Faris Ghalib Bakri / Hamzah M. AlQadiri / Marwan Hmoud Adwan

    BioMed Research International, Vol

    Identification Using Two Databases and Review of the Papers’ Major Findings

    2018  Volume 2018

    Abstract: Citation classics represent the highest impact work in a given field. We aim to identify and analyze the most frequently cited papers on brucellosis. We used the databases Scopus and Web of Science to determine the most frequently cited papers. The most ... ...

    Abstract Citation classics represent the highest impact work in a given field. We aim to identify and analyze the most frequently cited papers on brucellosis. We used the databases Scopus and Web of Science to determine the most frequently cited papers. The most cited fifty papers in each database were identified. We then ranked the papers according to the highest citation count recorded from any of the two databases. The most frequently cited paper received 964 citations and was by DelVecchio VG et al. reporting the complete genomic sequencing of Brucella melitensis. The papers were published in 30 journals led by the “Infection and Immunity” journal and the “Veterinary Microbiology” journal (each had 7 papers). Citation classics in brucellosis were all in English except one in French and were mostly of basic science type. In addition, we noticed that 12 articles that were identified among the highest fifty articles in one database were missed by the other database and vice versa. Therefore, we suggest that searching in more than one database would detect additional citation classics.
    Keywords Medicine ; R
    Subject code 001
    Language English
    Publishing date 2018-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Second Report of Chronic Granulomatous Disease in Jordan: Clinical and Genetic Description of 31 Patients From 21 Different Families, Including Families From Lybia and Iraq.

    Bakri, Faris Ghalib / Mollin, Michelle / Beaumel, Sylvain / Vigne, Bénédicte / Roux-Buisson, Nathalie / Al-Wahadneh, Adel Mohammed / Alzyoud, Raed Mohammed / Hayajneh, Wail Ahmad / Daoud, Ammar Khaled / Shukair, Mohammed Elian Abu / Karadshe, Mansour Fuad / Sarhan, Mahmoud Mohammad / Al-Ramahi, Jamal Ahmad Wadi / Fauré, Julien / Rendu, John / Stasia, Marie Jose

    Frontiers in immunology

    2021  Volume 12, Page(s) 639226

    Abstract: Chronic granulomatous Disease (CGD) is a rare innate immunodeficiency disorder caused by mutations in one of the six genes ( ...

    Abstract Chronic granulomatous Disease (CGD) is a rare innate immunodeficiency disorder caused by mutations in one of the six genes (
    Language English
    Publishing date 2021-03-05
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.639226
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Seroprevalence of measles, mumps, rubella, and varicella amongphysicians and nurses in Jordan.

    Bakri, Faris Ghalib / Abdelrahim, Zakaria Mohammad / Alkalbani, Alaqahira Samih / Khrais, Ghada Mohammad / Shamroukh, Deena Shamroukh / Hayajneh, Ferial Ahmad / Mahafza, Azmi

    Turkish journal of medical sciences

    2016  Volume 46, Issue 3, Page(s) 614–619

    Abstract: Background/aim: Measles, mumps, rubella, and varicella can affect susceptible healthcare workers who might subsequently spread the infection to susceptible patients and workers. Here, we aim to determine the seroprevalence of these infections among ... ...

    Abstract Background/aim: Measles, mumps, rubella, and varicella can affect susceptible healthcare workers who might subsequently spread the infection to susceptible patients and workers. Here, we aim to determine the seroprevalence of these infections among physicians and nurses and to compare the history of varicella with the results of varicella antibodies among study participants.
    Materials and methods: Two randomly selected groups, one group of physicians and one of nurses, from a university hospital in Jordan were interviewed and their serum IgG antibodies were measured.
    Results: The physicians and nurses group had 252 and 241 participants, respectively. The physicians group had significantly more males and younger participants. The percentage of individuals in the physician and nurse groups with positive antibodies to measles was 75.4% and 75.1%, respectively; mumps, 88.5% and 94.2%; rubella, 89.3% and 87.1%; and varicella, 92.1% and 92.5%. Immunity was similar between the 2 groups except for mumps, where significantly more nurses were immune. The positive and negative predictive values for the history of varicella to predict immunity in all participants were 95% and 13.5%, respectively.
    Conclusion: A small but important proportion of our healthcare workers are still susceptible to measles, mumps, rubella, and varicella. In addition, the recall history to varicella showed suboptimal ability to predict immunity.
    MeSH term(s) Antibodies, Viral ; Chickenpox ; Female ; Humans ; Jordan ; Male ; Measles ; Mumps ; Rubella ; Seroepidemiologic Studies
    Chemical Substances Antibodies, Viral
    Language English
    Publishing date 2016-04-19
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 1183461-4
    ISSN 1303-6165 ; 1300-0144
    ISSN (online) 1303-6165
    ISSN 1300-0144
    DOI 10.3906/sag-1502-115
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3242: Show issues Location:
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  6. Article ; Online: Hematologically important mutations: The autosomal forms of chronic granulomatous disease (third update).

    Roos, Dirk / van Leeuwen, Karin / Hsu, Amy P / Priel, Debra Long / Begtrup, Amber / Brandon, Rhonda / Rawat, Amit / Vignesh, Pandiarajan / Madkaikar, Manesha / Stasia, Marie José / Bakri, Faris Ghalib / de Boer, Martin / Roesler, Joachim / Köker, Nezihe / Köker, M Yavuz / Jakobsen, Marianne / Bustamante, Jacinta / Garcia-Morato, Maria Bravo / Shephard, Juan Luis Valdivieso /
    Cagdas, Deniz / Tezcan, Ilhan / Sherkat, Roya / Mortaz, Esmaeil / Fayezi, Abbas / Shahrooei, Mohammad / Wolach, Baruch / Blancas-Galicia, Lizbeth / Kanegane, Hirokazu / Kawai, Toshinao / Condino-Neto, Antonio / Vihinen, Mauno / Zerbe, Christa S / Holland, Steven M / Malech, Harry L / Gallin, John I / Kuhns, Douglas B

    Blood cells, molecules & diseases

    2021  Volume 92, Page(s) 102596

    Abstract: Chronic granulomatous disease (CGD) is an immunodeficiency disorder affecting about 1 in 250,000 individuals. CGD patients suffer from severe, recurrent bacterial and fungal infections. The disease is caused by mutations in the genes encoding the ... ...

    Abstract Chronic granulomatous disease (CGD) is an immunodeficiency disorder affecting about 1 in 250,000 individuals. CGD patients suffer from severe, recurrent bacterial and fungal infections. The disease is caused by mutations in the genes encoding the components of the leukocyte NADPH oxidase. This enzyme produces superoxide, which is subsequently metabolized to hydrogen peroxide and other reactive oxygen species (ROS). These products are essential for intracellular killing of pathogens by phagocytic leukocytes (neutrophils, eosinophils, monocytes and macrophages). The leukocyte NADPH oxidase is composed of five subunits, four of which are encoded by autosomal genes. These are CYBA, encoding p22
    MeSH term(s) Granulomatous Disease, Chronic/genetics ; Humans ; Mutation ; NADPH Oxidases/genetics
    Chemical Substances NADPH Oxidases (EC 1.6.3.-) ; CYBA protein, human (EC 1.6.3.1) ; NCF2 protein, human (EC 1.6.3.1) ; NCF4 protein, human (EC 1.6.3.1) ; neutrophil cytosolic factor 1 (EC 1.6.3.1)
    Language English
    Publishing date 2021-07-28
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1237083-6
    ISSN 1096-0961 ; 1079-9796
    ISSN (online) 1096-0961
    ISSN 1079-9796
    DOI 10.1016/j.bcmd.2021.102596
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1138: Show issues Location:
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  7. Article ; Online: Hematologically important mutations: X-linked chronic granulomatous disease (fourth update).

    Roos, Dirk / van Leeuwen, Karin / Hsu, Amy P / Priel, Debra Long / Begtrup, Amber / Brandon, Rhonda / Stasia, Marie José / Bakri, Faris Ghalib / Köker, Nezihe / Köker, M Yavuz / Madkaika, Manisha / de Boer, Martin / Garcia-Morato, Maria Bravo / Shephard, Juan Luis Valdivieso / Roesler, Joachim / Kanegane, Hirokazu / Kawai, Toshinao / Di Matteo, Gigliola / Shahrooei, Mohammad /
    Bustamante, Jacinta / Rawat, Amit / Vignesh, Pandiarajan / Mortaz, Esmaeil / Fayezi, Abbas / Cagdas, Deniz / Tezcan, Ilhan / Kitcharoensakkul, Maleewan / Dinauer, Mary C / Meyts, Isabelle / Wolach, Baruch / Condino-Neto, Antonio / Zerbe, Christa S / Holland, Steven M / Malech, Harry L / Gallin, John I / Kuhns, Douglas B

    Blood cells, molecules & diseases

    2021  Volume 90, Page(s) 102587

    Abstract: Chronic granulomatous disease (CGD) is an immunodeficiency disorder affecting about 1 in 250,000 individuals. CGD patients suffer from severe bacterial and fungal infections. The disease is caused by a lack of superoxide production by the leukocyte ... ...

    Abstract Chronic granulomatous disease (CGD) is an immunodeficiency disorder affecting about 1 in 250,000 individuals. CGD patients suffer from severe bacterial and fungal infections. The disease is caused by a lack of superoxide production by the leukocyte enzyme NADPH oxidase. Superoxide and subsequently formed other reactive oxygen species (ROS) are instrumental in killing phagocytosed micro-organisms in neutrophils, eosinophils, monocytes and macrophages. The leukocyte NADPH oxidase is composed of five subunits, of which the enzymatic component is gp91
    MeSH term(s) Chromosomes, Human, X/genetics ; Granulomatous Disease, Chronic/genetics ; Humans ; Mutation ; NADPH Oxidase 2/genetics
    Chemical Substances CYBB protein, human (EC 1.6.3.-) ; NADPH Oxidase 2 (EC 1.6.3.-)
    Language English
    Publishing date 2021-06-02
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Review
    ZDB-ID 1237083-6
    ISSN 1096-0961 ; 1079-9796
    ISSN (online) 1096-0961
    ISSN 1079-9796
    DOI 10.1016/j.bcmd.2021.102587
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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