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  1. Article ; Online: The Hippo-p53 pathway in megakaryopoiesis.

    Suraneni, Praveen K / Crispino, John D

    Haematologica

    2016  Volume 101, Issue 12, Page(s) 1446–1448

    MeSH term(s) Animals ; Humans ; Metabolic Networks and Pathways ; Protein-Serine-Threonine Kinases/metabolism ; Protein-Serine-Threonine Kinases/physiology ; Signal Transduction ; Thrombopoiesis/physiology ; Tumor Suppressor Protein p53/metabolism ; Tumor Suppressor Protein p53/physiology ; rhoA GTP-Binding Protein/physiology
    Chemical Substances Tumor Suppressor Protein p53 ; RHOA protein, human (124671-05-2) ; Hippo protein, human (EC 2.7.11.1) ; Protein-Serine-Threonine Kinases (EC 2.7.11.1) ; rhoA GTP-Binding Protein (EC 3.6.5.2)
    Language English
    Publishing date 2016-11-28
    Publishing country Italy
    Document type Editorial
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2016.156125
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.76: Show issues Location:
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  2. Article ; Online: LKB1/

    Marinaccio, Christian / Suraneni, Praveen / Celik, Hamza / Volk, Andrew / Wen, Qiang Jeremy / Ling, Te / Bulic, Marinka / Lasho, Terra / Koche, Richard P / Famulare, Christopher A / Farnoud, Noushin / Stein, Brady / Schieber, Michael / Gurbuxani, Sandeep / Root, David E / Younger, Scott T / Hoffman, Ronald / Gangat, Naseema / Ntziachristos, Panagiotis /
    Chandel, Navdeep S / Levine, Ross L / Rampal, Raajit K / Challen, Grant A / Tefferi, Ayalew / Crispino, John D

    Cancer discovery

    2021  Volume 11, Issue 6, Page(s) 1398–1410

    Abstract: The myeloproliferative neoplasms (MPN) frequently progress to blast phase disease, an aggressive form of acute myeloid leukemia. To identify genes that suppress disease progression, we performed a focused CRISPR/Cas9 screen and discovered that depletion ... ...

    Abstract The myeloproliferative neoplasms (MPN) frequently progress to blast phase disease, an aggressive form of acute myeloid leukemia. To identify genes that suppress disease progression, we performed a focused CRISPR/Cas9 screen and discovered that depletion of LKB1/
    MeSH term(s) AMP-Activated Protein Kinases/genetics ; Animals ; Disease Models, Animal ; Disease Progression ; Genes, Tumor Suppressor ; Leukemia, Myeloid, Acute/genetics ; Mice ; Mice, Inbred C57BL ; Mutation ; Myeloproliferative Disorders/genetics
    Chemical Substances Stk11 protein, mouse (EC 2.7.11.1) ; AMP-Activated Protein Kinases (EC 2.7.11.31)
    Language English
    Publishing date 2021-02-12
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2625242-9
    ISSN 2159-8290 ; 2159-8274
    ISSN (online) 2159-8290
    ISSN 2159-8274
    DOI 10.1158/2159-8290.CD-20-1353
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6916: Show issues Location:
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  3. Article ; Online: Dynamins 2 and 3 control the migration of human megakaryocytes by regulating CXCR4 surface expression and ITGB1 activity.

    Suraneni, Praveen K / Corey, Seth J / Hession, Michael J / Ishaq, Rameez / Awomolo, Arinola / Hasan, Shirin / Shah, Chirag / Liu, Hui / Wickrema, Amittha / Debili, Najet / Crispino, John D / Eklund, Elizabeth A / Chen, Yolande

    Blood advances

    2018  Volume 2, Issue 23, Page(s) 3540–3552

    Abstract: Megakaryocyte (MK) migration from the bone marrow periosteal niche toward the vascular niche is a prerequisite for proplatelet extension and release into the circulation. The mechanism for this highly coordinated process is poorly understood. Here we ... ...

    Abstract Megakaryocyte (MK) migration from the bone marrow periosteal niche toward the vascular niche is a prerequisite for proplatelet extension and release into the circulation. The mechanism for this highly coordinated process is poorly understood. Here we show that dynasore (DNSR), a small-molecule inhibitor of dynamins (DNMs), or short hairpin RNA knockdown of DNM2 and DNM3 impairs directional migration in a human MK cell line or MKs derived from cultured CD34
    MeSH term(s) Actin Cytoskeleton ; Cell Line ; Cell Membrane/metabolism ; Cell Movement ; Dynamin II/antagonists & inhibitors ; Dynamin II/genetics ; Dynamin II/metabolism ; Dynamin III/antagonists & inhibitors ; Dynamin III/genetics ; Dynamin III/metabolism ; Humans ; Integrin beta1/metabolism ; Megakaryocytes/cytology ; Megakaryocytes/metabolism ; RNA Interference ; RNA, Small Interfering/metabolism ; Receptors, CXCR4/metabolism ; rab GTP-Binding Proteins/metabolism ; rhoA GTP-Binding Protein/metabolism
    Chemical Substances CXCR4 protein, human ; Integrin beta1 ; RNA, Small Interfering ; Receptors, CXCR4 ; rab11 protein (EC 3.6.1.-) ; rab GTP-Binding Proteins (EC 3.6.5.2) ; rhoA GTP-Binding Protein (EC 3.6.5.2) ; Dynamin II (EC 3.6.5.5) ; Dynamin III (EC 3.6.5.5)
    Language English
    Publishing date 2018-12-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2876449-3
    ISSN 2473-9537 ; 2473-9529
    ISSN (online) 2473-9537
    ISSN 2473-9529
    DOI 10.1182/bloodadvances.2018021923
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Activation of JAK/STAT Signaling in Megakaryocytes Sustains Myeloproliferation

    Woods, Brittany / Chen, Wei / Chiu, Sophia / Marinaccio, Christian / Fu, Chunling / Gu, Lilly / Bulic, Marinka / Yang, Qiong / Zouak, Anouar / Jia, Shengxian / Suraneni, Praveen Kumar / Xu, Kailin / Levine, Ross L / Crispino, John D / Wen, Qiang Jeremy

    Clinical cancer research : an official journal of the American Association for Cancer Research

    2019  Volume 25, Issue 19, Page(s) 5901–5912

    Abstract: Purpose: The myeloproliferative neoplasms (MPN), including polycythemia vera, essential thrombocythemia, and primary myelofibrosis, are characterized by the expansion of the erythroid, megakaryocytic, and granulocytic lineages. A common feature of these ...

    Abstract Purpose: The myeloproliferative neoplasms (MPN), including polycythemia vera, essential thrombocythemia, and primary myelofibrosis, are characterized by the expansion of the erythroid, megakaryocytic, and granulocytic lineages. A common feature of these disorders is the presence of abnormal megakaryocytes, which have been implicated as causative agents in the development of bone marrow fibrosis. However, the specific contributions of megakaryocytes to MPN pathogenesis remain unclear.
    Experimental design: We used
    Results: JAK2
    Conclusions: Our observations reveal that JAK/STAT pathway activation in megakaryocytes induces myeloproliferation and is necessary for MPN maintenance
    MeSH term(s) Animals ; Bone Marrow/metabolism ; Bone Marrow/pathology ; Cell Proliferation/physiology ; Female ; Humans ; Janus Kinase 2/genetics ; Janus Kinase 2/metabolism ; Male ; Megakaryocytes/metabolism ; Megakaryocytes/pathology ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Myeloproliferative Disorders/genetics ; Myeloproliferative Disorders/metabolism ; Myeloproliferative Disorders/pathology ; Point Mutation ; STAT5 Transcription Factor/genetics ; STAT5 Transcription Factor/metabolism ; Signal Transduction
    Chemical Substances STAT5 Transcription Factor ; Jak2 protein, mouse (EC 2.7.10.2) ; Janus Kinase 2 (EC 2.7.10.2)
    Language English
    Publishing date 2019-06-19
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1225457-5
    ISSN 1557-3265 ; 1078-0432
    ISSN (online) 1557-3265
    ISSN 1078-0432
    DOI 10.1158/1078-0432.CCR-18-4089
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4223: Show issues Location:
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  5. Article ; Online: A CHAF1B-Dependent Molecular Switch in Hematopoiesis and Leukemia Pathogenesis.

    Volk, Andrew / Liang, Kaiwei / Suraneni, Praveen / Li, Xinyu / Zhao, Jianyun / Bulic, Marinka / Marshall, Stacy / Pulakanti, Kirthi / Malinge, Sebastien / Taub, Jeffrey / Ge, Yubin / Rao, Sridhar / Bartom, Elizabeth / Shilatifard, Ali / Crispino, John D

    Cancer cell

    2018  Volume 34, Issue 5, Page(s) 707–723.e7

    Abstract: CHAF1B is the p60 subunit of the chromatin assembly factor (CAF1) complex, which is responsible for assembly of histones H3.1/H4 heterodimers at the replication fork during S phase. Here we report that CHAF1B is required for normal hematopoiesis while ... ...

    Abstract CHAF1B is the p60 subunit of the chromatin assembly factor (CAF1) complex, which is responsible for assembly of histones H3.1/H4 heterodimers at the replication fork during S phase. Here we report that CHAF1B is required for normal hematopoiesis while its overexpression promotes leukemia. CHAF1B has a pro-leukemia effect by binding chromatin at discrete sites and interfering with occupancy of transcription factors that promote myeloid differentiation, such as CEBPA. Reducing Chaf1b activity by either heterozygous deletion or overexpression of a CAF1 dominant negative allele is sufficient to suppress leukemogenesis in vivo without impairing normal hematopoiesis.
    MeSH term(s) Adult ; Animals ; Binding Sites/physiology ; CCAAT-Enhancer-Binding Proteins/metabolism ; Cell Differentiation/physiology ; Cell Line, Tumor ; Cell Proliferation/genetics ; Chromatin/metabolism ; Chromatin Assembly Factor-1/genetics ; Chromatin Assembly Factor-1/metabolism ; Female ; Hematopoiesis/genetics ; Hematopoiesis/physiology ; Humans ; Jurkat Cells ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Nucleosomes/metabolism ; Protein Binding/physiology ; Proteins/genetics ; Proteins/metabolism
    Chemical Substances CCAAT-Enhancer-Binding Proteins ; CEBPA protein, mouse ; Chaf1b protein, mouse ; Chromatin ; Chromatin Assembly Factor-1 ; Cnot7 protein, mouse ; Nucleosomes ; Proteins
    Language English
    Publishing date 2018-11-30
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2078448-X
    ISSN 1878-3686 ; 1535-6108
    ISSN (online) 1878-3686
    ISSN 1535-6108
    DOI 10.1016/j.ccell.2018.10.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5650: Show issues Location:
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    Zs.MG 104: Show issues

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