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Article: [Emission characteristics of a diesel car fueled with coal based Fischer-Tropsch (F-T) diesel and fossil diesel blends].

Hu, Zhi-Yuan / Cheng, Liang / Tan, Pi-Qiang / Lou, Di-Ming

Huan jing ke xue= Huanjing kexue

2012 Volume 33, Issue 11, Page(s) 3733–3738

Abstract: ... global warming potential and acidification potential of F-T diesel fueled diesel car were also reduced. To sum up, coal ... coal based Fischer-Tropsch (F-T) diesel, and the blends of coal based F-T diesel and Shanghai local IV ... to different extents when fueled with coal based F-T diesel blends. Moreover, the aerosol generation potential ...

Abstract	According to the first type test cycle of China national standard GB 18352.3-2005, the CO, NO(x), HC, PM and CO2 emission characteristics of a PASSAT diesel car fueled with Shanghai local IV diesel, coal based Fischer-Tropsch (F-T) diesel, and the blends of coal based F-T diesel and Shanghai local IV diesel up to 10% and 50% by volume were analyzed respectively. And the environmental impacts such as decreased air quality, health impact, photochemical ozone, global warming, and acidification that could be caused by CO, NO(x), HC, PM and CO2 emission of the diesel car were also assessed. The results showed that under GB 18352.3-2005 No. 1 test driving cycle, which consisted of four urban driving cycles and one extra urban driving cycle, the CO, HC, PM and CO2 emissions were released mainly in the urban driving cycles whereas the NO(x) emissions occurred mainly in the extra urban driving cycle. Compared with Shanghai local IV diesel, all of the CO, NO(x), HC, PM and CO2 emissions of the diesel car decreased to different extents when fueled with coal based F-T diesel blends. Moreover, the aerosol generation potential, global warming potential and acidification potential of F-T diesel fueled diesel car were also reduced. To sum up, coal based F-T diesel would be one of the alternative fuels to diesel in China.
MeSH term(s)	Air Pollution/statistics & numerical data ; Cellulose/chemistry ; China ; Coal ; Conservation of Energy Resources/methods ; Gasoline/analysis ; Nitrogen Oxides/analysis ; Particulate Matter/analysis ; Vehicle Emissions
Chemical Substances	Coal ; Gasoline ; Nitrogen Oxides ; Particulate Matter ; Vehicle Emissions ; Cellulose (9004-34-6)
Language	Chinese
Publishing date	2012-11
Publishing country	China
Document type	English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
ISSN	0250-3301
ISSN	0250-3301
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Exposure to Sublethal Concentrations of Lead (Pb) Affects Ecologically Relevant Behaviors in House Sparrows (Passer domesticus).

Di Liberto, Joseph F / Griffith, Simon C / Hall, Cara J / Mendelsohn, Alexandra S / Swaddle, John P

Archives of environmental contamination and toxicology

2024 Volume 86, Issue 3, Page(s) 199–216

Abstract: Global contamination of environments with lead (Pb) poses threats to many ecosystems and populations. While exposure to Pb is toxic at high concentrations, recent literature has shown that lower concentrations can also cause sublethal, deleterious ... ...

Abstract	Global contamination of environments with lead (Pb) poses threats to many ecosystems and populations. While exposure to Pb is toxic at high concentrations, recent literature has shown that lower concentrations can also cause sublethal, deleterious effects. However, there remains relatively little causal investigation of how exposure to lower concentrations of environmental Pb affects ecologically important behaviors. Behaviors often represent first-line responses of an organism and its internal physiological, molecular, and genetic responses to a changing environment. Hence, better understanding how behaviors are influenced by pollutants such as Pb generates crucial information on how species are coping with the effects of pollution more broadly. To better understand the effects of sublethal Pb on behavior, we chronically exposed adult wild-caught, captive house sparrows (Passer domesticus) to Pb-exposed drinking water and quantified a suite of behavioral outcomes: takeoff flight performance, activity in a novel environment, and in-hand struggling and breathing rate while being handled by an experimenter. Compared to controls (un-exposed drinking water), sparrows exposed to environmentally relevant concentrations of Pb exhibited decreases in takeoff flight performance and reduced movements in a novel environment following 9-10 weeks of exposure. We interpret this suite of results to be consistent with Pb influencing fundamental neuro-muscular abilities, making it more difficult for exposed birds to mount faster movements and activities. It is likely that suppression of takeoff flight and reduced movements would increase the predation risk of similar birds in the wild; hence, we also conclude that the effects we observed could influence fitness outcomes for individuals and populations altering ecological interactions within more naturalistic settings.
MeSH term(s)	Humans ; Animals ; Sparrows/genetics ; Lead/toxicity ; Ecosystem ; Drinking Water
Chemical Substances	Lead (2P299V784P) ; Drinking Water
Language	English
Publishing date	2024-04-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	185986-9
ISSN	1432-0703 ; 0090-4341
ISSN (online)	1432-0703
ISSN	0090-4341
DOI	10.1007/s00244-024-01062-0
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Article ; Online: Peroxisome deficiency underlies failures in hepatic immune cell development and antigen presentation in a severe Zellweger disease model.

Parsons, Brendon D / Medina-Luna, Daniel / Scur, Michal / Pinelli, Marinella / Gamage, Gayani S / Chilvers, Rebecca A / Hamon, Yannick / Ahmed, Ibrahim H I / Savary, Stéphane / Makrigiannis, Andrew P / Braverman, Nancy E / Rodriguez-Alcazar, Juan F / Latz, Eicke / Karakach, Tobias K / Di Cara, Francesca

Cell reports

2024 Volume 43, Issue 2, Page(s) 113744

Abstract: Peroxisome biogenesis disorders (PBDs) represent a group of metabolic conditions that cause severe developmental defects. Peroxisomes are essential metabolic organelles, present in virtually every eukaryotic cell and mediating key processes in ... ...

Abstract	Peroxisome biogenesis disorders (PBDs) represent a group of metabolic conditions that cause severe developmental defects. Peroxisomes are essential metabolic organelles, present in virtually every eukaryotic cell and mediating key processes in immunometabolism. To date, the full spectrum of PBDs remains to be identified, and the impact PBDs have on immune function is unexplored. This study presents a characterization of the hepatic immune compartment of a neonatal PBD mouse model at single-cell resolution to establish the importance and function of peroxisomes in developmental hematopoiesis. We report that hematopoietic defects are a feature in a severe PBD murine model. Finally, we identify a role for peroxisomes in the regulation of the major histocompatibility class II expression and antigen presentation to CD4
MeSH term(s)	Animals ; Mice ; Zellweger Syndrome/metabolism ; Peroxisomes/metabolism ; Antigen Presentation ; Peroxisomal Disorders/metabolism
Language	English
Publishing date	2024-02-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2649101-1
ISSN	2211-1247 ; 2211-1247
ISSN (online)	2211-1247
ISSN	2211-1247
DOI	10.1016/j.celrep.2024.113744
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Article ; Online: Bias-corrected and doubly robust inference for the three-level longitudinal cluster-randomized trials with missing continuous outcomes and small number of clusters: Simulation study and application to a study for adults with serious mental illnesses.

Kang, Chaeryon / Zhang, Di / Schuster, James / Kogan, Jane / Nikolajski, Cara / Reynolds, Charles F

Contemporary clinical trials communications

2023 Volume 35, Page(s) 101194

Abstract: Longitudinal cluster-randomized designs have been popular tools for comparative effective research in clinical trials. The methodologies for the three-level hierarchical design with longitudinal outcomes need to be better understood under more pragmatic ... ...

Abstract	Longitudinal cluster-randomized designs have been popular tools for comparative effective research in clinical trials. The methodologies for the three-level hierarchical design with longitudinal outcomes need to be better understood under more pragmatic settings; that is, with a small number of clusters, heterogeneous cluster sizes, and missing outcomes. Generalized estimating equations (GEEs) have been frequently used when the distribution of data and the correlation model are unknown. Standard GEEs lead to bias and an inflated type I error rate due to the small number of available clinics and non-completely random missing data in longitudinal outcomes. We evaluate the performance of inverse probability weighted (IPW) estimating equations, with and without augmentation, for two types of missing data in continuous outcomes and individual-level treatment allocation mechanisms combined with two bias-corrected variance estimators. Our intensive simulation results suggest that the proposed augmented IPW method with bias-corrected variance estimation successfully prevents the inflation of false positive findings and improves efficiency when the number of clinics is small, with moderate to severe missing outcomes. Our findings are expected to aid researchers in choosing appropriate analysis methods for three-level longitudinal cluster-randomized designs. The proposed approaches were applied to analyze data from a longitudinal cluster-randomized clinical trial involving adults with serious mental illnesses.
Language	English
Publishing date	2023-07-28
Publishing country	Netherlands
Document type	Journal Article
ISSN	2451-8654
ISSN (online)	2451-8654
DOI	10.1016/j.conctc.2023.101194
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Article ; Online: Peroxisomes in host defense.

Di Cara, Francesca

PLoS pathogens

2020 Volume 16, Issue 7, Page(s) e1008636

MeSH term(s)	Animals ; Humans ; Immune System/physiology ; Peroxisomes/immunology
Language	English
Publishing date	2020-07-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2205412-1
ISSN	1553-7374 ; 1553-7374
ISSN (online)	1553-7374
ISSN	1553-7374
DOI	10.1371/journal.ppat.1008636
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Article: Towards early detection of neurodegenerative diseases: A gut feeling.

Makdissi, Stephanie / Parsons, Brendon D / Di Cara, Francesca

Frontiers in cell and developmental biology

2023 Volume 11, Page(s) 1087091

Abstract: The gastrointestinal tract communicates with the nervous system through a bidirectional network of signaling pathways called the gut-brain axis, which consists of multiple connections, including the enteric nervous system, the vagus nerve, the immune ... ...

Abstract	The gastrointestinal tract communicates with the nervous system through a bidirectional network of signaling pathways called the gut-brain axis, which consists of multiple connections, including the enteric nervous system, the vagus nerve, the immune system, endocrine signals, the microbiota, and its metabolites. Alteration of communications in the gut-brain axis is emerging as an overlooked cause of neuroinflammation. Neuroinflammation is a common feature of the pathogenic mechanisms involved in various neurodegenerative diseases (NDs) that are incurable and debilitating conditions resulting in progressive degeneration and death of neurons, such as in Alzheimer and Parkinson diseases. NDs are a leading cause of global death and disability, and the incidences are expected to increase in the following decades if prevention strategies and successful treatment remain elusive. To date, the etiology of NDs is unclear due to the complexity of the mechanisms of diseases involving genetic and environmental factors, including diet and microbiota. Emerging evidence suggests that changes in diet, alteration of the microbiota, and deregulation of metabolism in the intestinal epithelium influence the inflammatory status of the neurons linked to disease insurgence and progression. This review will describe the leading players of the so-called diet-microbiota-gut-brain (DMGB) axis in the context of NDs. We will report recent findings from studies in model organisms such as rodents and fruit flies that support the role of diets, commensals, and intestinal epithelial functions as an overlooked primary regulator of brain health. We will finish discussing the pivotal role of metabolisms of cellular organelles such as mitochondria and peroxisomes in maintaining the DMGB axis and how alteration of the latter can be used as early disease makers and novel therapeutic targets.
Language	English
Publishing date	2023-02-07
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2023.1087091
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Conference proceedings ; Online: Seismological studies for site effect characterization of Ancona city following the Mw 5.5 Costa Marchigiana-Pesarese earthquake (Central Italy)

Cultrera, G. / Vassallo, M. / Famiani, D. / Di Giulio, G. / Cara, F. / Marzorati, S. / Pacor, F. / Riccio, G. / Lovati, S. / Emersito, w.

XXVIII General Assembly of the International Union of Geodesy and Geophysics (IUGG)

2023

Abstract: We present the activities of EMERSITO, the INGV emergency task force with skills and experience in seismic response studies and in seismic microzonation, in the follow-up to the Mw 5.5 (ML 5.7) earthquake of November 9, 2022 06:07:25 UTC localized in the ...

Abstract	We present the activities of EMERSITO, the INGV emergency task force with skills and experience in seismic response studies and in seismic microzonation, in the follow-up to the Mw 5.5 (ML 5.7) earthquake of November 9, 2022 06:07:25 UTC localized in the Costa Marchigiana Pesarese area (Central Italy). Based on geological information and damage estimates in the epicentral areas, EMERSITO focused its intervention in Ancona, the capital of Regione Marche, located at about 40 km south of the epicenter. This city is located in an area characterized by a remarkable seismic hazard, as evidenced by the extensive damage of the 1972 earthquakes (Mw up to 4.7), with part of the urban territory susceptible to landslide phenomena. A temporary seismic network consisting of 11 seismic stations equipped with velocimeter and accelerometer was installed in different urban areas of the city, acquiring data in continuous mode for about 4 months. The analysis of ambient vibrations and aftershock recordings collected by the network suggests a variability of the site response depending on the outcropping lithologies. The peak frequencies from spectral ratio analysis range between 1 and 3 Hz for 6 stations, while other stations are characterized by peak frequencies between 3.5 and 9.5 Hz. The H/V noise spectral ratios do not show peaks with very high amplitudes (< 3), likely indicating the lack of strong impedance contrasts, at least in the shallow part of the subsoil.
Subject code	500
Language	English
Publishing date	2023-07-11
Publishing country	de
Document type	Conference proceedings ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Margarete Heck (1959-2023): Cell biologist, geneticist, and incandescent social spark.

Cobbe, Neville / Di Cara, Francesca / Spradling, Allan C / Vass, Sharron

The Journal of cell biology

2023 Volume 223, Issue 1

Language	English
Publishing date	2023-12-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	218154-x
ISSN	1540-8140 ; 0021-9525
ISSN (online)	1540-8140
ISSN	0021-9525
DOI	10.1083/jcb.202311145
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Conference proceedings ; Online: The subsoil of the city of Rome (Italy)

Vassallo, M. / Bobbio, A. / Cultrera, G. / Di Giulio, G. / Mercuri, A. / Esposito, A. / Milana, G. / Bordoni, P. / Ciaccio, M. / Cara, F.

XXVIII General Assembly of the International Union of Geodesy and Geophysics (IUGG)

Results from a dense temporary seismic network

2023

Abstract: We present the results from a temporary seismic network of 24 stations installed in the urban area of Rome (Italy) from January 10, 2021 until April 08, 2021, with the aim of studying the city's urban subsoil through analysis based on ambient seismic ... ...

Abstract	We present the results from a temporary seismic network of 24 stations installed in the urban area of Rome (Italy) from January 10, 2021 until April 08, 2021, with the aim of studying the city's urban subsoil through analysis based on ambient seismic noise. Rome is the largest Italian city (with about three million people) with a history of art, architecture and culture that influenced the world and dating back almost 3000 years ago. The city retains a monumental heritage characterized by a high fragility due to its age. Both the high number of inhabitants and the fragility of its monuments make the city particularly vulnerable to possible earthquakes, even if the seismic hazard of the area is considered as moderate. The continuous recordings from the network allowed the use of ambient seismic noise to derive spectral ratios at sites located in different geological and lithological contexts. Moreover, signals from regional earthquakes were surprisingly well recorded despite the high anthropic noise-level, showing a clear areal variability referable to site effects. In this case, we also benefit from a low-noise period due to the partial lockdown for COVID pandemia. Interferometric analyses based on seismic noise cross-correlation of acquired data, show that it is possible to reconstruct the surface waves at station pairs in the frequency band between 0.2 and 1 Hz. It is then possible to perform a 3D velocity model through Ambient Noise Tomography to characterize shapes, thickness and properties of different geological/lithological units of the subsoil of the city.
Subject code	550
Language	English
Publishing country	de
Document type	Conference proceedings ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Modified protocol for culturing

Weaver, Ceileigh M / Makdissi, Stephanie / Di Cara, Francesca

STAR protocols

2022 Volume 3, Issue 3, Page(s) 101588

Abstract: Here, we describe a protocol to ... ...

Abstract	Here, we describe a protocol to culture
MeSH term(s)	Actin Cytoskeleton ; Animals ; Cell Culture Techniques ; Drosophila ; Microscopy, Confocal
Language	English
Publishing date	2022-08-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2666-1667
ISSN (online)	2666-1667
DOI	10.1016/j.xpro.2022.101588
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