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  1. Article ; Online: Dynamic cycling with a unique Hsp90/Hsp70-dependent chaperone machinery and GAPDH is needed for heme insertion and activation of neuronal NO synthase.

    Morishima, Yoshihiro / Lau, Miranda / Pratt, William B / Osawa, Yoichi

    The Journal of biological chemistry

    2022  Volume 299, Issue 2, Page(s) 102856

    Abstract: Heat shock protein 90 (Hsp90) is known to mediate heme insertion and activation of heme-deficient neuronal nitric oxide (NO) synthase (apo-nNOS) in cells by a highly dynamic interaction that has been extremely difficult to study mechanistically with the ... ...

    Abstract Heat shock protein 90 (Hsp90) is known to mediate heme insertion and activation of heme-deficient neuronal nitric oxide (NO) synthase (apo-nNOS) in cells by a highly dynamic interaction that has been extremely difficult to study mechanistically with the use of subcellular systems. In that the heme content of many critical hemeproteins is regulated by Hsp90 and the heme chaperone GAPDH, the development of an in vitro system for the study of this chaperone-mediated heme regulation would be extremely useful. Here, we show that use of an antibody-immobilized apo-nNOS led not only to successful assembly of chaperone complexes but the ability to show a clear dependence on Hsp90 and GAPDH for heme-mediated activation of apo-nNOS. The kinetics of binding for Hsp70 and Hsp90, the ATP and K
    MeSH term(s) Heme/chemistry ; Hemeproteins/chemistry ; Hemeproteins/metabolism ; HSP70 Heat-Shock Proteins/chemistry ; HSP70 Heat-Shock Proteins/metabolism ; HSP90 Heat-Shock Proteins/chemistry ; HSP90 Heat-Shock Proteins/metabolism ; Molecular Chaperones/chemistry ; Molecular Chaperones/metabolism ; Protein Binding ; Nitric Oxide Synthase/chemistry ; Nitric Oxide Synthase/metabolism ; Enzymes, Immobilized ; Glyceraldehyde-3-Phosphate Dehydrogenases/chemistry ; Glyceraldehyde-3-Phosphate Dehydrogenases/metabolism ; Enzyme Activation
    Chemical Substances Heme (42VZT0U6YR) ; Hemeproteins ; HSP70 Heat-Shock Proteins ; HSP90 Heat-Shock Proteins ; Molecular Chaperones ; Nitric Oxide Synthase (EC 1.14.13.39) ; Enzymes, Immobilized ; Glyceraldehyde-3-Phosphate Dehydrogenases (EC 1.2.1.-)
    Language English
    Publishing date 2022-12-31
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1016/j.jbc.2022.102856
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.108: Show issues Location:
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  2. Book: The anticancer drugs

    Pratt, William B.

    1994  

    Author's details William B. Pratt
    Keywords Antineoplastic Agents ; Cytostatikum ; Antineoplastone ; Krebs ; Chemotherapie
    Subject Zytostatikum ; Cancerotoxischer Stoff ; Carcinostatikum ; Krebsmittel ; Antineoplastikum ; Anticarcinogen ; Antikarzinogen ; Anticancerogen ; Antineoplastisches Mittel ; Carcinom ; Malignom ; Maligner Tumor ; Neoplasma ; Karzinom ; Bösartiger Tumor ; Krebserkrankung
    Language English
    Size VIII, 352 S. : Ill., graph. Darst.
    Edition 2. ed.
    Publisher Oxford Univ. Press
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    Old title 1. Aufl. u.d.T. Pratt, William B.: The anticancer drugs
    HBZ-ID HT006397068
    ISBN 0-19-506738-X ; 0-19-506739-8 ; 978-0-19-506738-5 ; 978-0-19-506739-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1994 A 4772 order for loan Magazin

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  3. Book: Principles of drug action

    Pratt, William B.

    the basis of pharmacology

    1990  

    Author's details ed. by William B. Pratt
    Keywords Pharmacology
    Language English
    Size XIII, 836 S. : Ill., graph. Darst.
    Edition 3. ed.
    Publisher Churchill Livingstone
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    Old title Bis 2. Aufl. u.d.T. Goldstein, Avram: Principles of drug action
    HBZ-ID HT003649991
    ISBN 0-443-08676-1 ; 978-0-443-08676-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1990 A 7013 order for loan Magazin

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  4. Article ; Online: Long-term outcomes by bone marrow B-cell depletion from the R2W trial of bortezomib with cyclophosphamide and rituximab in Waldenstrőm macroglobulinaemia.

    de Tute, Ruth / Counsell, Nicholas / Clifton-Hadley, Laura / D'Sa, Shirley / Pratt, Guy / Campbell, Gavin / Campbell, Lauren / Sadler, Ross / Townsend, William / Popova, Bilyana / Smith, Paul / Schofield, Oliver / Owen, Roger / Auer, Rebecca

    Leukemia

    2024  Volume 38, Issue 4, Page(s) 822–828

    Abstract: ... 80.5% (95%CI:64.8-89.7) and 65.5% (95%CI:48.8-77.9). Persistent WM B-cells were demonstrable in 19/38 ... with BM B-cell depletion (<0.004%) compared to those who had persistent BM B-cells detectable at end ... regimen for treatment-naïve WM patients. BM B-cell depletion is independently associated with patient ...

    Abstract There remains a lack of consensus as to the most appropriate primary therapy in Waldenstrőm macroglobulinemia (WM). We evaluated a novel bortezomib-based combination and developed a sensitive WM-specific flow cytometry assay (limit of detection 0.004% of leucocytes) to assess bone marrow (BM) response. Sixty treatment-naïve WM patients were enroled into this phase II trial and randomised (2:1) to receive cyclophosphamide and rituximab with either bortezomib (BRC) or fludarabine (FCR). The primary objective was to assess the overall response rate (ORR) in eligible patients receiving BRC (N = 41). An ORR of 97.6% (95%CI:87.1-99.9) was observed; 27 (65.9%) patients remain alive without progression after 62.6 months median follow-up, with 2-, 3- and 5-year progression-free survival (PFS) rates of 92.7% (95%CI:79.0-97.6), 80.5% (95%CI:64.8-89.7) and 65.5% (95%CI:48.8-77.9). Persistent WM B-cells were demonstrable in 19/38 patients at the end of treatment (median 0.24%, range 0.02-11.2%). PFS was markedly longer in patients with BM B-cell depletion (<0.004%) compared to those who had persistent BM B-cells detectable at end of treatment (HR = 0.06, 95%CI:0.01-0.47, p < 0.001), and remained independently associated after adjusting for baseline risk stratification or investigator-assessed response. BRC is a tolerable, highly efficacious regimen for treatment-naïve WM patients. BM B-cell depletion is independently associated with patient outcomes.
    MeSH term(s) Humans ; Rituximab/therapeutic use ; Waldenstrom Macroglobulinemia/drug therapy ; Waldenstrom Macroglobulinemia/diagnosis ; Bortezomib/therapeutic use ; Bone Marrow ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Cyclophosphamide/therapeutic use
    Chemical Substances Rituximab (4F4X42SYQ6) ; Bortezomib (69G8BD63PP) ; Cyclophosphamide (8N3DW7272P)
    Language English
    Publishing date 2024-02-26
    Publishing country England
    Document type Randomized Controlled Trial ; Clinical Trial, Phase II ; Journal Article
    ZDB-ID 807030-1
    ISSN 1476-5551 ; 0887-6924
    ISSN (online) 1476-5551
    ISSN 0887-6924
    DOI 10.1038/s41375-024-02162-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2295: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Book: Fundamentals in chemotherapy

    Pratt, William B.

    1973  

    Author's details William B. Pratt
    Language English
    Size XIII, 332 S. ; 8-o
    Publisher Oxford Univ. Pr
    Publishing place New York, N.Y. u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT009599274
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1975 B 511 order for loan Magazin

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  6. Article ; Online: Targeting Hsp70 facilitated protein quality control for treatment of polyglutamine diseases.

    Davis, Amanda K / Pratt, William B / Lieberman, Andrew P / Osawa, Yoichi

    Cellular and molecular life sciences : CMLS

    2019  Volume 77, Issue 6, Page(s) 977–996

    Abstract: The polyglutamine (polyQ) diseases are a group of nine fatal, adult-onset neurodegenerative disorders characterized by the misfolding and aggregation of mutant proteins containing toxic expansions of CAG/polyQ tracts. The heat shock protein 90 and 70 ( ... ...

    Abstract The polyglutamine (polyQ) diseases are a group of nine fatal, adult-onset neurodegenerative disorders characterized by the misfolding and aggregation of mutant proteins containing toxic expansions of CAG/polyQ tracts. The heat shock protein 90 and 70 (Hsp90/Hsp70) chaperone machinery is a key component of cellular protein quality control, playing a role in the regulation of folding, aggregation, and degradation of polyQ proteins. The ability of Hsp70 to facilitate disaggregation and degradation of misfolded proteins makes it an attractive therapeutic target in polyQ diseases. Genetic studies have demonstrated that manipulation of Hsp70 and related co-chaperones can enhance the disaggregation and/or degradation of misfolded proteins in models of polyQ disease. Therefore, the development of small molecules that enhance Hsp70 activity is of great interest. However, it is still unclear if currently available Hsp70 modulators can selectively enhance disaggregation or degradation of misfolded proteins without perturbing other Hsp70 functions essential for cellular homeostasis. This review discusses the multifaceted role of Hsp70 in protein quality control and the opportunities and challenges Hsp70 poses as a potential therapeutic target in polyQ disease.
    MeSH term(s) Animals ; HSP70 Heat-Shock Proteins/metabolism ; Humans ; Huntington Disease/drug therapy ; Huntington Disease/metabolism ; Molecular Targeted Therapy ; Muscular Atrophy, Spinal/drug therapy ; Muscular Atrophy, Spinal/metabolism ; Peptides/metabolism ; Protein Aggregation, Pathological/drug therapy ; Protein Aggregation, Pathological/metabolism ; Protein Folding/drug effects ; Proteostasis Deficiencies/drug therapy ; Proteostasis Deficiencies/metabolism ; Spinocerebellar Ataxias/drug therapy ; Spinocerebellar Ataxias/metabolism
    Chemical Substances HSP70 Heat-Shock Proteins ; Peptides ; polyglutamine (26700-71-0)
    Language English
    Publishing date 2019-09-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1358415-7
    ISSN 1420-9071 ; 1420-682X
    ISSN (online) 1420-9071
    ISSN 1420-682X
    DOI 10.1007/s00018-019-03302-2
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 195: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  7. Book: The antimicrobial drugs

    Pratt, William B. / Fekety, Robert

    1986  

    Author's details William B. Pratt ; Robert Fekety
    Keywords Antiinfective Agents / therapeutic use ; Communicable Diseases / drug therapy ; Chemotherapeutikum ; Infektion
    Subject Ansteckung ; Erstinfektion ; Infektionen ; Chemotherapeutika
    Size 501 S. : graph. Darst.
    Edition 1. [Dr.]
    Publisher Oxford Univ. Press
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    New title 2. Aufl. u.d.T. Scholar, Eric M.: The antimicrobial drugs
    HBZ-ID HT002871418
    ISBN 0-19-503560-7 ; 0-19-503561-5 ; 978-0-19-503560-5 ; 978-0-19-503561-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    1987 A 141 order for loan Magazin

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  8. Book: CHEMOTHERAPY OF INFECTION

    Pratt, William B.

    1977  

    Author's details WILLIAM B. PRATT
    Keywords BACTERIAL INFECTIONS / DRUG THERAPY ; MYCOSES / DRUG THERAPY ; PARASITIC DISEASES / DRUG THERAPY ; VIRUS DISEASES / DRUG THERAPY ; Chemotherapeutikum ; Infektion
    Subject Ansteckung ; Erstinfektion ; Infektionen ; Chemotherapeutika
    Size XIII, 461 S. ; 23 CM
    Publisher OXFORD UNIV. PRESS
    Publishing place NEW YORK, N.Y
    Document type Book
    HBZ-ID HT000319149
    ISBN 0-19-502162-2 ; 978-0-19-502162-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1979 A 856 order for loan Magazin

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  9. Book ; Online: Tropospheric bromine monoxide vertical profiles retrieved across the Alaskan Arctic in springtime

    Brockway, Nathaniel / Peterson, Peter K. / Bigge, Katja / Hajny, Kristian D. / Shepson, Paul B. / Pratt, Kerri A. / Fuentes, Jose D. / Starn, Tim / Kaeser, Robert / Stirm, Brian H. / Simpson, William R.

    eISSN: 1680-7324

    2024  

    Abstract: Reactive halogen chemistry in the springtime Arctic causes ozone depletion events and alters the rate of pollution processing. There are still many uncertainties regarding this chemistry, including the multiphase recycling of halogens and how sea ice ... ...

    Abstract Reactive halogen chemistry in the springtime Arctic causes ozone depletion events and alters the rate of pollution processing. There are still many uncertainties regarding this chemistry, including the multiphase recycling of halogens and how sea ice impacts the source strength of reactive bromine. Adding to these uncertainties are the impacts of a rapidly warming Arctic. We present observations from the CHACHA (CHemistry in the Arctic: Clouds, Halogens, and Aerosols) field campaign based out of Utqiaġvik, Alaska, from mid-February to mid-April of 2022 to provide information on the vertical distribution of bromine monoxide (BrO), which is a tracer for reactive bromine chemistry. Data were gathered using the Heidelberg Airborne Imaging DOAS (differential optical absorption spectroscopy) Instrument (HAIDI) on the Purdue University Airborne Laboratory for Atmospheric Research (ALAR) and employing a unique sampling technique of vertically profiling the lower atmosphere with the aircraft via “porpoising” maneuvers. Observations from HAIDI were coupled to radiative transfer model calculations to retrieve mixing ratio profiles throughout the lower atmosphere (below 1000 m), with unprecedented vertical resolution (50 m) and total information gathered (average of 17.5 degrees of freedom) for this region. A cluster analysis was used to categorize 245 retrieved BrO mixing ratio vertical profiles into four common profile shapes. We often found the highest BrO mixing ratios at the Earth's surface with a mean of nearly 30 pmol mol −1 in the lowest 50 m, indicating an important role for multiphase chemistry on the snowpack in reactive bromine production. Most lofted-BrO profiles corresponded with an aerosol profile that peaked at the same altitude (225 m above the ground), suggesting that BrO was maintained due to heterogeneous reactions on particle surfaces aloft during these profiles. A majority (11 of 15) of the identified lofted-BrO profiles occurred on a single day, 19 March 2022, over an area covering more than 24 000 km ...
    Subject code 551
    Language English
    Publishing date 2024-01-03
    Publishing country de
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Book: The antimicrobial drugs

    Scholar, Eric M. / Pratt, William B.

    2000  

    Author's details Eric M. Scholar ; William B. Pratt
    Keywords Anti-Infective Agents ; Communicable Diseases / drug therapy
    Language English
    Size XII, 607 S. : Ill., graph. Darst.
    Edition 2. ed.
    Publisher Oxford Univ. Press
    Publishing place Oxford u.a.
    Publishing country United States
    Document type Book
    Old title 1. Aufl. u.d.T. Pratt, William B.: The antimicrobial drugs
    HBZ-ID HT012785127
    ISBN 0-19-512528-2 ; 0-19-512529-0 ; 978-0-19-512528-3 ; 978-0-19-512529-0
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    2000 A 3440 order for loan Magazin

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