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  1. Article ; Online: Multiple pulmonary opacities. An alarming sign?

    Brikman, Shay / Dori, Guy

    European journal of internal medicine

    2023  Volume 113, Page(s) 102–103

    MeSH term(s) Humans ; Lung/diagnostic imaging ; Tomography, X-Ray Computed
    Language English
    Publishing date 2023-03-13
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2023.03.012
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    Zs.A 2608: Show issues Location:
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  2. Article ; Online: High Frequency of Diffuse Idiopathic Skeletal Hyperostosis in Patients With Obesity Hypoventilation Syndrome.

    Brikman, Shay / Mader, Reuven / Bieber, Amir

    The Journal of rheumatology

    2024  

    Abstract: Diffuse idiopathic skeletal hyperostosis (DISH) is known to be associated with metabolic syndrome and with obesity in particular. The prevalence of DISH increases with age, with an average of 10% in those aged 70 years and older. ...

    Abstract Diffuse idiopathic skeletal hyperostosis (DISH) is known to be associated with metabolic syndrome and with obesity in particular. The prevalence of DISH increases with age, with an average of 10% in those aged 70 years and older.
    Language English
    Publishing date 2024-04-15
    Publishing country Canada
    Document type Letter
    ZDB-ID 194928-7
    ISSN 1499-2752 ; 0315-162X
    ISSN (online) 1499-2752
    ISSN 0315-162X
    DOI 10.3899/jrheum.2024-0081
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    Zs.A 1168: Show issues Location:
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    Zs.MO 135: Show issues

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  3. Article ; Online: High prevalence of diffuse idiopathic skeletal hyperostosis (DISH) among obese young patients - A retrospective observational study.

    Brikman, Shay / Lubani, Yazan / Mader, Reuven / Bieber, Amir

    Seminars in arthritis and rheumatism

    2023  Volume 65, Page(s) 152356

    Abstract: Objective: Diffuse idiopathic skeletal hyperostosis (DISH) is characterized by ossification of ligaments and entheses, and most commonly affects the spinal column. The prevalence of DISH is increasing with age and is considered uncommon before the age ... ...

    Abstract Objective: Diffuse idiopathic skeletal hyperostosis (DISH) is characterized by ossification of ligaments and entheses, and most commonly affects the spinal column. The prevalence of DISH is increasing with age and is considered uncommon before the age of 50 years, with an estimated prevalence of less than 5 %. DISH is known to be highly associated with metabolic syndrome and obesity. We aim to assess the prevalence of DISH among young (≤50 yr.) patients suffering from severe obesity (BMI of 35 kg/m
    Methods: A retrospective analysis assessing chest and spine radiographs (including Computed Tomography, CT) of patients with BMI≥35 visiting the bariatric ambulatory clinic in an academic medical center from 2013 to 2022. Patients included in the analysis were 31-50 years old. Diagnosis of DISH was made according to the Resnick criteria. The prevalence of DISH was calculated. Demographic, clinical and laboratory data were collected and compared between the DISH and non-DISH groups.
    Results: 183 young (mean age: 40.4; 118 females, 64.2 %) obese (BMI median: 40.6; range 35-73) patients were included in the radiographic review. DISH was diagnosed in 33 patients (18.0 %; 95 % CI: 13.1-24.2 %) which was significantly higher than the expected 10 % (Z = 3.62, p<.001); another 8 patients (4.4 %; 95 % CI: 2.2-8.4 %) were considered as "near DISH" (not fulfilling yet the Resnick criteria) as it represents a pre-disease state. Patients diagnosed with DISH were significantly older than patients without DISH (t = 4.54, p<.001), as the prevalence of DISH increased by age (linear association=14.95, p<.001). There was a statistically significantly higher prevalence of hypertension (χ2 = 8.30, p<.004), smoking (χ2 = 4.69, p<.03) and OSA (χ2 = 6.16, p<.013) in the DISH group as compared to their non-DISH counterparts.
    Conclusion: The prevalence of DISH among obese young patients was 18 %, which is much higher than in the general population. Early-onset DISH should be regarded as a musculoskeletal obesity-related complication.
    MeSH term(s) Adult ; Female ; Humans ; Male ; Middle Aged ; Hyperostosis, Diffuse Idiopathic Skeletal/diagnostic imaging ; Hyperostosis, Diffuse Idiopathic Skeletal/epidemiology ; Obesity/complications ; Obesity/epidemiology ; Prevalence ; Retrospective Studies ; Spine
    Language English
    Publishing date 2023-12-22
    Publishing country United States
    Document type Observational Study ; Journal Article
    ZDB-ID 120247-9
    ISSN 1532-866X ; 0049-0172
    ISSN (online) 1532-866X
    ISSN 0049-0172
    DOI 10.1016/j.semarthrit.2023.152356
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    Zs.A 790: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  4. Article ; Online: Comment on Neeland et al. The Impact of Empagliflozin on Obstructive Sleep Apnea and Cardiovascular and Renal Outcomes: An Exploratory Analysis of the EMPA-REG OUTCOME Trial. Diabetes Care 2020;43:3007-3015.

    Brikman, Shay / Dori, Guy

    Diabetes care

    2021  Volume 44, Issue 6, Page(s) e136

    MeSH term(s) Benzhydryl Compounds/adverse effects ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Glucosides/adverse effects ; Humans ; Sleep Apnea, Obstructive/drug therapy ; Sleep Apnea, Obstructive/epidemiology
    Chemical Substances Benzhydryl Compounds ; Glucosides ; empagliflozin (HDC1R2M35U)
    Language English
    Publishing date 2021-05-20
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 441231-x
    ISSN 1935-5548 ; 0149-5992
    ISSN (online) 1935-5548
    ISSN 0149-5992
    DOI 10.2337/dc21-0310
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    Zs.A 1434: Show issues Location:
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    Zs.MO 365: Show issues

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  5. Article ; Online: Sodium glucose cotransporter2 inhibitor-possible treatment for patients with diabetes, pulmonary disease and CO

    Brikman, Shay / Dori, Guy

    Medical hypotheses

    2020  Volume 139, Page(s) 109631

    Abstract: Chronic pulmonary diseases such as chronic obstructive pulmonary disease, obstructive sleep apnea and obesity hypoventilation syndrome are common conditions which share decreased pulmonary ventilation and ... ...

    Abstract Chronic pulmonary diseases such as chronic obstructive pulmonary disease, obstructive sleep apnea and obesity hypoventilation syndrome are common conditions which share decreased pulmonary ventilation and CO
    MeSH term(s) Carbon Dioxide/metabolism ; Diabetes Mellitus, Type 2 ; Glucose ; Humans ; Hypoglycemic Agents/therapeutic use ; Lung Diseases/complications ; Lung Diseases/drug therapy ; Sodium ; Sodium-Glucose Transporter 2 ; Sodium-Glucose Transporter 2 Inhibitors
    Chemical Substances Hypoglycemic Agents ; Sodium-Glucose Transporter 2 ; Sodium-Glucose Transporter 2 Inhibitors ; Carbon Dioxide (142M471B3J) ; Sodium (9NEZ333N27) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2020-02-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2020.109631
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    Zs.A 1132: Show issues Location:
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  6. Article ; Online: Beta-blockers in non-surgical patients with type A aortic dissection.

    Brikman, Shay / Dori, Guy

    Medical hypotheses

    2019  Volume 128, Page(s) 76–77

    Abstract: Type A aortic dissection (TAAD) is a catastrophic condition with 24-48% mortality during the first day, if patients are not surgically treated. Due to old age and associated co-morbidities surgeons may be reluctant to operate and patients are ... ...

    Abstract Type A aortic dissection (TAAD) is a catastrophic condition with 24-48% mortality during the first day, if patients are not surgically treated. Due to old age and associated co-morbidities surgeons may be reluctant to operate and patients are administered medical therapy for the end of reducing systolic blood pressure and heart rate. Beta-blockers (BB) are the "medications of choice". Based on physical and physiological considerations, it was hypothesized that BB may actually exacerbate TAAD.
    MeSH term(s) Adrenergic beta-Antagonists/therapeutic use ; Aneurysm, Dissecting/drug therapy ; Cardiac Output/drug effects ; Cardiology/methods ; Comorbidity ; Heart Rate/drug effects ; Hemodynamics ; Humans ; Models, Theoretical ; Myocardial Contraction/drug effects ; Tunica Intima/injuries
    Chemical Substances Adrenergic beta-Antagonists
    Language English
    Publishing date 2019-05-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2019.05.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1132: Show issues Location:
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  7. Article ; Online: Acute pancreatitis in a 61-year-old man with COVID-19.

    Brikman, Shay / Denysova, Veronika / Menzal, Husam / Dori, Guy

    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

    2020  Volume 192, Issue 30, Page(s) E858–E859

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/therapy ; Humans ; Male ; Middle Aged ; Pancreatitis/diagnostic imaging ; Pancreatitis/etiology ; Pancreatitis/therapy ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/therapy ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-09-02
    Publishing country Canada
    Document type Case Reports ; Journal Article
    ZDB-ID 215506-0
    ISSN 1488-2329 ; 0008-4409 ; 0820-3946
    ISSN (online) 1488-2329
    ISSN 0008-4409 ; 0820-3946
    DOI 10.1503/cmaj.201029
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    Ua VI Zs.136: Show issues Location:
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  8. Article: The Hyper-Inflammatory Response in Adults with Severe COVID-19 Pneumonia Differs from the Cytokine Storm of Hemophagocytic Syndrome.

    Brikman, Shay / Bieber, Amir / Dori, Guy

    The Israel Medical Association journal : IMAJ

    2020  Volume 22, Issue 8, Page(s) 505–513

    Abstract: Background: In this review we described the values of commonly available HScore laboratory markers in patients with coronavirus-19 (COVID-19)-pneumonia associated cytokine storm syndrome (CPN-CSS) and compared results with those of other forms cytokine ... ...

    Abstract Background: In this review we described the values of commonly available HScore laboratory markers in patients with coronavirus-19 (COVID-19)-pneumonia associated cytokine storm syndrome (CPN-CSS) and compared results with those of other forms cytokine storm syndrome (O-CSS) to determine a pattern for CPN-CSS. Twelve CPN-CSS studies and six O-CSS studies were included. CPN-CSS typically obtained a single HScore value (e.g., aspartate transaminase > 30 U/L) while failing all other HScore criteria. A typical pattern for CPN-CSS was revealed when compared to O-CSS: lymphopenia vs. pancytopenia and increased vs. decreased fibrinogen. Findings, other than HScore commonly found in CPN-CSS studies, showed elevated lactate dehydrogenase, D-dimer, and C-reactive protein. Although CPN-CSS studies describe severely ill patients, the HScore markers are typically less toxic that O-CSS.
    MeSH term(s) Aspartate Aminotransferases/blood ; C-Reactive Protein/metabolism ; COVID-19/blood ; COVID-19/complications ; Cytokine Release Syndrome/blood ; Cytokine Release Syndrome/etiology ; Ferritins/blood ; Fibrin Fibrinogen Degradation Products/metabolism ; Fibrinogen/metabolism ; Humans ; L-Lactate Dehydrogenase/blood ; Lymphohistiocytosis, Hemophagocytic/blood ; Lymphohistiocytosis, Hemophagocytic/complications ; Lymphopenia/virology ; Pancytopenia/etiology ; Patient Acuity ; Pneumonia/blood ; Pneumonia/virology ; SARS-CoV-2
    Chemical Substances Fibrin Fibrinogen Degradation Products ; fibrin fragment D ; Fibrinogen (9001-32-5) ; C-Reactive Protein (9007-41-4) ; Ferritins (9007-73-2) ; L-Lactate Dehydrogenase (EC 1.1.1.27) ; Aspartate Aminotransferases (EC 2.6.1.1)
    Language English
    Publishing date 2020-11-24
    Publishing country Israel
    Document type Journal Article ; Review
    ZDB-ID 2008291-5
    ISSN 1565-1088 ; 0021-2180
    ISSN 1565-1088 ; 0021-2180
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5470: Show issues Location:
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  9. Article: A comparison of the power of breathing sounds signals acquired with a smart stethoscope from a cohort of COVID-19 patients at peak disease, and pre-discharge from the hospital.

    Kasim, Nour / Bachner-Hinenzon, Noa / Brikman, Shay / Cheshin, Ori / Adler, Doron / Dori, Guy

    Biomedical signal processing and control

    2022  Volume 78, Page(s) 103920

    Abstract: Objectives: To characterize the frequencies of breathing sounds signals (BS) in COVID-19 patients at peak disease and pre-discharge from hospitalization using a Smart stethoscope.: Methods: Prospective cohort study conducted during the first COVID-19 ...

    Abstract Objectives: To characterize the frequencies of breathing sounds signals (BS) in COVID-19 patients at peak disease and pre-discharge from hospitalization using a Smart stethoscope.
    Methods: Prospective cohort study conducted during the first COVID-19 wave (April-August 2020) in Israel. COVID-19 patients (n = 19) were validated by SARS-Cov-2 PCR test. The healthy control group was composed of 153 volunteers who stated that they were healthy. Power of BS was calculated in the frequency ranges of 0-20, 0-200, and 0-2000 Hz.
    Results: The power calculated over frequency ranges 0-20, 20-200, and 200-2000 Hz contributed approximately 45%, 45%, and 10% to the total power calculated over the range 0-2000 Hz, respectively. Total power calculated from the right side of the back showed an increase of 45-80% during peak disease compared with the healthy controls (p < 0.05). The power calculated over the back, in the infrasound range, 0-20 Hz, and not in the 20-2000 Hz range, was greater for the healthy controls than for patients. Using all 3 ranges of frequencies for distinguishing peak disease from healthy controls resulted in sensitivity and specificity of 84% and 91%, respectively. Omitting the 0-20 Hz range resulted in sensitivity and specificity of 74% and 67%, respectively.
    Discussion: The BS power acquired from COVID-19 patients at peak disease was significantly greater than that at pre-discharge from the hospital. The infrasound range had a significant contribution to the total power. Although the source of the infrasound is not presently clear, it may serve as an automated diagnostic tool when more clinical experience is gained with this method.
    Language English
    Publishing date 2022-06-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2241886-6
    ISSN 1746-8108 ; 1746-8094
    ISSN (online) 1746-8108
    ISSN 1746-8094
    DOI 10.1016/j.bspc.2022.103920
    Database MEDical Literature Analysis and Retrieval System OnLINE

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