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  1. Article: Clinical Considerations and Practical Advice for People Living With Type 2 Diabetes Who Undertake Regular Exercise or Aim to Exercise Competitively.

    Scott, Sam N / Hayes, Charlotte / Zeuger, Thomas / Davies, Andrew P / Andrews, Rob C / Cocks, Matthew

    Diabetes spectrum : a publication of the American Diabetes Association

    2023  Volume 36, Issue 2, Page(s) 114–126

    Abstract: This article provides practical tips for advising people with type 2 diabetes on how to engage in regular exercise safely and effectively. Its focus is on individuals who wish to exceed the minimum physical activity recommendation of 150 minutes/week of ... ...

    Abstract This article provides practical tips for advising people with type 2 diabetes on how to engage in regular exercise safely and effectively. Its focus is on individuals who wish to exceed the minimum physical activity recommendation of 150 minutes/week of moderate-intensity exercise or even compete in their chosen sport. Health care professionals who work with such individuals must have a basic understanding of glucose metabolism during exercise, nutritional requirements, blood glucose management, medications, and sport-related considerations. This article reviews three key aspects of individualized care for physically active people with type 2 diabetes:
    Language English
    Publishing date 2023-05-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2211544-4
    ISSN 1040-9165
    ISSN 1040-9165
    DOI 10.2337/dsi22-0015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6232: Show issues Location:
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  2. Article ; Online: Associations between small ruminant lentivirus infection and total milk yield and somatic cell count in a dairy sheep flock

    Davies, Peers / Jones, Scott / Dunham, Stephen / Tarlinton, Rachael E.

    Veterinary Record. 2023 June 3, v. 192, no. 11 p.e2731-

    2023  

    Abstract: BACKGROUND: Small ruminant lentiviruses (SRLVs) are lentiviruses of sheep and goats, formerly known as maedi–visna (MV) in sheep and caprine encephalitis and arthritis in goats. In sheep, SRLVs commonly cause progressive pneumonia, wasting and indurative ...

    Abstract BACKGROUND: Small ruminant lentiviruses (SRLVs) are lentiviruses of sheep and goats, formerly known as maedi–visna (MV) in sheep and caprine encephalitis and arthritis in goats. In sheep, SRLVs commonly cause progressive pneumonia, wasting and indurative mastitis. SRLVs have a long latent period, and chronic production losses are often not recognised until very late. Few studies quantifying the production losses in ewes have been published, and none have been published under UK flock husbandry conditions. METHODS: Production records of milk yield and somatic cell count (SCC) from a dairy flock of 319 milking East Friesian × Lacaune ewes identified as MV infected via routine serological screening for SRLV antibodies were used in multivariable linear regression modelling to estimate the impact of SRLV status on total milk yield and SCC. RESULTS: Milk yield was reduced in seropositive ewes by 8.1%–9.2% over an entire lactation. SCC counts were not significantly different in SRLV‐infected and unifected animals. LIMITATIONS: Further parameters, such as body condition score or clinical mastitis, that were not available may have clarified the underlying cause of milk yield drop. CONCLUSIONS: The study demonstrates substantial production losses in an SRLV‐affected flock and highlights the impact of the virus on a farm's economic viability.
    Keywords Lentivirus ; arthritis ; body condition ; dairy sheep ; economic sustainability ; encephalitis ; farms ; flocks ; goats ; lactation ; latent period ; mastitis ; milk yield ; pneumonia ; regression analysis ; seroprevalence ; sheep ; somatic cell count ; viruses
    Language English
    Dates of publication 2023-0603
    Publishing place John Wiley & Sons, Ltd
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ZDB-ID 390015-0
    ISSN 2042-7670 ; 0042-4900
    ISSN (online) 2042-7670
    ISSN 0042-4900
    DOI 10.1002/vetr.2731
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

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  3. Article ; Online: Probing Degradation in Lithium Ion Batteries with On-Chip Electrochemistry Mass Spectrometry.

    Thornton, Daisy B / Davies, Bethan J V / Scott, Soren B / Aguadero, Ainara / Ryan, Mary P / Stephens, Ifan E L

    Angewandte Chemie (International ed. in English)

    2023  Volume 63, Issue 6, Page(s) e202315357

    Abstract: The rapid uptake of lithium ion batteries (LIBs) for large scale electric vehicle and energy storage applications requires a deeper understanding of the degradation mechanisms. Capacity fade is due to the complex interplay between phase transitions, ... ...

    Abstract The rapid uptake of lithium ion batteries (LIBs) for large scale electric vehicle and energy storage applications requires a deeper understanding of the degradation mechanisms. Capacity fade is due to the complex interplay between phase transitions, electrolyte decomposition and transition metal dissolution; many of these poorly understood parasitic reactions evolve gases as a side product. Here we present an on-chip electrochemistry mass spectrometry method that enables ultra-sensitive, fully quantified and time resolved detection of volatile species evolving from an operating LIB. The technique's electrochemical performance and mass transport is described by a finite element model and then experimentally used to demonstrate the variety of new insights into LIB performance. We show the versatility of the technique, including (a) observation of oxygen evolving from a LiNiMnCoO
    Language English
    Publishing date 2023-12-29
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202315357
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  4. Article ; Online: Structured serological testing is an essential component to investigating SARS-CoV-2 reinfection.

    Pallett, Scott J C / Jones, Rachael / Randell, Paul / Davies, Gary W / Moore, Luke S P

    The Lancet. Infectious diseases

    2021  Volume 21, Issue 5, Page(s) 598–599

    MeSH term(s) COVID-19 ; Humans ; Reinfection ; SARS-CoV-2
    Language English
    Publishing date 2021-01-20
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(20)30990-7
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5743: Show issues Location:
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  5. Article ; Online: Formulation of a Composite Nasal Spray Enabling Enhanced Surface Coverage and Prophylaxis of SARS-COV-2.

    Moakes, Richard J A / Davies, Scott P / Stamataki, Zania / Grover, Liam M

    Advanced materials (Deerfield Beach, Fla.)

    2021  Volume 33, Issue 26, Page(s) e2008304

    Abstract: Airborne pathogens pose high risks in terms of both contraction and transmission within the respiratory pathways, particularly the nasal region. However, there is little in the way of adequate intervention that can protect an individual or prevent ... ...

    Abstract Airborne pathogens pose high risks in terms of both contraction and transmission within the respiratory pathways, particularly the nasal region. However, there is little in the way of adequate intervention that can protect an individual or prevent further spread. This study reports on a nasal formulation with the capacity to combat such challenges, focusing on severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Formulation of a polysaccharide-based spray, known for its mucoadhesive properties, is undertaken and it is characterized for its mechanical, spray distribution, and antiviral properties. The ability to engineer key mechanical characteristics such as dynamic yield stresses and high coverage is shown, through systematic understanding of the composite mixture containing both gellan and λ-carrageenan. Furthermore, the spray systems demonstrate highly potent capacities to prevent SARS-CoV-2 infection in Vero cells, resulting in complete inhibition when either treating, the cells, or the virus, prior to challenging for infection. From this data, a mechanism for both prophylaxis and prevention is proposed; where entrapment within a polymeric coating sterically blocks virus uptake into the cells, inactivating the virus, and allowing clearance within the viscous medium. As such, a fully preventative spray is formulated, targeted at protecting the lining of the upper respiratory pathways against SARS-CoV-2.
    MeSH term(s) Animals ; COVID-19/pathology ; COVID-19/virology ; Carrageenan/chemistry ; Chlorocebus aethiops ; Drug Compounding ; Humans ; Nasal Sprays ; Polymers/chemistry ; Polymers/pharmacology ; Polysaccharides, Bacterial/chemistry ; SARS-CoV-2/isolation & purification ; SARS-CoV-2/physiology ; Vero Cells ; Virus Internalization/drug effects
    Chemical Substances Nasal Sprays ; Polymers ; Polysaccharides, Bacterial ; gellan gum (7593U09I4D) ; Carrageenan (9000-07-1)
    Language English
    Publishing date 2021-05-31
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1474949-X
    ISSN 1521-4095 ; 0935-9648
    ISSN (online) 1521-4095
    ISSN 0935-9648
    DOI 10.1002/adma.202008304
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  6. Article ; Online: Correction to: Clinical Practice Guidelines for the Immunological Management of Chromosome 22q11.2 Deletion Syndrome and Other Defects in Thymic Development.

    Mustillo, Peter J / Sullivan, Kathleen E / Chinn, Ivan K / Notarangelo, Luigi D / Haddad, Elie / Davies, E Graham / de la Morena, Maria Teresa / Hartog, Nicholas / Yu, Joyce E / Hernandez-Trujillo, Vivian P / Ip, Winnie / Franco, Jose / Gambineri, Eleonora / Hickey, Scott E / Varga, Elizabeth / Markert, M Louise

    Journal of clinical immunology

    2024  Volume 44, Issue 2, Page(s) 53

    Language English
    Publishing date 2024-01-22
    Publishing country Netherlands
    Document type Published Erratum
    ZDB-ID 779361-3
    ISSN 1573-2592 ; 0271-9142
    ISSN (online) 1573-2592
    ISSN 0271-9142
    DOI 10.1007/s10875-024-01655-3
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1640: Show issues Location:
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  7. Article ; Online: A Machine Learning-Based Image Segmentation Method to Quantify In Vitro Osteoclast Culture Endpoints.

    Davies, Bethan K / Hibbert, Andrew P / Roberts, Scott J / Roberts, Helen C / Tickner, Jennifer C / Holdsworth, Gill / Arnett, Timothy R / Orriss, Isabel R

    Calcified tissue international

    2023  Volume 113, Issue 4, Page(s) 437–448

    Abstract: ... detected a 70% reduction (p < 0.05) in osteoclast number, when cultured with 10 nM zoledronate and a dose ... dependent decrease with 1-10 μM ticagrelor (p < 0.05). Co-culture with MCF7 cells increased osteoclast ...

    Abstract Quantification of in vitro osteoclast cultures (e.g. cell number) often relies on manual counting methods. These approaches are labour intensive, time consuming and result in substantial inter- and intra-user variability. This study aimed to develop and validate an automated workflow to robustly quantify in vitro osteoclast cultures. Using ilastik, a machine learning-based image analysis software, images of tartrate resistant acid phosphatase-stained mouse osteoclasts cultured on dentine discs were used to train the ilastik-based algorithm. Assessment of algorithm training showed that osteoclast numbers strongly correlated between manual- and automatically quantified values (r = 0.87). Osteoclasts were consistently faithfully segmented by the model when visually compared to the original reflective light images. The ability of this method to detect changes in osteoclast number in response to different treatments was validated using zoledronate, ticagrelor, and co-culture with MCF7 breast cancer cells. Manual and automated counting methods detected a 70% reduction (p < 0.05) in osteoclast number, when cultured with 10 nM zoledronate and a dose-dependent decrease with 1-10 μM ticagrelor (p < 0.05). Co-culture with MCF7 cells increased osteoclast number by ≥ 50% irrespective of quantification method. Overall, an automated image segmentation and analysis workflow, which consistently and sensitively identified in vitro osteoclasts, was developed. Advantages of this workflow are (1) significantly reduction in user variability of endpoint measurements (93%) and analysis time (80%); (2) detection of osteoclasts cultured on different substrates from different species; and (3) easy to use and freely available to use along with tutorial resources.
    MeSH term(s) Mice ; Animals ; Osteoclasts ; Bone Resorption ; Zoledronic Acid ; Ticagrelor ; Coculture Techniques ; Cells, Cultured ; Acid Phosphatase/analysis ; Tartrate-Resistant Acid Phosphatase ; Cell Differentiation
    Chemical Substances Zoledronic Acid (6XC1PAD3KF) ; Ticagrelor (GLH0314RVC) ; Acid Phosphatase (EC 3.1.3.2) ; Tartrate-Resistant Acid Phosphatase (EC 3.1.3.2)
    Language English
    Publishing date 2023-08-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 304266-2
    ISSN 1432-0827 ; 0944-0747 ; 0008-0594 ; 0171-967X
    ISSN (online) 1432-0827
    ISSN 0944-0747 ; 0008-0594 ; 0171-967X
    DOI 10.1007/s00223-023-01121-z
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 317: Show issues Location:
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  8. Article ; Online: Managing mpox using a remote monitoring service.

    Rayment, Michael / Cole, Stephen / Heskin, Joseph / Khan, Sadia / Wright, Mike / Barrett, Jodian / Bird, James / Scott, Christopher / Byrne, Ruth / Girometti, Nicolo / Dosekun, Olamide / McSorley, John / Wallis, Gabriel / Bull, Lauren / Randell, Paul / Mughal, Nabeela / Moore, Luke S P / Davies, Gary W / Jones, Rachael

    The Journal of infection

    2023  Volume 87, Issue 2, Page(s) e36–e38

    MeSH term(s) Humans ; Mpox (monkeypox)/therapy ; Remote Consultation
    Language English
    Publishing date 2023-06-08
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2023.06.001
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  9. Article ; Online: Expression of E-cadherin by CD8

    Davies, Scott P / Ronca, Vincenzo / Wootton, Grace E / Krajewska, Natalia M / Bozward, Amber G / Fiancette, Rémi / Patten, Daniel A / Yankouskaya, Katharina / Reynolds, Gary M / Pat, Sofia / Osei-Bordom, Daniel C / Richardson, Naomi / Grover, Liam M / Weston, Christopher J / Oo, Ye H

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 853

    Abstract: The presence of ... ...

    Abstract The presence of CD8
    MeSH term(s) Humans ; Bile Ducts/metabolism ; Liver Cirrhosis, Biliary/pathology ; CD8-Positive T-Lymphocytes/metabolism ; Epithelial Cells/metabolism ; Cadherins/metabolism
    Chemical Substances Cadherins
    Language English
    Publishing date 2024-01-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-44910-2
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  10. Article ; Online: A Milestone In Botanical Mosquito Repellents: Novel PMD-Based Formulation Protects More Than Twice As Long As High-Concentration Deet and Other Leading Products.

    Carroll, Scott P / Venturino, Jeffrey / Davies, John H

    Journal of the American Mosquito Control Association

    2019  Volume 35, Issue 3, Page(s) 186–191

    Abstract: The use of skin-applied repellents is the primary method recommended by the Centers for Disease Control and Prevention for personal protection against biting mosquitoes. Historically, the majority of long-efficacy mosquito repellents have ... ...

    Abstract The use of skin-applied repellents is the primary method recommended by the Centers for Disease Control and Prevention for personal protection against biting mosquitoes. Historically, the majority of long-efficacy mosquito repellents have been
    MeSH term(s) Adult ; Aedes ; Animals ; Culex ; Cyclohexane Monoterpenes ; Female ; Humans ; Insect Repellents ; Male ; Menthol/analogs & derivatives ; Middle Aged ; Mosquito Control ; Mosquito Vectors ; Plant Extracts ; Young Adult
    Chemical Substances Cyclohexane Monoterpenes ; Insect Repellents ; Plant Extracts ; citriodiol ; Menthol (1490-04-6) ; terpin (MPF495B08R)
    Language English
    Publishing date 2019-10-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 632618-3
    ISSN 1943-6270 ; 8756-971X
    ISSN (online) 1943-6270
    ISSN 8756-971X
    DOI 10.2987/19-6824.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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