LIVIVO - Search results -

Search results

Result 1 - 10 of total 1461

Search options

Article ; Online: Relative Efficacy of Vitamin D

Balachandar, Rakesh / Pullakhandam, Raghu / Kulkarni, Bharati / Sachdev, Harshpal Singh

2021 Volume 13, Issue 10

Abstract: Background: Widespread prevalence of vitamin D deficiency has been documented globally. Commonly ... with either ergocalciferol (vitamin D: Methods: Randomized and non-randomized controlled studies evaluating relative ... cholecalciferol intervention was more efficacious in improving vitamin D status (serum levels of total 25(OH)D and ...

Abstract	Background: Widespread prevalence of vitamin D deficiency has been documented globally. Commonly used interventions to address this deficiency include supplementation and/or fortification with either ergocalciferol (vitamin D Methods: Randomized and non-randomized controlled studies evaluating relative efficacy of ergocalciferol and cholecalciferol were systematically reviewed to synthesize quantitative and qualitative evidence as per the recommendations of according to "Preferred Reporting Items for Systematic reviews and Meta-analysis" guidelines. Search terms were constructed on the basis of the "participants", "intervention", "control", "outcome" and "study type" (PICOS) strategy to systematically search the popular electronic databases. Relevant data from studies meeting inclusion and exclusion criteria were extracted and analyzed. Meta-regression, subgroup and sensitivity analyses were performed to investigate the influence of study-level characteristics including intervention dosage, frequency of dosing, interval between the last dose and test for outcome assessment, participant characteristics and analytical methods. Results: Apparently healthy human participants ( Conclusions: Compared to ergocalciferol, cholecalciferol intervention was more efficacious in improving vitamin D status (serum levels of total 25(OH)D and 25(OH)D
MeSH term(s)	Cholecalciferol/blood ; Ergocalciferols/blood ; Humans ; Multivariate Analysis ; Parathyroid Hormone/blood ; Publication Bias ; Regression Analysis ; Risk
Chemical Substances	Ergocalciferols ; Parathyroid Hormone ; Cholecalciferol (1C6V77QF41)
Language	English
Publishing date	2021-09-23
Publishing country	Switzerland
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu13103328
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Association of maternal vitamin D status with the risk of preeclampsia.

Nema, Juhi / Wadhwani, Nisha / Randhir, Karuna / Dangat, Kamini / Pisal, Hemlata / Kadam, Vrushali / Mehendale, Savita / Wagh, Girija / Kulkarni, Bharati / Sachdev, Harshpal Singh / Fall, Caroline / Gupte, Sanjay / Joshi, Sadhana

Food & function

2023 Volume 14, Issue 10, Page(s) 4859–4865

Abstract: The aim of this study was to examine serum vitamin D concentrations from early pregnancy ... vitamin D concentrations (25(OH)D) were estimated in their samples using commercially available ELISA kits ...

Abstract	The aim of this study was to examine serum vitamin D concentrations from early pregnancy until delivery in women who did and did not develop preeclampsia. This longitudinal study was carried out in Pune, India. A total of 1154 women with singleton pregnancies were recruited in early pregnancy from two hospitals. Blood samples were collected and stored at four time points across gestation: V1 = 11-14 weeks, V2 = 18-22 weeks, V3 = 26-28 weeks and V4 = at delivery. 108 women who developed preeclampsia (PE) and 216 who did not develop PE (Non-PE) were randomly selected from the remainder. Serum 25-hydroxy vitamin D concentrations (25(OH)D) were estimated in their samples using commercially available ELISA kits. Independent
MeSH term(s)	Pregnancy ; Female ; Humans ; Pre-Eclampsia/epidemiology ; Longitudinal Studies ; India/epidemiology ; Vitamin D ; Vitamins ; Vitamin D Deficiency/complications
Chemical Substances	Vitamin D (1406-16-2) ; Vitamins
Language	English
Publishing date	2023-05-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2612033-1
ISSN	2042-650X ; 2042-6496
ISSN (online)	2042-650X
ISSN	2042-6496
DOI	10.1039/d3fo00007a
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Bonn / Germany

Z 7872: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Prevalence and Correlates of Vitamin D Deficiency Among Children and Adolescents From a Nationally Representative Survey in India.

Rana, Garima / Abraham, Ransi Ann / Sachdev, Harshpal Singh / Nair, K Madhavan / Kumar, Geeta Trilok / Agarwal, Praween Kumar / Johnston, Robert / Wagt, Arjan De / Sarna, Avina / Acharya, Rajib / Porwal, Akash / Khan, Nizamuddin / Ramesh, Sowmya / Bharti, Rahul / Kalaivani, M / Ramakrishnan, Lakshmy

Indian pediatrics

2023 Volume 60, Issue 3, Page(s) 202–206

Abstract: Objective: To evaluate the prevalence of vitamin D deficiency (VDD) and its correlates ...

Abstract	Objective: To evaluate the prevalence of vitamin D deficiency (VDD) and its correlates among apparently healthy children and adolescents. Methods: We carried out a secondary analysis of data of Comprehensive National Nutrition Survey 2016-18 to analyze the pre-valence and predictors of VDD among Indian children and adolescents. Results: The over-all prevalence of VDD in preschool children (1-4 years), school age (5-9 years) children, and adolescents (10-19 years) was 13.7%, 18.2%, and 23.9%, respectively. Age, living in urban area, and winter season were significantly associated with VDD. Vegetarian diet and high-income households were the main risk factors observed in 5-19 years age category. Female sex and less than three hour of physical activity/week were independent risk factors among adolescents. Conclusion: The prevalence and determinants of VDD across different age-groups are reported, and these should be interpreted and addressed to decrease the burden of VDD in India.
MeSH term(s)	Child, Preschool ; Humans ; Female ; Adolescent ; Child ; Vitamin D ; Prevalence ; Vitamin D Deficiency/epidemiology ; Nutritional Status ; India/epidemiology
Chemical Substances	Vitamin D (1406-16-2)
Language	English
Publishing date	2023-01-02
Publishing country	India
Document type	Journal Article
ZDB-ID	402594-5
ISSN	0974-7559 ; 0019-6061
ISSN (online)	0974-7559
ISSN	0019-6061
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 859: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Indian Academy of Pediatrics Revised (2021) Guidelines on Prevention and Treatment of Vitamin D Deficiency and Rickets.

Indian pediatrics

2021 Volume 59, Issue 2, Page(s) 142–158

Abstract: Justification: The emerging literature on prevalence of vitamin D deficiency in India, prevention ... and treatment strategies of rickets, and extra-skeletal benefits of vitamin D suggest the need ... for revising the existing guidelines for prevention and treatment of vitamin D deficiency in India ...

Abstract	Justification: The emerging literature on prevalence of vitamin D deficiency in India, prevention and treatment strategies of rickets, and extra-skeletal benefits of vitamin D suggest the need for revising the existing guidelines for prevention and treatment of vitamin D deficiency in India. Objectives: To review the emerging literature on vitamin D prevalence and need for universal vitamin D supplementation. To suggest optimum vitamin D therapy for treatment of asymptomatic and symptomatic vitamin D deficiency, and rickets. To evaluate the extra-skeletal health benefits of vitamin D in children. Process: A National consultative committee was formed that comprised of clinicians, epidemiologists, endocrinologists, and nutritionists. The Committee conducted deliberations on different aspects of vitamin D deficiency and rickets through ten online meetings between March and September, 2021. A draft guideline was formulated, which was reviewed and approved by all Committee members. Recommendations: The group reiterates the serum 25-hydroxy vitamin D cutoffs proposed for vitamin D deficiency, insufficiency, and sufficiency as <12 ng/mL, 12-20 ng/mL and >20 ng/mL, respectively. Vitamin D toxicity is defined as serum 25OHD >100 ng/mL with hypercalcemia and/or hypercalciuria. Vitamin D supplementation in doses of 400 IU/day is recommended during infancy; however, the estimated average requirement in older children and adolescents (400-600 IU/day, respectively) should be met from diet and natural sources like sunlight. Rickets and vitamin D deficiency should be treated with oral cholecalciferol, preferably in a daily dosing schedule (2000 IU below 1 year of age and 3000 IU in older children) for 12 weeks. If compliance to daily dosing cannot be ensured, intermittent regimens may be prescribed for children above 6 months of age. Universal vitamin D supplementation is not recommended in childhood pneumonia, diarrhea, tuberculosis, HIV and non-infectious conditions like asthma, atopic dermatitis, and developmental disorders. Serum 25-hydroxy vitamin D level of >20 ng/mL should be maintained in children with conditions at high-risk for vitamin deficiency, like nephrotic syndrome, chronic liver disease, chronic renal failure, and intake of anticonvulsants or glucocorticoids.
MeSH term(s)	Adolescent ; Child ; Cholecalciferol/therapeutic use ; Dietary Supplements ; Humans ; Pediatrics ; Rickets/drug therapy ; Rickets/prevention & control ; Vitamin D ; Vitamin D Deficiency/drug therapy ; Vitamin D Deficiency/epidemiology ; Vitamin D Deficiency/prevention & control ; Vitamins/therapeutic use
Chemical Substances	Vitamins ; Vitamin D (1406-16-2) ; Cholecalciferol (1C6V77QF41)
Language	English
Publishing date	2021-12-29
Publishing country	India
Document type	Journal Article
ZDB-ID	402594-5
ISSN	0974-7559 ; 0019-6061
ISSN (online)	0974-7559
ISSN	0019-6061
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 859: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: A Non-immunogenic Bivalent d-Protein Potently Inhibits Retinal Vascularization and Tumor Growth.

Marinec, Paul S / Landgraf, Kyle E / Uppalapati, Maruti / Chen, Gang / Xie, Daniel / Jiang, Qiyang / Zhao, Yanlong / Petriello, Annalise / Deshayes, Kurt / Kent, Stephen B H / Ault-Riche, Dana / Sidhu, Sachdev S

ACS chemical biology

2021 Volume 16, Issue 3, Page(s) 548–556

Abstract: We report a general approach to engineering multivalent d-proteins with antibody-like activities ...

Abstract	We report a general approach to engineering multivalent d-proteins with antibody-like activities
MeSH term(s)	Amino Acid Sequence ; Animals ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Bevacizumab/pharmacology ; Binding Sites ; Drug Evaluation, Preclinical ; Eye/drug effects ; Female ; Humans ; Mice ; Models, Molecular ; Neoplasms/drug therapy ; Peptide Library ; Peptides/chemistry ; Peptides/pharmacology ; Protein Binding ; Protein Conformation ; Protein Multimerization ; Rabbits ; Receptors, Vascular Endothelial Growth Factor/chemistry ; Receptors, Vascular Endothelial Growth Factor/metabolism ; Retinal Vessels/drug effects ; Vascular Endothelial Growth Factor A/antagonists & inhibitors
Chemical Substances	Antineoplastic Agents ; Peptide Library ; Peptides ; Vascular Endothelial Growth Factor A ; Bevacizumab (2S9ZZM9Q9V) ; Receptors, Vascular Endothelial Growth Factor (EC 2.7.10.1)
Language	English
Publishing date	2021-02-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1554-8937
ISSN (online)	1554-8937
DOI	10.1021/acschembio.1c00017
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Retraction Note to: Changes in Cathepsin D and Beclin-1 mRNA and protein expression by the excitotoxin quinolinic acid in human astrocytes and neurons.

Braidy, Nady / Brew, Bruce J / Inestrosa, Nibaldo C / Chung, Roger / Sachdev, Perminder / Guillemin, Gilles J

Metabolic brain disease

2023 Volume 38, Issue 6, Page(s) 2197

Language	English
Publishing date	2023-06-05
Publishing country	United States
Document type	Retraction of Publication
ZDB-ID	632824-6
ISSN	1573-7365 ; 0885-7490
ISSN (online)	1573-7365
ISSN	0885-7490
DOI	10.1007/s11011-023-01241-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 2155: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Vitamin D Sufficiency through Sunshine in Infants?

Goswami, R / S Sachdev, H P

Indian pediatrics

2017 Volume 54, Issue 2, Page(s) 103–104

MeSH term(s)	Humans ; Infant ; Sunlight ; Vitamin D ; Vitamin D Deficiency ; Vitamins
Chemical Substances	Vitamins ; Vitamin D (1406-16-2)
Language	English
Publishing date	2017-02-21
Publishing country	India
Document type	Journal Article ; Comment
ZDB-ID	402594-5
ISSN	0974-7559 ; 0019-6061
ISSN (online)	0974-7559
ISSN	0019-6061
DOI	10.1007/s13312-017-1009-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 859: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: D-(+)-Pinitol, an oviposition stimulant for the pipevine swallowtail butterfly,Battus philenor.

Papaj, D R / Feeny, P / Sachdev-Gupta, K / Rosenberry, L

Journal of chemical ecology

2013 Volume 18, Issue 5, Page(s) 799–815

Abstract: ... by contact with alcoholic extracts of host foliage.D-(+)-Pinitol was isolated and identified from leaf ...

Abstract	Oviposition by females of the pipevine swallowtail butterfly,Battus philenor, was stimulated by contact with alcoholic extracts of host foliage.D-(+)-Pinitol was isolated and identified from leaf material of one host species,Aristolochia macrophylla (Aristolochiaceae). In combination with chloroform-soluble components of host leaf material, this compound was comparable to the parent extract in stimulating oviposition.
Language	English
Publishing date	2013-11-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	800130-3
ISSN	1573-1561 ; 0098-0331
ISSN (online)	1573-1561
ISSN	0098-0331
DOI	10.1007/BF00994616
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Bonn / Germany

Z 76/724: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article: Relative Efficacy of Vitamin D2 and Vitamin D3 in Improving Vitamin D Status: Systematic Review and Meta-Analysis

Balachandar, Rakesh / Pullakhandam, Raghu / Kulkarni, Bharati / Sachdev, Harshpal Singh

Nutrients. 2021 Sept. 23, v. 13, no. 10

2021

Abstract: Background: Widespread prevalence of vitamin D deficiency has been documented globally. Commonly ... cholecalciferol (vitamin D₃) for raising the serum levels of vitamin D metabolites and functional indicators ... The quantitative analysis suggested higher efficacy of cholecalciferol than ergocalciferol in improving total 25(OH)D (mean ...

Abstract	Background: Widespread prevalence of vitamin D deficiency has been documented globally. Commonly used interventions to address this deficiency include supplementation and/or fortification with either ergocalciferol (vitamin D₂) or cholecalciferol (vitamin D₃), but the relative efficacy of these two vitamers is unclear. The current study aimed to evaluate the relative efficacy of ergocalciferol (vitamin D₂) and cholecalciferol (vitamin D₃) for raising the serum levels of vitamin D metabolites and functional indicators including serum parathyroid (PTH) levels, isometric muscle strength, hand grip strength and bone mineral density. Methods: Randomized and non-randomized controlled studies evaluating relative efficacy of ergocalciferol and cholecalciferol were systematically reviewed to synthesize quantitative and qualitative evidence as per the recommendations of according to “Preferred Reporting Items for Systematic reviews and Meta-analysis” guidelines. Search terms were constructed on the basis of the “participants”, “intervention”, “control”, “outcome” and “study type” (PICOS) strategy to systematically search the popular electronic databases. Relevant data from studies meeting inclusion and exclusion criteria were extracted and analyzed. Meta-regression, subgroup and sensitivity analyses were performed to investigate the influence of study-level characteristics including intervention dosage, frequency of dosing, interval between the last dose and test for outcome assessment, participant characteristics and analytical methods. Results: Apparently healthy human participants (n = 1277) from 24 studies were included for meta-analysis. The quantitative analysis suggested higher efficacy of cholecalciferol than ergocalciferol in improving total 25(OH)D (mean difference: 15.69, 95%CI: 9.46 to 21.93 nmol/L) and reducing PTH levels, consistently across variable participant demographics, dosage and vehicle of supplementation. Meta-regression suggested smaller differences in the efficacy of cholecalciferol and ergocalciferol at lower doses. Average daily dose was the single significant predictor of effect size, as revealed by multivariate meta-regression analysis. Conclusions: Compared to ergocalciferol, cholecalciferol intervention was more efficacious in improving vitamin D status (serum levels of total 25(OH)D and 25(OH)D₃) and regulating PTH levels, irrespective of the participant demographics, dosage and vehicle of supplementation.
Keywords	average daily intake ; blood serum ; bone density ; cholecalciferol ; demographic statistics ; ergocalciferol ; hand strength ; humans ; meta-analysis ; metabolites ; quantitative analysis ; regression analysis ; systematic review
Language	English
Dates of publication	2021-0923
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu13103328
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Article ; Online: A Potent d-Protein Antagonist of VEGF-A is Nonimmunogenic, Metabolically Stable, and Longer-Circulating in Vivo.

Uppalapati, Maruti / Lee, Dong Jun / Mandal, Kalyaneswar / Li, Hongyan / Miranda, Les P / Lowitz, Joshua / Kenney, John / Adams, Jarrett J / Ault-Riché, Dana / Kent, Stephen B H / Sidhu, Sachdev S

ACS chemical biology

2016 Volume 11, Issue 4, Page(s) 1058–1065

Abstract: Polypeptides composed entirely of d-amino acids and the achiral amino acid glycine (d-proteins ... agent. Specifically, d-proteins are resistant to degradation by proteases and are anticipated to be ... nonimmunogenic. Furthermore, d-proteins are manufactured chemically and can be engineered to have other desirable ...

Abstract	Polypeptides composed entirely of d-amino acids and the achiral amino acid glycine (d-proteins) inherently have in vivo properties that are proposed to be near-optimal for a large molecule therapeutic agent. Specifically, d-proteins are resistant to degradation by proteases and are anticipated to be nonimmunogenic. Furthermore, d-proteins are manufactured chemically and can be engineered to have other desirable properties, such as improved stability, affinity, and pharmacokinetics. Thus, a well-designed d-protein therapeutic would likely have significant advantages over l-protein drugs. Toward the goal of developing d-protein therapeutics, we previously generated RFX001.D, a d-protein antagonist of natural vascular endothelial growth factor A (VEGF-A) that inhibited binding to its receptor. However, RFX001.D is unstable at physiological temperatures (Tm = 33 °C). Here, we describe RFX037.D, a variant of RFX001.D with extreme thermal stability (Tm > 95 °C), high affinity for VEGF-A (Kd = 6 nM), and improved receptor blocking. Comparison of the two enantiomeric forms of RFX037 revealed that the d-protein is more stable in mouse, monkey, and human plasma and has a longer half-life in vivo in mice. Significantly, RFX037.D was nonimmunogenic in mice, whereas the l-enantiomer generated a strong immune response. These results confirm the potential utility of synthetic d-proteins as alternatives to therapeutic antibodies.
MeSH term(s)	Calibration ; Circular Dichroism ; Humans ; Mass Spectrometry ; Reference Standards ; Surface Plasmon Resonance ; Vascular Endothelial Growth Factor A/antagonists & inhibitors
Chemical Substances	Vascular Endothelial Growth Factor A
Language	English
Publishing date	2016-04-15
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ISSN	1554-8937
ISSN (online)	1554-8937
DOI	10.1021/acschembio.5b01006
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED